Professor | Bowen Wu | Asia Growth Partners

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Name	Bowen Wu
Contact Information	bowen_wu@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

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Name

Bowen Wu

Contact Information

bowen_wu@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	2007.09-2011.06 Bachelor's Degree: China Pharmaceutical University, Pharmacy 2011.09-2016.06 PhD: Zhejiang University, Pharmacology, Supervisor: Professor Lou Yijia Supported by National Youth Talent Project
Work Experience	2016.10-2021.05 - Stanford University - Postdoctoral Researcher, Co-supervisor: Cornelia M. Weyand 2021.05-2022.08 - Mayo Clinic - Research Associate 2022.10-Present - Zhejiang University - Researcher under the 'Hundred Talents Program'

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

2007.09-2011.06 Bachelor's Degree: China Pharmaceutical University, Pharmacy
2011.09-2016.06 PhD: Zhejiang University, Pharmacology, Supervisor: Professor Lou Yijia
Supported by National Youth Talent Project

Work Experience

2016.10-2021.05 - Stanford University - Postdoctoral Researcher, Co-supervisor: Cornelia M. Weyand
2021.05-2022.08 - Mayo Clinic - Research Associate
2022.10-Present - Zhejiang University - Researcher under the 'Hundred Talents Program'

Areas of Focus	Autoimmune Diseases Immunometabolism
Publications	Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation, Wu B, Zhao TV, Jin K, Hu Z, Abdel MP, Warrington KJ, Goronzy JJ, Weyand CM, 2021 Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells, Wu B, Qiu J, Zhao TV, Wang Y, Maeda T, Goronzy IN, Akiyama M, Ohtsuki S, Jin K, Tian L, Goronzy JJ, Weyand CM, 2020 A new way to maintain CD8(+) T-cell quiescence: interaction between CD8alpha and PILRalpha, Jin, K., and Wu, B., 2022 Metabolic Fitness of T Cells in Autoimmune Disease, Wu B, Goronzy JJ, Weyand CM, 2020 The metabolic signature of T cells in rheumatoid arthritis, Weyand CM, Wu B, Goronzy JJ, 2020 Peroxiredoxin-2 nitrosylation facilitates cardiomyogenesis of mouse embryonic stem cells via XBP-1s/PI3K pathway, Wu B, Yu H, Wang Y, Pan Z, Zhang Y, Li T, Li L, Zhang W, Ge L, Chen Y, Ho CK, Zhu D, Huang X, Lou Y, 2016 The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages, Hu, Z., Zhao, T.V., Huang, T., Ohtsuki, S., Jin, K., Goronzy, I.N., Wu, B., Abdel, M.P., Bettencourt, J.W., Berry, G.J., 2022 NOTCH-induced rerouting of endosomal trafficking disables regulatory T-cells in vasculitis, Jin K, Wen Z, Wu B, Zhang H, Qiu J, Wang Y, Warrington KJ, Berry G, Goronzy JJ, Weyand CM, 2021 The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation, Li Y, Shen Y, Jin K, Wen Z, Cao W, Wu B, Wen R, Tian L, Berry GJ, Goronzy JJ, Weyand CM, 2019 N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation, Wen Z, Jin K, Shen Y, Yang Z, Li Y, Wu B, Tian L, Shoor S, Roche NE, Goronzy JJ, Weyand CM, 2019 Premalignant alteration assessment in liver-like tissue derived from embryonic stem cells by aristolochic acid I exposure, Li T, Jin K, Zhu DY, Li L, Mao ZR, Wu BW, Wang YF, Pan ZF, Li LJ, Xiang CS, Su KK, Lou YJ, 2016 Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion, Li L, Pan ZF, Huang X, Wu BW, Li T, Kang MX, Ge RS, Hu XY, Zhang YH, Ge LJ, Zhu DY, Wu YL, Lou YJ, 2016 Hepatic Premalignant Alterations Triggered by Human Nephrotoxin Aristolochic Acid I in Canines, Jin K, Su KK, Li T, Zhu XQ, Wang Q, Ge RS, Pan ZF, Wu BW, Ge LJ, Zhang YH, Wang YF, Shen GF, Zhu DY, Xiang CS, Li LJ, Lou YJ, 2016 Peroxisome proliferator-activated receptorbeta/delta activation is essential for modulating p-Foxo1/Foxo1 status in functional insulin-positive cell differentiation, Li L, Li T, Zhang Y, Pan Z, Wu B, Huang X, Zhang Y, Mei Y, Ge L, Shen G, Ge RS, Zhu D, Lou Y, 2015 The outstanding antitumor capacity of CD4(+) T helper lymphocytes, Li T, Wu B, Yang T, Zhang L, Jin K, 2020 [Expression of Junctophilin 1 during cardiogenesis of mouse embryonic stem cells and rat embryos], Liang, X.G., Wu, B.W., Zhang, W.C., Zhou, L.M., Zhu, D.Y., and Lou, Y.J, 2012 [Embryonic stem cells and regeneration-promoting drug research & development], Lou, Y.J., Li, L., and Wu, B.W., 2012

Areas of Focus

Autoimmune Diseases
Immunometabolism

Publications

Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation, Wu B, Zhao TV, Jin K, Hu Z, Abdel MP, Warrington KJ, Goronzy JJ, Weyand CM, 2021
Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells, Wu B, Qiu J, Zhao TV, Wang Y, Maeda T, Goronzy IN, Akiyama M, Ohtsuki S, Jin K, Tian L, Goronzy JJ, Weyand CM, 2020
A new way to maintain CD8(+) T-cell quiescence: interaction between CD8alpha and PILRalpha, Jin, K., and Wu, B., 2022
Metabolic Fitness of T Cells in Autoimmune Disease, Wu B, Goronzy JJ, Weyand CM, 2020
The metabolic signature of T cells in rheumatoid arthritis, Weyand CM, Wu B, Goronzy JJ, 2020
Peroxiredoxin-2 nitrosylation facilitates cardiomyogenesis of mouse embryonic stem cells via XBP-1s/PI3K pathway, Wu B, Yu H, Wang Y, Pan Z, Zhang Y, Li T, Li L, Zhang W, Ge L, Chen Y, Ho CK, Zhu D, Huang X, Lou Y, 2016
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages, Hu, Z., Zhao, T.V., Huang, T., Ohtsuki, S., Jin, K., Goronzy, I.N., Wu, B., Abdel, M.P., Bettencourt, J.W., Berry, G.J., 2022
NOTCH-induced rerouting of endosomal trafficking disables regulatory T-cells in vasculitis, Jin K, Wen Z, Wu B, Zhang H, Qiu J, Wang Y, Warrington KJ, Berry G, Goronzy JJ, Weyand CM, 2021
The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation, Li Y, Shen Y, Jin K, Wen Z, Cao W, Wu B, Wen R, Tian L, Berry GJ, Goronzy JJ, Weyand CM, 2019
N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation, Wen Z, Jin K, Shen Y, Yang Z, Li Y, Wu B, Tian L, Shoor S, Roche NE, Goronzy JJ, Weyand CM, 2019
Premalignant alteration assessment in liver-like tissue derived from embryonic stem cells by aristolochic acid I exposure, Li T, Jin K, Zhu DY, Li L, Mao ZR, Wu BW, Wang YF, Pan ZF, Li LJ, Xiang CS, Su KK, Lou YJ, 2016
Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion, Li L, Pan ZF, Huang X, Wu BW, Li T, Kang MX, Ge RS, Hu XY, Zhang YH, Ge LJ, Zhu DY, Wu YL, Lou YJ, 2016
Hepatic Premalignant Alterations Triggered by Human Nephrotoxin Aristolochic Acid I in Canines, Jin K, Su KK, Li T, Zhu XQ, Wang Q, Ge RS, Pan ZF, Wu BW, Ge LJ, Zhang YH, Wang YF, Shen GF, Zhu DY, Xiang CS, Li LJ, Lou YJ, 2016
Peroxisome proliferator-activated receptorbeta/delta activation is essential for modulating p-Foxo1/Foxo1 status in functional insulin-positive cell differentiation, Li L, Li T, Zhang Y, Pan Z, Wu B, Huang X, Zhang Y, Mei Y, Ge L, Shen G, Ge RS, Zhu D, Lou Y, 2015
The outstanding antitumor capacity of CD4(+) T helper lymphocytes, Li T, Wu B, Yang T, Zhang L, Jin K, 2020
[Expression of Junctophilin 1 during cardiogenesis of mouse embryonic stem cells and rat embryos], Liang, X.G., Wu, B.W., Zhang, W.C., Zhou, L.M., Zhu, D.Y., and Lou, Y.J, 2012
[Embryonic stem cells and regeneration-promoting drug research & development], Lou, Y.J., Li, L., and Wu, B.W., 2012

Autoimmune Diseases Immunometabolism Rheumatoid Arthritis T Cells Metabolic Regulation Inflammation Mitochondria Tnf Biogenesis Tissue Inflammation Therapeutic Targets

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