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Xuefei Zhou
Medical School
Zhejiang University
Zhejiang
Language: English, Chinese
Nucleic Acid
Drug Delivery
Nano Carrier
Tumor
Immunotherapy
Microenvironment
Gene Therapy
Polymer
Autophagy
Fibrosis
Areas of Focus
- Nucleic Acid Drug Delivery
- Nano Drug Carrier Design
- Tumor Immunotherapy
- Tumor Microenvironment Regulation
Work Experience
- 2021.01-present - Zhejiang University Fourth Affiliated Hospital - Associate Researcher
Academic Background & Achievements
- 2011-2015 Bachelor of Engineering: Zhejiang University, College of Chemical and Biological Engineering
- 2015-2020 Doctor of Engineering: Zhejiang University, College of Chemical and Biological Engineering (National Scholarship, Zhejiang Province Outstanding Graduate)
- 2018-2020 Joint PhD Student: University of North Carolina at Chapel Hill (CSC funded, Co-supervisor: Leaf Huang)
Publications
- RNA-based modulation of macrophage-mediated efferocytosis potentiates antitumor immunity in colorectal cancer, X. Zhou*, D. Li, S. Xia, X. Ma, R. Li, Y. Mu, Z. Liu, L. Zhang, Q. Zhou, W. Zhuo, K. Ding, A. Lin, W. Liu, X. Liu*, T. Zhou*, 2024
- Impact of protein corona and PEGylation on the accumulation and efficacy of lysosome-disrupting lipid nanoparticles in KRAS-mutated cancer, H. Yang, J. Wang, X. Zhou, D. Fu, C. Le, J. Wei, Y. Qian, Y. Fang, T. Jin, X. Kong, C. Yu, D. Song, Y. Wang, X. Zhou, T. Zhou, Q. Zhou, X. Liu, Q. Xiao, K. Ding, 2024
- Sulfoxide-containing polymers conjugated prodrug micelles with enhanced anticancer activity and reduced intestinal toxicity, Y. Wang, J. Wang, J. Li, Y. Mu, J. Ying, Z. Liu, M. Wu, Y. Geng, X. Zhou, T. Zhou, Y. Shen, L. Sun, X. Liu, Q. Zhou, 2024
- Protein Kinase STK24 Promotes Tumor Immune Evasion via the AKT-PD-L1 Axis, N. Wang, Y. Jiang, M. Li, H. Wang, J. Pan, Y. Tang, S. Xie, Y. Xu, X. Li, X. Zhou, P. Xu, W. Lin, X. Wang, 2024
- Neutrophil Extracellular Traps-Inhibiting and Fouling-Resistant Polysulfoxides Potently Prevent Postoperative Adhesion, Tumor Recurrence, and Metastasis, J. Wang, Y. Wang, J. Li, J. Ying, Y. Mu, X. Zhang, X. Zhou, L. Sun, H. Jiang, W. Zhuo, Y. Shen, T. Zhou, 2024
- Surface-anchored microbial enzyme-responsive solid lipid nanoparticles enabling colonic budesonide release for ulcerative colitis treatment, Y. Zhang, L. Wang, Z. D. Wang, Q. Zhou, X. Zhou, T. Zhou, Y. X. Guan, X. Liu, 2023
- Liver fibrosis therapy based on biomimetic nanoparticles which deplete activated hepatic stellate cells, S. Xia#, Z. Liu#, J. Cai#, H. Ren, Q. Li, H. Zhang, J. Yue, Q. Zhou, T. Zhou, L. Wang*, X. Liu*, X. Zhou*, 2023
- Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses, M. Wang, B. Rousseau, K. Qiu, G. Huang, Y. Zhang, H. Su, C. Le Bihan-Benjamin, I. Khati, O. Artz, M. B. Foote, Y. Y. Cheng, K. H. Lee, M. Z. Miao, Y. Sun, P. J. Bousquet, M. Hilmi, E. Dumas, A. S. Hamy, F. Reyal, L. Lin, P. M. Armistead, W. Song, A. Vargason, J. C. Arthur, Y. Liu, J. Guo, X. Zhou, J. Nguyen, Y. He, J. P. Ting, A. C. Anselmo, L. Huang, 2023
- Macrophage-evading and tumor-specific apoptosis inducing nanoparticles for targeted cancer therapy, Z. Liu#, X. Zhou#, Q. Li, Y. Shen, T. Zhou, X. Liu, 2023
- Nanoprodrug ratiometrically integrating autophagy inhibitor and genotoxic agent for treatment of triple-negative breast cancer, H. Wang, H. Bai, J. Wang, X. Zhou, H. Chen, L. Wang, H. Ren, Z. Liu, W. Zhuo, Z. Zhou, J. Tang, Z. Li, J. Wang, Y. Shen, T. Zhou, X. Liu, 2022
- Relaxin gene delivery modulates macrophages to resolve cancer fibrosis and synergizes with immune checkpoint blockade therapy, X. Zhou, Y. Liu, M. Hu, M. Wang, X. Liu, L. Huang, 2021
- Macrophage-Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention, X. Zhou, X. Liu, L. Huang, 2021
- Celastrol nanoemulsion induces immunogenicity and downregulates PD-L1 to boost abscopal effect in melanoma therapy, N. Qiu, Y. Liu, Q. Liu, Y. Chen, L. Shen, M. Hu, X. Zhou, Y. Shen, J. Gao, L. Huang, 2021
- Tumor-targeted gene therapy with lipid nanoparticles inhibits tumor-associated adipocytes and remodels the immunosuppressive tumor microenvironment in triple-negative breast cancer, Y. Liu, K. Tiruthani, M. Wang, X. Zhou, N. Qiu, Y. Xiong, C. V. Pecot, R. Liu, L. Huang, 2021
- Autophagy-inhibiting polymer as an effective nonviral cancer gene therapy vector with inherent apoptosis-sensitizing ability, J. Wang#, X. Zhou#, H. Wang, Q. Xiao, K. Ding, X. Dong, S. Xu, B. Shen, J. Sun, Z. Zhou, J. Tang, X. Liu, Y. Shen, 2020
- Nanoparticle-enhanced chemo-immunotherapy to trigger robust antitumor immunity, J. Liang, H. Wang, W. Ding, J. Huang, X. Zhou, H. Wang, X. Dong, G. Li, E. Chen, F. Zhou, H. Fan, J. Xia, B. Shen, D. Cai, P. Lan, H. Jiang, J. Ling, Z. Cheng, X. Liu, J. Sun, 2020
- Relaxin-FOLFOX-IL-12 triple combination therapy engages memory response and achieves long-term survival in colorectal cancer liver metastasis, M. Hu, X. Zhou, Y. Wang, K. Guan, L. Huang, 2020
- Tumor neoantigen heterogeneity impacts bystander immune inhibition of pancreatic cancer growth, M. Das, X. Zhou, Y. Liu, A. Das, B. G. Vincent, J. Li, R. Liu, L. Huang, 2020
- SAHA (vorinostat) facilitates functional polymer-based gene transfection via upregulation of ROS and synergizes with TRAIL gene delivery for cancer therapy, X. Zhou, Z. Liu, H. Wang, X. Liu, Z. Zhou, J. Tang, X. Liu, M. Zheng, Y. Shen, 2019
- Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy, M. Hu, Y. Wang, L. Xu, S. An, Y. Tang, X. Zhou, J. Li, R. Liu, L. Huang, 2019
- New path to treating pancreatic cancer: TRAIL gene delivery targeting the fibroblast-enriched tumor microenvironment, H. Jiang#, S. Wang#, X. Zhou#, L. Wang, L. Ye, Z. Zhou, J. Tang, X. Liu, L. Teng, Y. Shen, 2018
- Nonviral cancer gene therapy: Delivery cascade and vector nanoproperty integration, Z. Zhou, X. Liu, D. Zhu, Y. Wang, Z. Zhang, X. Zhou, N. Qiu, X. Chen, Y. Shen, 2017
- Jumping the nuclear envelope barrier: Improving polyplex-mediated gene transfection efficiency by a selective CDK1 inhibitor RO-3306, X. Zhou, X. Liu, B. Zhao, X. Liu, D. Zhu, N. Qiu, Q. Zhou, Y. Piao, Z. Zhou, J. Tang, Y. Shen, 2016
Awards
- National Scholarship
- Zhejiang Province Outstanding Graduate
