2011-2015 Bachelor of Engineering: Zhejiang University, College of Chemical and Biological Engineering
2015-2020 Doctor of Engineering: Zhejiang University, College of Chemical and Biological Engineering (National Scholarship, Zhejiang Province Outstanding Graduate)
2018-2020 Joint PhD Student: University of North Carolina at Chapel Hill (CSC funded, Co-supervisor: Leaf Huang)
2021.01-present - Zhejiang University Fourth Affiliated Hospital - Associate Researcher
National Scholarship
Zhejiang Province Outstanding Graduate
Research
Nucleic Acid Drug Delivery Nano Drug Carrier Design Tumor Immunotherapy Tumor Microenvironment Regulation
RNA-based modulation of macrophage-mediated efferocytosis potentiates antitumor immunity in colorectal cancer, X. Zhou*, D. Li, S. Xia, X. Ma, R. Li, Y. Mu, Z. Liu, L. Zhang, Q. Zhou, W. Zhuo, K. Ding, A. Lin, W. Liu, X. Liu*, T. Zhou*, 2024
Impact of protein corona and PEGylation on the accumulation and efficacy of lysosome-disrupting lipid nanoparticles in KRAS-mutated cancer, H. Yang, J. Wang, X. Zhou, D. Fu, C. Le, J. Wei, Y. Qian, Y. Fang, T. Jin, X. Kong, C. Yu, D. Song, Y. Wang, X. Zhou, T. Zhou, Q. Zhou, X. Liu, Q. Xiao, K. Ding, 2024
Sulfoxide-containing polymers conjugated prodrug micelles with enhanced anticancer activity and reduced intestinal toxicity, Y. Wang, J. Wang, J. Li, Y. Mu, J. Ying, Z. Liu, M. Wu, Y. Geng, X. Zhou, T. Zhou, Y. Shen, L. Sun, X. Liu, Q. Zhou, 2024
Protein Kinase STK24 Promotes Tumor Immune Evasion via the AKT-PD-L1 Axis, N. Wang, Y. Jiang, M. Li, H. Wang, J. Pan, Y. Tang, S. Xie, Y. Xu, X. Li, X. Zhou, P. Xu, W. Lin, X. Wang, 2024
Neutrophil Extracellular Traps-Inhibiting and Fouling-Resistant Polysulfoxides Potently Prevent Postoperative Adhesion, Tumor Recurrence, and Metastasis, J. Wang, Y. Wang, J. Li, J. Ying, Y. Mu, X. Zhang, X. Zhou, L. Sun, H. Jiang, W. Zhuo, Y. Shen, T. Zhou, 2024
Surface-anchored microbial enzyme-responsive solid lipid nanoparticles enabling colonic budesonide release for ulcerative colitis treatment, Y. Zhang, L. Wang, Z. D. Wang, Q. Zhou, X. Zhou, T. Zhou, Y. X. Guan, X. Liu, 2023
Liver fibrosis therapy based on biomimetic nanoparticles which deplete activated hepatic stellate cells, S. Xia#, Z. Liu#, J. Cai#, H. Ren, Q. Li, H. Zhang, J. Yue, Q. Zhou, T. Zhou, L. Wang*, X. Liu*, X. Zhou*, 2023
Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses, M. Wang, B. Rousseau, K. Qiu, G. Huang, Y. Zhang, H. Su, C. Le Bihan-Benjamin, I. Khati, O. Artz, M. B. Foote, Y. Y. Cheng, K. H. Lee, M. Z. Miao, Y. Sun, P. J. Bousquet, M. Hilmi, E. Dumas, A. S. Hamy, F. Reyal, L. Lin, P. M. Armistead, W. Song, A. Vargason, J. C. Arthur, Y. Liu, J. Guo, X. Zhou, J. Nguyen, Y. He, J. P. Ting, A. C. Anselmo, L. Huang, 2023
Macrophage-evading and tumor-specific apoptosis inducing nanoparticles for targeted cancer therapy, Z. Liu#, X. Zhou#, Q. Li, Y. Shen, T. Zhou, X. Liu, 2023
Nanoprodrug ratiometrically integrating autophagy inhibitor and genotoxic agent for treatment of triple-negative breast cancer, H. Wang, H. Bai, J. Wang, X. Zhou, H. Chen, L. Wang, H. Ren, Z. Liu, W. Zhuo, Z. Zhou, J. Tang, Z. Li, J. Wang, Y. Shen, T. Zhou, X. Liu, 2022
Relaxin gene delivery modulates macrophages to resolve cancer fibrosis and synergizes with immune checkpoint blockade therapy, X. Zhou, Y. Liu, M. Hu, M. Wang, X. Liu, L. Huang, 2021
Macrophage-Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention, X. Zhou, X. Liu, L. Huang, 2021
Celastrol nanoemulsion induces immunogenicity and downregulates PD-L1 to boost abscopal effect in melanoma therapy, N. Qiu, Y. Liu, Q. Liu, Y. Chen, L. Shen, M. Hu, X. Zhou, Y. Shen, J. Gao, L. Huang, 2021
Tumor-targeted gene therapy with lipid nanoparticles inhibits tumor-associated adipocytes and remodels the immunosuppressive tumor microenvironment in triple-negative breast cancer, Y. Liu, K. Tiruthani, M. Wang, X. Zhou, N. Qiu, Y. Xiong, C. V. Pecot, R. Liu, L. Huang, 2021
Autophagy-inhibiting polymer as an effective nonviral cancer gene therapy vector with inherent apoptosis-sensitizing ability, J. Wang#, X. Zhou#, H. Wang, Q. Xiao, K. Ding, X. Dong, S. Xu, B. Shen, J. Sun, Z. Zhou, J. Tang, X. Liu, Y. Shen, 2020
Nanoparticle-enhanced chemo-immunotherapy to trigger robust antitumor immunity, J. Liang, H. Wang, W. Ding, J. Huang, X. Zhou, H. Wang, X. Dong, G. Li, E. Chen, F. Zhou, H. Fan, J. Xia, B. Shen, D. Cai, P. Lan, H. Jiang, J. Ling, Z. Cheng, X. Liu, J. Sun, 2020
Relaxin-FOLFOX-IL-12 triple combination therapy engages memory response and achieves long-term survival in colorectal cancer liver metastasis, M. Hu, X. Zhou, Y. Wang, K. Guan, L. Huang, 2020
Tumor neoantigen heterogeneity impacts bystander immune inhibition of pancreatic cancer growth, M. Das, X. Zhou, Y. Liu, A. Das, B. G. Vincent, J. Li, R. Liu, L. Huang, 2020
SAHA (vorinostat) facilitates functional polymer-based gene transfection via upregulation of ROS and synergizes with TRAIL gene delivery for cancer therapy, X. Zhou, Z. Liu, H. Wang, X. Liu, Z. Zhou, J. Tang, X. Liu, M. Zheng, Y. Shen, 2019
Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy, M. Hu, Y. Wang, L. Xu, S. An, Y. Tang, X. Zhou, J. Li, R. Liu, L. Huang, 2019
New path to treating pancreatic cancer: TRAIL gene delivery targeting the fibroblast-enriched tumor microenvironment, H. Jiang#, S. Wang#, X. Zhou#, L. Wang, L. Ye, Z. Zhou, J. Tang, X. Liu, L. Teng, Y. Shen, 2018
Nonviral cancer gene therapy: Delivery cascade and vector nanoproperty integration, Z. Zhou, X. Liu, D. Zhu, Y. Wang, Z. Zhang, X. Zhou, N. Qiu, X. Chen, Y. Shen, 2017
Jumping the nuclear envelope barrier: Improving polyplex-mediated gene transfection efficiency by a selective CDK1 inhibitor RO-3306, X. Zhou, X. Liu, B. Zhao, X. Liu, D. Zhu, N. Qiu, Q. Zhou, Y. Piao, Z. Zhou, J. Tang, Y. Shen, 2016
