Professor | Shan Bo | Asia Growth Partners

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Name	Shan Bo
Language ability	Chinese, English
Province	Zhejiang

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Name

Shan Bo

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	2009-2015 PhD: Shanghai Institute of Life Sciences, Chinese Academy of Sciences 2005-2009 Bachelor's: Shandong University, School of Life Sciences Achievement: Published 18 SCI research papers as first author or co-author
Work Experience	2022-present - Zhejiang University Translational Medicine Institute/Zhejiang University First Affiliated Hospital - Researcher/Doctoral Supervisor 2017-2021 - UT Southwestern Medical Center - Postdoctoral Researcher 2015-2017 - Shanghai Institute of Nutrition Sciences, Chinese Academy of Sciences - Postdoctoral Researcher
Awards	National High-Level Talent Youth Project Recipient

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

2009-2015 PhD: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
2005-2009 Bachelor's: Shandong University, School of Life Sciences
Achievement: Published 18 SCI research papers as first author or co-author

Work Experience

2022-present - Zhejiang University Translational Medicine Institute/Zhejiang University First Affiliated Hospital - Researcher/Doctoral Supervisor
2017-2021 - UT Southwestern Medical Center - Postdoctoral Researcher
2015-2017 - Shanghai Institute of Nutrition Sciences, Chinese Academy of Sciences - Postdoctoral Researcher

Awards

National High-Level Talent Youth Project Recipient

Areas of Focus	Mechanisms of formation and maintenance of adipose tissue physiological and pathological microenvironment Immune regulatory role of perivascular cells Identification and functional study of preadipokines
Publications	Multilayered omics Reveal Sex- and Depot-Dependent Adipose Progenitor Cell Heterogeneity, Shan B., Barker, C., Shao M., Zhang, Q., Gupta R.K.and Wu Y., 2022 Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity, Shan B., Shao M., Zhang Q., Hepler C., Paschoal V., Barnes S., Vishvanath L., An Y., Malladi V., Strand D., Gupta O., Oh D., and Gupta R.K., 2020 The Metabolic ER stress sensor IRE1a suppresses alternative activation of macrophages and impairs energy expenditure in obesity, Shan B., Wang X., Wu Y., Xu C., Xia ZX., Shao M., Zhao F., Liu Y., Nan F., Li J., Rui L., Duan S. and Liu Y., 2017 Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual, Shan B., Shao M., Zhang Q., An Y., Vishvanath L., and Gupta R.K., 2021 Dual role for Inositol-requiring Enzyme 1a in promoting the development of hepatocellular carcinoma during diet-induced obesity, Wu Y., Shan B., Dai J., Xia Z., Cai J., Chen T., Lv S., Feng Y., Zheng L., Wang Y., Liu J., Xie D., Rui L., Liu J. and Liu Y., 2018 Hepatic IRE1a regulates fasting/diet-induced metabolic adaptive programs through the XBP1-PPARa Axis, Shao M., Shan B., Deng Y., Liu Y., Yan C., Wu Y., Mao T., Qiu Y., Zhou Y., Jiang S., Jia W., Li J., Li J., Rui L., Yang L., and Liu Y., 2014 Inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury, Cai J., Zhang X., Chen P., Li Y., Liu S., Liu Q., Zhang H., Song K., Liu J., Shan B.#, and Liu Y., 2022 Distinct functional properties of perinatal versus adult adipose progenitor subpopulations, Zhang Q., Shan B., Guo L., Shao M., Vishvanath L., Elmquist G., Xu L. and Gupta R.K., 2022 Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice, Hepler C., Shan B., Zhang Q., Henry G.H., Shao M., Vishvanath L., Ghaben A.L., Mobley A.B., Strand D., Hon G., Gupta R.K., 2018 Pathologic HIF1a signaling drives adipose progenitor dysfunction in obesity, Shao M., Hepler C., Zhang Q., Shan B., Vishvanath L., Henry G., Zhao S., An Y., Wu Y., Strand D., Gupta R.K., 2021 The mitochondrial dicarboxylate carrier prevents hepatic lipotoxicity by inhibiting white adipocyte lipolysis, An Y., Chen S., Deng Y., Wang Z, Funcke J., Shah M., Shan B., Gordillo R., Yoshino J., Klein S., Kusminski C., Scherer P., 2021 De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity, Shao M., Vishvanath L., Busbuso N., Hepler C., Shan B., Sharma A., Chen S., Yu X., An Y., Zhu Y., Holland W., Gupta R.K., 2018 ZFP423 controls EBF2 coactivator recruitment and PPARg occupancy to determine the thermogenic plasticity of adipocytes, Shao M., Zhang Q., Truong A., Shan B., Vishvanath L., Li L., Seale, P., and Gupta R.K., 2021 Adiponectin preserves metabolic fitness during aging, Li N., Zhao S., Zhang Z., Zhu Y., Gliniak C.M., Vishvanath L., An Y., Wang M., Deng Y., Zhu Q., Shan B., Sherwood A., Onodera T., Oz O.K., Gordillo R., Gupta R.K., Liu M., Horvath T., Dixit V.D., and Sherer P.E., 2021 Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots, Peics J., Vishvanath L., Zhang Q., Shan B., Pedersen T., and Gupta R.K., 2020 Fibroblast Growth Factor 21 is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts ER stress-induced Hepatic Steatosis, Jiang S., Yan C., Fang Q., Shao M., Zhang Y., Liu Y, Deng Y., Shan B., Liu J., Li H., Yang L., Zhou J., Dai Z., Liu Y. and Jia W., 2014 Adipose Tissue Macrophage in Immune Regulation of Metabolism, Qiu Y., Shan B., Yang L., and Liu Y., 2016

Areas of Focus

Mechanisms of formation and maintenance of adipose tissue physiological and pathological microenvironment
Immune regulatory role of perivascular cells
Identification and functional study of preadipokines

Publications

Multilayered omics Reveal Sex- and Depot-Dependent Adipose Progenitor Cell Heterogeneity, Shan B.*, Barker, C.*, Shao M.*, Zhang, Q., Gupta R.K.and Wu Y., 2022
Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity, Shan B.*, Shao M.*, Zhang Q., Hepler C., Paschoal V., Barnes S., Vishvanath L., An Y., Malladi V., Strand D., Gupta O., Oh D., and Gupta R.K., 2020
The Metabolic ER stress sensor IRE1a suppresses alternative activation of macrophages and impairs energy expenditure in obesity, Shan B.*, Wang X.*, Wu Y.*, Xu C., Xia ZX., Shao M., Zhao F., Liu Y., Nan F., Li J., Rui L., Duan S. and Liu Y., 2017
Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual, Shan B.*, Shao M.*, Zhang Q., An Y., Vishvanath L., and Gupta R.K., 2021
Dual role for Inositol-requiring Enzyme 1a in promoting the development of hepatocellular carcinoma during diet-induced obesity, Wu Y.*, Shan B.*, Dai J., Xia Z., Cai J., Chen T., Lv S., Feng Y., Zheng L., Wang Y., Liu J., Xie D., Rui L., Liu J. and Liu Y., 2018
Hepatic IRE1a regulates fasting/diet-induced metabolic adaptive programs through the XBP1-PPARa Axis, Shao M.*, Shan B.*, Deng Y., Liu Y., Yan C., Wu Y., Mao T., Qiu Y., Zhou Y., Jiang S., Jia W., Li J., Li J., Rui L., Yang L., and Liu Y., 2014
Inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury, Cai J., Zhang X., Chen P., Li Y., Liu S., Liu Q., Zhang H., Song K., Liu J., Shan B.#, and Liu Y., 2022
Distinct functional properties of perinatal versus adult adipose progenitor subpopulations, Zhang Q., Shan B., Guo L., Shao M., Vishvanath L., Elmquist G., Xu L. and Gupta R.K., 2022
Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice, Hepler C., Shan B., Zhang Q., Henry G.H., Shao M., Vishvanath L., Ghaben A.L., Mobley A.B., Strand D., Hon G., Gupta R.K., 2018
Pathologic HIF1a signaling drives adipose progenitor dysfunction in obesity, Shao M., Hepler C., Zhang Q., Shan B., Vishvanath L., Henry G., Zhao S., An Y., Wu Y., Strand D., Gupta R.K., 2021
The mitochondrial dicarboxylate carrier prevents hepatic lipotoxicity by inhibiting white adipocyte lipolysis, An Y., Chen S., Deng Y., Wang Z, Funcke J., Shah M., Shan B., Gordillo R., Yoshino J., Klein S., Kusminski C., Scherer P., 2021
De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity, Shao M., Vishvanath L., Busbuso N., Hepler C., Shan B., Sharma A., Chen S., Yu X., An Y., Zhu Y., Holland W., Gupta R.K., 2018
ZFP423 controls EBF2 coactivator recruitment and PPARg occupancy to determine the thermogenic plasticity of adipocytes, Shao M., Zhang Q., Truong A., Shan B., Vishvanath L., Li L., Seale, P., and Gupta R.K., 2021
Adiponectin preserves metabolic fitness during aging, Li N., Zhao S., Zhang Z., Zhu Y., Gliniak C.M., Vishvanath L., An Y., Wang M., Deng Y., Zhu Q., Shan B., Sherwood A., Onodera T., Oz O.K., Gordillo R., Gupta R.K., Liu M., Horvath T., Dixit V.D., and Sherer P.E., 2021
Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots, Peics J., Vishvanath L., Zhang Q., Shan B., Pedersen T., and Gupta R.K., 2020
Fibroblast Growth Factor 21 is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts ER stress-induced Hepatic Steatosis, Jiang S., Yan C., Fang Q., Shao M., Zhang Y., Liu Y, Deng Y., Shan B., Liu J., Li H., Yang L., Zhou J., Dai Z., Liu Y. and Jia W., 2014
Adipose Tissue Macrophage in Immune Regulation of Metabolism, Qiu Y., Shan B., Yang L., and Liu Y., 2016

Adipose Tissue Microenvironment Physiological Pathological Perivascular Cells Immune Regulation Preadipokines Identification Function Mechanisms

Fei Yang - Zhejiang University

Haibin Wang - Xiamen University

Xin Huang - Zhejiang University

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