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Shan Bo
Medical School
Zhejiang University
Zhejiang
Language: Chinese, English
Adipose Tissue
Microenvironment
Physiological
Pathological
Perivascular Cells
Immune Regulation
Preadipokines
Identification
Function
Mechanisms
Areas of Focus
- Mechanisms of formation and maintenance of adipose tissue physiological and pathological microenvironment
- Immune regulatory role of perivascular cells
- Identification and functional study of preadipokines
Work Experience
- 2022-present - Zhejiang University Translational Medicine Institute/Zhejiang University First Affiliated Hospital - Researcher/Doctoral Supervisor
- 2017-2021 - UT Southwestern Medical Center - Postdoctoral Researcher
- 2015-2017 - Shanghai Institute of Nutrition Sciences, Chinese Academy of Sciences - Postdoctoral Researcher
Academic Background & Achievements
- 2009-2015 PhD: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
- 2005-2009 Bachelor's: Shandong University, School of Life Sciences
- Achievement: Published 18 SCI research papers as first author or co-author
Publications
- Multilayered omics Reveal Sex- and Depot-Dependent Adipose Progenitor Cell Heterogeneity, Shan B.*, Barker, C.*, Shao M.*, Zhang, Q., Gupta R.K.and Wu Y., 2022
- Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity, Shan B.*, Shao M.*, Zhang Q., Hepler C., Paschoal V., Barnes S., Vishvanath L., An Y., Malladi V., Strand D., Gupta O., Oh D., and Gupta R.K., 2020
- The Metabolic ER stress sensor IRE1a suppresses alternative activation of macrophages and impairs energy expenditure in obesity, Shan B.*, Wang X.*, Wu Y.*, Xu C., Xia ZX., Shao M., Zhao F., Liu Y., Nan F., Li J., Rui L., Duan S. and Liu Y., 2017
- Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual, Shan B.*, Shao M.*, Zhang Q., An Y., Vishvanath L., and Gupta R.K., 2021
- Dual role for Inositol-requiring Enzyme 1a in promoting the development of hepatocellular carcinoma during diet-induced obesity, Wu Y.*, Shan B.*, Dai J., Xia Z., Cai J., Chen T., Lv S., Feng Y., Zheng L., Wang Y., Liu J., Xie D., Rui L., Liu J. and Liu Y., 2018
- Hepatic IRE1a regulates fasting/diet-induced metabolic adaptive programs through the XBP1-PPARa Axis, Shao M.*, Shan B.*, Deng Y., Liu Y., Yan C., Wu Y., Mao T., Qiu Y., Zhou Y., Jiang S., Jia W., Li J., Li J., Rui L., Yang L., and Liu Y., 2014
- Inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury, Cai J., Zhang X., Chen P., Li Y., Liu S., Liu Q., Zhang H., Song K., Liu J., Shan B.#, and Liu Y., 2022
- Distinct functional properties of perinatal versus adult adipose progenitor subpopulations, Zhang Q., Shan B., Guo L., Shao M., Vishvanath L., Elmquist G., Xu L. and Gupta R.K., 2022
- Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice, Hepler C., Shan B., Zhang Q., Henry G.H., Shao M., Vishvanath L., Ghaben A.L., Mobley A.B., Strand D., Hon G., Gupta R.K., 2018
- Pathologic HIF1a signaling drives adipose progenitor dysfunction in obesity, Shao M., Hepler C., Zhang Q., Shan B., Vishvanath L., Henry G., Zhao S., An Y., Wu Y., Strand D., Gupta R.K., 2021
- The mitochondrial dicarboxylate carrier prevents hepatic lipotoxicity by inhibiting white adipocyte lipolysis, An Y., Chen S., Deng Y., Wang Z, Funcke J., Shah M., Shan B., Gordillo R., Yoshino J., Klein S., Kusminski C., Scherer P., 2021
- De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity, Shao M., Vishvanath L., Busbuso N., Hepler C., Shan B., Sharma A., Chen S., Yu X., An Y., Zhu Y., Holland W., Gupta R.K., 2018
- ZFP423 controls EBF2 coactivator recruitment and PPARg occupancy to determine the thermogenic plasticity of adipocytes, Shao M., Zhang Q., Truong A., Shan B., Vishvanath L., Li L., Seale, P., and Gupta R.K., 2021
- Adiponectin preserves metabolic fitness during aging, Li N., Zhao S., Zhang Z., Zhu Y., Gliniak C.M., Vishvanath L., An Y., Wang M., Deng Y., Zhu Q., Shan B., Sherwood A., Onodera T., Oz O.K., Gordillo R., Gupta R.K., Liu M., Horvath T., Dixit V.D., and Sherer P.E., 2021
- Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots, Peics J., Vishvanath L., Zhang Q., Shan B., Pedersen T., and Gupta R.K., 2020
- Fibroblast Growth Factor 21 is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts ER stress-induced Hepatic Steatosis, Jiang S., Yan C., Fang Q., Shao M., Zhang Y., Liu Y, Deng Y., Shan B., Liu J., Li H., Yang L., Zhou J., Dai Z., Liu Y. and Jia W., 2014
- Adipose Tissue Macrophage in Immune Regulation of Metabolism, Qiu Y., Shan B., Yang L., and Liu Y., 2016
Awards
- National High-Level Talent Youth Project Recipient
