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Chang Yang
Medical School
Zhejiang University
Zhejiang
Language: Chinese, English
Leukemia
Innovative Therapies
Arsenic Trioxide
Pml Protein
Zinc Finger Structure
Protein Degradation
Nucleic Acid Aptamers
Conjugated Drugs
Cancer Therapy
Molecular Mechanism
Areas of Focus
- Research on innovative therapies for leukemia
- Study on the effects of arsenic trioxide on the zinc finger structure of PML protein and its molecular mechanism of protein degradation
- Screening of nucleic acid aptamers and construction of conjugated drugs
Work Experience
- 2020/07-Present - Zhejiang University School of Medicine - Postdoctoral Researcher
Academic Background & Achievements
- 2011/09-2015/06 Bachelor's Degree in Pharmacy: Zhejiang University
- 2015/09-2020/06 Ph.D. in Pharmacology: Zhejiang University, Supervisor: Naranmandura
Publications
- Hyperthermia Selectively Destabilizes Oncogenic Fusion Proteins, Maimaitiyiming Y., Wang Q.Q., Yang C., Ogra Y., Lou Y., Smith C.A., Hussain L., Shao Y.M., Lin J., Liu J., Wang L., Zhu Y., Lou H., Huang Y., Li X., Chang K.J., Chen H., Li H., Huang Y., Tse E., Sun J., Bu N., Chiou S.H., Zhang Y.F., Hua H.Y., Ma L.Y., Huang P., Ge M.H., Cao F.L., Cheng X., Sun H., Zhou J., Vasliou V., Xu P., Jin J., Bjorklund M., Zhu H.H., Hsu C.H., Naranmandura H., 2021
- Aptamers: an emerging navigation tool of therapeutic agents for targeted cancer therapy, Yang C., Jiang Y., Hao S.H., Yan X.Y., Hong D.F., Naranmandura H., 2022
- Venetoclax-Ponatinib for T315I/compound-mutated Ph+ acute lymphoblastic leukemia, Wang H., Yang C., Shi T., Zhang Y., Qian J., Wang Y., Hu Y., Mao L., Ye X., Xi Z., Shou L., Fu C., Naranmandura H., Jin J., Zhu HH., 2022
- Synthesis and characterization of CD133 targeted aptamer-drug conjugates for precision therapy of anaplastic thyroid cancer, Ge M.H., Zhu XH, Shao YM, Wang C, Huang P, Wang Y, Jiang Y, Maimaitiyiming Y, Chen E, Yang C., Naranmandura H., 2021
- Integrity of Zinc Finger Motifs in PML Protein is Necessary for Inducing its Protein Degradation by Antimony, Yang C., Hao R., Lan Y.F., Chen Y.J., Wang C., Bu Na., Wang Q.Q., Hussain L., Ma L.Y., Maimaitiyiming Y., Lu X.Y., Naranmandura H., 2019
- Rapid Identification of Specific DNA Aptamers Precisely Targeting CD33 Positive Leukemia Cells through Paired Cell Based Approach, Yang C., Wang Y., Ge M.H., Fu Y.J., Hao R., Islam K., Huang P., Chen F., Sun J., Hong D.F., Naranmandura H., 2019
- Novel insights into the role of aptamers in the fight against cancer, Maimaitiyiming Y., Hong DF, Yang C., Naranmandura H., 2019
- Selection and characterization of novel DNA aptamer against colorectal carcinoma Caco-2 cells, Maimaitiyiming Y., Yang C., Wang Y., Hussain L., Naranmandura H., 2019
- Phenylarsine Oxide Can Induce the Arsenite-Resistance Mutant PML Protein Solubility Changes, Jiang YH, Chen YJ, Wang C, Lan YF, Yang C, Wang QQ, Hussain L, Maimaitiying Y, Islam K, Naranmandura H., 2017
- Phenylarsine oxide (PAO) induces apoptosis in HepG2 cells via ROS-mediated mitochondria and ER-stress dependent signaling pathways, Huang P, Zhang YH, Zheng XW, Liu YJ, Zhang H, Fang L, Zhang YW, Yang C, Islam K, Wang C, Naranmandura H., 2017
- The Involvement of ER-stress and ROS Generation in Difenoconazole-Induced Hepatocellular Toxicity, Zhuang SL, Bao LL, Wang HF, Zhang M, Yang C, Zhou XY, Wu Y, Rehman W, Naranmandura H., 2015
