Professor | Chang Yang | Asia Growth Partners

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Name	Chang Yang
Contact Information	3110103752@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

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Name

Chang Yang

Contact Information

3110103752@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	2011/09-2015/06 Bachelor's Degree in Pharmacy: Zhejiang University 2015/09-2020/06 Ph.D. in Pharmacology: Zhejiang University, Supervisor: Naranmandura
Work Experience	2020/07-Present - Zhejiang University School of Medicine - Postdoctoral Researcher

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

2011/09-2015/06 Bachelor's Degree in Pharmacy: Zhejiang University
2015/09-2020/06 Ph.D. in Pharmacology: Zhejiang University, Supervisor: Naranmandura

Work Experience

2020/07-Present - Zhejiang University School of Medicine - Postdoctoral Researcher

Areas of Focus	Research on innovative therapies for leukemia Study on the effects of arsenic trioxide on the zinc finger structure of PML protein and its molecular mechanism of protein degradation Screening of nucleic acid aptamers and construction of conjugated drugs
Publications	Hyperthermia Selectively Destabilizes Oncogenic Fusion Proteins, Maimaitiyiming Y., Wang Q.Q., Yang C., Ogra Y., Lou Y., Smith C.A., Hussain L., Shao Y.M., Lin J., Liu J., Wang L., Zhu Y., Lou H., Huang Y., Li X., Chang K.J., Chen H., Li H., Huang Y., Tse E., Sun J., Bu N., Chiou S.H., Zhang Y.F., Hua H.Y., Ma L.Y., Huang P., Ge M.H., Cao F.L., Cheng X., Sun H., Zhou J., Vasliou V., Xu P., Jin J., Bjorklund M., Zhu H.H., Hsu C.H., Naranmandura H., 2021 Aptamers: an emerging navigation tool of therapeutic agents for targeted cancer therapy, Yang C., Jiang Y., Hao S.H., Yan X.Y., Hong D.F., Naranmandura H., 2022 Venetoclax-Ponatinib for T315I/compound-mutated Ph+ acute lymphoblastic leukemia, Wang H., Yang C., Shi T., Zhang Y., Qian J., Wang Y., Hu Y., Mao L., Ye X., Xi Z., Shou L., Fu C., Naranmandura H., Jin J., Zhu HH., 2022 Synthesis and characterization of CD133 targeted aptamer-drug conjugates for precision therapy of anaplastic thyroid cancer, Ge M.H., Zhu XH, Shao YM, Wang C, Huang P, Wang Y, Jiang Y, Maimaitiyiming Y, Chen E, Yang C., Naranmandura H., 2021 Integrity of Zinc Finger Motifs in PML Protein is Necessary for Inducing its Protein Degradation by Antimony, Yang C., Hao R., Lan Y.F., Chen Y.J., Wang C., Bu Na., Wang Q.Q., Hussain L., Ma L.Y., Maimaitiyiming Y., Lu X.Y., Naranmandura H., 2019 Rapid Identification of Specific DNA Aptamers Precisely Targeting CD33 Positive Leukemia Cells through Paired Cell Based Approach, Yang C., Wang Y., Ge M.H., Fu Y.J., Hao R., Islam K., Huang P., Chen F., Sun J., Hong D.F., Naranmandura H., 2019 Novel insights into the role of aptamers in the fight against cancer, Maimaitiyiming Y., Hong DF, Yang C., Naranmandura H., 2019 Selection and characterization of novel DNA aptamer against colorectal carcinoma Caco-2 cells, Maimaitiyiming Y., Yang C., Wang Y., Hussain L., Naranmandura H., 2019 Phenylarsine Oxide Can Induce the Arsenite-Resistance Mutant PML Protein Solubility Changes, Jiang YH, Chen YJ, Wang C, Lan YF, Yang C, Wang QQ, Hussain L, Maimaitiying Y, Islam K, Naranmandura H., 2017 Phenylarsine oxide (PAO) induces apoptosis in HepG2 cells via ROS-mediated mitochondria and ER-stress dependent signaling pathways, Huang P, Zhang YH, Zheng XW, Liu YJ, Zhang H, Fang L, Zhang YW, Yang C, Islam K, Wang C, Naranmandura H., 2017 The Involvement of ER-stress and ROS Generation in Difenoconazole-Induced Hepatocellular Toxicity, Zhuang SL, Bao LL, Wang HF, Zhang M, Yang C, Zhou XY, Wu Y, Rehman W, Naranmandura H., 2015

Areas of Focus

Research on innovative therapies for leukemia
Study on the effects of arsenic trioxide on the zinc finger structure of PML protein and its molecular mechanism of protein degradation
Screening of nucleic acid aptamers and construction of conjugated drugs

Publications

Hyperthermia Selectively Destabilizes Oncogenic Fusion Proteins, Maimaitiyiming Y., Wang Q.Q., Yang C., Ogra Y., Lou Y., Smith C.A., Hussain L., Shao Y.M., Lin J., Liu J., Wang L., Zhu Y., Lou H., Huang Y., Li X., Chang K.J., Chen H., Li H., Huang Y., Tse E., Sun J., Bu N., Chiou S.H., Zhang Y.F., Hua H.Y., Ma L.Y., Huang P., Ge M.H., Cao F.L., Cheng X., Sun H., Zhou J., Vasliou V., Xu P., Jin J., Bjorklund M., Zhu H.H., Hsu C.H., Naranmandura H., 2021
Aptamers: an emerging navigation tool of therapeutic agents for targeted cancer therapy, Yang C., Jiang Y., Hao S.H., Yan X.Y., Hong D.F., Naranmandura H., 2022
Venetoclax-Ponatinib for T315I/compound-mutated Ph+ acute lymphoblastic leukemia, Wang H., Yang C., Shi T., Zhang Y., Qian J., Wang Y., Hu Y., Mao L., Ye X., Xi Z., Shou L., Fu C., Naranmandura H., Jin J., Zhu HH., 2022
Synthesis and characterization of CD133 targeted aptamer-drug conjugates for precision therapy of anaplastic thyroid cancer, Ge M.H., Zhu XH, Shao YM, Wang C, Huang P, Wang Y, Jiang Y, Maimaitiyiming Y, Chen E, Yang C., Naranmandura H., 2021
Integrity of Zinc Finger Motifs in PML Protein is Necessary for Inducing its Protein Degradation by Antimony, Yang C., Hao R., Lan Y.F., Chen Y.J., Wang C., Bu Na., Wang Q.Q., Hussain L., Ma L.Y., Maimaitiyiming Y., Lu X.Y., Naranmandura H., 2019
Rapid Identification of Specific DNA Aptamers Precisely Targeting CD33 Positive Leukemia Cells through Paired Cell Based Approach, Yang C., Wang Y., Ge M.H., Fu Y.J., Hao R., Islam K., Huang P., Chen F., Sun J., Hong D.F., Naranmandura H., 2019
Novel insights into the role of aptamers in the fight against cancer, Maimaitiyiming Y., Hong DF, Yang C., Naranmandura H., 2019
Selection and characterization of novel DNA aptamer against colorectal carcinoma Caco-2 cells, Maimaitiyiming Y., Yang C., Wang Y., Hussain L., Naranmandura H., 2019
Phenylarsine Oxide Can Induce the Arsenite-Resistance Mutant PML Protein Solubility Changes, Jiang YH, Chen YJ, Wang C, Lan YF, Yang C, Wang QQ, Hussain L, Maimaitiying Y, Islam K, Naranmandura H., 2017
Phenylarsine oxide (PAO) induces apoptosis in HepG2 cells via ROS-mediated mitochondria and ER-stress dependent signaling pathways, Huang P, Zhang YH, Zheng XW, Liu YJ, Zhang H, Fang L, Zhang YW, Yang C, Islam K, Wang C, Naranmandura H., 2017
The Involvement of ER-stress and ROS Generation in Difenoconazole-Induced Hepatocellular Toxicity, Zhuang SL, Bao LL, Wang HF, Zhang M, Yang C, Zhou XY, Wu Y, Rehman W, Naranmandura H., 2015

Leukemia Innovative Therapies Arsenic Trioxide Pml Protein Zinc Finger Structure Protein Degradation Nucleic Acid Aptamers Conjugated Drugs Cancer Therapy Molecular Mechanism

Naranmandura Hua - Zhejiang University

Haibo Wang - Zhejiang University

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