PhD: Sichuan University, West China School of Stomatology
Selected for the Overseas High-Level Talent Youth Project
Received the 2017 IADR China Young Scholar Award
Current - Zhejiang University, Researcher and Doctoral Supervisor
12 years - Team of Prof. J.Silvio Gutkind, USA, Associate Researcher
IADR China Young Scholar Award (2017)
Research
Molecular Cell Biology Tumor Immunology Molecular Mechanisms of Oral Diseases
CTLA-4 blockade induces tumor pyroptosis via CD8+ T cells in head and neck squamous cell carcinoma, Wang S, Wu Z, Zhu S, Wan S, Zhang M, Zhang B, Yang Q, Xiao Y, Li H, Mao L, Wang Z, Gutkind JS, 2023
Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC, Saddawi-Konefka R, O’Farrell A, Faraji F, Clubb L, Allevato M, Jensen S, Yung B, Wang Z, Wu V, Anang N, Msari R, Schokrpur S, Pietryga I, Molinolo A, Mesirov J, Simon A, Fox B, Bui J, Sharabi A, Cohen E, Califano J, Gutkind JS, 2022
Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy, Hingorani D, Allevato M, Camargo M, Lesperance J, Quraishi M, Aguilera J, Franiak-Pietryga I, Scanderbeg D, Wang Z, Molinolo A, Alvarado D, Sharabi A, Bui J, Cohen E, Adams S, Gutkind JS, Advani S, 2022
Microneedle-mediated intratumoral delivery of anti-CTLA-4 promotes cDC1-dependent eradication of oral squamous cell carcinoma with limited irAEs, Gilardi M, Saddawi-Konefka R, Wu V, Lopez-Ramirez M, Wang Z, Soto F, Ramms D, Proietto M, Mikulski Z, Miki H, Sharabi A, Kupor D, Rueda R, Hollern D, Wang J, Gutkind JS, 2022
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity, Swaney D, Ramms D, Wang Z, Park J, Goto Y, Soucheray M, Bhola N, Kim K, Zheng F, McGregor M, Herrington K, O’Keefe R, Jin N, VanLandingham N, Foussard H, Dollen J, Bouhaddou M, Jimenez-Morales D, Obernier K, Kreisberg J, Kim M, Johnson D, Jura N, Grandis J, Gutkind JS, Ideker T, Krogan N, 2021
EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1, Ando T, Arang A, Wang Z, Costea D, Feng X, Goto Y, Izumi H, Gilardi M, Ando K, Gutkind JS, 2021
Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer, Wang Z, Goto Y, Allevato M, Wu V, Saddawi-Konefka R, Gilardi M, Alvarado D, Yung B, O’Farrell A, Molinolo A, Duvvuri U, Grandis J, Califano J, Cohen E, Gutkind JS, 2021
Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions, Gutkind JS, Molinolo A, Wu X, Wang Z, Nachmanson D, Harismendy O, Alexandrov L, Wuertz B, Ondrey F, Laronde D, Rock L, Rosin M, Coffey C, Butler V, Bengtson L, Hsu C, Bauman J, Hewitt S, Cohen E, Chow S, Lippman S, Szabo E, 2021
Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis, Yoon H, Tang C, Banerjee S, Yebra M, Noh S, Burgoyne A, Torre J, Siena M, Liu M, Klug L, Choi Y, Hosseini M, Delgado A, Wang Z, French R, Lowy A, DeMatteo R, Heinrich M, Molinolo A, Gutkind JS, Harismendy O, Sicklick J, 2021
Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK–YAP signaling axis, Goto Y, Ando T, Izumi H, Feng X, Arang N, Gilardi M, Wang Z, Ando K, Gutkind JS, 2020
Tipifarnib as a Precision Therapy for HRAS-Mutant Head and Neck Squamous Cell Carcinomas, Gilardi M, Wang Z, Proietto M, Chillà A, Calleja-Valera J, Goto Y, Vanoni M, Janes M, Mikulski Z, Gualberto A, Molinolo A, Ferrara N, Burrows F, Gutkind JS, 2020
Pathway-specific genome editing of PI3K/mTOR tumor suppressor genes reveals that PTEN loss contributes to cetuximab resistance in head and neck cancer, Izumi H, Wang Z, Goto Y, Ando T, Wu X, Zhang X, Li H, Johnson D, Grandis JR, Gutkind JS, 2020
YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity, Yuan Y, Park J, Feng A, Awasthi P, Wang Z, Chen Q, Iglesias-Bartolome R, 2020
Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling, Stratman A, Farrelly O, Mikelis C, Miller M, Wang Z, Pham V, Davis A, Burns M, Pezoa S, Castranova D, Yano J, Kilts T, Davis G, Gutkind JS, Weinstein B, 2020
ZBP1 (DAI/DLM-1) promotes osteogenic differentiation while inhibiting adipogenic differentiation in mesenchymal stem cells through a positive feedback loop of Wnt/β-catenin signaling, Zhao X, Xie L, Wang Z, Wang J, Xu H, Han X, Bai D, Deng P, 2020
Syngeneic animal model of tobacco-associated oral cancer reveals the activity of in situ anti-CTLA-4, Wang Z, Wu V, Allevato A, Gilardi M, He Y, Callejas-Valera J, Vitale-Cross l, Martin D, Amornphimoltham P, Mcdermott J, Yung B, Goto Y, Molinolo A, Sharabi A, Cohen E, Chen Q, Lyons G, Alexandrov L, Gutkind JS, 2019
4E-BP1 is a head and neck cancer tumor suppressor protein reactivated by mTOR inhibition, Wang Z, Feng X, Molinolo A, Martin D, Vitale-Cross L, Nohata N, Ando M, Wahba A, Amornphimoltham P, Wu X, Gilardi M, Allevato M, Wu V, Steffen D, Tofilon P, Sonenberg N, Califano J, Chen Q, Lippman S, Gutkind JS, 2019
A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK, Feng X, Arang N, Rigiracciolo D, Lee J, Yeerna H, Wang Z, Lubrano S, Kishore A, Pachter J, Konig G, Maggiolini M, KostenisE, Schlaepfer D, Tamayo P, Chen Q, Ruppin E, Gutkind JS, 2019
Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy, Sahu A, Lee J, Wang Z, Zhang G, Iglesias-Bartolomé R, Tian T, Wei, Z, Miao B, Nair N, Ponomarova O, Friedman A, Amzallag A, Moll T, Kasumova G, Greninger P, Egan R, Damon E, Frederick D, Jerby-Arnon L, Wagner A, Cheng K, Park S, Robinson W, Gardner K, Boland G, Hannenhalli S, Herlyn M, Benes C, Flaherty K, Luo J, Gutkind JS, Ruppin E, 2019
Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial, Day T, Shirai K, O'Brien P, Matheus M, Godwin K, Sood A, Kompelli A, Vick J, Martin D, Vitale-Cross L, Callejas-Varela J, Wang Z, Wu X, Harismendy O, Molinolo A, Lippman S, Waes C, Szabo E, Gutkind JS, 2019
Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells, Wu X, Yeerna H, Goto Y, Ando T, Wu V, Zhang X, Wang Z, Amornphimoltham P, Murphy AN, Tamayo P, Chen Q, Lippman SM, Gutkind JS, 2019
Dual-functional guanosine-based hydrogel integrating localized delivery and anticancer activities for cancer therapy, Zhao H, Feng H, Liu J, Tang F, Du Y, Ji N, Xie L, Zhao X, Wang Z, Chen Q, 2019
Assembly and activation of the Hippo signalome by FAT1 tumor suppressor, Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS, 2018
mTOR Co-targeting Strategies for Head and Neck Cancer Therapy, Wang Z, Valera J, Zhao X, Chen Q, Gutkind JS, 2017
Prognostic value from integrative analysis of transcription factors c-Jun and Fra-1 in oral squamous cell carcinoma: a multicenter cohort study, Xu H, Jin X, Yuan Y, Deng P, Jiang L, Zeng X, Li X, Wang Z, Chen Q, 2017
LRP6 is identified as a potential prognostic marker for oral squamous cell carcinoma via MALDI-IMS, Yuan Y, Xie X, Jiang Y, Wei Z, Wang P, Chen F, Li X, Sun C, Zhao H, Jiang L, Zhou Y, Dan H, Feng M, Liu R, Wang Z, Chen Q, 2017
Roles of FGFR in oral carcinogenesis, Xie X, Wang Z, Chen F, Yuan Y, Wang J, Liu R, Chen Q, 2016
Emerging Cancer Biomarkers for HNSCC Detection and Therapeutic Intervention, Patel V, Wang Z, Chen Q, Rusling JF, Molinolo AA, Gutkind JS, 2016
A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers
Keywords
Cell BiologyMolecular BiologySignal TransductionCancerImmunotherapyOral DiseasesTumor MicroenvironmentClinical SamplesAnimal ModelsDrug Development
Area of Focus
Cancer | Immune Response | Tumor Microenvironment | Immunotherapy | Cytokines | T Cells | Nk Cells | Macrophages | Inflammation | Signal Transduction
