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Zhen Wang
Medical School
Zhejiang University
Zhejiang
Language: Chinese, English
Tumor Microenvironment
Tumor Immunity
Breast Cancer
Tumor Metastasis
Neutrophils
Immune Microenvironment
Triple-Negative Breast Cancer
Metabolic Reprogramming
Pre-Metastatic Niche
Cd62Ldim Neutrophils
Areas of Focus
- Tumor Microenvironment and Tumor Immunity
- Breast Cancer and Tumor Metastasis
Work Experience
- 2022/12-present - Zhejiang University School of Medicine - Distinguished Researcher
- 2019/06-present - Second Affiliated Hospital of Zhejiang University School of Medicine, Breast Surgery - Attending Physician
- 2018/08-2019/05 - Second Affiliated Hospital of Zhejiang University School of Medicine, Breast Surgery (formerly Oncology Surgery) - Physician
Academic Background & Achievements
- 2015/07-2018/06 Ph.D. in Oncology: Zhejiang University School of Medicine
- 2008/08-2015/06 Master's in Clinical Medicine (7-year program): Zhejiang University School of Medicine
Publications
- Tumor-derived HMGB1 induces CD62Ldim neutrophil polarization and promotes lung metastasis in triple-negative breast cancer, Wang Z#, Yang C#, Li L, Jin X, Zhang Z, Zheng H, Pan J, Shi L, Jiang Z, Su K, Li B, Shao X, Qiu F, Yan J, Huang J*, 2020
- CD62Ldim Neutrophils Specifically Migrate to the Lung and Participate in the Formation of the Pre-Metastatic Niche of Breast Cancer, Wang Z#, Yang C#, Li L, Zhang Z, Pan J, Su K, Chen W, Li J, Qiu F, Huang J*, 2020
- Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis, Yang C#, Wang Z#, Li L#, Zhang Z, Jin X, Wu P, Sun S, Pan J, Su K, Jia F, Zhang L, Wang H, Yu X, Shao X, Wang K, Qiu F, Yan J, Huang J*, 2021
- \"γδT Cell-IL17A-Neutrophil\" Axis Drives Immunosuppression and Confers Breast Cancer Resistance to High-Dose Anti-VEGFR2 Therapy, Zhang Z#, Yang C#, Li L, Zhu Y, Su K, Zhai L, Wang Z*, Huang J*, 2021
- Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming, Morrissey SM, Zhang F, Ding C, Montoya-Durango DE, Hu X, Yang C, Wang Z, Yuan F, Fox M, Zhang HG, Guo H, Tieri D, Kong M, Watson CT, Mitchell RA, Zhang X, McMasters KM, Huang J, Yan J*, 2021
- Cross-talk between the gut microbiota and monocyte-like macrophages mediates an inflammatory response to promote colitis-associated tumourigenesis, Yang Y#, Li L#, Xu C#, Wang Y, Wang Z, Chen M, Jiang Z, Pan J, Yang C, Li X, Song K, Yan J, Xie W, Wu X, Chen Z, Yuan Y, Zheng S, Yan J, Huang J*, Qiu F*, 2020
