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Xingxing Dai
Medical School
Zhejiang University
Zhejiang
Language: Chinese, English
Mrna Degradation
Germ Cells
Nuclear Compartmentalization
Nanoparticles
Oocyte Development
Embryo Development
Premature Ovarian Failure
Reproductive Biology
Cell Biology
Molecular Mechanisms
Areas of Focus
- Function and mechanism of different mRNA degradation pathways in germ cells
- Physiological significance and regulatory mechanisms of nuclear compartmentalization in germ cells
- Impact of specific targeted nanoparticles on germ cells
- Mechanisms of oocyte and embryo development
- Premature ovarian failure
Work Experience
- 2022 - Present - Zhejiang University School of Medicine Fourth Affiliated Hospital - Distinguished Researcher
Academic Background & Achievements
- 2015 - Bachelor's Degree: Shandong Agricultural University, Bioengineering
- 2020 - PhD: Zhejiang University, Cell Biology
- 2022 - Postdoctoral Research: Zhejiang University School of Medicine Fourth Affiliated Hospital
- China Association for Science and Technology Youth Talent
Publications
- Biallelic variants in MAD2L1BP (p31comet) cause female infertility characterized by oocyte maturation arrest, Huang LL, Li WQ, Dai XX, Zhao S, Xu B, Wang FS, Jin RT, Luo LH, Wu LM, Jiang X, Cheng Y, Zou JQ, Xu CL, Tong XH, Fan HY, Zhao H, Bao JQ, 2023
- PABPN1 functions as a hub in the assembly of nuclear mRNA processing domains that are essential for oocyte development, Dai XX, Pi SB, Zhao LW, Wu YW, Shen JL, Zhang SY, Sha QQ, Fan HY, 2022
- CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development, Dai XX, Jiang ZY, Wu YW, Sha QQ, Liu Y, Ding JY, Xi WD, Li J, Fan HY, 2021
- Oocyte meiosis-coupled poly(A) polymerase α phosphorylation and activation trigger maternal mRNA translation in mice, Jiang JC, Zhang H, Cao LR, Dai XX, Zhao LW, Liu HB, Fan HY, 2021
- The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis, Dai XX, Jiang Y, Gu JH, Jiang ZY, Wu YW, Yu C, Yin H, Zhang J, Shi QH, Shen L, Sha QQ, Fan HY, 2021
- CFP1-dependent histone H3K4 trimethylation in murine oocytes facilitates ovarian follicle recruitment and ovulation in a cell-nonautonomous manner, Sha QQ, Jiang Y, Yu C, Xiang Y, Dai XX, Jiang JC, Ou XH, Fan HY, 2020
- A combinatorial code for mRNA 3'-UTR-mediated translational control in the mouse oocyte, Dai XX, Jiang JC, Sha QQ, Jiang Y, Ou XH, Fan HY, 2019
- CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte, Sha QQ, Yu JL, Guo JX, Dai XX, Jiang JC, Zhang YL, Yu C, Ji SY, Jiang Y, Zhang SY, Shen L, Ou XH, Fan HY, 2018
- CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes, Sha QQ, Dai XX, Jiang JC, Yu C, Jiang Y, Liu J, Ou XH, Zhang SY, Fan HY, 2018
- CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes, Yu C, Fan X, Sha QQ, Wang HH, Li BT, Dai XX, Shen L, Liu J, Wang L, Liu K, Tang F, Fan HY, 2017
- A MAPK cascade couples maternal mRNA translation and degradation to meiotic cell cycle progression in mouse oocytes, Sha QQ, Dai XX, Dang Y, Tang F, Liu J, Zhang YL, Fan HY, 2017
Awards
- China Association for Science and Technology Youth Talent
