Professor | Xingxing Dai | Asia Growth Partners

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Name	Xingxing Dai
Contact Information	daixx1992@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Xingxing Dai

Contact Information

daixx1992@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	2015 - Bachelor's Degree: Shandong Agricultural University, Bioengineering 2020 - PhD: Zhejiang University, Cell Biology 2022 - Postdoctoral Research: Zhejiang University School of Medicine Fourth Affiliated Hospital China Association for Science and Technology Youth Talent
Work Experience	2022 - Present - Zhejiang University School of Medicine Fourth Affiliated Hospital - Distinguished Researcher
Awards	China Association for Science and Technology Youth Talent

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

2015 - Bachelor's Degree: Shandong Agricultural University, Bioengineering
2020 - PhD: Zhejiang University, Cell Biology
2022 - Postdoctoral Research: Zhejiang University School of Medicine Fourth Affiliated Hospital
China Association for Science and Technology Youth Talent

Work Experience

2022 - Present - Zhejiang University School of Medicine Fourth Affiliated Hospital - Distinguished Researcher

Awards

China Association for Science and Technology Youth Talent

Areas of Focus	Function and mechanism of different mRNA degradation pathways in germ cells Physiological significance and regulatory mechanisms of nuclear compartmentalization in germ cells Impact of specific targeted nanoparticles on germ cells Mechanisms of oocyte and embryo development Premature ovarian failure
Publications	Biallelic variants in MAD2L1BP (p31comet) cause female infertility characterized by oocyte maturation arrest, Huang LL, Li WQ, Dai XX, Zhao S, Xu B, Wang FS, Jin RT, Luo LH, Wu LM, Jiang X, Cheng Y, Zou JQ, Xu CL, Tong XH, Fan HY, Zhao H, Bao JQ, 2023 PABPN1 functions as a hub in the assembly of nuclear mRNA processing domains that are essential for oocyte development, Dai XX, Pi SB, Zhao LW, Wu YW, Shen JL, Zhang SY, Sha QQ, Fan HY, 2022 CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development, Dai XX, Jiang ZY, Wu YW, Sha QQ, Liu Y, Ding JY, Xi WD, Li J, Fan HY, 2021 Oocyte meiosis-coupled poly(A) polymerase α phosphorylation and activation trigger maternal mRNA translation in mice, Jiang JC, Zhang H, Cao LR, Dai XX, Zhao LW, Liu HB, Fan HY, 2021 The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis, Dai XX, Jiang Y, Gu JH, Jiang ZY, Wu YW, Yu C, Yin H, Zhang J, Shi QH, Shen L, Sha QQ, Fan HY, 2021 CFP1-dependent histone H3K4 trimethylation in murine oocytes facilitates ovarian follicle recruitment and ovulation in a cell-nonautonomous manner, Sha QQ, Jiang Y, Yu C, Xiang Y, Dai XX, Jiang JC, Ou XH, Fan HY, 2020 A combinatorial code for mRNA 3'-UTR-mediated translational control in the mouse oocyte, Dai XX, Jiang JC, Sha QQ, Jiang Y, Ou XH, Fan HY, 2019 CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte, Sha QQ, Yu JL, Guo JX, Dai XX, Jiang JC, Zhang YL, Yu C, Ji SY, Jiang Y, Zhang SY, Shen L, Ou XH, Fan HY, 2018 CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes, Sha QQ, Dai XX, Jiang JC, Yu C, Jiang Y, Liu J, Ou XH, Zhang SY, Fan HY, 2018 CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes, Yu C, Fan X, Sha QQ, Wang HH, Li BT, Dai XX, Shen L, Liu J, Wang L, Liu K, Tang F, Fan HY, 2017 A MAPK cascade couples maternal mRNA translation and degradation to meiotic cell cycle progression in mouse oocytes, Sha QQ, Dai XX, Dang Y, Tang F, Liu J, Zhang YL, Fan HY, 2017

Areas of Focus

Function and mechanism of different mRNA degradation pathways in germ cells
Physiological significance and regulatory mechanisms of nuclear compartmentalization in germ cells
Impact of specific targeted nanoparticles on germ cells
Mechanisms of oocyte and embryo development
Premature ovarian failure

Publications

Biallelic variants in MAD2L1BP (p31comet) cause female infertility characterized by oocyte maturation arrest, Huang LL, Li WQ, Dai XX, Zhao S, Xu B, Wang FS, Jin RT, Luo LH, Wu LM, Jiang X, Cheng Y, Zou JQ, Xu CL, Tong XH, Fan HY, Zhao H, Bao JQ, 2023
PABPN1 functions as a hub in the assembly of nuclear mRNA processing domains that are essential for oocyte development, Dai XX, Pi SB, Zhao LW, Wu YW, Shen JL, Zhang SY, Sha QQ, Fan HY, 2022
CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development, Dai XX, Jiang ZY, Wu YW, Sha QQ, Liu Y, Ding JY, Xi WD, Li J, Fan HY, 2021
Oocyte meiosis-coupled poly(A) polymerase α phosphorylation and activation trigger maternal mRNA translation in mice, Jiang JC, Zhang H, Cao LR, Dai XX, Zhao LW, Liu HB, Fan HY, 2021
The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis, Dai XX, Jiang Y, Gu JH, Jiang ZY, Wu YW, Yu C, Yin H, Zhang J, Shi QH, Shen L, Sha QQ, Fan HY, 2021
CFP1-dependent histone H3K4 trimethylation in murine oocytes facilitates ovarian follicle recruitment and ovulation in a cell-nonautonomous manner, Sha QQ, Jiang Y, Yu C, Xiang Y, Dai XX, Jiang JC, Ou XH, Fan HY, 2020
A combinatorial code for mRNA 3'-UTR-mediated translational control in the mouse oocyte, Dai XX, Jiang JC, Sha QQ, Jiang Y, Ou XH, Fan HY, 2019
CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte, Sha QQ, Yu JL, Guo JX, Dai XX, Jiang JC, Zhang YL, Yu C, Ji SY, Jiang Y, Zhang SY, Shen L, Ou XH, Fan HY, 2018
CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes, Sha QQ, Dai XX, Jiang JC, Yu C, Jiang Y, Liu J, Ou XH, Zhang SY, Fan HY, 2018
CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes, Yu C, Fan X, Sha QQ, Wang HH, Li BT, Dai XX, Shen L, Liu J, Wang L, Liu K, Tang F, Fan HY, 2017
A MAPK cascade couples maternal mRNA translation and degradation to meiotic cell cycle progression in mouse oocytes, Sha QQ, Dai XX, Dang Y, Tang F, Liu J, Zhang YL, Fan HY, 2017

Mrna Degradation Germ Cells Nuclear Compartmentalization Nanoparticles Oocyte Development Embryo Development Premature Ovarian Failure Reproductive Biology Cell Biology Molecular Mechanisms

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