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Lin Yang
Medical School
Zhejiang University
Zhejiang
Language: Chinese, English
Membrane Protein
Drug Design
Mechanism Research
Protac
Molecular Glue
Lead Compounds
Natural Products
Target Discovery
Synthesis
Activity Evaluation
Areas of Focus
- Rational drug design and mechanism research based on membrane protein structure
- Discovery of small molecule lead compounds and new drug discovery based on PROTAC and molecular glue
- Discovery of new targets based on natural products, and their drug design, synthesis, and activity evaluation
- Discovery of efficient drug chemistry methods
Work Experience
- 2021.02 - 2024.04 - University of Michigan, Medical School - Postdoctoral Researcher
- 2019.05 - 2021.01 - University of Texas at Austin, Department of Chemistry - Postdoctoral Researcher
- 2010.09 - 2019.05 - University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry - Assistant Researcher
Academic Background & Achievements
- 2006.09 - 2010.06 Bachelor of Science: Sichuan University
- 2010.09 - 2019.05 Ph.D., Assistant Researcher: University of Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry
- 2019.05 - 2021.01 Postdoctoral Researcher: University of Texas at Austin, Department of Chemistry
- 2021.02 - 2024.04 Postdoctoral Researcher: University of Michigan, Medical School
Publications
- Discovery of SMD-3040 as a potent and selective SMARCA2 PROTAC degrader with strong in vivo antitumor activity, Yang, L.; Tu, W.; Huang, L.; Miao, B.; Kaneshige, A.; Jiang, W.; Leng, L.; Wang, M.; Wen, B.; Sun, D.; Wang, S., 2023
- Enantioselective Total Synthesis of Andrographolide and 14-Hydroxy-Colladonin: Carbonyl Reductive Coupling and trans-Decalin Formation via Hydrogen Transfer, Yang, L.; Wurm, T.; Poudel, B. S.; Krische, M. J., 2020
- Stereoselective Access to Polypropionates Expedited by the Double Hydroboration of Allenes: Total Synthesis of Antitumor (−)-Pironetin, Yang, L.; Kong, L.; Gu, Q.; Shao, S.; Lin, G.-Q.; Hong, R., 2020
- Integration of Novel Strategy and Methods: Total Synthesis of Antitumor Lasonolide A, Yang, L.; Hong, R., 2019
- Enantioconvergent and Concise Synthesis of Lasonolide A, Yang, L.; Lin, Z.-M.; Shao, S,-J.; Zhao, Q.; Hong, R., 2018
- Stereodivergent Synthesis of Functionalized Tetrahydropyrans Accelerated by Mechanism-Based Allylboration and Bioinspired Oxa-Michael Cyclization, Yang, L.; Lin, Z.-M.; Huang, S.-H.; Hong, R., 2016
- Synthesis of Polyketide Stereoarrays Enabled by a Traceless Oxonia-Cope Rearrangement, Yang, L.; He, G.-L.; Yin, R.-F.; Zhu, L.-L.; Wang, X.-X.; Hong, R., 2014
- A Modular Synthesis of Antitumor Macrolide (–)-Lasonolide A, Yang, L.; Lin, Z.; Zheng, K.; Kong, L.; Hong, R., 2020
Awards
- Sichuan Province Earthquake Relief Volunteer Service Advanced Individual (2008)
- Shimadzu Technology Festival Second Prize, Sichuan University (2009)
- National Inspirational Scholarship (2008, 2009)
- China Soong Ching Ling Foundation · Sichuan University Earthquake Disaster Area Student Completion Award First Prize (2008, 2009)
- Best Seminar Presenter (2015)
- University of Chinese Academy of Sciences 'Three Good Students' (2015)
- National Scholarship for Doctoral Students, University of Chinese Academy of Sciences (2015)
- Wang Yao Excellent Doctoral Scholarship, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (2016)
- First Prize for Graduate Academic Achievement, American Chemical Society Shanghai Chapter (2016)
- Excellent Graduate of University of Chinese Academy of Sciences (2017)
- Excellent Graduate of Beijing (2017)
- Adamas Academic Paper Award (2017)
- SIOC Advanced Individual Nomination Award (2019)
- National High-Level Young Talent (2023)
