Professor | Sijia Liu | Asia Growth Partners

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Name	Sijia Liu
Contact Information	sijia.liu@zju.edu.cn
Language ability	Chinese, English, Dutch
Province	Zhejiang

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Name

Sijia Liu

Contact Information

sijia.liu@zju.edu.cn

Language ability

Chinese, English, Dutch

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	PhD: Leiden University, Basic Medicine Supervised by Peter ten Dijke, member of the Royal Netherlands Academy of Arts and Sciences, European Academy of Sciences and Arts, and EMBO
Work Experience	Postdoctoral Researcher - Leiden University Medical Center - Research on COVID-19 related pulmonary fibrosis Distinguished Researcher - Zhejiang University School of Medicine - Research on cell signal transduction in cancer and fibrotic diseases

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

PhD: Leiden University, Basic Medicine
Supervised by Peter ten Dijke, member of the Royal Netherlands Academy of Arts and Sciences, European Academy of Sciences and Arts, and EMBO

Work Experience

Postdoctoral Researcher - Leiden University Medical Center - Research on COVID-19 related pulmonary fibrosis
Distinguished Researcher - Zhejiang University School of Medicine - Research on cell signal transduction in cancer and fibrotic diseases

Areas of Focus	Research on cell signal transduction in cancer and fibrotic diseases Application of organ-on-chip in basic medical clinical translation
Publications	Ras homolog family member J (RHOJ): a key regulator of chemoresistance associated with epithelial-mesenchymal transition, Liu S, Ren J, Zhang L, 2023 Deubiquitylating Enzymes in Cancer and Immunity, Ren J#, Yu P#, Liu S#, Li R, Niu X, Chen Y, Zhang Z, Zhou F, Zhang L, 2023 Differential optineurin expression controls TGFβ signaling and is a key determinant for metastasis of triple negative breast cancer, Liu S, van Dinther M, Hagenaars SC, Gu Y, Kuipers TB, Mei H, Gomez-Puerto MC, Mesker WE, Ten Dijke P, 2023 Developing advanced cell culture models to study COVID-19-associated pulmonary fibrosis, Liu S, Wang Y, Thaler M, Van Schadewijk A, Van Huizen M, Cohen D, Kikkert M, Van Hemert MV, Ten Dijke P, Hiemstra P, Van der Does AM, 2022 USP8 promotes cancer progression and extracellular vesicle-mediated CD8+ T cell exhaustion by deubiquitinating the TGF-β receptor TβRII, Xie F, Zhou X, Li H, Su P, Liu S, Li R, Zou J, Wei X, Pan C, Zhang Z, Zheng M, Liu Z, Meng X, Ovaa H, Ten Dijke P, Zhou F, Zhang L, 2022 RNF12 is regulated by AKT phosphorylation and promotes TGF-β driven breast cancer metastasis, Huang Y#, Liu S#, Shan M, Hagenaars SC, Mesker WE, Cohen D, Wang L, Zheng Z, Devilee P, Tollenaar RAEM, Li Z, Song Y, Zhang L, Li D, Ten Dijke P, 2022 Establishment of Embryonic Zebrafish Xenograft Assays to Investigate TGF-β Family Signaling in Human Breast Cancer Progression, Li C, Ma J, Groenewoud A, Ren J, Liu S, Snaar-Jagalska BE, Ten Dijke P, 2022 Uncovering the deubiquitinase activity landscape of breast cancer, Liu S, Ten Dijke P, 2021 The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma, Caja L, Dadras MS, Mezheyeuski A, Rodrigues-Junior DM, Liu S, Webb AT, Gomez-Puerto MC, Ten Dijke P, Heldin CH, Moustakas A, 2021 Intramuscular expression of plasmid-encoded FVII-Fc immunoconjugate for tumor immunotherapy by targeting tumoral blood vessels and cells, Ma L, Wang G, Liu S, Bi F, Liu M, Wang G, 2021 Targeting the TGFβ signaling for cancer therapy, Liu S, Ren J, Ten Dijke P, 2021 The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma, Dadras MS, Caja L, Mezheyeuski A, Liu S, Gélabert C, Gomez-Puerto MC, Gallini R, Rubin CJ, Ten Dijke P, Heldin CH, Moustakas A, 2021 A Small-Molecule Activity-Based Probe for Monitoring UCHL1 Activity in Live Cells and Zebrafish Embryos, Kooij R#, Liu S#, Sapmaz A#, Xin BT, Janssen GMC, van Veelen PA, Ovaa H, Dijke PT, Geurink PP, 2020 Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis, Liu S, González-Prieto R, Zhang M, Geurink PP, Kooij R, Iyengar PV, van Dinther M, Bos E, Zhang X, Le Dévédec SE, van de Water B, Koning RI, Zhu HJ, Mesker WE, Vertegaal ACO, Ovaa H, Zhang L, Martens JWM, Ten Dijke P, 2020 Invasive Behavior of Human Breast Cancer Cells in Embryonic Zebrafish, Ren J#, Liu S#, Cui C, Ten Dijke P, 2017 Regulation of the TGF-β pathway by deubiquitinases in cancer, Liu S, de Boeck M, van Dam H, Ten Dijke P, 2016 Mutational activation of BRAF confers sensitivity to transforming growth factor β inhibitors in human cancer cells, Spender LC, Ferguson GJ, Liu S, Cui C, Girotti MR, Sibbet G, Higgs EB, Shuttleworth MK, Hamilton T, Lorigan P, Weller M, Vincent DF, Sansom OJ, Frame M, ten Dijke P, Marais R, Inman GJ, 2016 Electroneutralized amphiphilic triblock copolymer with a peptide dendron for efficient muscular gene delivery, Pu L, Geng Y, Liu S, Chen J, Luo K, Wang G, Gu Z, 2014 Pluronic L64-mediated stable HIF-1α expression in muscle for therapeutic angiogenesis in mouse hindlimb ischemia, Song H, Liu S, Li C, Geng Y, Wang G, Gu Z, 2014 Safe and efficient local gene delivery into skeletal muscle via a combination of Pluronic L64 and modified electrotransfer, Liu S#, Ma L#, Tan R, Geng Y, Wang G, Gu Z, 2014

Areas of Focus

Research on cell signal transduction in cancer and fibrotic diseases
Application of organ-on-chip in basic medical clinical translation

Publications

Ras homolog family member J (RHOJ): a key regulator of chemoresistance associated with epithelial-mesenchymal transition, Liu S, Ren J, Zhang L*, 2023
Deubiquitylating Enzymes in Cancer and Immunity, Ren J#, Yu P#, Liu S#, Li R, Niu X, Chen Y, Zhang Z*, Zhou F*, Zhang L*, 2023
Differential optineurin expression controls TGFβ signaling and is a key determinant for metastasis of triple negative breast cancer, Liu S, van Dinther M, Hagenaars SC, Gu Y, Kuipers TB, Mei H, Gomez-Puerto MC, Mesker WE, Ten Dijke P*, 2023
Developing advanced cell culture models to study COVID-19-associated pulmonary fibrosis, Liu S, Wang Y, Thaler M, Van Schadewijk A, Van Huizen M, Cohen D, Kikkert M, Van Hemert MV, Ten Dijke P, Hiemstra P, Van der Does AM*, 2022
USP8 promotes cancer progression and extracellular vesicle-mediated CD8+ T cell exhaustion by deubiquitinating the TGF-β receptor TβRII, Xie F, Zhou X, Li H, Su P, Liu S, Li R, Zou J, Wei X, Pan C, Zhang Z, Zheng M, Liu Z, Meng X, Ovaa H, Ten Dijke P, Zhou F, Zhang L*, 2022
RNF12 is regulated by AKT phosphorylation and promotes TGF-β driven breast cancer metastasis, Huang Y#*, Liu S#, Shan M, Hagenaars SC, Mesker WE, Cohen D, Wang L, Zheng Z, Devilee P, Tollenaar RAEM, Li Z, Song Y, Zhang L*, Li D*, Ten Dijke P, 2022
Establishment of Embryonic Zebrafish Xenograft Assays to Investigate TGF-β Family Signaling in Human Breast Cancer Progression, Li C, Ma J, Groenewoud A, Ren J, Liu S, Snaar-Jagalska BE, Ten Dijke P*, 2022
Uncovering the deubiquitinase activity landscape of breast cancer, Liu S*, Ten Dijke P, 2021
The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma, Caja L, Dadras MS, Mezheyeuski A, Rodrigues-Junior DM, Liu S, Webb AT, Gomez-Puerto MC, Ten Dijke P, Heldin CH, Moustakas A*, 2021
Intramuscular expression of plasmid-encoded FVII-Fc immunoconjugate for tumor immunotherapy by targeting tumoral blood vessels and cells, Ma L, Wang G, Liu S, Bi F, Liu M, Wang G*, 2021
Targeting the TGFβ signaling for cancer therapy, Liu S, Ren J, Ten Dijke P*, 2021
The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma, Dadras MS, Caja L, Mezheyeuski A, Liu S, Gélabert C, Gomez-Puerto MC, Gallini R, Rubin CJ, Ten Dijke P, Heldin CH, Moustakas A*, 2021
A Small-Molecule Activity-Based Probe for Monitoring UCHL1 Activity in Live Cells and Zebrafish Embryos, Kooij R#, Liu S#, Sapmaz A#, Xin BT, Janssen GMC, van Veelen PA, Ovaa H, Dijke PT*, Geurink PP*, 2020
Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis, Liu S, González-Prieto R, Zhang M, Geurink PP, Kooij R, Iyengar PV, van Dinther M, Bos E, Zhang X, Le Dévédec SE, van de Water B, Koning RI, Zhu HJ, Mesker WE, Vertegaal ACO, Ovaa H, Zhang L, Martens JWM, Ten Dijke P*, 2020
Invasive Behavior of Human Breast Cancer Cells in Embryonic Zebrafish, Ren J#, Liu S#, Cui C, Ten Dijke P*, 2017
Regulation of the TGF-β pathway by deubiquitinases in cancer, Liu S, de Boeck M, van Dam H, Ten Dijke P*, 2016
Mutational activation of BRAF confers sensitivity to transforming growth factor β inhibitors in human cancer cells, Spender LC, Ferguson GJ, Liu S, Cui C, Girotti MR, Sibbet G, Higgs EB, Shuttleworth MK, Hamilton T, Lorigan P, Weller M, Vincent DF, Sansom OJ, Frame M, ten Dijke P, Marais R, Inman GJ*, 2016
Electroneutralized amphiphilic triblock copolymer with a peptide dendron for efficient muscular gene delivery, Pu L, Geng Y, Liu S, Chen J, Luo K, Wang G*, Gu Z*, 2014
Pluronic L64-mediated stable HIF-1α expression in muscle for therapeutic angiogenesis in mouse hindlimb ischemia, Song H, Liu S, Li C, Geng Y, Wang G*, Gu Z*, 2014
Safe and efficient local gene delivery into skeletal muscle via a combination of Pluronic L64 and modified electrotransfer, Liu S#, Ma L#, Tan R, Geng Y, Wang G*, Gu Z*, 2014

Cancer Fibrosis Cell Signaling Organ-On-Chip Clinical Translation Breast Cancer Deubiquitinase Small Molecule Drugs Fluorescent Probes Covid-19

Hongshan Guo - Zhejiang University

Li-Rong Chen - Zhejiang University

Fuming Qiu - Zhejiang University

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