Professor | Lei Li | Asia Growth Partners

Name

Lei Li

Contact Information

lli@bio.ecnu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	East China Normal University
Faculty	Life Sciences
Academic Background & Achievements	2013 PhD: East China Normal University Published over 30 academic papers as first/communicating author in journals like PNAS, Nature Communications, and Cell Death & Differentiation
Work Experience	2015/09 - Present, East China Normal University, School of Life Sciences
Awards	2016: Shanghai Youth Science and Technology Star 2015: Second Prize, Shanghai Biochemistry Association Academic Newcomer

University/Lab Affiliation and Title

East China Normal University

Faculty

Life Sciences

Academic Background & Achievements

2013 PhD: East China Normal University
Published over 30 academic papers as first/communicating author in journals like PNAS, Nature Communications, and Cell Death & Differentiation

Work Experience

Awards

Areas of Focus	Ubiquitin-independent protein degradation pathways in diseases (aging, tumors) Drug target discovery and regulatory mechanisms in bone diseases
Publications	REGγ activation of 20S proteasomes degrades multiple substrate proteins such as CK1δ, GSK3β, CK1ε, Lats1, and Smad7, Lei Li, 2013 REGγ promotes skin cancer, colon cancer, and thyroid cancer development and lung cancer metastasis, Lei Li, 2015 Phosphorylation modification of NIP30 is a molecular switch regulating REGγ-proteasome function, Lei Li, 2020

Areas of Focus

Ubiquitin-independent protein degradation pathways in diseases (aging, tumors)
Drug target discovery and regulatory mechanisms in bone diseases

Publications

REGγ activation of 20S proteasomes degrades multiple substrate proteins such as CK1δ, GSK3β, CK1ε, Lats1, and Smad7, Lei Li, 2013
REGγ promotes skin cancer, colon cancer, and thyroid cancer development and lung cancer metastasis, Lei Li, 2015
Phosphorylation modification of NIP30 is a molecular switch regulating REGγ-proteasome function, Lei Li, 2020

Protein Degradation Ubiquitin-Independent Aging Tumors Regγ 20S Proteasome Drug Targets Bone Diseases Molecular Regulation Pathway Mechanisms

Lei Li - East China Normal University

Zhengjiang Qian - University of Chinese Academy of Sciences

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