Areas of Focus
- Ubiquitin-independent protein degradation pathways in diseases (aging, tumors)
- Drug target discovery and regulatory mechanisms in bone diseases
Work Experience
- 2015/09 - Present, East China Normal University, School of Life Sciences
Academic Background & Achievements
- 2013 PhD: East China Normal University
- Published over 30 academic papers as first/communicating author in journals like PNAS, Nature Communications, and Cell Death & Differentiation
Publications
- REGγ activation of 20S proteasomes degrades multiple substrate proteins such as CK1δ, GSK3β, CK1ε, Lats1, and Smad7, Lei Li, 2013
- REGγ promotes skin cancer, colon cancer, and thyroid cancer development and lung cancer metastasis, Lei Li, 2015
- Phosphorylation modification of NIP30 is a molecular switch regulating REGγ-proteasome function, Lei Li, 2020
Awards
- 2016: Shanghai Youth Science and Technology Star
- 2015: Second Prize, Shanghai Biochemistry Association Academic Newcomer
