Professor | Xu Lingyan | Asia Growth Partners

Name	Xu Lingyan
Contact Information	lyxu@bio.ecnu.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Xu Lingyan

Contact Information

lyxu@bio.ecnu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	East China Normal University
Faculty	Life Sciences
Academic Background & Achievements	2005-2010 PhD in Biochemistry and Molecular Biology/Endocrine Metabolic Diseases, Shanghai Institute for Biological Sciences, CAS 2001-2005 Bachelor of Science in Biochemistry and Molecular Biology, Fudan University Awards: National Natural Science Foundation of China 'Outstanding Youth', Shanghai 'Pujiang Talent Plan', East China Normal University 'Zijiang Outstanding Young Scholar'
Work Experience	2017-present Researcher, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University 2011-2016 Postdoctoral Fellow (Visiting Fellow), NIDDK, NIH, USA 2010-2011 Assistant Researcher, Shanghai Institute for Biological Sciences, CAS
Awards	National Natural Science Foundation of China 'Outstanding Youth' Shanghai 'Pujiang Talent Plan' East China Normal University 'Zijiang Outstanding Young Scholar'

University/Lab Affiliation and Title

East China Normal University

Faculty

Life Sciences

Academic Background & Achievements

2005-2010 PhD in Biochemistry and Molecular Biology/Endocrine Metabolic Diseases, Shanghai Institute for Biological Sciences, CAS
2001-2005 Bachelor of Science in Biochemistry and Molecular Biology, Fudan University
Awards: National Natural Science Foundation of China 'Outstanding Youth', Shanghai 'Pujiang Talent Plan', East China Normal University 'Zijiang Outstanding Young Scholar'

Work Experience

2017-present Researcher, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University
2011-2016 Postdoctoral Fellow (Visiting Fellow), NIDDK, NIH, USA
2010-2011 Assistant Researcher, Shanghai Institute for Biological Sciences, CAS

Awards

National Natural Science Foundation of China 'Outstanding Youth'
Shanghai 'Pujiang Talent Plan'
East China Normal University 'Zijiang Outstanding Young Scholar'

Areas of Focus	Aging Biology Adipose Tissue Aging and Metabolic Dysfunction
Publications	Local Hyperthermia Therapy Induces Browning of White Fat and Treats Obesity, Li Y, Wang D, Ping X, Zhang Y, Zhang T, Wang L, Jin L, Zhao W, Guo M, Shen F, Meng M, Chen X, Zheng Y, Wang J, Li D, Zhang Q, Hu C, Xu L, Ma X, 2022 AAV-Mediated Nuclear Localized PGC1α4 Delivery in Muscle Ameliorates Sarcopenia and Aging-associated Metabolic Dysfunctions, Guo M, Zhang J, Ma Y, Zhu Z, Zuo H, Yao J, Wu X, Wang D, Yu J, Meng M, Liu C, Zhang Y, Chen J, Lu J, Ding S, Hu C, Ma X, Xu L, 2023 Fibroblast growth factor 6 promotes adipocyte progenitor cell proliferation for adipose tissue homeostasis, Liu C, Meng M, Xu B, Xu Y, Li G, Cao Y, Wang D, Qiu J, Yu J, Xu L, Ma X, Hu C, 2023 Irisin ameliorates age-associated sarcopenia and metabolic dysfunction, Guo M, Yao J, Li J, Zhang J, Wang D, Zuo H, Zhang Y, Xu B, Zhong Y, Shen F, Lu J, Ding S, Hu C, Xu L, Xiao J, Ma X, 2023 A fluorinated peptide with high serum- and lipid-tolerance for the delivery of siRNA drugs to treat obesity and metabolic dysfunction, Qiu J, Fan Q, Xu S, Wang D, Chen J, Wang S, Hu T, Ma X, Cheng Y, Xu L, 2022 Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents, Yu J, Chen X, Zhang Y, Cui X, Zhang Z, Guo W, Wang D, Huang S, Chen Y, Hu Y, Zhao C, Qiu J, Li Y, Meng M, Guo M, Shen F, Zhang M, Zhou B, Gu X, Wang J, Wang X, Ma X, Xu L, 2022 FOXA3 induction under endoplasmic reticulum stress contributes to non-alcoholic fatty liver disease, Liu C, Zhou B, Meng M, Zhao W, Wang D, Yuan Y, Zheng Y, Qiu J, Li Y, Li G, Xiong X, Bian H, Zhang H, Wang H, Ma X, Hu C, Xu L, Lu Y, 2021 PPARγ agonists delay age-associated metabolic disease and extend longevity, Xu L, Ma X, Verma N, Perie L, Pendse J, Shamloo S, Marie Josephson A, Wang D, Qiu J, Guo M, Ping X, Allen M, Noguchi A, Springer D, Shen F, Liu C, Zhang S, Li L, Li J, Xiao J, Lu J, Du Z, Luo J, Aleman JO, Leucht P, Mueller E, 2020 C/EBPδ-Slug-Lox1 axis promotes metastasis of lung adenocarcinoma via oxLDL uptake, Wang D, Cheng X, Li Y, Guo M, Zhao W, Qiu J, Zheng Y, Meng M, Ping X, Chen X, Wang S, Luo J, Luo Q, Ma X, Xu L, 2020 Ablation of PPARγ in subcutaneous fat exacerbates age-associated obesity and metabolic decline, Xu L, Ma X, Verma NK, Wang D, Gavrilova O, Proia RL, Finkel T, Mueller E, 2018

Areas of Focus

Aging Biology
Adipose Tissue Aging and Metabolic Dysfunction

Publications

Local Hyperthermia Therapy Induces Browning of White Fat and Treats Obesity, Li Y, Wang D, Ping X, Zhang Y, Zhang T, Wang L, Jin L, Zhao W, Guo M, Shen F, Meng M, Chen X, Zheng Y, Wang J, Li D, Zhang Q, Hu C, Xu L, Ma X, 2022
AAV-Mediated Nuclear Localized PGC1α4 Delivery in Muscle Ameliorates Sarcopenia and Aging-associated Metabolic Dysfunctions, Guo M, Zhang J, Ma Y, Zhu Z, Zuo H, Yao J, Wu X, Wang D, Yu J, Meng M, Liu C, Zhang Y, Chen J, Lu J, Ding S, Hu C, Ma X, Xu L, 2023
Fibroblast growth factor 6 promotes adipocyte progenitor cell proliferation for adipose tissue homeostasis, Liu C, Meng M, Xu B, Xu Y, Li G, Cao Y, Wang D, Qiu J, Yu J, Xu L, Ma X, Hu C, 2023
Irisin ameliorates age-associated sarcopenia and metabolic dysfunction, Guo M, Yao J, Li J, Zhang J, Wang D, Zuo H, Zhang Y, Xu B, Zhong Y, Shen F, Lu J, Ding S, Hu C, Xu L, Xiao J, Ma X, 2023
A fluorinated peptide with high serum- and lipid-tolerance for the delivery of siRNA drugs to treat obesity and metabolic dysfunction, Qiu J, Fan Q, Xu S, Wang D, Chen J, Wang S, Hu T, Ma X, Cheng Y, Xu L, 2022
Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents, Yu J, Chen X, Zhang Y, Cui X, Zhang Z, Guo W, Wang D, Huang S, Chen Y, Hu Y, Zhao C, Qiu J, Li Y, Meng M, Guo M, Shen F, Zhang M, Zhou B, Gu X, Wang J, Wang X, Ma X, Xu L, 2022
FOXA3 induction under endoplasmic reticulum stress contributes to non-alcoholic fatty liver disease, Liu C, Zhou B, Meng M, Zhao W, Wang D, Yuan Y, Zheng Y, Qiu J, Li Y, Li G, Xiong X, Bian H, Zhang H, Wang H, Ma X, Hu C, Xu L, Lu Y, 2021
PPARγ agonists delay age-associated metabolic disease and extend longevity, Xu L, Ma X, Verma N, Perie L, Pendse J, Shamloo S, Marie Josephson A, Wang D, Qiu J, Guo M, Ping X, Allen M, Noguchi A, Springer D, Shen F, Liu C, Zhang S, Li L, Li J, Xiao J, Lu J, Du Z, Luo J, Aleman JO, Leucht P, Mueller E, 2020
C/EBPδ-Slug-Lox1 axis promotes metastasis of lung adenocarcinoma via oxLDL uptake, Wang D, Cheng X, Li Y, Guo M, Zhao W, Qiu J, Zheng Y, Meng M, Ping X, Chen X, Wang S, Luo J, Luo Q, Ma X, Xu L, 2020
Ablation of PPARγ in subcutaneous fat exacerbates age-associated obesity and metabolic decline, Xu L, Ma X, Verma NK, Wang D, Gavrilova O, Proia RL, Finkel T, Mueller E, 2018

Aging Biology Adipose Tissue Metabolic Dysfunction Brown Fat Molecular Mechanisms Systemic Lipid Metabolism Hsf1 Foxa3-Pparγ Therapeutic Strategies

Xinran Ma - East China Normal University

Xinran Ma - East China Normal University

Le Rongrong - Tongji University

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