Current - Group Leader: Spermatogonial Stem Cell Research Group, Institute of Zoology, Chinese Academy of Sciences
Zhu Li Yuehua Excellent Teacher Award: Chinese Academy of Sciences
Research
Infertility Treatment Technologies Spermatogonial Stem Cell Proliferation and Differentiation
Transcription factor PBX4 regulates limb development and haematopoiesis in mice, Ning Y, Duo S, Lin X, Zhang H, Fei J, Zhang B, Zeng Y, Xie D, Chen J, Liu X, Han C, 2024
A CRISPR/Cas9-based kinome screen identifies ErbB signaling as a new regulator of human naïve pluripotency and totipotency, Li J, Lin X, Xie L, Zhao J, Han C, Deng H, Xu J, 2023
Loss of RBFOX2 inhibits meiotic initiation in male mice, Yan L, Chen J, Ning Y, Han C, 2023
Metabolic dysregulation in patients with premature ovarian insufficiency revealed by integrated transcriptomic, methylomic and metabolomic analyses, Lu C, Qin C, Fu Z, Wang L, Yi Y, Xin M, Zhen X, Han C, Lu C, 2022
Identification and characterization of BEND2 as a key regulator of meiosis during mouse spermatogenesis, Ma, L., Xie, D., Luo, M., Lin, X., Nie, H., Chen, J., Gao, C., Duo, S., and Han, C., 2022
MicroRNA-202 safeguards meiotic progression by preventing premature SEPARASE-mediated REC8 cleavage, Chen, J., Gao, C., Luo, M., Zheng, C., Lin, X., Ning, Y., Ma, L., He, W., Xie, D., Liu, K., Hong, K., Han, C., 2022
The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis, Chen, J., Gao, C., Lin, X., Ning, Y., He, W., Zheng, C., Zhang, D., Yan, L., Jiang, B., Zhao, Y., Hossen, MA., Han, C., 2021
Non-canonical RNA polyadenylation polymerase FAM46C is essential for fastening sperm head and flagellum in mice, Zheng, C., Ouyang, YC., Jiang, B., Lin, X., Chen, J., Dong, MZ., Zhuang, X., Yuan, S., Sun, QY., Han C., 2019
The transcription factor SOX30 is a key regulator of mouse spermiogenesis, Zhang, D., Xie, D., Lin, X., Ma, L., Chen, J., Wang, Y., Duo, S., Feng, Y., Zheng, C., Jiang, B., Ning, Y., Han, C., 2018
Reprogramming p53-Deficient Germline Stem Cells Into Pluripotent State by Nanog, Feng, Y., Ning, Y., Lin, X., Zhang, D., Liao, S., Zheng, C., Chen J., Wang Y., Ma L., Xie D., Han C., 2018
Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint, Hu, X., Shen, B., Liao, S., Ning, Y., Ma, L., Chen, J., Lin, X., Zhang, D., Li, Z., Zheng, C., Feng, Y., Huang, X., Han C., 2017
Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation, Tu, Z., Bayazit, M. B., Liu, H., Zhang, J., Busayavalasa, K., Risal, S., Shao, J., Satyanarayana, A., Coppola, V., Tessarollo, L., Singh, M., Zheng, C., Han, C., Chen, Z., Kaldis, P., Gustafsson, J. A., and Liu, K., 2017
Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression, Chen, M., Zhang, L., Cui, X., Lin, X., Li, Y., Wang, Y., Wang, Y., Qin, Y., Chen, D., Han, C., Zhou, B., Huff, V., and Gao, F., 2017
Retinoic Acid Is Sufficient for the In Vitro Induction of Mouse Spermatocytes, Wang S., Wang Xx., Wu Yj., and Han, C., 2016
Expression dynamics, relationships, and transcriptional regulations of diverse transcripts in mouse spermatogenic cells, Lin, X., Han, M., Cheng, L., Chen, J., Zhang, Z., Shen, T., Wang, M., Wen, B., Ni, T., and Han, C., 2016
Transcription Factor RFX2 Is a Key Regulator of Mouse Spermiogenesis, Wu, Y., Hu, X., Li, Z., Wang, M., Li, S., Wang, X., Lin, X., Liao, S., Zhang, Z., Feng, X., Wang, S., Cui, X., Wang, Y., Gao, F., Hess, R. A., and Han, C., 2016
BMP4 Cooperates with Retinoic Acid to Induce the Expression of Differentiation Markers in Cultured Mouse Spermatogonia, Yang, Y., Feng, Y., Feng, X., Liao, S., Wang, X., Gan, H., Wang, L., Lin, X., and Han, C., 2016
Precision Medicine: What Challenges Are We Facing?, Xue, Y., Lameijer, E. W., Ye, K., Zhang, K., Chang, S., Wang, X., Wu, J., Gao, G., Zhao, F., Li, J., Han, C., Xu, S., Xiao, J., Yang, X., Ying, X., Zhang, X., Chen, W. H., Liu, Y., Zhang, Z., Huang, K., and Yu, J., 2016
Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis, Gao, Y., Bai, X., Zhang, D., Han, C., Yuan, J., Liu, W., Cao, X., Chen, Z., Shangguan, F., Zhu, Z., Gao, F., and Qin, Y., 2016
Confocal Microscopic Analysis of the Spindle and Chromosome Configurations of in vitro-Matured Oocytes from Different Types of Polycystic Ovary Syndrome Patients, Zhu, L., Han, C. S., Cao, Z. L., Wang, Z. B., Han, R. G., Wang, B., and Sun, Q. Y., 2015
IGF-1R Signaling Is Essential for the Proliferation of Cultured Mouse Spermatogonial Stem Cells by Promoting the G2/M Progression of the Cell Cycle, Wang S., Wang Xx., Wu Yj., and Han, C., 2015
Which one is the real matchmaker for the pair?, Han, C., 2014
Generation of male germ cells from mouse induced pluripotent stem cells in vitro, Li, Y., Wang, X., Feng, X., Liao, S., Zhang, D., Cui, X., Gao, F., and Han, C., 2014
Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis, Gan, H., Wen, L., Liao, S., Lin, X., Ma, T., Liu, J., Song, C.-x., Wang, M., He, C., Han, C., and Tang, F., 2013
Genome-wide Loss of 5-hmC is a Novel Epigenetic Feature of Huntington's Disease, Wang, F., Yang, Y., Lin, X., Wang, J. Q., Wu, Y. S., Xie, W., Wang, D., Zhu, S., Liao, Y. Q., Sun, Q., Yang, Y. G., Guo, C., Han, C., and Tang, T. S., 2013
HSF2BP represses BNC1 transcriptional activity by sequestering BNC1 to the cytoplasm, Wu, Y., Liao, S., Wang, X., Wang, S., Wang, M., and Han, C., 2013
SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60, Shi, Y., Zhuang, X., Xu, B., Hua, J., Liao, S., Shi, Q., Cooke, H. J., Han, C., 2013
Integrative Proteomic and Transcriptomic Analyses Reveal Multiple Post-transcriptional Regulatory Mechanisms of Mouse Spermatogenesis, Gan, H., Cai, T., Lin, X., Wu, Y., Wang, X., Yang, F., and Han, C., 2013
Mining and characterization of ubiquitin E3 ligases expressed in the mouse testis, Hou, X., Zhang, W., Xiao, Z., Gan, H., Lin, X., Liao, S., and Han, C., 2012
Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells, Zhang, Y., Wang, S., Wang, X., Liao, S., Wu, Y., and Han, C., 2012
piRNA profiling during specific stages of mouse spermatogenesis, Gan, H., Lin, X., Zhang, Z., Zhang, W., Liao, S., Wang, L., and Han, C., 2011
SLXL1, a novel acrosomal protein, interacts with DKKL1 and is involved in fertilization in mice, Zhuang, X. J., Hou, X. J., Liao, S. Y., Wang, X. X., Cooke, H. J., Zhang, M., and Han, C., 2011
Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37, Shi, Y. Q., Liao, S. Y., Zhuang, X. J., and Han, C. S., 2011
Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas, Liu, Z., Lin, X., Cai, Z., Zhang, Z., Han, C., Jia, S., Meng, A., and Wang, Q., 2011
Meta-analysis of genome-wide and replication association studies on prostate cancer, Liu, H., Wang, B., and Han, C., 2011
GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway, Yang, Y., and Han, C., 2010
Male germ cell-specific protein Trs4 binds to multiple proteins, Shi, Y. Q., Li, Y. C., Hu, X. Q., Liu, T., Liao, S. Y., Guo, J., Huang, L., Hu, Z. Y., Tang, A. Y., Lee, K. F., Yeung, W. S., Han, C. S., and Liu, Y. X., 2009
Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase, Nian, H., Zhang, W., Shi, H., Zhao, Q., Xie, Q., Liao, S., Zhang, Y., Zhang, Z., Wang, C., and Han, C., 2008
Uncoupling protein 2 protects testicular germ cells from hyperthermia-induced apoptosis, Zhang, K., Shang, Y., Liao, S., Zhang, W., Nian, H., Liu, Y., Chen, Q., and Han, C., 2007
RNF151, a testis-specific RING finger protein, interacts with dysbindin, Nian, H., Fan, C., Liao, S., Shi, Y., Zhang, K., Liu, Y., and Han, C., 2007
In vitro propagation of spermatogonial stem cells from KM mice, Shi, Y. Q., Wang, Q. Z., Liao, S. Y., Zhang, Y., Liu, Y. X., and Han, C. S., 2006
In vivo drug target discovery: identifying the best targets from the genome, Walke, D. W., Han, C., Shaw, J., Wann, E., Zambrowicz, B., and Sands, A., 2001
Antiviral activities of the soluble extracellular domains of type I interferon receptors, Han, C. S., Chen, Y., Ezashi, T., and Roberts, R. M., 2001
