Achievement: Discovered heterogeneity and regularity in human iPS neural differentiation
2005-2009 - University of Wisconsin-Madison - Postdoctoral Research
2009-2011 - University of Wisconsin-Madison - Assistant Scientist
2011-present - Chinese Academy of Sciences - Researcher
Young and Middle-aged Leading Talent in Scientific and Technological Innovation (2020)
National Candidate of the Ten Thousand Talents Program (2019)
Outstanding Scientific Achievement Award of the Chinese Academy of Sciences (2020)
Stem Cell Research Innovation Award (2019)
Stem Cell Achievement Transformation Award (2018)
First Prize of the Seventh Outstanding Contribution Award of Chinese Overseas (2018)
First Prize of Chinese Medical Science and Technology Award (2018)
Third Prize of Chinese Medical Science and Technology Award (2017)
Research
Neural differentiation mechanisms Human development and cell differentiation uniqueness Stem cell medical transformation
Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice., J. Liu, Z. Hou, J. Wu, K. Liu, D. Li, T. Gao, W. Liu, B. An, Y. Sun, F. Mo, L. Wang, Y. Wang, J. Hao, B. Hu, 2021
Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis., J. Wu, D. Song, Z. Li, B. Guo, Y. Xiao, W. Liu, L. Liang, C. Feng, T. Gao, Y. Chen, Y. Li, Z. Wang, J. Wen, S. Yang, P. Liu, L. Wang, Y. Wang, L. Peng, G. N. Stacey, Z. Hu, G. Feng, W. Li, Y. Huo, R. Jin, N. Shyh-Chang, Q. Zhou, L. Wang, B. Hu, H. Dai, J. Hao, 2020
First case of COVID-19 infused with hESC derived immunity- and matrix-regulatory cells., J. Wu, Z. Hu, L. Wang, Y. Tan, W. Hou, Z. Li, T. Gao, J. Fan, B. Guo, H. Dai, W. Li, J. Hao, R. Jin, B. Hu, 2020
Phase 1 trial for treatment of COVID-19 patients with pulmonary fibrosis using hESC-IMRCs., J. Wu, X. Zhou, Y. Tan, L. Wang, T. Li, Z. Li, T. Gao, J. Fan, B. Guo, W. Li, J. Hao, X. Wang, B. Hu, 2020
Stem Cell Therapy for Parkinson's Disease., F. Han, B. Hu, 2020
Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome., W. Zhu, B. Zhang, M. Li, F. Mo, T. Mi, Y. Wu, Z. Teng, Q. Zhou, W. Li, B. Hu, 2019
Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids., Y. Xu, Y. Qiu, B. Zhang, G. Chen, Q. Chen, M. Wang, F. Mo, J. Xu, J. Wu, R. Zhang, M. Cheng, N. Zhang, B. Lyu, W. Zhu, M. Wu, Q. Ye, D. Zhang, J. Man, X. Li, J. Cui, Z. Xu, B. Hu, X. Zhou, C. Qin, 2019
The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies., L. Wang, W. Wu, Q. Gu, Z. Liu, Q. Li, Z. Li, J. Fang, W. Liu, J. Wu, Y. Zhang, L. Wang, H. Xu, W. Li, B. Hu, Q. Zhou, Z. Yin, J. Hao, 2019
Reactive Amphiphilic Conjugated Polymers for Inhibiting Amyloid beta Assembly., H. Sun, J. Liu, S. Li, L. Zhou, J. Wang, L. Liu, F. Lv, Q. Gu, B. Hu, Y. Ma, S. Wang, 2019
Precise immune tolerance for hPSC derivatives in clinical application., W. Zhu, M. Li, Y. Wu, B. Hu, 2018
SIRT6 deficiency results in developmental retardation in cynomolgus monkeys., W. Zhang, H. Wan, G. Feng, J. Qu, J. Wang, Y. Jing, R. Ren, Z. Liu, L. Zhang, Z. Chen, S. Wang, Y. Zhao, Z. Wang, Y. Yuan, Q. Zhou, W. Li, G.H. Liu, B. Hu, 2018
Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids., B. Zhang, Y. He, Y. Xu, F. Mo, T. Mi, Q. Shen, C. Li, Y. Li, J. Liu, Y. Wu, G. Chen, W. Zhu, C. Qin, B. Hu, G. Zhou, 2018
A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs., M. Wu, D. Zhang, C. Bi, T. Mi, W. Zhu, L. Xia, Z. Teng, B. Hu, Y. Wu, 2018
Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease., Y. Wang, W. Zhu, M. Wu, Y. Wu, Z. Liu, L. Liang, C. Sheng, J. Hao, L. Wang, W. Li, Q. Zhou, B. Hu, 2018
Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis., X. Wang, T. Li, T. Cui, D. Yu, C. Liu, L. Jiang, G. Feng, L. Wang, R. Fu, X. Zhang, J. Hao, Y. Wang, L. Wang, Q. Zhou, W. Li, B. Hu, 2018
Generation of clinical-grade functional cardiomyocytes from human embryonic stem cells in chemically defined conditions., Y. Tan, P. Han, Q. Gu, G. Chen, L. Wang, R. Ma, J. Wu, C. Feng, Y. Zhang, L. Wang, B. Hu, W. Li, J. Hao, Q. Zhou, 2018
Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions., Z. Li, L. Wang, L. Wang, G. Feng, X. Yuan, C. Liu, K. Xu, Y. Li, H. Wan, Y. Zhang, Y. Li, X. Li, W. Li, Q. Zhou, B. Hu, 2018
A fully defined static suspension culture system for large-scale human embryonic stem cell production., X. Li, R. Ma, Q. Gu, L. Liang, L. Wang, Y. Zhang, X. Wang, X. Liu, Z. Li, J. Fang, J. Wu, Y. Wang, W. Li, B. Hu, L. Wang, Q. Zhou, J. Hao, 2018
Zinc finger E-box-binding homeobox 1 (ZEB1) is required for neural differentiation of human embryonic stem cells., Y. Jiang, L. Yan, L. Xia, X. Lu, W. Zhu, D. Ding, M. Du, D. Zhang, H. Wang, B. Hu, 2018
RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells., G. Chen, D. Zhang, L. Zhang, G. Feng, B. Zhang, Y. Wu, W. Li, Y. Zhang, B. Hu, 2018
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly., L. Yuan, X. Huang, Z. Liu, F. Zhang, X. Zhu, J. Yu, X. Ji, Y.P. Xu, G. Li, C. Li, H. Wang, Y. Deng, M. Wu, M. Cheng, Q. Ye, D. Xie, X. Li, X. Wang, W. Shi, B. Hu, P.Y. Shi, Z. Xu, C. Qin, 2017
The zinc finger E-box-binding homeobox 1 (Zeb1) promotes the conversion of mouse fibroblasts into functional neurons., L. Yan, Y. Li, Z. Shi, X. Lu, J. Ma, B. Hu, J. Jiao, H. Wang, 2017
Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo., K. Qian, H. Huang, A. Peterson, B. Hu, N.J. Maragakis, G.L. Ming, H. Chen, S.C. Zhang, 2017
High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1., P. Liu, K. Liu, H. Gu, W. Wang, J. Gong, Y. Zhu, Q. Zhao, J. Cao, C. Han, F. Gao, Q. Chen, W. Li, J. Jiao, B. Hu, Q. Zhou, T. Zhao, 2017
Rat embryonic stem cells produce fertile offspring through tetraploid complementation., T. Li, G. Feng, Y. Li, M. Wang, J. Mao, J. Wang, X. Li, X. Wang, B. Qu, L.Y. Wang, X. Zhang, H. Wan, T. Cui, C. Wan, L. Liu, X. Zhao, B. Hu, W. Li, Q. Zhou, 2017
Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations., Q. Gu, J. Wang, L. Wang, Z. Liu, W. Zhu, Y. Tan, W. Han, J. Wu, C. Feng, J. Fang, L. Liu, L. Wang, W. Li, X. Zhao, B. Hu, J. Hao, Q. Zhou, 2017
Tet3-Mediated DNA Demethylation Contributes to the Direct Conversion of Fibroblast to Functional Neuron., J. Zhang, S. Chen, D. Zhang, Z. Shi, H. Li, T. Zhao, B. Hu, Q. Zhou, J. Jiao, 2016
Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells., C. Zhang, J. Cao, X. Li, H. Xu, W. Wang, L. Wang, X. Zhao, W. Li, J. Jiao, B. Hu, Q. Zhou, T. Zhao, 2016
Conversion of Fibroblasts to Parvalbumin Neurons by One Transcription Factor, Ascl1, and the Chemical Compound Forskolin., Z. Shi, J. Zhang, S. Chen, Y. Li, X. Lei, H. Qiao, Q. Zhu, B. Hu, Q. Zhou, J. Jiao, 2016
ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance., K. Liu, Q. Zhao, P. Liu, J. Cao, J. Gong, C. Wang, W. Wang, X. Li, H. Sun, C. Zhang, Y. Li, M. Jiang, S. Zhu, Q. Sun, J. Jiao, B. Hu, X. Zhao, W. Li, Q. Chen, Q. Zhou, T. Zhao, 2016
Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells., Z. Li, H. Wan, G. Feng, L. Wang, Z. He, Y. Wang, X.J. Wang, W. Li, Q. Zhou, B. Hu, 2016
Phosphatidic Acid Improves Reprogramming to Pluripotency by Reducing Apoptosis., Y. Jiang, M. Du, M. Wu, Y. Zhu, X. Zhao, X. Cao, X. Li, P. Long, W. Li, B. Hu, 2016
Phase II Multicenter, Randomized, Double-Blind Controlled Study of Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cells in the Prophylaxis of Chronic Graft-Versus-Host Disease After HLA-Haploidentical Stem-Cell Transplantation., L. Gao, Y. Zhang, B. Hu, J. Liu, P. Kong, S. Lou, Y. Su, T. Yang, H. Li, Y. Liu, C. Zhang, L. Gao, L. Zhu, Q. Wen, P. Wang, X. Chen, J. Zhong, X. Zhang, 2016
Regulations in the United States for cell transplantation clinical trials in neurological diseases., H. Zhu, Y. Tan, Q. Gu, W. Han, Z. Li, J. S. Meyer, B. Hu, 2015
Immunogenicity and functional evaluation of iPSC-derived organs for transplantation., L. Wang, J. Cao, Y. Wang, T. Lan, L. Liu, W. Wang, N. Jin, J. Gong, C. Zhang, F. Teng, G. Yan, C. Li, J. Li, H. Wan, B. Hu, W. Li, X. Zhao, Z. Qi, T. Zhao, Q. Zhou, 2015
One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system., H. Wan, C. Feng, F. Teng, S. Yang, B. Hu, Y. Niu, A.P. Xiang, W. Fang, W. Ji, W. Li, X. Zhao, Q. Zhou, 2015
Estrogen therapy to treat retinopathy in newborn mice., W. Shi, L.I. Zhu, Y. Wang, B. Hu, H. Xiao, G. Zhou, C. Chen, 2015
Human-derived neural progenitors functionally replace astrocytes in adult mice., H. Chen, K. Qian, W. Chen, B. Hu, L.W.t. Blackbourn, Z. Du, L. Ma, H. Liu, K.M. Knobel, M. Ayala, S.C. Zhang, 2015
Rapid and efficient assembly of transcription activator-like effector genes by USER cloning., S. Wang, W. Li, S. Wang, B. Hu, 2014
Drastic alleviation of neovascularization in oxygen induced retinopathy of mice following intravitreal bone marrow stromal cell transplantation., L. Cong, H. Xiao, B. Hu, G. Zhou, 2014
Induced pluripotency for translational research., M. Wu, G. Chen, B. Hu, 2013
Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice., L. Ma, B. Hu, Y. Liu, S.C. Vermilyea, H. Liu, L. Gao, Y. Sun, X. Zhang, S.C. Zhang, 2012
Specification of functional neurons and glia from human pluripotent stem cells., Y. Jiang, M. Zhang, B. Hu, 2012
Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation., J. Hao, D. Campagnolo, R. Liu, W. Piao, S. Shi, B. Hu, R. Xiang, Q. Zhou, T. Vollmer, L. Van Kaer, A. La Cava, F.D. Shi, 2011
Directed Differentiation of Neural-stem cells and Subtype-Specific Neurons from hESCs, in Cellular Programming and Reprogramming: Methods and Protocols., B. Hu, S. Zhang, 2010
Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency., B. Hu, J. Weick, J. Yu, L. Ma, X. Zhang, J. Thomson, S. Zhang, 2010
Differentiation of spinal motor neurons from pluripotent human stem cells., B. Hu, S. Zhang, 2009
Differentiation of human oligodendrocytes from pluripotent stem cells., B. Hu, Z. Du, S. Zhang, 2009
Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects., B. Hu, Z. Du, X. Li, M. Ayala, S. Zhang, 2009
Cre recombination-mediated cassette exchange for building versatile transgenic human embryonic stem cells lines., Z. Du, B. Hu, M. Ayala, B. Sauer, S. Zhang, 2009
Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules., X. Li, B. Hu, S. Jones, Y. Zhang, T. Lavaute, Z. Du, S. Zhang, 2008
