Professor | Fan Guo | Asia Growth Partners

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Name	Fan Guo
Contact Information	guofan@ioz.ac.cn
Language ability	Chinese, English
Province	Beijing

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Name

Fan Guo

Contact Information

guofan@ioz.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Chinese Academy of Sciences
Faculty	Institute of Zoology
Academic Background & Achievements	2008 - Bachelor's Degree: Wuhan University 2014 - Doctorate: University of Chinese Academy of Sciences Achievement: Published in top journals like Nature, Cell, Nature Genetics Achievement: Selected in China's top ten life science advances
Work Experience	2017-03 to 2021-04 - Sichuan University - Researcher, PI, Doctoral Supervisor 2021-05 to Present - Institute of Zoology, Chinese Academy of Sciences - Researcher, PI
Awards	Outstanding Youth Science Fund National Distinguished Youth Science Fund First Prize in the Fifth Maternal and Child Health Science and Technology Award

University/Lab Affiliation and Title

Chinese Academy of Sciences

Faculty

Institute of Zoology

Academic Background & Achievements

2008 - Bachelor's Degree: Wuhan University
2014 - Doctorate: University of Chinese Academy of Sciences
Achievement: Published in top journals like Nature, Cell, Nature Genetics
Achievement: Selected in China's top ten life science advances

Work Experience

2017-03 to 2021-04 - Sichuan University - Researcher, PI, Doctoral Supervisor
2021-05 to Present - Institute of Zoology, Chinese Academy of Sciences - Researcher, PI

Awards

Outstanding Youth Science Fund
National Distinguished Youth Science Fund
First Prize in the Fifth Maternal and Child Health Science and Technology Award

Areas of Focus	Epigenetic regulation during early embryonic development and related diseases
Publications	Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene expression., Liang D., R. Yan, X. Long, D. Ji, B. Song, M. Wang, F. Zhang, X. Cheng, F. Sun, R. Zhu, X. Hou, T. Wang, W. Zou, Y. Zhang, Z. Pu, J. Zhang, Z. Zhang, Y. Liu, Y. Hu, X. He, Y. Cao and F. Guo, 2024 Generation of rat forebrain tissues in mice., Huang, J., B. He, X. Yang, X. Long, Y. Wei, L. Li, M. Tang, Y. Gao, Y. Fang, W. Ying, Z. Wang, C. Li, Y. Zhou, S. Li, L. Shi, S. Choi, H. Zhou, F. Guo, H. Yang and J. Wu, 2024 Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development., Yan, R., X. Cheng, C. Gu, Y. Xu, X. Long, J. Zhai, F. Sun, J. Qian, Y. Du, H. Wang and F. Guo, 2023 Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture., Zhai, J., Y. Xu, H. Wan, R. Yan, J. Guo, R. Skory, L. Yan, X. Wu, F. Sun, G. Chen, W. Zhao, K. Yu, W. Li, F. Guo, N. Plachta and H. Wang, 2023 Primate gastrulation and early organogenesis at single-cell resolution., Zhai, J., J. Guo, H. Wan, L. Qi, L. Liu, Z. Xiao, L. Yan, D. A. Schmitz, Y. Xu, D. Yu, X. Wu, W. Zhao, K. Yu, X. Jiang, F. Guo, J. Wu and H. Wang, 2022 Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing., Yan, R., C. Gu, D. You, Z. Huang, J. Qian, Q. Yang, X. Cheng, L. Zhang, H. Wang, P. Wang and F. Guo, 2021 Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis., Zhou, C., Y. Sun, R. Yan, Y. Liu, E. Zuo, C. Gu, L. Han, Y. Wei, X. Hu, R. Zeng, Y. Li, H. Zhou, F. Guo and H. Yang, 2019 Integrative single-cell analysis of transcriptome, DNA methylome and chromatin accessibility in mouse oocytes., Gu, C., S. Liu, Q. Wu, L. Zhang and F. Guo, 2019 Single-cell multi-omics sequencing of human early embryos., Li, L., F. Guo, Y. Gao, Y. Ren, P. Yuan, L. Yan, R. Li, Y. Lian, J. Li, B. Hu, J. Gao, L. Wen, F. Tang and J. Qiao, 2018 Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells., Guo, F., L. Li, J. Li, X. Wu, B. Hu, P. Zhu, L. Wen and F. Tang, 2017 The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells., Guo, F., L. Yan, H. Guo, L. Li, B. Hu, Y. Zhao, J. Yong, Y. Hu, X. Wang, Y. Wei, W. Wang, R. Li, J. Yan, X. Zhi, Y. Zhang, H. Jin, W. Zhang, Y. Hou, P. Zhu, J. Li, L. Zhang, S. Liu, Y. Ren, X. Zhu, L. Wen, Y. Q. Gao, F. Tang and J. Qiao, 2015 Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote., Guo, F., X. Li, D. Liang, T. Li, P. Zhu, H. Guo, X. Wu, L. Wen, T. P. Gu, B. Hu, C. P. Walsh, J. Li, F. Tang and G. L. Xu, 2014 The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes., Gu, T. P., F. Guo, H. Yang, H. P. Wu, G. F. Xu, W. Liu, Z. G. Xie, L. Shi, X. He, S. G. Jin, K. Iqbal, Y. G. Shi, Z. Deng, P. E. Szabo, G. P. Pfeifer, J. Li and G. L. Xu, 2011

Areas of Focus

Epigenetic regulation during early embryonic development and related diseases

Publications

Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene expression., Liang D., R. Yan, X. Long, D. Ji, B. Song, M. Wang, F. Zhang, X. Cheng, F. Sun, R. Zhu, X. Hou, T. Wang, W. Zou, Y. Zhang, Z. Pu, J. Zhang, Z. Zhang, Y. Liu, Y. Hu, X. He, Y. Cao and F. Guo, 2024
Generation of rat forebrain tissues in mice., Huang, J., B. He, X. Yang, X. Long, Y. Wei, L. Li, M. Tang, Y. Gao, Y. Fang, W. Ying, Z. Wang, C. Li, Y. Zhou, S. Li, L. Shi, S. Choi, H. Zhou, F. Guo, H. Yang and J. Wu, 2024
Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development., Yan, R., X. Cheng, C. Gu, Y. Xu, X. Long, J. Zhai, F. Sun, J. Qian, Y. Du, H. Wang and F. Guo, 2023
Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture., Zhai, J., Y. Xu, H. Wan, R. Yan, J. Guo, R. Skory, L. Yan, X. Wu, F. Sun, G. Chen, W. Zhao, K. Yu, W. Li, F. Guo, N. Plachta and H. Wang, 2023
Primate gastrulation and early organogenesis at single-cell resolution., Zhai, J., J. Guo, H. Wan, L. Qi, L. Liu, Z. Xiao, L. Yan, D. A. Schmitz, Y. Xu, D. Yu, X. Wu, W. Zhao, K. Yu, X. Jiang, F. Guo, J. Wu and H. Wang, 2022
Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing., Yan, R., C. Gu, D. You, Z. Huang, J. Qian, Q. Yang, X. Cheng, L. Zhang, H. Wang, P. Wang and F. Guo, 2021
Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis., Zhou, C., Y. Sun, R. Yan, Y. Liu, E. Zuo, C. Gu, L. Han, Y. Wei, X. Hu, R. Zeng, Y. Li, H. Zhou, F. Guo and H. Yang, 2019
Integrative single-cell analysis of transcriptome, DNA methylome and chromatin accessibility in mouse oocytes., Gu, C., S. Liu, Q. Wu, L. Zhang and F. Guo, 2019
Single-cell multi-omics sequencing of human early embryos., Li, L., F. Guo, Y. Gao, Y. Ren, P. Yuan, L. Yan, R. Li, Y. Lian, J. Li, B. Hu, J. Gao, L. Wen, F. Tang and J. Qiao, 2018
Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells., Guo, F., L. Li, J. Li, X. Wu, B. Hu, P. Zhu, L. Wen and F. Tang, 2017
The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells., Guo, F., L. Yan, H. Guo, L. Li, B. Hu, Y. Zhao, J. Yong, Y. Hu, X. Wang, Y. Wei, W. Wang, R. Li, J. Yan, X. Zhi, Y. Zhang, H. Jin, W. Zhang, Y. Hou, P. Zhu, J. Li, L. Zhang, S. Liu, Y. Ren, X. Zhu, L. Wen, Y. Q. Gao, F. Tang and J. Qiao, 2015
Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote., Guo, F., X. Li, D. Liang, T. Li, P. Zhu, H. Guo, X. Wu, L. Wen, T. P. Gu, B. Hu, C. P. Walsh, J. Li, F. Tang and G. L. Xu, 2014
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes., Gu, T. P., F. Guo, H. Yang, H. P. Wu, G. F. Xu, W. Liu, Z. G. Xie, L. Shi, X. He, S. G. Jin, K. Iqbal, Y. G. Shi, Z. Deng, P. E. Szabo, G. P. Pfeifer, J. Li and G. L. Xu, 2011

Epigenetics Embryonic Development Gene Expression Cell Differentiation Chromatin Dna Methylation Histone Modification Non-Coding Rna Signal Transduction Transcription Factors

Baoyang Hu - Chinese Academy of Sciences

Yu Qiong Hu - Chinese Academy of Sciences

Feng Guihai - Chinese Academy of Sciences

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