Professor | 郭帆 | 数字化转型顾问

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Name	郭帆
Contact Information	guofan@ioz.ac.cn
Language ability	中文, 英文
Province	北京

Upload Avatar (500 x 500)

Name

郭帆

Contact Information

guofan@ioz.ac.cn

Language ability

中文, 英文

Province

北京

University/Lab Affiliation and Title	中国科学院
Faculty	Institute of Zoology
Academic Background & Achievements	2008 - 学士学位: 武汉大学 2014 - 博士学位: 中国科学院大学成就: 在《Nature》、《Cell》、《Nature Genetics》等顶级期刊发表论文成就: 入选中国生命科学十大进展
Work Experience	2017-03 至 2021-04 - 四川大学 - 研究员、课题组长PI、博士生导师 2021-05 至今 - 中国科学院动物研究所 - 研究员、PI
Awards	优秀青年科学基金国家杰出青年科学基金第五届妇幼健康科学技术奖一等奖

University/Lab Affiliation and Title

中国科学院

Faculty

Institute of Zoology

Academic Background & Achievements

2008 - 学士学位: 武汉大学
2014 - 博士学位: 中国科学院大学
成就: 在《Nature》、《Cell》、《Nature Genetics》等顶级期刊发表论文
成就: 入选中国生命科学十大进展

Work Experience

2017-03 至 2021-04 - 四川大学 - 研究员、课题组长PI、博士生导师
2021-05 至今 - 中国科学院动物研究所 - 研究员、PI

Awards

优秀青年科学基金
国家杰出青年科学基金
第五届妇幼健康科学技术奖一等奖

Areas of Focus	早期胚胎发育及相关疾病的表观遗传调控
Publications	Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene expression., Liang D., R. Yan, X. Long, D. Ji, B. Song, M. Wang, F. Zhang, X. Cheng, F. Sun, R. Zhu, X. Hou, T. Wang, W. Zou, Y. Zhang, Z. Pu, J. Zhang, Z. Zhang, Y. Liu, Y. Hu, X. He, Y. Cao and F. Guo, 2024 Generation of rat forebrain tissues in mice., Huang, J., B. He, X. Yang, X. Long, Y. Wei, L. Li, M. Tang, Y. Gao, Y. Fang, W. Ying, Z. Wang, C. Li, Y. Zhou, S. Li, L. Shi, S. Choi, H. Zhou, F. Guo, H. Yang and J. Wu, 2024 Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development., Yan, R., X. Cheng, C. Gu, Y. Xu, X. Long, J. Zhai, F. Sun, J. Qian, Y. Du, H. Wang and F. Guo, 2023 Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture., Zhai, J., Y. Xu, H. Wan, R. Yan, J. Guo, R. Skory, L. Yan, X. Wu, F. Sun, G. Chen, W. Zhao, K. Yu, W. Li, F. Guo, N. Plachta and H. Wang, 2023 Primate gastrulation and early organogenesis at single-cell resolution., Zhai, J., J. Guo, H. Wan, L. Qi, L. Liu, Z. Xiao, L. Yan, D. A. Schmitz, Y. Xu, D. Yu, X. Wu, W. Zhao, K. Yu, X. Jiang, F. Guo, J. Wu and H. Wang, 2022 Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing., Yan, R., C. Gu, D. You, Z. Huang, J. Qian, Q. Yang, X. Cheng, L. Zhang, H. Wang, P. Wang and F. Guo, 2021 Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis., Zhou, C., Y. Sun, R. Yan, Y. Liu, E. Zuo, C. Gu, L. Han, Y. Wei, X. Hu, R. Zeng, Y. Li, H. Zhou, F. Guo and H. Yang, 2019 Integrative single-cell analysis of transcriptome, DNA methylome and chromatin accessibility in mouse oocytes., Gu, C., S. Liu, Q. Wu, L. Zhang and F. Guo, 2019 Single-cell multi-omics sequencing of human early embryos., Li, L., F. Guo, Y. Gao, Y. Ren, P. Yuan, L. Yan, R. Li, Y. Lian, J. Li, B. Hu, J. Gao, L. Wen, F. Tang and J. Qiao, 2018 Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells., Guo, F., L. Li, J. Li, X. Wu, B. Hu, P. Zhu, L. Wen and F. Tang, 2017 The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells., Guo, F., L. Yan, H. Guo, L. Li, B. Hu, Y. Zhao, J. Yong, Y. Hu, X. Wang, Y. Wei, W. Wang, R. Li, J. Yan, X. Zhi, Y. Zhang, H. Jin, W. Zhang, Y. Hou, P. Zhu, J. Li, L. Zhang, S. Liu, Y. Ren, X. Zhu, L. Wen, Y. Q. Gao, F. Tang and J. Qiao, 2015 Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote., Guo, F., X. Li, D. Liang, T. Li, P. Zhu, H. Guo, X. Wu, L. Wen, T. P. Gu, B. Hu, C. P. Walsh, J. Li, F. Tang and G. L. Xu, 2014 The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes., Gu, T. P., F. Guo, H. Yang, H. P. Wu, G. F. Xu, W. Liu, Z. G. Xie, L. Shi, X. He, S. G. Jin, K. Iqbal, Y. G. Shi, Z. Deng, P. E. Szabo, G. P. Pfeifer, J. Li and G. L. Xu, 2011

Areas of Focus

早期胚胎发育及相关疾病的表观遗传调控

Publications

Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene expression., Liang D., R. Yan, X. Long, D. Ji, B. Song, M. Wang, F. Zhang, X. Cheng, F. Sun, R. Zhu, X. Hou, T. Wang, W. Zou, Y. Zhang, Z. Pu, J. Zhang, Z. Zhang, Y. Liu, Y. Hu, X. He, Y. Cao and F. Guo, 2024
Generation of rat forebrain tissues in mice., Huang, J., B. He, X. Yang, X. Long, Y. Wei, L. Li, M. Tang, Y. Gao, Y. Fang, W. Ying, Z. Wang, C. Li, Y. Zhou, S. Li, L. Shi, S. Choi, H. Zhou, F. Guo, H. Yang and J. Wu, 2024
Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development., Yan, R., X. Cheng, C. Gu, Y. Xu, X. Long, J. Zhai, F. Sun, J. Qian, Y. Du, H. Wang and F. Guo, 2023
Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture., Zhai, J., Y. Xu, H. Wan, R. Yan, J. Guo, R. Skory, L. Yan, X. Wu, F. Sun, G. Chen, W. Zhao, K. Yu, W. Li, F. Guo, N. Plachta and H. Wang, 2023
Primate gastrulation and early organogenesis at single-cell resolution., Zhai, J., J. Guo, H. Wan, L. Qi, L. Liu, Z. Xiao, L. Yan, D. A. Schmitz, Y. Xu, D. Yu, X. Wu, W. Zhao, K. Yu, X. Jiang, F. Guo, J. Wu and H. Wang, 2022
Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing., Yan, R., C. Gu, D. You, Z. Huang, J. Qian, Q. Yang, X. Cheng, L. Zhang, H. Wang, P. Wang and F. Guo, 2021
Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis., Zhou, C., Y. Sun, R. Yan, Y. Liu, E. Zuo, C. Gu, L. Han, Y. Wei, X. Hu, R. Zeng, Y. Li, H. Zhou, F. Guo and H. Yang, 2019
Integrative single-cell analysis of transcriptome, DNA methylome and chromatin accessibility in mouse oocytes., Gu, C., S. Liu, Q. Wu, L. Zhang and F. Guo, 2019
Single-cell multi-omics sequencing of human early embryos., Li, L., F. Guo, Y. Gao, Y. Ren, P. Yuan, L. Yan, R. Li, Y. Lian, J. Li, B. Hu, J. Gao, L. Wen, F. Tang and J. Qiao, 2018
Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells., Guo, F., L. Li, J. Li, X. Wu, B. Hu, P. Zhu, L. Wen and F. Tang, 2017
The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells., Guo, F., L. Yan, H. Guo, L. Li, B. Hu, Y. Zhao, J. Yong, Y. Hu, X. Wang, Y. Wei, W. Wang, R. Li, J. Yan, X. Zhi, Y. Zhang, H. Jin, W. Zhang, Y. Hou, P. Zhu, J. Li, L. Zhang, S. Liu, Y. Ren, X. Zhu, L. Wen, Y. Q. Gao, F. Tang and J. Qiao, 2015
Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote., Guo, F., X. Li, D. Liang, T. Li, P. Zhu, H. Guo, X. Wu, L. Wen, T. P. Gu, B. Hu, C. P. Walsh, J. Li, F. Tang and G. L. Xu, 2014
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes., Gu, T. P., F. Guo, H. Yang, H. P. Wu, G. F. Xu, W. Liu, Z. G. Xie, L. Shi, X. He, S. G. Jin, K. Iqbal, Y. G. Shi, Z. Deng, P. E. Szabo, G. P. Pfeifer, J. Li and G. L. Xu, 2011

表观遗传胚胎发育基因表达细胞分化染色质 Dna甲基化组蛋白修饰非编码Rna 信号转导转录因子

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