2012 - Doctor of Science: University of Chinese Academy of Sciences
Published over 60 papers in journals like Cell, Science, Nature
Granted over 20 invention patents
Research selected multiple times for 'Top Ten Advances in Chinese Science' and 'Top Ten Advances in Chinese Life Sciences'
Several gene and cell therapy drugs based on work progress have entered clinical trial stages
2013 - Present: Chinese Academy of Sciences, Institute of Zoology
National Outstanding Youth Science Fund
Excellent Youth Science Fund
International Award from the Japanese Society for Laboratory Animal Science
Youth Scientist Award from the Chinese Academy of Sciences
Outstanding Scientific Achievement Award (Outstanding Contributor) from the Chinese Academy of Sciences
Zhu Li Yuehua Excellent Teacher Award from the Chinese Academy of Sciences
Research
Development of mammalian engineering biology as a new enabling platform Exploration of mechanisms and pathways for mammalian organ regeneration and repair Development of new biological treatment methods for major diseases
All-RNA-mediated targeted gene integration in mammalian cells with rationally engineered R2 retrotransposons, Chen Y, Luo S, Hu Y, Mao B, Wang X, Lu Z, Shan Q, Zhang J, Wang S, Feng G, Wang C, Liang C, Tang N, Niu R, Wang J, Han J, Yang N, Wang H, Zhou Q, Li W, 2024
Therapeutic In Vivo Gene Editing Achieved by a Hypercompact CRISPR-Cas12f1 System Delivered with All-in-One Adeno-Associated Virus, Cui T, Cai B, Tian Y, Liu X, Liang C, Gao Q, Li B, Ding Y, Li R, Zhou Q, Li W, Teng F, 2024
High-efficiency targeted transgene integration via primed micro-homologues, Wang C, Fang S, Chen Y, Tang N, Jiao G, Hu Y, Li J, Shan Q, Wang X, Feng G, Zhou Q, Li W, 2023
A sustainable mouse karyotype created by programmed chromosome fusion, Wang LB, Li ZK, Wang LY, Xu K, Ji TT, Mao YH, Ma SN, Liu T, Tu CF, Zhao Q, Fan XN, Liu C, Wang LY, Shu YJ, Yang N, Zhou Q, Li W, 2022
Synergistic engineering of CRISPR-Cas nucleases enables robust mammalian genome editing, Chen Y, Hu Y, Wang X, Luo S, Yang N, Chen Y, Li Z, Zhou Q, Li W, 2022
Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons, He ZQ, Li YH, Feng GH, Yuan XW, Lu ZB, Dai M, Hu YP, Zhang Y, Zhou Q, Li W, 2022
Metagenomic discovery of novel CRISPR-Cas13 systems, Hu Y, Chen Y, Xu J, Wang X, Luo S, Mao B, Zhou Q, Li W, 2022
SARS-CoV-2 detection with CRISPR diagnostics, Guo L, Sun X, Wang X, Liang C, Jiang H, Gao Q, Dai M, Qu B, Fang S, Mao Y, Chen Y, Feng G, Gu Q, Wang RR, Zhou Q, Li W, 2020
Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer, Wang LY, Li ZK, Wang LB, Liu C, Sun XH, Feng GH, Wang JQ, Li YF, Qiao LY, Nie H, Jiang LY, Sun H, Xie YL, Ma SN, Wan HF, Lu FL, Li W, Zhou Q, 2020
Treating Bietti crystalline dystrophy in a high-fat diet-exacerbated murine model using gene therapy, Qu B, Wu S, Jiao G, Zou X, Li Z, Guo L, Sun X, Huang C, Sun Z, Zhang Y, Li H, Zhou Q, Sui R, Li W, 2020
Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon, Mao J, Xu K, Han J, Feng G, Zhang Y, Li W, 2020
CDetection: CRISPR-Cas12b-based DNA detection with sub-attomolar sensitivity and single-base specificity, Teng F, Guo L, Cui T, Wang XG, Xu K, Gao Q, Zhou Q, Li W, 2019
Enhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds, Teng F, Li J, Cui T, Xu K, Guo L, Gao Q, Feng G, Chen C, Han D, Zhou Q, Li W, 2019
Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I, Li Y, Wang L, Zhang L, He Z, Feng G, Sun H, Wang J, Li Z, Liu C, Han J, Mao J, Li P, Yuan X, Jiang L, Zhang Y, Zhou Q, Li W, 2019
Asymmetric expression of LincGET biases cell fate in two-cell mouse embryos, Wang J, Wang L, Feng G, Wang Y, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W, Zhou Q, 2018
Repurposing CRISPR-Cas12b for mammalian genome engineering, Teng F, Cui T, Feng G, Guo L, Xu K, Gao Q, Li T, Li J, Zhou Q, Li W, 2018
SIRT6 deficiency results in developmental retardation in cynomolgus monkeys, Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W, Liu G, Hu B, 2018
Generation of bimaternal and bipaternal mice from hypomethylated haploid escs with imprinting region deletions, Li ZK, Wang LY, Wang LB, Feng GH, Yuan XW, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W, Zhou Q, Hu BY, 2018
Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation, Xu K, Yang Y, Feng GH, Sun BF, Chen JQ, Li YF, Chen YS, Zhang XX, Wang CX, Jiang LY, Liu C, Zhang ZY, Wang XJ, Zhou Q, Yang YG, Li W, 2017
Generation and application of mouse-rat allodiploid embryonic stem cells, Li X, Cui XL, Wang JQ, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W, Zhou Q, 2016
One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system, Wan HF, Feng CJ, Teng F, Yang SH, Hu BY, Niu YY, Xiang P, Fang WZ, Ji WZ, Li W, Zhao XY, Zhou Q, 2015
Genetic modification and screening in rat using haploid embryonic stem cells, Li W, Li X, Li TD, Jiang MG, Wan HF, Luo GZ, Feng CJ, Cui XL, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha JH, Xiao YM, Wang L, Liu ZH, Wang XJ, Zhao XY, Zhou Q, 2014
Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems, Li W, Teng F, Li T, Zhou Q, 2013
Androgenetic haploid embryonic stem cells produce live transgenic mice, Li W, Shuai L, Wan H, Dong M, Wang M, Sang L, Feng C, Luo GZ, Li T, Li X, Wang L, Zheng QY, Sheng C, Wu HJ, Liu Z, Liu L, Wang L, Wang XJ, Zhao XY, Zhou Q, 2012
iPS cells produce viable mice through tetraploid complementation, Zhao XY, Li W, Lv Z, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F, Zhou Q, 2009
