Professor | Hu Zheng | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Hu Zheng
Contact Information	albert.cheng@ioz.ac.cn
Language ability	English, Chinese
Province	Beijing

Upload Avatar (500 x 500)

Name

Hu Zheng

Contact Information

albert.cheng@ioz.ac.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Chinese Academy of Sciences
Faculty	Institute of Zoology
Academic Background & Achievements	2014 - PhD: Massachusetts Institute of Technology, Department of Computational and Systems Biology Achievement: Identified H3K27ac as a marker of active enhancers; analyzed RNA alternative splicing in cancer metastasis and erythropoiesis; developed CRISPR-on gene activation tool
Work Experience	2014 - Joined The Jackson Laboratory, USA as one of the first Jackson Scholars 2015-07 - Established independent laboratory at The Jackson Laboratory and later at Arizona State University

University/Lab Affiliation and Title

Chinese Academy of Sciences

Faculty

Institute of Zoology

Academic Background & Achievements

2014 - PhD: Massachusetts Institute of Technology, Department of Computational and Systems Biology
Achievement: Identified H3K27ac as a marker of active enhancers; analyzed RNA alternative splicing in cancer metastasis and erythropoiesis; developed CRISPR-on gene activation tool

Work Experience

2014 - Joined The Jackson Laboratory, USA as one of the first Jackson Scholars
2015-07 - Established independent laboratory at The Jackson Laboratory and later at Arizona State University

Areas of Focus	Development of new methods for genome, epigenome, and transcriptome editing and sensing Development of 3D genome structure imaging technology Study of changes in 3D genome, epigenome, and transcriptome in development and disease Development of novel gene therapies Establishment of computational models for artificial DNA/RNA binding proteins and guide RNA design
Publications	Simultaneous multifunctional transcriptome engineering by CRISPR RNA scaffold, Liu, Z., Jillette N., Robson, P., Cheng, A.W., 2023 CRISPR-mediated multiplexed live cell imaging of nonrepetitive genomic loci with one guide RNA per locus, Clow, P.A., Du, M., Jillette, N., Taghbalout, A., Zhu, J.J., Cheng, A.W., 2022 Live-cell imaging shows uneven segregation of extrachromosomal DNA elements and transcriptionally active extrachromosomal DNA hubs in cancer, Yi, E., Gujar, A.D., Guthrie, M., Kim, H., Zhao, D., Johnson K.C., Amin, S.B., Costa, M.L., Yu, Q., Das, S., Jillette, N., Clow, P.A., Cheng, A.W., Verhaak, R.G.W., 2022 JACKIE: Fast enumeration of genome-wide single- and multi-copy CRISPR target sites and their off-target numbers, Zhu, J.J., Cheng, A.W., 2022 CRISPR Artificial Splicing Factors, Du, M., Jillette, N., Zhu, J.J., Li, S., Cheng, A.W., 2020 C11orf95-RELA Reprograms 3D Epigenome in Supratentorial Ependymoma, Zhu, J.J., Jillette, N., Li X., Cheng, A.W., Lau C.C., 2020 Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways, Taghbalout, A., Du, M., Jillette, N., Rosikiewicz, W. Rath, A., Heinen, C., Li, S., Cheng, A.W., 2019 Split Selectable Markers, Jillette, N., Du, M., Zhu, J.J., Cardoz, P., Cheng, A.W., 2019 Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling, Cheng, A.W., Jillette, N., Lee, P., Plaskon, D., Fujiwara, Y., Wang, W., Taghbalout, A., Wang, H., 2016 Muscleblind-like 1 (Mbnl1) regulates pre-mRNA alternative splicing during terminal erythropoiesis, Cheng, A.W., Shi, J., Wong, P., Luo, K.L., Trepman, P., Wang, E.T., Choi, H., Burge, C.B., Lodish, H.F., 2014 Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system, Cheng, A.W., Wang, H., Yang, H, Shi, L., Katz, Y., Theunissen, T.W., Rangarajan, S., Shivalila, C.S., Dadon, D.B., Jaenisch, R., 2013 One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering, Yang, H., Wang, H., Shivalila, C.S., Cheng, A.W., Shi, L., Jaenisch, R., 2013 One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering, Wang, H., Yang, H., Shivalila, C.S., Dawlaty, M.M., Cheng, A.W., Zhang, F., Jaenisch, R., 2013 Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase, Buganim, Y., Faddah D.A., Cheng, A.W., Itskovich, E., Markoulaki, S., Gantz, K., Klemm S.L., van Oudenaarden A., Jaenisch, R., 2012 An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype, Shapiro, I.M., Cheng, A.W., Flytzanis, N.C., Balsamo, M., Condeelis, J.S., Oktay, M.H., Burge, C.B., Gertler, F.B., 2011 Histone H3K27ac separates active from poised enhancers and predicts developmental state, Creyghton, M.P., Cheng A.W., Welstead, G.G., Kooistra, T., Carey, B.W., Steine, E.J., Hanna, J., Lodato, M.A., Frampton, G.M., Sharp, P.A., Boyer, L.A., Young, R.A., Jaenisch, R., 2010

Areas of Focus

Development of new methods for genome, epigenome, and transcriptome editing and sensing
Development of 3D genome structure imaging technology
Study of changes in 3D genome, epigenome, and transcriptome in development and disease
Development of novel gene therapies
Establishment of computational models for artificial DNA/RNA binding proteins and guide RNA design

Publications

Simultaneous multifunctional transcriptome engineering by CRISPR RNA scaffold, Liu, Z., Jillette N., Robson, P., Cheng, A.W., 2023
CRISPR-mediated multiplexed live cell imaging of nonrepetitive genomic loci with one guide RNA per locus, Clow, P.A., Du, M., Jillette, N., Taghbalout, A., Zhu, J.J., Cheng, A.W., 2022
Live-cell imaging shows uneven segregation of extrachromosomal DNA elements and transcriptionally active extrachromosomal DNA hubs in cancer, Yi, E., Gujar, A.D., Guthrie, M., Kim, H., Zhao, D., Johnson K.C., Amin, S.B., Costa, M.L., Yu, Q., Das, S., Jillette, N., Clow, P.A., Cheng, A.W., Verhaak, R.G.W., 2022
JACKIE: Fast enumeration of genome-wide single- and multi-copy CRISPR target sites and their off-target numbers, Zhu, J.J., Cheng, A.W., 2022
CRISPR Artificial Splicing Factors, Du, M., Jillette, N., Zhu, J.J., Li, S., Cheng, A.W., 2020
C11orf95-RELA Reprograms 3D Epigenome in Supratentorial Ependymoma, Zhu, J.J., Jillette, N., Li X., Cheng, A.W., Lau C.C., 2020
Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways, Taghbalout, A., Du, M., Jillette, N., Rosikiewicz, W. Rath, A., Heinen, C., Li, S., Cheng, A.W., 2019
Split Selectable Markers, Jillette, N., Du, M., Zhu, J.J., Cardoz, P., Cheng, A.W., 2019
Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling, Cheng, A.W., Jillette, N., Lee, P., Plaskon, D., Fujiwara, Y., Wang, W., Taghbalout, A., Wang, H., 2016
Muscleblind-like 1 (Mbnl1) regulates pre-mRNA alternative splicing during terminal erythropoiesis, Cheng, A.W., Shi, J., Wong, P., Luo, K.L., Trepman, P., Wang, E.T., Choi, H., Burge, C.B., Lodish, H.F., 2014
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system, Cheng, A.W., Wang, H., Yang, H, Shi, L., Katz, Y., Theunissen, T.W., Rangarajan, S., Shivalila, C.S., Dadon, D.B., Jaenisch, R., 2013
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering, Yang, H., Wang, H., Shivalila, C.S., Cheng, A.W., Shi, L., Jaenisch, R., 2013
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering, Wang, H., Yang, H., Shivalila, C.S., Dawlaty, M.M., Cheng, A.W., Zhang, F., Jaenisch, R., 2013
Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase, Buganim, Y., Faddah D.A., Cheng, A.W., Itskovich, E., Markoulaki, S., Gantz, K., Klemm S.L., van Oudenaarden A., Jaenisch, R., 2012
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype, Shapiro, I.M., Cheng, A.W., Flytzanis, N.C., Balsamo, M., Condeelis, J.S., Oktay, M.H., Burge, C.B., Gertler, F.B., 2011
Histone H3K27ac separates active from poised enhancers and predicts developmental state, Creyghton, M.P., Cheng A.W., Welstead, G.G., Kooistra, T., Carey, B.W., Steine, E.J., Hanna, J., Lodato, M.A., Frampton, G.M., Sharp, P.A., Boyer, L.A., Young, R.A., Jaenisch, R., 2010

Genome Editing Epigenome Transcriptome 3D Genome Gene Therapy Crispr Rna Splicing Synthetic Biology Computational Models Dna/Rna Binding

Haoyi Wang - Chinese Academy of Sciences

Wei Tuo - Chinese Academy of Sciences

Ming Wang - Chinese Academy of Sciences

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us