2009 - PhD in Molecular Cell Biology: University of Washington
Developed the Calling Card technology based on transposons
Published over 50 SCI academic papers with over 10,000 citations
2009-2014 - Postdoctoral Researcher at Whitehead Institute, MIT
2014-present - Group Leader of Gene Engineering Technology Group, Institute of Zoology, Chinese Academy of Sciences
National Natural Science Foundation Excellent Young Scientists Fund
Chinese Academy of Sciences Stem Cell Leading Project
Ministry of Science and Technology Stem Cell and Regenerative Medicine Key R&D Program
Research
Development and application of gene engineering technology Gene editing technology in T cells and stem cells Molecular mechanisms of X chromosome inactivation in early embryonic development
Improving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathway., Li N, Tang N, Cheng C, Hu T, Wei X, Han W, Wang H#, 2020
Recent advances of genome editing and related technologies in China., Sun W, Wang H#, 2020
Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation., An C, Feng G, Zhang J, Cao S, Wang Y, Wang N, Lu F, Zhou Q, Wang H#, 2020
TGF β Inhibition via CRISPR Promotes the Long-Term Efficacy of CAR-T Cells Against Solid Tumors., Tang N, Cheng C, Zhang X, Qiao M, Li N, Mu W, Wei X, Han W, Wang H#, 2020
Argonaute proteins from human gastrointestinal bacteria catalyze DNA-guided cleavage of single- and double- stranded DNA at 37 °C., Cao Y, Sun W, Wang J, Sheng G, Xiang G, Zhang T, Shi W, Li C, Wang Y, Zhao F#, Wang H#, 2019
Gene-edited babies: What went wrong and what could go wrong., Wang H, Yang H#, 2019
In vitro transcribed sgRNA causes cell death by inducing interferon release., Mu W, Tang N, Cheng C, Sun W, Wei X, Wang H#, 2019
Bacteria-free minicircle DNA system to generate integration-free CAR-T cells., Cheng C, Tang N, Li J, Cao S, Zhang T, Wei X, Wang H#, 2019
Editing porcine IGF2 regulatory element improved meat production in Chinese Bama pigs., Xiang G, Ren J, Hai T, Fu R, Yu D, Wang J, Li W, Wang H#, Zhou Q#, 2018
Extended pluripotent stem cells facilitate mouse model generation., Xiang G, Wang H#, 2018
5′ capped and 3′ polyA-tailed sgRNAs enhance the efficiency of CRISPR-Cas9 system., Mu W, Zhang Y, Xue X, Liu L, Wei X, Wang H#, 2018
CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells., Zhang Y, Zhang X, Cheng C, Mu W, Liu X, Li N, Wei X, Liu X, Xia C, Wang H#, 2017
Temperature effect on CRISPR-Cas9 mediated genome editing., Xiang G, Zhang X, An C, Cheng C, Wang H#, 2017
CRISPR-Cas9 mediated multiplex gene editing in CAR-T cells., Liu X, Zhang Y, Cheng C, Cheng WA, Zhang X, Li N, Xia C, Wei X, Liu X, Wang H#, 2017
Questions about NgAgo., Burgess S, Cheng L#, Gu F, Huang J, Huang Z, Lin S#, Li J, Li W, Qin W, Sun W, Songyang Z, Wei W#, Wu Q, Wang H#, Wang X, Xiong JW, Xi J, Yang H, Zhou B, Zhang B, 2016
Delivery of Cas9 protein into mouse zygotes through a series of electroporation dramatically increased the efficiency of model creation., Wang W, Kutny PM, Byers SL, Longstaff CJ, DaCosta MJ, Pang C, Zhang Y, Taft RA, Buaas FW, Wang H#, 2016
Generating Mouse Models Using CRISPR-Cas9 Mediated Genome Editing., Qin W, Kutny PM, Maser RS, Dion SL, Lamont JD, Zhang Y, Perry GA, Wang H#, 2016
Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling., Cheng AW#, Jillette N, Lee P, Plaskon D, Fujiwara Y, Wang W, Taghbalout A, Wang H#, 2016
CRISPR-Cas9 mediated genome editing and guide RNA design., Wiles MV, Qin W, Cheng AW, Wang H#, 2015
Efficient CRISPR/Cas9-mediated genome editing in mice by zygote electroporation of nuclease., Qin W, Dion SL, Kutny PM, Zhang Y, Cheng AW, Jillette NL, Malhotra A, Geurts AM, Chen YG, Wang H#, 2015
Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency., Theunissen T, Powell B, Wang H, Mitalipova M, Faddah D, Reddy J, Fan Z, Maetzel D, Ganz K, Shi L, Lungjangwa T, Imsoonthornruksa S, Stelzer Y, Rangarajan S, D’Alessio A, Zhang J, Gao Q, Dawlaty M, Young R, Gray N, Jaenisch R, 2014
Generating genetically modified mice using CRISPR/Cas-mediated genome engineering., Yang H, Wang H, Jaenisch R, 2014
Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells., Maetzel D, Sarkar S, Wang H, Mosleh LA, Cheng AW, Xu P, Gao Q, Mitalipova M, Jaenisch R, 2014
Multiplexed activation of endogenous genes by CRISPR-on, a RNA-guided transcriptional activator system., Cheng AW, Wang H, Yang H, Shi L, Katz Y, Rangarajan S, Theunissen TW, Shivalila CS, Dadon DB, Jaenisch R, 2013
One-step generation of mice carrying reporter and conditional allele by CRISPR/Cas mediated genome editing., Yang H, Wang H, Shivalila CS, Cheng AW, Shi L, Jaenisch R, 2013
Expression of Nanog is biallelic and equally variable as other pluripotency factors., Faddah D, Wang H, Buganim Y, Cheng AW, Jaenisch R, 2013
TALEN-mediated editing of the Mouse Y Chromosome., Wang H, Hu YC, Markoulaki S, Welstead GG, Shivalila CS, Cheng AW, Pyntikova T, Dadon D, Voytas DF, Bogdanove AJ, Page DC, Jaenisch R, 2013
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas mediated genome engineering., Wang H, Yang H, Shivalila CS, Dawlaty MM, Cheng AW, Zhang F, Jaenisch R, 2013
Keywords
Gene EngineeringCrisprStem CellsT CellsX ChromosomeEmbryonic DevelopmentGenome EditingBiotechnologyMolecular BiologyRegenerative Medicine
