Professor | Leqian Yu | Asia Growth Partners

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Name	Leqian Yu
Contact Information	leqianyu@ioz.ac.cn
Language ability	English, Chinese, Japanese
Province	Beijing

Upload Avatar (500 x 500)

Name

Leqian Yu

Contact Information

leqianyu@ioz.ac.cn

Language ability

English, Chinese, Japanese

Province

Beijing

University/Lab Affiliation and Title	Chinese Academy of Sciences
Faculty	Institute of Zoology
Academic Background & Achievements	2017 - PhD: Kyoto University, Japan Supported by National Youth Talent Fund Published over 10 papers in top journals like Nature and Cell Obtained 4 international patents Selected in MIT Technology Review China's '35 Innovators Under 35' in 2021
Work Experience	Postdoctoral Research - University of Texas Southwestern Medical Center 2022-08 - Present: Researcher at Institute of Zoology, Chinese Academy of Sciences
Awards	2021: Selected in MIT Technology Review China's '35 Innovators Under 35'

University/Lab Affiliation and Title

Chinese Academy of Sciences

Faculty

Institute of Zoology

Academic Background & Achievements

2017 - PhD: Kyoto University, Japan
Supported by National Youth Talent Fund
Published over 10 papers in top journals like Nature and Cell
Obtained 4 international patents
Selected in MIT Technology Review China's '35 Innovators Under 35' in 2021

Work Experience

Postdoctoral Research - University of Texas Southwestern Medical Center
2022-08 - Present: Researcher at Institute of Zoology, Chinese Academy of Sciences

Awards

2021: Selected in MIT Technology Review China's '35 Innovators Under 35'

Areas of Focus	Construction of human early embryonic development, organ formation, and disease models based on human pluripotent stem cells Research on key events in human early embryonic development using pluripotent stem cells and microfluidic chip technology Construction and application of induced pluripotent stem cells from different species
Publications	3D Reconstruction of a Gastrulating Human Embryo, Xiao, Z.; Cui, L.; Yuan, Y.; He, N.; Xie, X.; Lin, S.; Yang, X.; Zhang, X.; Shi, P.; Wei, Zh.; Li,Y.; Wang, H.; Wang, X.; Wei, Y.; Guo, J.; Yu, L., 2024 Blastocyst-like structures generated from human pluripotent stem cells, Yu, L.; Wei, Y.; Duan, J.; Schmitz, D. A.; Sakurai, M.; Wang, L.; Wang, K.; Zhao, S.; Hon, G. C.; Wu, J., 2021 Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans, Liu, T.; Li, J.; Yu, L.; Sun, H.; Li, J.; Dong, G.; Hu, Y.; Li, Y.; Shen, Y.; Wu, J.; Gu, Y., 2021 Cell competition constitutes a barrier for interspecies chimerism, Zheng, C.; Hu, Y.; Sakurai, M.; Pinzon-Arteaga, C. A.; Li, J.; Wei, Y.; Okamura, D.; Ravaux, B.; Barlow, H. R.; Yu, L.; Sun, H.; Chen, E. H.; Gu, Y.; Wu, J., 2021 Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk, Yu, L.; Logsdon, D.; Pinzon-Arteaga, C.A.; Duan, J.; Ezashi, T.; Wei, Y.; Oura, S.; Liu, L.; Wang, L.; Liu, K.; Ding, X.; Zhan, L.; Zhang, J.; Nahar, A.; Stobbe, C.; Katz-Jaffe, M.; Schoolcraft, W.B.; Tan, T.; Hon, G.C.; Yuan, Y.; Wu, J., 2023 An aggregation of human embryonic and trophoblast stem cells reveals the role of trophectoderm on epiblast differentiation, Wu, X.; Zhao, W.; Wu, H.; Zhang, Q.; Wang, Y.; Yu, K.; Zhai, J.; Mo, F.; Wang, M.; Li, S.; Zhu, X.; Liang, X.; Hu, B.; Liu, G. H.; Wu, J.; Wang, H.; Guo, F.; Yu, L., 2023 Dissecting embryonic and extraembryonic lineage crosstalk with stem cell co-culture, Wei Y; Zhang E; Yu L; Ci B; Sakurai M; Guo L; Zhang X; Lin S; Takii S; Liu L; Liu J; Schmitz DA; Su T; Zhang J; Shen Q; Ding Y; Zhan L; Sun HX; Zheng C; Xu L; Okamura D; Ji W; Tan T; Wu J., 2023 Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification, Yu, L.; Wei, Y.; Sun, H.; Mahdi, A. K.; Pinzon Arteaga, C. A.; Sakurai, M.; Schmitz, D. A.; Zheng, C.; Ballard, E. D.; Li, J.; Tanaka, N.; Kohara, A.; Okamura, D.; Mutto, A. A.; Gu, Y.; Ross, P. J.; Wu, J., 2020 Derivation of sheep embryonic stem cells under optimized conditions, Vilarino, M.; Soto, D.A.; Bogliotti, Y. S.; Yu, L.; Zhang, Y.; Wang, C.; Paulson, E.; Zhong, C.; Jin, C.; Izpisua Belmonte, J. C.; Wu, J.; Ross, P .J., 2020 Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring, Li, J.; Zhang, L.; Yu, L.; Minami, I.; Miyagawa, S.; Horning, M.; Dong, J.; Qiao, J.; Qu, X.; Hua, Y.; Fujimoto, N.; Shiba, Y.; Zhao, Y.; Tang, F.; Chen, Y.; Sawa, Y.; Tang, C.; Liu, L., 2020 Clonal Isolation of Human Pluripotent Stem Cells on Nanofibrous Substrates Reveals an Advanced Subclone for Cardiomyocyte Differentiation, Yu, L.; Li, J.; Itsunari, M.; Qu, X.; Miyagawa, S.; Fujimoto, N.; Hasegawa, K.; Chen, Y.; Sawa, Y.; Kotera, H.; Liu, L., 2019 Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures, Li, R.; Zhong, C.; Yu, Y.; Liu, H.; Sakurai, M.; Yu, L.; Min, Z.; Shi, L.; Wei, Y.; Takahashi, Y.; Liao, H.; Qiao, J.; Deng, H.; Nunez-Delicado, E.; Rodriguez Esteban, C.; Wu, J.; Izpisua Belmonte, J. C., 2019 Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells, Zhang, Y.; Li, T.; Preissl, S.; Amaral, M.L.; Grinstein, J.D.; Farah, E.N.; Destici, E.; Qiu, Y.; Hu, R. Lee, A.Y.; Chee, S.; Ma, K.; Ye, Z.; Zhu, Q.; Huang, H.; Fang, R.; Yu, L.; Izpisua Belmonte, J.C.; Wu, J.; Evans, S.M.; Chi, N.C.; Ren B., 2019 Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system, Xu, J.; Yu, L.; Guo, J.; Xiang, J.; Zheng, Z.; Gao, D.; Shi, B.; Hao, H.; Jiao, D.; Zhong, L.; Wang, Y.; Wu, J.; Wei, H.; Han, J., 2019 Low Cell-Matrix Adhesion Reveals Two Novel Subtypes of Human Pluripotent Stem Cells, Yu, L.; Li, J.; Hong, J.; Takashima, Y.; Fujimoto, N.; Nakajima, M.; Dong, X.; Dang, Y.; Yang, W.; Okita, K.; Luo, C.; Tang, F.; Chen, Y.; Tang, C.; Kotera, H.; Liu, L., 2018 Human Pluripotent Stem Cell-Derived Cardiac Tissue-Like Constructs for Repairing of the Infarcted Myocardium, Li, J.; Minami, I.; Yu, L.; Shiozaki, M.; Shiba, Y.; Yajima, S.; Morone, N.; Fukushima, S.; Yoshioka, M.; Li, S.; Qiao, J.; Li, X.; Wang, L.; Kotera, H.; Miyagawa, S.; Nakatsuji, N.; Sawa, Y.; Chen, Y.; Liu, L., 2017 Culture substrates made of elastomeric micro-tripod arrays for long-term expansion of human pluripotent stem cells, Li, J.; Zhang, F.; Yu, L.; Fujimoto, N.; Yoshioka, M.; Li, X.; Shi, J.; Kotera, H.; Liu, L.; Chen, Y., 2017 On chip purification of hiPSC-derived cardiomyocytes using a fishnet-like microstructure, Li, X.; Yu, L.; Li, J.; Minami, I.; Nakajima, M.; Noda, Y.; Kotera, H.; Liu, L.; Chen, Y., 2016 Induction and Differentiation of Human Induced Pluripotent Stem Cells into Functional Cardiomyocytes on a Compartmented Monolayer of Gelatin Nanofibers, Tang, Y.; Liu, L.; Li, J.; Yu, L.; Wang, L.; Shi, J.; Chen, Y., 2016 Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers, Li, J.; Minami, I.; Yu, L.; Tsuji, K.; Nakajima, M.; Qiao, J.; Suzuki, M.; Shimono, K.; Nakatsuji, N.; Kotera, H.; Liu, L.; Chen, Y., 2016 Effective Motor Neuron Differentiation of Hipscs on a Patch Made of Crosslinked Monolayer Gelatin Nanofibers, Tang, Y.; Liu, L.; Li, J.; Yu, L.; Severino, F. P. U.; Wang, L.; Shi, J.; Tu, X.; Torre, V.; Chen, Y., 2016

Areas of Focus

Construction of human early embryonic development, organ formation, and disease models based on human pluripotent stem cells
Research on key events in human early embryonic development using pluripotent stem cells and microfluidic chip technology
Construction and application of induced pluripotent stem cells from different species

Publications

3D Reconstruction of a Gastrulating Human Embryo, Xiao, Z.; Cui, L.; Yuan, Y.; He, N.; Xie, X.; Lin, S.; Yang, X.; Zhang, X.; Shi, P.; Wei, Zh.; Li,Y.; Wang, H.; Wang, X.; Wei, Y.; Guo, J.; Yu, L., 2024
Blastocyst-like structures generated from human pluripotent stem cells, Yu, L.; Wei, Y.; Duan, J.; Schmitz, D. A.; Sakurai, M.; Wang, L.; Wang, K.; Zhao, S.; Hon, G. C.; Wu, J., 2021
Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans, Liu, T.; Li, J.; Yu, L.; Sun, H.; Li, J.; Dong, G.; Hu, Y.; Li, Y.; Shen, Y.; Wu, J.; Gu, Y., 2021
Cell competition constitutes a barrier for interspecies chimerism, Zheng, C.; Hu, Y.; Sakurai, M.; Pinzon-Arteaga, C. A.; Li, J.; Wei, Y.; Okamura, D.; Ravaux, B.; Barlow, H. R.; Yu, L.; Sun, H.; Chen, E. H.; Gu, Y.; Wu, J., 2021
Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk, Yu, L.; Logsdon, D.; Pinzon-Arteaga, C.A.; Duan, J.; Ezashi, T.; Wei, Y.; Oura, S.; Liu, L.; Wang, L.; Liu, K.; Ding, X.; Zhan, L.; Zhang, J.; Nahar, A.; Stobbe, C.; Katz-Jaffe, M.; Schoolcraft, W.B.; Tan, T.; Hon, G.C.; Yuan, Y.; Wu, J., 2023
An aggregation of human embryonic and trophoblast stem cells reveals the role of trophectoderm on epiblast differentiation, Wu, X.; Zhao, W.; Wu, H.; Zhang, Q.; Wang, Y.; Yu, K.; Zhai, J.; Mo, F.; Wang, M.; Li, S.; Zhu, X.; Liang, X.; Hu, B.; Liu, G. H.; Wu, J.; Wang, H.; Guo, F.; Yu, L., 2023
Dissecting embryonic and extraembryonic lineage crosstalk with stem cell co-culture, Wei Y; Zhang E; Yu L; Ci B; Sakurai M; Guo L; Zhang X; Lin S; Takii S; Liu L; Liu J; Schmitz DA; Su T; Zhang J; Shen Q; Ding Y; Zhan L; Sun HX; Zheng C; Xu L; Okamura D; Ji W; Tan T; Wu J., 2023
Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification, Yu, L.; Wei, Y.; Sun, H.; Mahdi, A. K.; Pinzon Arteaga, C. A.; Sakurai, M.; Schmitz, D. A.; Zheng, C.; Ballard, E. D.; Li, J.; Tanaka, N.; Kohara, A.; Okamura, D.; Mutto, A. A.; Gu, Y.; Ross, P. J.; Wu, J., 2020
Derivation of sheep embryonic stem cells under optimized conditions, Vilarino, M.; Soto, D.A.; Bogliotti, Y. S.; Yu, L.; Zhang, Y.; Wang, C.; Paulson, E.; Zhong, C.; Jin, C.; Izpisua Belmonte, J. C.; Wu, J.; Ross, P .J., 2020
Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring, Li, J.; Zhang, L.; Yu, L.; Minami, I.; Miyagawa, S.; Horning, M.; Dong, J.; Qiao, J.; Qu, X.; Hua, Y.; Fujimoto, N.; Shiba, Y.; Zhao, Y.; Tang, F.; Chen, Y.; Sawa, Y.; Tang, C.; Liu, L., 2020
Clonal Isolation of Human Pluripotent Stem Cells on Nanofibrous Substrates Reveals an Advanced Subclone for Cardiomyocyte Differentiation, Yu, L.; Li, J.; Itsunari, M.; Qu, X.; Miyagawa, S.; Fujimoto, N.; Hasegawa, K.; Chen, Y.; Sawa, Y.; Kotera, H.; Liu, L., 2019
Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures, Li, R.; Zhong, C.; Yu, Y.; Liu, H.; Sakurai, M.; Yu, L.; Min, Z.; Shi, L.; Wei, Y.; Takahashi, Y.; Liao, H.; Qiao, J.; Deng, H.; Nunez-Delicado, E.; Rodriguez Esteban, C.; Wu, J.; Izpisua Belmonte, J. C., 2019
Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells, Zhang, Y.; Li, T.; Preissl, S.; Amaral, M.L.; Grinstein, J.D.; Farah, E.N.; Destici, E.; Qiu, Y.; Hu, R. Lee, A.Y.; Chee, S.; Ma, K.; Ye, Z.; Zhu, Q.; Huang, H.; Fang, R.; Yu, L.; Izpisua Belmonte, J.C.; Wu, J.; Evans, S.M.; Chi, N.C.; Ren B., 2019
Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system, Xu, J.; Yu, L.; Guo, J.; Xiang, J.; Zheng, Z.; Gao, D.; Shi, B.; Hao, H.; Jiao, D.; Zhong, L.; Wang, Y.; Wu, J.; Wei, H.; Han, J., 2019
Low Cell-Matrix Adhesion Reveals Two Novel Subtypes of Human Pluripotent Stem Cells, Yu, L.; Li, J.; Hong, J.; Takashima, Y.; Fujimoto, N.; Nakajima, M.; Dong, X.; Dang, Y.; Yang, W.; Okita, K.; Luo, C.; Tang, F.; Chen, Y.; Tang, C.; Kotera, H.; Liu, L., 2018
Human Pluripotent Stem Cell-Derived Cardiac Tissue-Like Constructs for Repairing of the Infarcted Myocardium, Li, J.; Minami, I.; Yu, L.; Shiozaki, M.; Shiba, Y.; Yajima, S.; Morone, N.; Fukushima, S.; Yoshioka, M.; Li, S.; Qiao, J.; Li, X.; Wang, L.; Kotera, H.; Miyagawa, S.; Nakatsuji, N.; Sawa, Y.; Chen, Y.; Liu, L., 2017
Culture substrates made of elastomeric micro-tripod arrays for long-term expansion of human pluripotent stem cells, Li, J.; Zhang, F.; Yu, L.; Fujimoto, N.; Yoshioka, M.; Li, X.; Shi, J.; Kotera, H.; Liu, L.; Chen, Y., 2017
On chip purification of hiPSC-derived cardiomyocytes using a fishnet-like microstructure, Li, X.; Yu, L.; Li, J.; Minami, I.; Nakajima, M.; Noda, Y.; Kotera, H.; Liu, L.; Chen, Y., 2016
Induction and Differentiation of Human Induced Pluripotent Stem Cells into Functional Cardiomyocytes on a Compartmented Monolayer of Gelatin Nanofibers, Tang, Y.; Liu, L.; Li, J.; Yu, L.; Wang, L.; Shi, J.; Chen, Y., 2016
Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers, Li, J.; Minami, I.; Yu, L.; Tsuji, K.; Nakajima, M.; Qiao, J.; Suzuki, M.; Shimono, K.; Nakatsuji, N.; Kotera, H.; Liu, L.; Chen, Y., 2016
Effective Motor Neuron Differentiation of Hipscs on a Patch Made of Crosslinked Monolayer Gelatin Nanofibers, Tang, Y.; Liu, L.; Li, J.; Yu, L.; Severino, F. P. U.; Wang, L.; Shi, J.; Tu, X.; Torre, V.; Chen, Y., 2016

Pluripotent Stem Cells Embryonic Development Organ Formation Disease Models Microfluidic Technology Induced Pluripotency Cross-Species Stem Cell Application Human Embryo Biotechnology

Haoyi Wang - Chinese Academy of Sciences

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