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于乐谦
leqianyu@ioz.ac.cn
英语, 中文, 日语
北京
中国科学院
Institute of Zoology
  • 2017年 - 博士:日本京都大学
  • 获得国家级青年人才基金支持
  • 在Nature和Cell等顶级期刊上发表了10余篇论文
  • 获得4项国际专利
  • 2021年入选MIT科技评论中国“35岁以下科技创新35人”
  • 博士后研究 - 美国得克萨斯大学西南医学中心
  • 2022年8月至今:中国科学院动物研究所研究员
  • 2021年:入选MIT科技评论中国“35岁以下科技创新35人”
基于人类多能干细胞构建人类早期胚胎发育、器官形成及疾病模型
结合多能干细胞与微流控芯片技术研究人类早期胚胎发育关键事件
不同物种诱导多能性干细胞的构建与应用
  • 3D Reconstruction of a Gastrulating Human Embryo, Xiao, Z.; Cui, L.; Yuan, Y.; He, N.; Xie, X.; Lin, S.; Yang, X.; Zhang, X.; Shi, P.; Wei, Zh.; Li,Y.; Wang, H.; Wang, X.; Wei, Y.; Guo, J.; Yu, L., 2024
  • Blastocyst-like structures generated from human pluripotent stem cells, Yu, L.; Wei, Y.; Duan, J.; Schmitz, D. A.; Sakurai, M.; Wang, L.; Wang, K.; Zhao, S.; Hon, G. C.; Wu, J., 2021
  • Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans, Liu, T.; Li, J.; Yu, L.; Sun, H.; Li, J.; Dong, G.; Hu, Y.; Li, Y.; Shen, Y.; Wu, J.; Gu, Y., 2021
  • Cell competition constitutes a barrier for interspecies chimerism, Zheng, C.; Hu, Y.; Sakurai, M.; Pinzon-Arteaga, C. A.; Li, J.; Wei, Y.; Okamura, D.; Ravaux, B.; Barlow, H. R.; Yu, L.; Sun, H.; Chen, E. H.; Gu, Y.; Wu, J., 2021
  • Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk, Yu, L.; Logsdon, D.; Pinzon-Arteaga, C.A.; Duan, J.; Ezashi, T.; Wei, Y.; Oura, S.; Liu, L.; Wang, L.; Liu, K.; Ding, X.; Zhan, L.; Zhang, J.; Nahar, A.; Stobbe, C.; Katz-Jaffe, M.; Schoolcraft, W.B.; Tan, T.; Hon, G.C.; Yuan, Y.; Wu, J., 2023
  • An aggregation of human embryonic and trophoblast stem cells reveals the role of trophectoderm on epiblast differentiation, Wu, X.; Zhao, W.; Wu, H.; Zhang, Q.; Wang, Y.; Yu, K.; Zhai, J.; Mo, F.; Wang, M.; Li, S.; Zhu, X.; Liang, X.; Hu, B.; Liu, G. H.; Wu, J.; Wang, H.; Guo, F.; Yu, L., 2023
  • Dissecting embryonic and extraembryonic lineage crosstalk with stem cell co-culture, Wei Y; Zhang E; Yu L; Ci B; Sakurai M; Guo L; Zhang X; Lin S; Takii S; Liu L; Liu J; Schmitz DA; Su T; Zhang J; Shen Q; Ding Y; Zhan L; Sun HX; Zheng C; Xu L; Okamura D; Ji W; Tan T; Wu J., 2023
  • Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification, Yu, L.; Wei, Y.; Sun, H.; Mahdi, A. K.; Pinzon Arteaga, C. A.; Sakurai, M.; Schmitz, D. A.; Zheng, C.; Ballard, E. D.; Li, J.; Tanaka, N.; Kohara, A.; Okamura, D.; Mutto, A. A.; Gu, Y.; Ross, P. J.; Wu, J., 2020
  • Derivation of sheep embryonic stem cells under optimized conditions, Vilarino, M.; Soto, D.A.; Bogliotti, Y. S.; Yu, L.; Zhang, Y.; Wang, C.; Paulson, E.; Zhong, C.; Jin, C.; Izpisua Belmonte, J. C.; Wu, J.; Ross, P .J., 2020
  • Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring, Li, J.; Zhang, L.; Yu, L.; Minami, I.; Miyagawa, S.; Horning, M.; Dong, J.; Qiao, J.; Qu, X.; Hua, Y.; Fujimoto, N.; Shiba, Y.; Zhao, Y.; Tang, F.; Chen, Y.; Sawa, Y.; Tang, C.; Liu, L., 2020
  • Clonal Isolation of Human Pluripotent Stem Cells on Nanofibrous Substrates Reveals an Advanced Subclone for Cardiomyocyte Differentiation, Yu, L.; Li, J.; Itsunari, M.; Qu, X.; Miyagawa, S.; Fujimoto, N.; Hasegawa, K.; Chen, Y.; Sawa, Y.; Kotera, H.; Liu, L., 2019
  • Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures, Li, R.; Zhong, C.; Yu, Y.; Liu, H.; Sakurai, M.; Yu, L.; Min, Z.; Shi, L.; Wei, Y.; Takahashi, Y.; Liao, H.; Qiao, J.; Deng, H.; Nunez-Delicado, E.; Rodriguez Esteban, C.; Wu, J.; Izpisua Belmonte, J. C., 2019
  • Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells, Zhang, Y.; Li, T.; Preissl, S.; Amaral, M.L.; Grinstein, J.D.; Farah, E.N.; Destici, E.; Qiu, Y.; Hu, R. Lee, A.Y.; Chee, S.; Ma, K.; Ye, Z.; Zhu, Q.; Huang, H.; Fang, R.; Yu, L.; Izpisua Belmonte, J.C.; Wu, J.; Evans, S.M.; Chi, N.C.; Ren B., 2019
  • Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system, Xu, J.; Yu, L.; Guo, J.; Xiang, J.; Zheng, Z.; Gao, D.; Shi, B.; Hao, H.; Jiao, D.; Zhong, L.; Wang, Y.; Wu, J.; Wei, H.; Han, J., 2019
  • Low Cell-Matrix Adhesion Reveals Two Novel Subtypes of Human Pluripotent Stem Cells, Yu, L.; Li, J.; Hong, J.; Takashima, Y.; Fujimoto, N.; Nakajima, M.; Dong, X.; Dang, Y.; Yang, W.; Okita, K.; Luo, C.; Tang, F.; Chen, Y.; Tang, C.; Kotera, H.; Liu, L., 2018
  • Human Pluripotent Stem Cell-Derived Cardiac Tissue-Like Constructs for Repairing of the Infarcted Myocardium, Li, J.; Minami, I.; Yu, L.; Shiozaki, M.; Shiba, Y.; Yajima, S.; Morone, N.; Fukushima, S.; Yoshioka, M.; Li, S.; Qiao, J.; Li, X.; Wang, L.; Kotera, H.; Miyagawa, S.; Nakatsuji, N.; Sawa, Y.; Chen, Y.; Liu, L., 2017
  • Culture substrates made of elastomeric micro-tripod arrays for long-term expansion of human pluripotent stem cells, Li, J.; Zhang, F.; Yu, L.; Fujimoto, N.; Yoshioka, M.; Li, X.; Shi, J.; Kotera, H.; Liu, L.; Chen, Y., 2017
  • On chip purification of hiPSC-derived cardiomyocytes using a fishnet-like microstructure, Li, X.; Yu, L.; Li, J.; Minami, I.; Nakajima, M.; Noda, Y.; Kotera, H.; Liu, L.; Chen, Y., 2016
  • Induction and Differentiation of Human Induced Pluripotent Stem Cells into Functional Cardiomyocytes on a Compartmented Monolayer of Gelatin Nanofibers, Tang, Y.; Liu, L.; Li, J.; Yu, L.; Wang, L.; Shi, J.; Chen, Y., 2016
  • Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers, Li, J.; Minami, I.; Yu, L.; Tsuji, K.; Nakajima, M.; Qiao, J.; Suzuki, M.; Shimono, K.; Nakatsuji, N.; Kotera, H.; Liu, L.; Chen, Y., 2016
  • Effective Motor Neuron Differentiation of Hipscs on a Patch Made of Crosslinked Monolayer Gelatin Nanofibers, Tang, Y.; Liu, L.; Li, J.; Yu, L.; Severino, F. P. U.; Wang, L.; Shi, J.; Tu, X.; Torre, V.; Chen, Y., 2016
多能干细胞 胚胎发育 器官形成 疾病模型 微流控技术 诱导多能性 跨物种 干细胞应用 人类胚胎 生物技术

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