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Zhenbo Wang
wangzb@ioz.ac.cn
English, Chinese
Beijing
Chinese Academy of Sciences
Institute of Zoology
  • 2010-07 - PhD in Developmental Biology: Institute of Zoology, Chinese Academy of Sciences
  • 2004-07 - Bachelor of Science: College of Biological Sciences, China Agricultural University
  • 2017-01 to Present - Institute of Zoology, Chinese Academy of Sciences - Researcher
  • 2013-01 to 2016-12 - Institute of Zoology, Chinese Academy of Sciences - Associate Researcher
  • 2012-07 to 2012-12 - Institute of Zoology, Chinese Academy of Sciences - Assistant Researcher
  • 2010-07 to 2012-06 - Institute of Zoology, Chinese Academy of Sciences - Postdoctoral Researcher
  • 2006-06 to 2008-06 - University of Ottawa Health Institute - Visiting Graduate Student
  • Youth Science and Technology Award of the Chinese Zoological Society (2017)
  • Member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2017)
  • First Prize in Natural Science of the National Maternal and Child Health Science and Technology Award (2015)
  • Youth Science and Technology Award of the Reproductive Biology Branch of the Chinese Zoological Society (2015)
  • First Prize for Outstanding Scientific and Technological Achievements of the National Population and Family Planning Commission (2011)
Mechanisms of mammalian follicle development and oocyte maturation
Fertilization mechanisms
Oocyte-derived female infertility mechanisms
Fertility maintenance and remodeling
  • SRSF2 is required for mRNA splicing during spermatogenesis., Lei WL, Du Z, Meng TG, Su R, Li YY, Liu W, Sun SM, Liu MY, Hou Y, Zhang CH, Gui Y, Schatten H, Han Z, Liu C, Sun F, Wang ZB, Qian WP, Sun QY, 2023
  • A heterozygous ZP2 mutation causes zona pellucida defects and female infertility in mouse and human., Liu SL, Zuo HY, Zhao BW, Guo JN, Liu WB, Lei WL, Li YY, Ouyang YC, Hou Y, Han ZM, Wang WZ, Sun QY, Wang ZB, 2023
  • NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition., Meng TG, Guo JN, Zhu L, Yin Y, Wang F, Han ZM, Lei L, Ma XS, Xue Y, Yue W, Nie XQ, Zhao ZH, Zhang HY, Sun SM, Ouyang YC, Hou Y, Schatten H, Ju Z, Ou XH, Wang ZB, Wong CC, Li Z, Sun QY, 2023
  • Mad2 is dispensable for accurate chromosome segregation but becomes essential when oocytes are subjected to environmental stress., Qiao JY, Zhou Q, Xu K, Yue W, Lei WL, Li YY, Gu LJ, Ouyang YC, Hou Y, Schatten H, Meng TG, Wang ZB, Sun QY, 2023
  • Supplementation of mitochondria from endometrial mesenchymal stem cells improves oocyte quality in aged mice., Zhang Q, Hao JX, Liu BW, Ouyang YC, Guo JN, Dong MZ, Wang ZB, Gao F, Yao YQ, 2022
  • SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing., Liu W, Lu X, Zhao ZH, Su R, Li QL, Xue Y, Gao Z, Sun SS, Lei WL, Li L, An G, Liu H, Han Z, Ouyang YC, Hou Y, Wang ZB, Sun QY, Liu J, 2022
  • Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 transcription in oocyte meiosis., Meng TG, Lei WL, Lu X, Liu XY, Ma XS, Nie XQ, Zhao ZH, Li QN, Huang L, Hou Y, Ouyang YC, Li L, Tang TS, Schatten H, Xie W, Gao SR, Ou XH, Wang ZB, Sun QY, 2022
  • PPP4C facilitates homologous recombination DNA repair by dephosphorylating PLK1 during early embryo development., Dong MZ, Ouyang YC, Gao SC, Ma XS, Hou Y, Schatten H, Wang ZB, Sun QY, 2022
  • Nature aging., Zhu FY, Wang LL, Meng TG, Wang RL, Yang ZX, Cao Y, Zhu GY, Jin Z, Gao LL, Zeng WT, Wang ZB, Sun QY, Zhang D, 2021
  • Identification of a heterozygous variant of ZP2 as a novel cause of empty follicle syndrome in humans and mice., Shen Y, Guo J, Zhang X, Wang X, Zhu S, Chen D, Xiong W, Lu G, Liu X, Dai C, Gong F, Wang Y, Lin G, Wang Z, Xu W, 2022
  • Kinetochore scaffold 1 regulates SAC function during mouse oocyte meiotic maturation., Yue W, Wang Y, Meng TG, Zhang HY, Zhang XR, Ouyang YC, Hou Y, Schatten H, Wang ZB, Sun QY, 2022
  • Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis., Lei WL, Li YY, Meng TG, Ning Y, Sun SM, Zhang CH, Gui Y, Wang ZB, Qian WP, Sun QY, 2021
  • FBXO34 Regulates the G2/M Transition and Anaphase Entry in Meiotic Oocytes., Zhao BW, Sun SM, Xu K, Li YY, Lei WL, Li L, Liu SL, Ouyang YC, Sun QY, Wang ZB, 2021
  • PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome., Meng TG, Zhou Q, Ma XS, Liu XY, Meng QR, Huang XJ, Liu HL, Lei WL, Zhao ZH, Ouyang YC, Hou Y, Schatten H, Ou XH, Wang ZB, Gao SR, Sun QY, 2020
  • RNA-Seq transcriptome reveals different molecular responses during human and mouse oocyte maturation and fertilization., Zhao ZH, Meng TG, Li A, Schatten H, Wang ZB, Sun QY, 2020
  • Cell division cycle 23 is required for mouse oocyte meiotic maturation., Zhou Q, Li J, Yue W, Li A, Meng TG, Lei WL, Fan LH, Ouyang YC, Schatten H, Wang ZB, Sun QY, 2020
  • Deletion of BAF250a affects oocyte epigenetic modifications and embryonic development., Zhou Q, Meng QR, Meng TG, He QL, Zhao ZH, Li QN, Lei WL, Liu SZ, Schatten H, Wang ZB, Sun QY, 2020
  • Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation., Meng TG, Lu X, Guo L, Hou GM, Ma XS, Li QN, Huang L, Fan LH, Zhao ZH, Ou XH, OuYang YC, Schatten H, Li L, Wang ZB, Sun QY, 2019
  • Effects of Fullerenol Nanoparticles on Rat Oocyte Meiosis Resumption., Lei R, Bai X, Chang Y, Li J, Qin Y, Chen K, Gu W, Xia S, Zhang J, Wang Z, Xing G, 2018
  • Geminin deletion in pre-meiotic DNA replication stage causes spermatogenesis defect and infertility., Yuan Y, Ma XS, Liang QX, Xu ZY, Huang L, Meng TG, Lin F, Schatten H, Wang ZB, Sun QY, 2017
  • Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice., Meng TG, Hu MW, Ma XS, Huang L, Liang QX, Yuan Y, Hou Y, Wang H, Schatten H, Wang ZB, Sun QY, 2017
  • Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity., Hu MW, Meng TG, Jiang ZZ, Dong MZ, Schatten H, Xu X, Wang ZB, Sun QY, 2016
  • Geminin Deletion in Mouse Oocytes Results in Impaired Embryo Development and Reduced Fertility., Ma XS, Lin F, Wang ZW, Hu MW, Huang L, Meng TG, Jiang ZZ, Schatten H, Wang ZB, Sun QY, 2016
  • LKB1 acts as a critical gatekeeper of ovarian primordial follicle pool., Jiang ZZ, Hu MW, Ma XS, Schatten H, Fan HY, Wang ZB, Sun QY, 2016
  • Deletion of Mylk1 in oocytes causes delayed morula-to-blastocyst transition and reduced fertility without affecting folliculogenesis and oocyte maturation in mice., Liang QX, Zhang QH, Qi ST, Wang ZW, Hu MW, Ma XS, Zhu MS, Schatten H, Wang ZB, Sun QY, 2015
Follicle Development Oocyte Maturation Fertilization Infertility Reproductive Biology Stem Cells Mammalian Oocyte Fertility Mechanisms

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