1995-1998 Master's in Cell Biology: Beijing Normal University
1999-2002 PhD in Physiology: Institute of Zoology, Chinese Academy of Sciences
Postdoctoral Research: Ottawa Health Research Institute, Canada
Recipient of National Science Fund for Distinguished Young Scholars
Leader in the National Ten Thousand Talents Program
2021.12–Present - Vice President, Beijing Institute of Stem Cell and Regenerative Medicine
2017.05–Present - Director, State Key Laboratory of Stem Cell and Reproductive Biology
2013.01–2017.05 - Deputy Director, State Key Laboratory of Stem Cell and Reproductive Biology
2006.09–Present - Researcher, Doctoral Supervisor, Group Leader of Reproductive Physiology, State Key Laboratory of Stem Cell and Reproductive Biology
2003.12–2005.12 - Postdoctoral Researcher, Ottawa Health Research Institute, Canada
2003.01–2006.09 - Associate Researcher, National Key Laboratory of Reproductive Biology
2002.01–2002.12 - Assistant Researcher, National Key Laboratory of Reproductive Biology
1998.07–2002.01 - Research Intern, National Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
2023: Selected as one of the 'Top Ten Advances in Life Sciences in China'
2023: Tan Jiazhen Life Science Innovation Award
2023: Stem Cell Research Innovation Scientist Award by the Chinese Society for Cell Biology
2023: First Prize in Natural Science Award, Fifth Maternal and Child Health Science and Technology Award
2023: First Prize in Science and Technology Award by the Chinese Society of Laboratory Animal Science
2017: Second Prize in National Maternal and Child Health Science and Technology Award
2011: First Prize in National Population and Family Planning Commission's Excellent Scientific and Technological Achievement Award
2008: Second Prize in the Ministry of Education's Higher Education Scientific Research Excellent Achievement Award
2021: 'Silver Award for Leading Goose, Flapping Wings Award' by the University of Chinese Academy of Sciences
2020: 'Zhu Li Yuehua Excellent Teacher Award' by the Chinese Academy of Sciences
2020: Excellent Mentor Award by the Chinese Academy of Sciences
Research
Early Embryo Development Placental Development and Pathology Stem Cells and Female Fertility
A multi-tissue metabolome atlas reveals core signatures and critical nodes of metabolic reprogramming in female primates during pregnancy., Yu D, Wan H, Tong C, Guang L, Chen G, Su J, Zhang L, Wang Y, Xiao Z, Zhai J, Ma W, Liang K, Liu T, Wang Y, Peng Z, Luo L, Yu R, Li W, Qi H, Wang H, Shyh-Chang N., 2024
Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy., Wang M, Liu Y, Sun R, Liu F, Li J, Yan L, Zhang J, Xie X, Li D, Wang Y, Li S, Zhu X, Li R, Lu F, Xiao Z, Wang H., 2024
Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics., Wang Y, Deng W, Lee D, Yan L, Lu Y, Dong S, Huntoon K, Antony A, Li X, Ye R, Zhao Y, Zhao F, Schrank BR, Ha J, Kang M, Yang M, Gong P, Lorenzi PL, Tan L, Gallup TD, Tang SK, Yang Z, Li J, Sanford NN, Wang H, Kim BYS, Jiang W., 2024
The in vitro culture of mammalian embryos., Wu X, Zhai J, Li Q, Wang H., 2023
Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids., Wu H, Huang XY, Sun MX, Wang Y, Zhou HY, Tian Y, He BJ, Wu AP, Wang H, Qin CF., 2023
Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture., Zhai J, Xu Y, Wan H, Yan R, Guo J, Skory R, Yan L, Wu X, Sun F, Chen G, Zhao W, Yu K, Li W, Guo F, Plachta N, Wang H., 2023
Identifying a dynamic transcriptomic landscape of the cynomolgus macaque placenta spanning during pregnancy at single-cell resolution., Jiang X, Zhai J, Xiao Z, Wu X, Zhang D, Wan H, Xu Y, Qi L, Wang M, Yu D, Liu Y, Wu H, Sun R, Xia S, Yu K, Guo J, Wang H., 2023
A differentiation roadmap of murine placentation at single-cell resolution., Jiang X, Wang Y, Xiao Z, Yan L, Guo S, Wang Y, Wu H, Zhao X, Lu X, Wang H., 2023
Primate gastrulation and early organogenesis at single-cell resolution., Zhai J, Guo J, Wan H, Qi L, Liu L, Xiao Z, Yan L, Schmitz DA, Xu Y, Yu D, Wu X, Zhao W, Yu K, Jiang X, Guo F, Wu J, Wang H., 2022
Dissecting the fate of 1 Foxl2-expressing cells in fetal ovary using lineage tracing and Single-Cell Transcriptomics., Zhou JJ, Jiang XX, Wu HW, Zhang LJ, Chen M, Chen M, Shen ZM, Guo XD, Wang H, Gao F., 2022
Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development., Yan R, Cheng X, Gu C, Xu YH, Long X, Zhai JL, Sun FY, Qian JJ, Du YR, Wang H, Guo F., 2023
Current understanding in deciphering trophoblast cell differentiation during human placentation., Li Q, Wu H, Wang Y, Wang H., 2022
A Uterus-Inspired Niche Drives Blastocyst Development to the Early Organogenesis., Gu Z, Guo J, Zhai J, Feng G, Wang X, Gao Z, Li K, Ji S, Wang L, Xu Y, Chen X, Wang Y, Guo S, Yang M, Li L, Hua H, Jiang L, Wen Y, Wang L, Hao J, Li W, Wang S, Wang H, Gu Q., 2022
Deciphering the dynamics of the ovarian reserve in cynomolgus monkey through a quantitative morphometric study., Tu W, Ni D, Yang H, Zhao F, Yang C, Zhao X, Guo Z, Yu K, Wang J, Hu Z, Chen Z, Zhao Y, Wang Z, Gao F, Yan L, Yang X, Zhu L, Wang H., 2022
A Single-Cell Characterization of Human Post-implantation Embryos Cultured In Vitro Delineates Morphogenesis in Primary Syncytialization., Wang Y, Jiang X, Jia L, Wu X, Wu H, Wang Y, Li Q, Yu R, Wang H, Xiao Z, Liang X., 2022
LMNA Determines Nuclear Morphology During Syncytialization of Human Trophoblast Stem Cells., Wang Y, Wu H, Jiang X, Jia L, Wang M, Rong Y, Chen S, Wang Y, Xiao Z, Liang X, Wang H., 2022
Human embryonic development: from peri-implantation to gastrulation., Zhai J, Xiao Z, Wang Y, Wang H., 2022
De novo generation of macrophage from placenta-derived hemogenic endothelium., Liang G, Zhou C, Jiang X, Zhang Y, Huang B, Gao S, Kang Z, Ma D, Wang F, Gottgens B, Wang H, Han JJ, Liu F., 2021
Molecular evidence suggesting the persistence of residual SARS-CoV-2 and immune responses in the placentas of pregnant patients recovered from COVID-19., Wu H, Liao S, Wang Y, Guo M, Lin X, Wu J, Wang R, Lv D, Wu D, He M, Hu B, Long R, Peng J, Yang H, Yin H, Wang X, Huang Z, Lan K, Zhou Y, Zhang W, Xiao Z, Zhao Y, Deng D, Wang H., 2021
Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing., Yan R, Gu C, You D, Huang Z, Qian J, Yang Q, Cheng X, Zhang L, Wang H, Wang P, Guo F., 2021
Reconstruction of functional uterine tissues through recellularizing the decellularized rat uterine scaffolds by MSCs in vivo and in vitro., Li X, Wang Y, Ma R, Liu X, Song B, Duan Y, Guo J, Feng G, Cui T, Wang L, Hao J, Wang H, Gu Q., 2021
Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization., Qu Y, Chen Q, Guo S, Ma C, Lu Y, Shi J, Liu S, Zhou T, Noda T, Qian J, Zhang L, Zhu X, Lei X, Cao Y, Li W, Li W, Plachta N, Matzuk MM, Ikawa M, Duan E, Zhang Y, Wang H., 2021
Human umbilical cord mesenchymal stem cells restore the ovarian metabolome and rescue premature ovarian insufficiency in mice., Zhao Y, Ma J, Yi P, Wu J, Zhao F, Tu W, Liu W, Li T, Deng Y, Hao J, Wang H, Yan L., 2020
Clinical analysis of human umbilical cord mesenchymal stem cell allotransplantation in patients with premature ovarian insufficiency., Yan L, Wu Y, Li L, Wu J, Zhao F, Gao Z, Liu W, Li T, Fan Y, Hao J, Liu J, Wang H., 2020
Progress in deciphering trophoblast cell differentiation during human placentation., Xiao Z, Yan L, Liang X, Wang H., 2020
Keratins are asymmetrically inherited fate determinants in the mammalian embryo., Lim HYG, Alvarez YD, Gasnier M, Wang Y, Tetlak P, Bissiere S, Wang H, Biro M, Plachta N., 2020
In vitro culture of cynomolgus monkey embryos beyond early gastrulation., Ma H, Zhai J, Wan H, Jiang X, Wang X, Wang L, Xiang Y, He X, Zhao ZA, Zhao B, Zheng P, Li L, Wang H., 2019
Tracing the origin of the placental trophoblast cells in mouse embryo development., Guo S, Cui X, Jiang X, Duo S, Li S, Gao F, Wang H., 2020
Tubulin detyrosination promotes human trophoblast syncytium formation., Wang R, Yu R, Zhu C, Lin HY, Lu X, Wang H., 2019
Comparative analysis of mesenchymal stem cells derived from amniotic plate under serum-free condition., Ma J, Wu J, Han L, Jiang X, Yan L, Hao J, Wang H., 2019
Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta., Liu Y, Fan X, Wang R, Lu X, Dang YL, Wang H, Lin HY, Zhu C, Ge H, Cross JC, Wang H., 2018
Three macrophage subsets are identified in the uterus during early human pregnancy., Jiang X, Du MR, Li M, Wang H., 2018
Plac8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration., Chang WL, Liu YW, Dang YL, Jiang XX, Xu H, Huang X, Wang YL, Wang H, Zhu C, Xue LQ, Lin HY, Meng W, Wang H., 2018
Fine-Tuned and Cell-Cycle-Restricted Expression of Fusogenic Protein Syncytin-2 Maintains Functional Placental Syncytia., Lu X, Wang R, Zhu C, Wang H, Lin HY, Gu Y, Cross JC, Wang H., 2017
Pilot study of large-scale production of mutant pigs by ENU mutagenesis., Hai T, Cao C, Shang H, Guo W, Mu Y, Yang S, Zhang Y, Zheng Q, Zhang T, Wang X, Liu Y, Kong Q, Li K, Wang D, Qi M, Hong Q, Zhang R, Wang X, Jia Q, Wang X, Qin G, Li Y, Luo A, Jin W, Yao J, Huang J, Zhang H, Li M, Xie X, Zheng X, Guo K, Wang Q, Zhang S, Li L, Xie F, Zhang Y, Weng X, Yin Z, Hu K, Cong Y, Zheng P, Zou H, Xin L, Xia J, Ruan J, Li H, Zhao W, Yuan J, Liu Z, Gu W, Li M, Wang Y, Wang H, Yang S, Liu Z, Wei H, Zhao J, Zhou Q, Meng A., 2017
Uterine Fluid in Pregnancy: A Biological and Clinical Outlook., Zhang Y, Wang Q, Wang H, Duan EK., 2017
