1994 - Bachelor's in Animal Physiology and Biochemistry: China Agricultural University
2002 - PhD in Physiology: Gunma University, Japan
Discovered the first mammalian subcortical maternal complex (SCMC)
Postdoctoral Research - Japan Society for the Promotion of Science (JSPS) and National Institutes of Health (NIH), USA
2009 - Present - Group Leader, Molecular Embryo Development Biology Research Group, Institute of Zoology, Chinese Academy of Sciences
NIDDK Nancy Nossal Fellowship Award
NIH Fellow Award for Research Excellence
Research
Molecular mechanisms of early mammalian embryonic development Maternal regulation of early embryonic development
Structural basis of the subcortical maternal complex and its implications in reproductive disorders, Chi Q, Ou G, Qin D, Han Z, Li J, Xiao Q, Gao Z, Xu C, Qi Q, Liu Q, Liu S, Li J, Guo L, Lu Y, Chen J, Wang X, Shi H, Li L*, Deng D*, 2024
Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation, Nie X, Xu Q, Xu C, Chen F, Wang Q, Qin D, Wang R, Gao Z, Lu X, Yang X, Wu Y, Gu C, Xie W*, Li L*, 2023
ASH2L regulates postnatal neurogenesis through Onecut2-mediated inhibition of TGF-βsignaling pathway, Xu Y, Dai S, Duan C, Zhang Z, Liu P, Liu C, Du H, Lu X, Hu S, Li L, Teng Z*, Liu C*, 2023
BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing, Yao X, Wang C, Sun L, Yan L, Chen X, Lv Z, Xie X, Tian S, Liu W, Li L*, Zhang H*, Liu J*, 2023
Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 in oocyte meiosis, Meng T, Lei W, Liu X, Liu XY, Ma X, Nie X, Zhao Z, Li Q, Huang L, Hou Y, OuYang Y, Li L, Tang T, Schatten H, Xie W, Gao S, Ou XH*, Wang Z*, and Sun QY*, 2022
Cnot8 eliminates naive regulation networks and is essential for naive-to-formative pluripotency transition, Quan Y, Wang M, Xu C, Wang X, Qin D, Lin Y, Lu X, Lu F*, Li L*, 2022
Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development, Xiong Z, Xu K, Lin Z, Kong F, Wang Q, Quan Y, Sha Q, Li F, Zou Z, Liu L, Ji S, Chen Y, Zhang H, Fang J, Yu G, Liu B, Wang L, Wang H, Deng H, Yang X, Fan H, Li L*, Xie W*, 2022
In vitro investigation of mammalian early embryonic development (in Chinese), Wang Z, Zhang J, Li L*, 2022
In vitro investigation of mammalian peri-implantation embryogenesis, Quan Y, Wang X, Li L*, 2022
BCAS2 is involved in alternative splicing and mouse oocyte development, Zhang J, Liu W, Li G, Xu C, Nie X, Qin D, Wang Q, Lu X, Liu J, Li L*, 2022
Ash2l-1 is essential for mouse early hematopoietic development of yolk sac (in Chinese), Wang X, Lu X, Xiang Y, Li L*, 2021
Formative pluripotent stem cells show features of epiblast cells poised for gastrulation, Wang X, Xiang Y, Yu Y, Wang R, Zhang Y, Xu Q, Sun H, Zhao Z, Jiang X, Wang XQ, Lu X, Qin D, Zhang J, Quan Y, Shyh-Chang N, Wang H, Xie W*, Li L*, 2021
Stabilizing formative pluripotent states with germ cell competency, Shyn-Chang N* and Li L*, 2021
Retinoic acid promotes metabolic maturation of human embryonic stem cell-derived cardiomyocytes, Miao S, Zhao D, Wang X, Ni X, Fang X, Yu M, Ye L, Yang J, Wu H, Han X, Qu L, Li L, Lan F, Shen Z, Lei W, Zhao ZA, Hu S, 2020
Comments on 'In vitro culture of cynomolgus monkey embryos beyond early gastrulation', Ma H, Wang H*, Zheng P*, Li L*, 2020
Epigenomic analysis of gastrulation reveals a unique chromatin state for primed pluripotency, Xiang Y, Zhang Y, Xu Q, Zhou C, Liu B, Du Z, Zhang K, Zhang B, Wang X, Gayen S, Liu L, Wang Y, Li Y, Wang Q, Kalantry S, Li L, Xie W, 2020
In vitro culture of cynomolgus monkey embryos beyond early gastrulation, Ma H, Zhai J, Wan H, Jiang X, Wang X, Wang L, Xiang Y, He X, Zhao Z, Zhao B, Zheng P*, Li L*, Wang H*, 2019
The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution, Qin D, Gao Z, Xiao Y, Zhang X, Ma H, Yu X, Nie X, Fan N, Wang X, OuYang Y, Sun QY, Yi Z, Li L*, 2019
Compression generated by a 3D supracellular actomyosin cortex promotes embryonic stem cell colony growth and expression of Nanog and Oct4, Du J, Fan Y, Guo Z, Wang Y, Zheng X, Huang C, Liang B, Gao L, Cao Y, Chen Y, Zhang X, Li L, Xu L, Wu C, Weitz D, Feng X, 2019
Putting stem cells on a low-fat diet switches their pluripotent state, Jiang Z, Guang L, Li L, Shyh-Chang N, 2019
Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation, Meng T, Lu X, Guo L, Hou G, Ma X, Li Q, Huang L, Fan L, Zhao Z, Ou X, OuYang Y, Schatten H, Li L, Wang Z, Sun QY, 2019
An oocyte-embryo-specific subcortical maternal complex in mammals (in Chinese), Wang X, Qin D, Lu X, Li L*, 2018
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs, Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q, 2018
Whole-transcriptome splicing profiling of E7.5 mouse primary germ layers reveals frequent usage of alternative promoter during early embryogenesis, Lu X, Zhao Z, Wang X, Zhang X, Zhai Y, Deng W, Yi Z*, Li L*, 2018
Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles, Gao Z, Zhang X, Yu X, Qin D, Yu Y, Liu W, Xiang Y, Xiao Y, Lu X, Yi Z, Li L*, 2018
ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast, Yu Y, Wang X, Zhang X, Zhai Y, Lu X, Ma H, Zhu K, Zhao T, Jiao J, Zhao Z*, Li L*, 2018
Dynamic epigenomic landscapes during early lineage specification, Zhang Y, Xiang Y, Yin Q, Du Z, Peng X, Wang Q, Fidalgo M, Xia W, Li Y, Zhao Z, Zhang W, Ma J, Xu F, Wang J, Li L, Xie W, 2018
A maternal functional module in the mammalian oocyte-to-embryo transition, Lu X, Gao Z, Qin D, Li L*, 2017
MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production, Zhang L, Zhang X, Zhang X, Lu Y, Li L, Cui S, 2017
First cell lineage specification in mammalian early development (in Chinese), Nie X, Lu X, Li L*, 2017
BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis, Liu W Wang F, Xu Q, Shi J, Zhang X, Lu X, Gao Z, Ma H, Zhao Z, Duan E, Gao F, Gao S*, Yi Z*, Li L*, 2017
Trp-Asp (WD) repeat domain 1 is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation, Xiao Y, Ma H, Wan P, Qin D, Zhang X, Xiang Y, Wang X, Liu W, Chen J*, Yi Z*, and Li L*, 2017
BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis, Liu Y, Lu X, Shi J, Yu X, Zhang X, Zhu K, Yi Z, Duan E, Li L*, 2016
MicroRNA-127 Promotes Mesendoderm Differentiation of Mouse Embryonic Stem Cells by Targeting Left-right Determination Factor 2, Ma H, Lin Y, Zhao Z, Lu X, Yu Y, Zhang X, Wang Q*, Li L*, 2016
Maternal BCAS2 protects genomic integrity in mouse early embryonic development, Xu Q, Wang F, Xiang Y, Zhang X, Zhao Z, Gao Z, Liu W, Lu X, Liu Y, Yu X, Wang H, Huang J, Yi Z, Gao S*, Li L*, 2015
The roles of ERAS during cell lineage specification of mouse early embryonic development, Zhao Z-A, Yu Y, Ma H-X, Wang X, Lu X, Zhai Y, Zhang X-X, Wang H, Li L*, 2015
Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability, Zhao B, Zhang W, Duan Y, Lu Y, Cun Y, Li C, Guo K, Nie W, Li L, Zhang R, Zheng P, 2015
Identification of a human subcortical maternal complex, Zhu K, Yan L, Zhang X, Lu X, Wang T, Yan J, Liu X, Qiao J*, Li L*, 2015
The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics, Yu X, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang Z, Zheng P, Zhu M, Wang H, Sun QY, Dean J*, Li L*, 2014
Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms, Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q, Duan E, Wang H, 2014
Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice, Fu Z, Wang B, Wang S, Wu W, Wang Q, Chen Y, Kong S, Lu J, Tang Z, Ran H, Tu Z, He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang YL, Li L, Wang F, Gao S, Wang H, 2014
The maternal to zygotic transition in mammals, Li L*, Lu X and Dean J*, 2013
WASH inhibits autophagy through suppression of Beclin 1 ubiquitination, Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B, Li C, Dai Z, Hou N, Cheng X, Sun Q, Li L, Yang X, Fan Z, 2013
The N-terminus of FILIA forms an atypical KH domain with a unique extension involved in interaction with RNA, Wang J, Xu M, Zhu K, Li L*, Liu X*, 2012
Regulation of asymmetrical cytokinesis by cAMP during meiosis I in mouse oocytes, Chen D, Zhang Y, Yi Q, Huang Y, Hou H, Zhang Y, Hao Q, Cooke HJ, Li L, Sun QY, Shi Q, 2012
Maternal Control of Early Mouse Development, Li L*, Zheng P and Dean J*, 2010
A Subcortical Maternal Complex Essential for Pre-implantation Mouse Embryogenesis, Li L*, Baibakov B and Dean J, 2008
Maternally Derived FILIA/MATER Complex Localizes Asymmetrically in Cleavage Stage Mouse Embryos, Ohsugi M, Zheng P, Baibakov B, Li L, and Dean J, 2008
Promotion of b-Cell Differentiation by Conophylline in Fetal and Neonatal Rat Pancreas, Ogata T, Li L, Yamada S, Yamamoto Y, Tanaka Y, Takei I, Umezawa K and Kojima I, 2004
Activin A and Betacellulin: Effect on Regeneration of Pancreatic b-Cells in Neonatal Streptozotocin-treated Rats, Li L, Yi Z, Seno M, and Kojima I, 2004
Betacellulin Improved Glucose Metabolism by Promoting Conversion of Intra-islet Precursor Cells to-cells in Streptozotocin-treated Diabetic Mice, Li L, Seno M, Yamada H, and Kojima I, 2003
Promotion of β-cell Regeneration by Betacellulin in 90% Pancreatectomized Rats, Li L, Seno M, Yamada H, and Kojima I, 2001
