1990 - Bachelor's in Biochemistry: East China University of Science and Technology
1993 - Master's: Shanghai Institute of Entomology, Chinese Academy of Sciences
1996 - PhD: Shanghai Institute of Biochemistry, Chinese Academy of Sciences
1996-2009 - University of Massachusetts Medical School - Postdoctoral, Lecturer, Research Assistant Professor
2009-present - Institute of Zoology, Chinese Academy of Sciences - Researcher
American Heart Association Postdoctoral Fellowship (1999–2001)
American Heart Association - Scientist Development Grant (2004.1-2008.12)
Research
Structure and contraction mechanism of muscle systems Cell movement and intracellular material transport Application of protein molecular motors in nanomachines
Locusta migratoria flight muscle troponin partially activates thin filament in a calcium-dependent manner., Hui-Fang Liang and Xiang-dong Li, 2022
Effects of the IQ1 motif of Drosophila myosin-5 on the calcium interaction of calmodulin., Ning Zhang, Shu-Jie Zhou, Huan-Hong Ji, and Xiang-dong Li, 2022
Effects of Mutations in the Phenamacril-Binding Site of Fusarium Myosin-1 on Its Motor Function and Phenamacril Sensitivity., Tong Ni, Min Yuan, Huan-Hong Ji, Guangfei Tang, Yun Chen, Zhonghua Ma, and Xiang-dong Li, 2020
Identification and characterization of troponin genes in Locusta migratoria., Hui-Fang Liang, Jing Li, and Xiang-dong Li, 2020
The cargo adaptor proteins RILPL2 and melanophilin co-regulate myosin-5a motor activity., Qing-Juan Cao, Ning Zhang, Rui Zhou, Lin-Lin Yao, and Xiang-dong Li, 2019
Regulation of Myosin-5b by Rab11a and the Rab11 family interacting protein 2., Huan-Hong Ji, Lin-Lin Yao, Chang Liu, and Xiang-dong Li, 2019
Regulation of Class V Myosin., Ning Zhang, Lin-Lin Yao, and Xiang-dong Li, 2018
Characterization of Blebbistatin Inhibition of Smooth Muscle Myosin and Nonmuscle Myosin-2., Hai-Man Zhang, Huan-Hong Ji, Tong Ni, Rong-Na Ma, Aibing Wang, and Xiang-dong Li, 2017
Directional Transportation of Assembled Molecular Linear Motors., Ning Zhang and Xiang-dong Li, 2017
Calmodulin in complex with the first IQ motif of myosin-5a functions as an intact calcium sensor., Mei Shen, Ning Zhang, Sanduo Zheng, Wen-Bo Zhang, Hai-Man Zhang, Zekuan Lu, Qian Peter Su, Yujie Sun, Keqiong Ye, and Xiang-dong Li, 2016
Alternative Exon-encoding Regions of Locusta migratoria Muscle Myosin Modulate the pH dependence of ATPase Activity., Jing Li, Zekuan Lu, Jing He, Qianquan Chen, Xianhui Wang, Le Kang, and Xiang-dong Li, 2016
Cytochrome P450 gene, CYP4G15, modulates hydrocarbon production in the pea aphid, Acyrthosiphon pisum., Nan Chen, Yong-Liang Fan, Yu Bai, Xiang-dong Li, Zhan-Feng Zhang, and Tong-Xian Liu, 2016
Identification of the isoform-specific interactions between the tail and the head of class V myosin., Lin-Lin Yao, Mei Shen, Zekuan Lu, Mitsuo Ikebe, and Xiang-dong Li, 2016
The Globular Tail Domain of Myosin-5a Functions As a Dimer in Regulating the Motor Activity., Wen-Bo Zhang, Lin-Lin Yao, and Xiang-dong Li, 2016
TRAFD1 (FLN29) Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption., Hanna Witwick, Hong Jia, Artem Kutikov, Pablo Reyes-Gutierrez, Xiang-dong Li, Paul R. Odgren, 2015
A small molecule species-specifically inhibits Fusarium myosin I., Chengqi Zhang, Yun Chen, Yanni Yin, Huan-Hong Ji, Won-Bo Shim, Yiping Hou, Mingguo Zhou, Xiang-dong Li, and Zhonghua Ma, 2015
The motor function of Drosophila melanogaster myosin-5 is activated by calcium and cargo-binding protein dRab11., Huan-Hong Ji, Hai-Man Zhang, Mei Shen, Lin-Lin Yao, and Xiang-dong Li, 2015
Melanophilin Stimulates Myosin-5a Motor Function by Allosterically Inhibiting the Interaction between the Head and Tail of Myosin-5a., Lin-Lin Yao, Qing-Juan Cao, Hai-Man Zhang, Jie Zhang, Yang Cao, and Xiang-dong Li, 2015
Mouse Myosin-19 is a Plus-end-directed, High-duty Ratio Molecular Motor., Zekuan Lu, Xiao-Nan Ma, Hai-Man Zhang, Huan-Hong Ji, Hao Ding, Jie Zhang, Dan Luo, Yujie Sun, and Xiang-dong Li, 2014
Drosophila myosin-xx functions as an actin-binding protein to facilitate the interaction between zyx102 and actin., Yang Cao, Howard D. White, and Xiang-dong Li, 2014
Cooperation between the Two Heads of Smooth Muscle Myosin Is Essential for Full Activation of the Motor Function by Phosphorylation., Rong-Na Ma, Katsuhide Mabuchi, Jing Li, Zekuan Lu, Chih-Lueh Albert Wang, and Xiang-dong Li, 2013
Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a., Zekuan Lu, Mei Shen, Yang Cao, Hai-Man Zhang, Lin-Lin Yao, and Xiang-dong Li, 2012
果蝇非常规肌球蛋白的结构与功能., 曹洋,沈梅，张洁，李向东, 2011
The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIA., Nobuhisa Umeki, Hyun Suk Jung, Shinya Watanabe, Tsuyoshi Sakai, Xiang-dong Li, Reiko Ikebe, Roger Craig, and Mitsuo Ikebe, 2009
The globular tail domain puts on the brake to stop the ATPase cycle of the myosin Va., Xiang-dong Li, Hyun Suk Jung, Qizhi Wang, Reiko Ikebe, Roger Craig, and Mitsuo Ikebe, 2008
Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity., Zhiping Wang, Jeffrey G. Edwards, Nathan Riley, D. William Provance, Jr., Ryan Karcher, Xiang-dong Li, Ian G. Davison, Mitsuo Ikebe, John A. Mercer, Julie A. Kauer, and Michael D. Ehlers, 2008
Myosin Va becomes a low duty ratio motor in the inhibited form., Osamu Sato, Xiang-dong Li, and Mitsuo Ikebe, 2007
The globular tail domain of myosin Va functions as an inhibitor of the myosin Va motor., Xiang-dong Li, Hyun Suk Jung, Katsuhide Mabuchi, Roger Craig, and Mitsuo Ikebe, 2006
Activation of Myosin Va function by melanophilin, a specific docking partner of Myosin Va., Xiang-dong Li, Reiko Ikebe, and Mitsuo Ikebe, 2005
Ca2+ induced activation of ATPase activity of myosin Va is accompanied with a large conformational change., Xiang-dong Li, Katsuhide Mabuchi, Reiko Ikebe, and Mitsuo Ikebe, 2004
Two functional heads are required for full activation of smooth muscle myosin., Xiang-dong Li and Mitsuo Ikebe, 2003
F-actin and myosin II binding domains in supervillin., Yu Chen, Norio Takizawa, Jessica L Crowley, Sang W. Oh, Cheryl L. Gatto, Taketoshi Kambara, Osamu Sato, Xiang-dong Li, Mitsuo Ikebe, and Elizabeth J. Luna, 2003
Toxicity of Cinnamomin-A new type II ribosome-inactivating protein to ballworm and mosquito., Xin Zhou, Xiang-dong Li, Jian-zhong Yuan, Zhen-hua Tang, and Wang-yi Li, 2000
The interaction between the regulatory light chain domains on two heads is critical for regulation of smooth muscle myosin., Xiang-dong Li, Junya Saito, Reiko Ikebe, Katsuhide Mabuchi, and Mitsuo Ikebe, 2000
Effects of mutations in the g-phosphate binding site of myosin on its motor function., Xiang-dong Li, Troy E. Rhodes, Reiko Ikebe, Taketoshi Kambara, Howard D. White and Mitsuo Ikebe, 1998
A proposed position of a disulfide bridge in the molecules of cinnamomin and porrectin-two new type II ribosome-inactivating proteins isolated from the seeds of camphor trees., Wang-yi Liu, Huai-yang Chen, Wen-feng Chen, Xiang-dong Li, Norbert Ulbrich and Werner Schroder, 1997
Large-scale purification of two new ribosome-inactivating proteins --- cinnamomin and camphorin from the seed of Cinnamomum camphora., Xiang-dong Li, Wen-feng Chen, Wang-yi Liu, and Gui-hai Wang, 1997
核糖体失活蛋白研究进展。, 李向东，刘望夷, 1997
核糖体失活蛋白结构功能与分布。, 李向东,刘望夷, 1997
Purification of a new ribosome-inactivating protein from the seeds of Cinnamomum porrectum and characterization of the RNA N-glycosidase activity of the toxic protein., Xiang-dong Li, Wang-yi Liu, and Ching-i Niu, 1996
Topological requirements for recognition and cleavage of DNA by ribosome-inactivating proteins., Jun Ling, Xiang-dong Li, Xiao-hua Wu, and Wang-yi Liu, 1995
