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李向东
nlixd@ioz.ac.cn
英语, 中文
北京
中国科学院
Institute of Zoology
  • 1990 - 生物化学学士: 华东化工学院
  • 1993 - 硕士: 中国科学院上海昆虫研究所
  • 1996 - 博士: 中国科学院上海生物化学研究所
  • 1996-2009 - 马萨诸塞大学医学院 - 博士后, 讲师, 研究助理教授
  • 2009-至今 - 中国科学院动物研究所 - 研究员
  • 美国心脏协会博士后奖学金 (1999–2001)
  • 美国心脏协会 - 科学家发展奖 (2004.1-2008.12)
肌肉系统的结构与收缩机理
细胞运动与细胞内物质转运
蛋白质分子马达在纳米机器中的应用
  • Locusta migratoria flight muscle troponin partially activates thin filament in a calcium-dependent manner., Hui-Fang Liang and Xiang-dong Li, 2022
  • Effects of the IQ1 motif of Drosophila myosin-5 on the calcium interaction of calmodulin., Ning Zhang, Shu-Jie Zhou, Huan-Hong Ji, and Xiang-dong Li, 2022
  • Effects of Mutations in the Phenamacril-Binding Site of Fusarium Myosin-1 on Its Motor Function and Phenamacril Sensitivity., Tong Ni, Min Yuan, Huan-Hong Ji, Guangfei Tang, Yun Chen, Zhonghua Ma, and Xiang-dong Li, 2020
  • Identification and characterization of troponin genes in Locusta migratoria., Hui-Fang Liang, Jing Li, and Xiang-dong Li, 2020
  • The cargo adaptor proteins RILPL2 and melanophilin co-regulate myosin-5a motor activity., Qing-Juan Cao, Ning Zhang, Rui Zhou, Lin-Lin Yao, and Xiang-dong Li, 2019
  • Regulation of Myosin-5b by Rab11a and the Rab11 family interacting protein 2., Huan-Hong Ji, Lin-Lin Yao, Chang Liu, and Xiang-dong Li, 2019
  • Regulation of Class V Myosin., Ning Zhang, Lin-Lin Yao, and Xiang-dong Li, 2018
  • Characterization of Blebbistatin Inhibition of Smooth Muscle Myosin and Nonmuscle Myosin-2., Hai-Man Zhang, Huan-Hong Ji, Tong Ni, Rong-Na Ma, Aibing Wang, and Xiang-dong Li, 2017
  • Directional Transportation of Assembled Molecular Linear Motors., Ning Zhang and Xiang-dong Li, 2017
  • Calmodulin in complex with the first IQ motif of myosin-5a functions as an intact calcium sensor., Mei Shen, Ning Zhang, Sanduo Zheng, Wen-Bo Zhang, Hai-Man Zhang, Zekuan Lu, Qian Peter Su, Yujie Sun, Keqiong Ye, and Xiang-dong Li, 2016
  • Alternative Exon-encoding Regions of Locusta migratoria Muscle Myosin Modulate the pH dependence of ATPase Activity., Jing Li, Zekuan Lu, Jing He, Qianquan Chen, Xianhui Wang, Le Kang, and Xiang-dong Li, 2016
  • Cytochrome P450 gene, CYP4G15, modulates hydrocarbon production in the pea aphid, Acyrthosiphon pisum., Nan Chen, Yong-Liang Fan, Yu Bai, Xiang-dong Li, Zhan-Feng Zhang, and Tong-Xian Liu, 2016
  • Identification of the isoform-specific interactions between the tail and the head of class V myosin., Lin-Lin Yao, Mei Shen, Zekuan Lu, Mitsuo Ikebe, and Xiang-dong Li, 2016
  • The Globular Tail Domain of Myosin-5a Functions As a Dimer in Regulating the Motor Activity., Wen-Bo Zhang, Lin-Lin Yao, and Xiang-dong Li, 2016
  • TRAFD1 (FLN29) Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption., Hanna Witwick, Hong Jia, Artem Kutikov, Pablo Reyes-Gutierrez, Xiang-dong Li, Paul R. Odgren, 2015
  • A small molecule species-specifically inhibits Fusarium myosin I., Chengqi Zhang, Yun Chen, Yanni Yin, Huan-Hong Ji, Won-Bo Shim, Yiping Hou, Mingguo Zhou, Xiang-dong Li, and Zhonghua Ma, 2015
  • The motor function of Drosophila melanogaster myosin-5 is activated by calcium and cargo-binding protein dRab11., Huan-Hong Ji, Hai-Man Zhang, Mei Shen, Lin-Lin Yao, and Xiang-dong Li, 2015
  • Melanophilin Stimulates Myosin-5a Motor Function by Allosterically Inhibiting the Interaction between the Head and Tail of Myosin-5a., Lin-Lin Yao, Qing-Juan Cao, Hai-Man Zhang, Jie Zhang, Yang Cao, and Xiang-dong Li, 2015
  • Mouse Myosin-19 is a Plus-end-directed, High-duty Ratio Molecular Motor., Zekuan Lu, Xiao-Nan Ma, Hai-Man Zhang, Huan-Hong Ji, Hao Ding, Jie Zhang, Dan Luo, Yujie Sun, and Xiang-dong Li, 2014
  • Drosophila myosin-xx functions as an actin-binding protein to facilitate the interaction between zyx102 and actin., Yang Cao, Howard D. White, and Xiang-dong Li, 2014
  • Cooperation between the Two Heads of Smooth Muscle Myosin Is Essential for Full Activation of the Motor Function by Phosphorylation., Rong-Na Ma, Katsuhide Mabuchi, Jing Li, Zekuan Lu, Chih-Lueh Albert Wang, and Xiang-dong Li, 2013
  • Calmodulin bound to the first IQ motif is responsible for calcium-dependent regulation of myosin 5a., Zekuan Lu, Mei Shen, Yang Cao, Hai-Man Zhang, Lin-Lin Yao, and Xiang-dong Li, 2012
  • 果蝇非常规肌球蛋白的结构与功能., 曹洋,沈梅,张洁,李向东, 2011
  • The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIA., Nobuhisa Umeki, Hyun Suk Jung, Shinya Watanabe, Tsuyoshi Sakai, Xiang-dong Li, Reiko Ikebe, Roger Craig, and Mitsuo Ikebe, 2009
  • The globular tail domain puts on the brake to stop the ATPase cycle of the myosin Va., Xiang-dong Li, Hyun Suk Jung, Qizhi Wang, Reiko Ikebe, Roger Craig, and Mitsuo Ikebe, 2008
  • Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity., Zhiping Wang, Jeffrey G. Edwards, Nathan Riley, D. William Provance, Jr., Ryan Karcher, Xiang-dong Li, Ian G. Davison, Mitsuo Ikebe, John A. Mercer, Julie A. Kauer, and Michael D. Ehlers, 2008
  • Myosin Va becomes a low duty ratio motor in the inhibited form., Osamu Sato, Xiang-dong Li, and Mitsuo Ikebe, 2007
  • The globular tail domain of myosin Va functions as an inhibitor of the myosin Va motor., Xiang-dong Li, Hyun Suk Jung, Katsuhide Mabuchi, Roger Craig, and Mitsuo Ikebe, 2006
  • Activation of Myosin Va function by melanophilin, a specific docking partner of Myosin Va., Xiang-dong Li, Reiko Ikebe, and Mitsuo Ikebe, 2005
  • Ca2+ induced activation of ATPase activity of myosin Va is accompanied with a large conformational change., Xiang-dong Li, Katsuhide Mabuchi, Reiko Ikebe, and Mitsuo Ikebe, 2004
  • Two functional heads are required for full activation of smooth muscle myosin., Xiang-dong Li and Mitsuo Ikebe, 2003
  • F-actin and myosin II binding domains in supervillin., Yu Chen, Norio Takizawa, Jessica L Crowley, Sang W. Oh, Cheryl L. Gatto, Taketoshi Kambara, Osamu Sato, Xiang-dong Li, Mitsuo Ikebe, and Elizabeth J. Luna, 2003
  • Toxicity of Cinnamomin-A new type II ribosome-inactivating protein to ballworm and mosquito., Xin Zhou, Xiang-dong Li, Jian-zhong Yuan, Zhen-hua Tang, and Wang-yi Li, 2000
  • The interaction between the regulatory light chain domains on two heads is critical for regulation of smooth muscle myosin., Xiang-dong Li, Junya Saito, Reiko Ikebe, Katsuhide Mabuchi, and Mitsuo Ikebe, 2000
  • Effects of mutations in the g-phosphate binding site of myosin on its motor function., Xiang-dong Li, Troy E. Rhodes, Reiko Ikebe, Taketoshi Kambara, Howard D. White and Mitsuo Ikebe, 1998
  • A proposed position of a disulfide bridge in the molecules of cinnamomin and porrectin-two new type II ribosome-inactivating proteins isolated from the seeds of camphor trees., Wang-yi Liu, Huai-yang Chen, Wen-feng Chen, Xiang-dong Li, Norbert Ulbrich and Werner Schroder, 1997
  • Large-scale purification of two new ribosome-inactivating proteins --- cinnamomin and camphorin from the seed of Cinnamomum camphora., Xiang-dong Li, Wen-feng Chen, Wang-yi Liu, and Gui-hai Wang, 1997
  • 核糖体失活蛋白研究进展。, 李向东,刘望夷, 1997
  • 核糖体失活蛋白结构功能与分布。, 李向东,刘望夷, 1997
  • Purification of a new ribosome-inactivating protein from the seeds of Cinnamomum porrectum and characterization of the RNA N-glycosidase activity of the toxic protein., Xiang-dong Li, Wang-yi Liu, and Ching-i Niu, 1996
  • Topological requirements for recognition and cleavage of DNA by ribosome-inactivating proteins., Jun Ling, Xiang-dong Li, Xiao-hua Wu, and Wang-yi Liu, 1995
  • 马拉硫磷羧酸酯酶在小菜蛾抗药性中的作用., 李向东, 唐振华, 1993
肌肉结构 收缩 无脊椎动物 昆虫 发育 调节 细胞骨架 分子马达 纳米机器 能量转换

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