Professor | Xin Li | Asia Growth Partners

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Name	Xin Li
Contact Information	xinli@ioz.ac.cn
Language ability	English, Chinese
Province	Beijing

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Name

Xin Li

Contact Information

xinli@ioz.ac.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Chinese Academy of Sciences
Faculty	Institute of Zoology
Academic Background & Achievements	2015 - PhD in Developmental Biology: Northeast Agricultural University Established rat haploid embryonic stem cells with pluripotency and gamete functionality (Cell Stem Cell 2014) First cross-species hybrid allodiploid embryonic stem cells with stable genome and pluripotency (Cell 2016) Revealed intergenerational inheritance of paternal metabolic traits via tsRNA (Science 2016, Nature Cell Biology 2018)
Work Experience	2016-2021 - University of California, San Diego and MIT - Postdoctoral Research 2021-Present - Chinese Academy of Sciences, Institute of Zoology - Research Group Leader

University/Lab Affiliation and Title

Chinese Academy of Sciences

Faculty

Institute of Zoology

Academic Background & Achievements

2015 - PhD in Developmental Biology: Northeast Agricultural University
Established rat haploid embryonic stem cells with pluripotency and gamete functionality (Cell Stem Cell 2014)
First cross-species hybrid allodiploid embryonic stem cells with stable genome and pluripotency (Cell 2016)
Revealed intergenerational inheritance of paternal metabolic traits via tsRNA (Science 2016, Nature Cell Biology 2018)

Work Experience

2016-2021 - University of California, San Diego and MIT - Postdoctoral Research
2021-Present - Chinese Academy of Sciences, Institute of Zoology - Research Group Leader

Areas of Focus	Stem Cell and Development Epigenetics and Aging Cancer Stem Cells and Metastasis
Publications	CellPolaris: Decoding Cell Fate through Generalization Transfer Learning of Gene Regulatory Networks, Guihai Feng, Xin Qin, Jiahao Zhang, Wuliang Huang, et al., Xin Li, 2023 GeneCompass: Deciphering Universal Gene Regulatory Mechanisms with Knowledge-Informed Cross-Species Foundation Model, Xiaodong Yang, Guole Liu, Guihai Feng, Dechao Bu, Pengfei Wang, Jie Jiang, et al., Xin Li, 2023 Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis, Yun Zhang, Joana Liu Donaher, Sunny Das, Xin Li, et al., 2022 Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging, Li X, Wang J, Wang L, Gao Y, Feng G, Li G, Zou J, Yu M, Li YF, Liu C, Yuan XW, Zhao L, Ouyang H, Zhu JK, Li W, Zhou Q, Zhang K, 2022 Tissue repair and regeneration with endogenous stem cells, Xia HM, Li Xin, Gao WW, Fu X, Ronnie H. Fang, Zhang LF, Zhang Kang, 2018 Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs, Zhang Y, Zhang X, Shi J, Tuorto F, Li Xin, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q, 2018 Generation and application of mouse-rat allodiploid embryonic stem cells, Li Xin, Cui XL, Wang JQ, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W, Zhou Q, 2016 A novel long intergenic noncoding RNA indispensable for the cleavage of mouse two-cell embryos, Wang JQ, Li Xin, Wang L, Li J, Zhao Y, Bou G, Li Y, Jiao G, Shen X, Wei R, Liu S, Xie B, Lei L, Li W, Zhou Q, Liu Z, 2016 Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder, Chen Q, Yan M, Cao Z, Li Xin, Zhang Y, Shi J, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E#, Zhai Q, Zhou Q, 2016 Co-participation of paternal and maternal genomes before blastocyst stage is not required for full-term development of mouse embryos, Li Xin, Wang J., Wang L., Wan H., Li Y., Li TD., Wang Y., Shuai L., Mao Y., Cui X., Wang L., Liu Z., Zhou Q, 2015 Generation of cell-type-specific gene mutations by expressing the sgRNA of the CRISPR system from the RNA polymerase II promoters, Wang J, Li Xin, Zhao Y., Li J., Zhou Q., and Liu Z., 2015 Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq, Shi J., Chen Q., Li Xin, Zheng X., Zhang Y., Qiao J., Tang F., Tao Y., Zhou Q., and Duan E., 2015 Genetic modification and screening in rat using haploid embryonic stem cells, Li Wei, Li Xin, Li TD, Jiang MG, Wan H, Luo GZ, Feng C, Cui X, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha J, Xiao Y, Wang L, Liu Z, Wang XJ, Zhao XY, Zhou Q, 2014 Assessing reprogramming by chimera formation and Tetraploid complementation, Li Xin, Xia BL, Li W, Zhou Q, 2014

Areas of Focus

Stem Cell and Development
Epigenetics and Aging
Cancer Stem Cells and Metastasis

Publications

CellPolaris: Decoding Cell Fate through Generalization Transfer Learning of Gene Regulatory Networks, Guihai Feng, Xin Qin, Jiahao Zhang, Wuliang Huang, et al., Xin Li*, 2023
GeneCompass: Deciphering Universal Gene Regulatory Mechanisms with Knowledge-Informed Cross-Species Foundation Model, Xiaodong Yang, Guole Liu, Guihai Feng, Dechao Bu, Pengfei Wang, Jie Jiang, et al., Xin Li*, 2023
Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis, Yun Zhang, Joana Liu Donaher, Sunny Das, Xin Li, et al., 2022
Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging, Li X, Wang J, Wang L, Gao Y, Feng G, Li G, Zou J, Yu M, Li YF, Liu C, Yuan XW, Zhao L, Ouyang H, Zhu JK, Li W, Zhou Q, Zhang K, 2022
Tissue repair and regeneration with endogenous stem cells, Xia HM*, Li Xin*, Gao WW*, Fu X, Ronnie H. Fang, Zhang LF, Zhang Kang, 2018
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs, Zhang Y*, Zhang X*, Shi J*, Tuorto F*, Li Xin*, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q, 2018
Generation and application of mouse-rat allodiploid embryonic stem cells, Li Xin*, Cui XL*, Wang JQ*, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W*, Zhou Q*, 2016
A novel long intergenic noncoding RNA indispensable for the cleavage of mouse two-cell embryos, Wang JQ*, Li Xin*, Wang L*, Li J, Zhao Y, Bou G, Li Y, Jiao G, Shen X, Wei R, Liu S, Xie B, Lei L, Li W, Zhou Q, Liu Z, 2016
Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder, Chen Q*, Yan M*, Cao Z*, Li Xin*, Zhang Y*, Shi J*, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E#, Zhai Q, Zhou Q, 2016
Co-participation of paternal and maternal genomes before blastocyst stage is not required for full-term development of mouse embryos, Li Xin*, Wang J.*, Wang L.*, Wan H., Li Y., Li TD., Wang Y., Shuai L., Mao Y., Cui X., Wang L., Liu Z., Zhou Q, 2015
Generation of cell-type-specific gene mutations by expressing the sgRNA of the CRISPR system from the RNA polymerase II promoters, Wang J*, Li Xin*, Zhao Y., Li J., Zhou Q., and Liu Z., 2015
Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq, Shi J.*, Chen Q.*, Li Xin*, Zheng X.*, Zhang Y.*, Qiao J., Tang F., Tao Y., Zhou Q., and Duan E., 2015
Genetic modification and screening in rat using haploid embryonic stem cells, Li Wei*, Li Xin*, Li TD*, Jiang MG*, Wan H, Luo GZ, Feng C, Cui X, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha J, Xiao Y, Wang L, Liu Z, Wang XJ, Zhao XY, Zhou Q, 2014
Assessing reprogramming by chimera formation and Tetraploid complementation, Li Xin*, Xia BL*, Li W, Zhou Q, 2014

Stem Cells Development Epigenetics Aging Cancer Metastasis Cell Signaling Gene Regulation Microenvironment Regenerative Medicine

Jing Qu - Chinese Academy of Sciences

Guang-Hui Liu - Chinese Academy of Sciences

Hongmei Liu - Chinese Academy of Sciences

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