Professor | 李鑫 | 数字化转型顾问

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Name	李鑫
Contact Information	xinli@ioz.ac.cn
Language ability	英语, 中文
Province	北京

Upload Avatar (500 x 500)

Name

李鑫

Contact Information

xinli@ioz.ac.cn

Language ability

英语, 中文

Province

北京

University/Lab Affiliation and Title	中国科学院
Faculty	Institute of Zoology
Academic Background & Achievements	2015 - 发育生物学博士: 东北农业大学建立具有多能性和配子功能特性的大鼠单倍体胚胎干细胞（Cell Stem Cell 2014）首例具有稳定基因组和多能性的跨物种杂合异源二倍体胚胎干细胞（Cell 2016）揭示了通过tsRNA为载体的父本代谢异常性状的跨代遗传机制（Science 2016，Nature Cell Biology 2018）
Work Experience	2016-2021 - 加州大学圣地亚哥分校和麻省理工学院 - 博士后研究 2021-至今 - 中国科学院动物研究所 - 研究组组长

University/Lab Affiliation and Title

中国科学院

Faculty

Institute of Zoology

Academic Background & Achievements

2015 - 发育生物学博士: 东北农业大学
建立具有多能性和配子功能特性的大鼠单倍体胚胎干细胞（Cell Stem Cell 2014）
首例具有稳定基因组和多能性的跨物种杂合异源二倍体胚胎干细胞（Cell 2016）
揭示了通过tsRNA为载体的父本代谢异常性状的跨代遗传机制（Science 2016，Nature Cell Biology 2018）

Work Experience

2016-2021 - 加州大学圣地亚哥分校和麻省理工学院 - 博士后研究
2021-至今 - 中国科学院动物研究所 - 研究组组长

Areas of Focus	干细胞与发育表观遗传与衰老肿瘤干细胞与癌症转移
Publications	CellPolaris: Decoding Cell Fate through Generalization Transfer Learning of Gene Regulatory Networks, Guihai Feng, Xin Qin, Jiahao Zhang, Wuliang Huang, et al., Xin Li, 2023 GeneCompass: Deciphering Universal Gene Regulatory Mechanisms with Knowledge-Informed Cross-Species Foundation Model, Xiaodong Yang, Guole Liu, Guihai Feng, Dechao Bu, Pengfei Wang, Jie Jiang, et al., Xin Li, 2023 Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis, Yun Zhang, Joana Liu Donaher, Sunny Das, Xin Li, et al., 2022 Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging, Li X, Wang J, Wang L, Gao Y, Feng G, Li G, Zou J, Yu M, Li YF, Liu C, Yuan XW, Zhao L, Ouyang H, Zhu JK, Li W, Zhou Q, Zhang K, 2022 Tissue repair and regeneration with endogenous stem cells, Xia HM, Li Xin, Gao WW, Fu X, Ronnie H. Fang, Zhang LF, Zhang Kang, 2018 Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs, Zhang Y, Zhang X, Shi J, Tuorto F, Li Xin, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q, 2018 Generation and application of mouse-rat allodiploid embryonic stem cells, Li Xin, Cui XL, Wang JQ, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W, Zhou Q, 2016 A novel long intergenic noncoding RNA indispensable for the cleavage of mouse two-cell embryos, Wang JQ, Li Xin, Wang L, Li J, Zhao Y, Bou G, Li Y, Jiao G, Shen X, Wei R, Liu S, Xie B, Lei L, Li W, Zhou Q, Liu Z, 2016 Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder, Chen Q, Yan M, Cao Z, Li Xin, Zhang Y, Shi J, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E#, Zhai Q, Zhou Q, 2016 Co-participation of paternal and maternal genomes before blastocyst stage is not required for full-term development of mouse embryos, Li Xin, Wang J., Wang L., Wan H., Li Y., Li TD., Wang Y., Shuai L., Mao Y., Cui X., Wang L., Liu Z., Zhou Q, 2015 Generation of cell-type-specific gene mutations by expressing the sgRNA of the CRISPR system from the RNA polymerase II promoters, Wang J, Li Xin, Zhao Y., Li J., Zhou Q., and Liu Z., 2015 Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq, Shi J., Chen Q., Li Xin, Zheng X., Zhang Y., Qiao J., Tang F., Tao Y., Zhou Q., and Duan E., 2015 Genetic modification and screening in rat using haploid embryonic stem cells, Li Wei, Li Xin, Li TD, Jiang MG, Wan H, Luo GZ, Feng C, Cui X, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha J, Xiao Y, Wang L, Liu Z, Wang XJ, Zhao XY, Zhou Q, 2014 Assessing reprogramming by chimera formation and Tetraploid complementation, Li Xin, Xia BL, Li W, Zhou Q, 2014

Areas of Focus

干细胞与发育
表观遗传与衰老
肿瘤干细胞与癌症转移

Publications

CellPolaris: Decoding Cell Fate through Generalization Transfer Learning of Gene Regulatory Networks, Guihai Feng, Xin Qin, Jiahao Zhang, Wuliang Huang, et al., Xin Li*, 2023
GeneCompass: Deciphering Universal Gene Regulatory Mechanisms with Knowledge-Informed Cross-Species Foundation Model, Xiaodong Yang, Guole Liu, Guihai Feng, Dechao Bu, Pengfei Wang, Jie Jiang, et al., Xin Li*, 2023
Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis, Yun Zhang, Joana Liu Donaher, Sunny Das, Xin Li, et al., 2022
Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging, Li X, Wang J, Wang L, Gao Y, Feng G, Li G, Zou J, Yu M, Li YF, Liu C, Yuan XW, Zhao L, Ouyang H, Zhu JK, Li W, Zhou Q, Zhang K, 2022
Tissue repair and regeneration with endogenous stem cells, Xia HM*, Li Xin*, Gao WW*, Fu X, Ronnie H. Fang, Zhang LF, Zhang Kang, 2018
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs, Zhang Y*, Zhang X*, Shi J*, Tuorto F*, Li Xin*, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q, 2018
Generation and application of mouse-rat allodiploid embryonic stem cells, Li Xin*, Cui XL*, Wang JQ*, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W*, Zhou Q*, 2016
A novel long intergenic noncoding RNA indispensable for the cleavage of mouse two-cell embryos, Wang JQ*, Li Xin*, Wang L*, Li J, Zhao Y, Bou G, Li Y, Jiao G, Shen X, Wei R, Liu S, Xie B, Lei L, Li W, Zhou Q, Liu Z, 2016
Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder, Chen Q*, Yan M*, Cao Z*, Li Xin*, Zhang Y*, Shi J*, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E#, Zhai Q, Zhou Q, 2016
Co-participation of paternal and maternal genomes before blastocyst stage is not required for full-term development of mouse embryos, Li Xin*, Wang J.*, Wang L.*, Wan H., Li Y., Li TD., Wang Y., Shuai L., Mao Y., Cui X., Wang L., Liu Z., Zhou Q, 2015
Generation of cell-type-specific gene mutations by expressing the sgRNA of the CRISPR system from the RNA polymerase II promoters, Wang J*, Li Xin*, Zhao Y., Li J., Zhou Q., and Liu Z., 2015
Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq, Shi J.*, Chen Q.*, Li Xin*, Zheng X.*, Zhang Y.*, Qiao J., Tang F., Tao Y., Zhou Q., and Duan E., 2015
Genetic modification and screening in rat using haploid embryonic stem cells, Li Wei*, Li Xin*, Li TD*, Jiang MG*, Wan H, Luo GZ, Feng C, Cui X, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha J, Xiao Y, Wang L, Liu Z, Wang XJ, Zhao XY, Zhou Q, 2014
Assessing reprogramming by chimera formation and Tetraploid complementation, Li Xin*, Xia BL*, Li W, Zhou Q, 2014

干细胞发育表观遗传衰老癌症转移细胞信号基因调控微环境再生医学

胡宝洋 - 中国科学院

王皓毅 - 中国科学院

顾奇 - 中国科学院

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