Upload Avatar (500 x 500)
李磊
lil@ioz.ac.cn
中文, 英语, 日语
北京
中国科学院
Institute of Zoology
  • 1994 - 动物生理生化专业本科: 中国农业大学
  • 2002 - 生理学博士: 日本群马大学
  • 发现了哺乳动物第一个母源复合体SCMC
  • 博士后研究 - 日本学术振兴会(JSPS)和美国国立卫生研究院(NIH)
  • 2009 - 至今 - 分子胚胎发育生物学研究组组长, 中国科学院动物研究所
  • NIDDK Nancy Nossal 奖学金奖
  • NIH 研究优秀奖
哺乳动物早期胚胎发育的分子机制
早期胚胎发育的母源调控
  • Structural basis of the subcortical maternal complex and its implications in reproductive disorders, Chi Q, Ou G, Qin D, Han Z, Li J, Xiao Q, Gao Z, Xu C, Qi Q, Liu Q, Liu S, Li J, Guo L, Lu Y, Chen J, Wang X, Shi H, Li L*, Deng D*, 2024
  • Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation, Nie X, Xu Q, Xu C, Chen F, Wang Q, Qin D, Wang R, Gao Z, Lu X, Yang X, Wu Y, Gu C, Xie W*, Li L*, 2023
  • ASH2L regulates postnatal neurogenesis through Onecut2-mediated inhibition of TGF-βsignaling pathway, Xu Y, Dai S, Duan C, Zhang Z, Liu P, Liu C, Du H, Lu X, Hu S, Li L, Teng Z*, Liu C*, 2023
  • BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing, Yao X, Wang C, Sun L, Yan L, Chen X, Lv Z, Xie X, Tian S, Liu W, Li L*, Zhang H*, Liu J*, 2023
  • Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 in oocyte meiosis, Meng T, Lei W, Liu X, Liu XY, Ma X, Nie X, Zhao Z, Li Q, Huang L, Hou Y, OuYang Y, Li L, Tang T, Schatten H, Xie W, Gao S, Ou XH*, Wang Z*, and Sun QY*, 2022
  • Cnot8 eliminates naive regulation networks and is essential for naive-to-formative pluripotency transition, Quan Y, Wang M, Xu C, Wang X, Qin D, Lin Y, Lu X, Lu F*, Li L*, 2022
  • Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development, Xiong Z, Xu K, Lin Z, Kong F, Wang Q, Quan Y, Sha Q, Li F, Zou Z, Liu L, Ji S, Chen Y, Zhang H, Fang J, Yu G, Liu B, Wang L, Wang H, Deng H, Yang X, Fan H, Li L*, Xie W*, 2022
  • In vitro investigation of mammalian early embryonic development (in Chinese), Wang Z, Zhang J, Li L*, 2022
  • In vitro investigation of mammalian peri-implantation embryogenesis, Quan Y, Wang X, Li L*, 2022
  • BCAS2 is involved in alternative splicing and mouse oocyte development, Zhang J, Liu W, Li G, Xu C, Nie X, Qin D, Wang Q, Lu X, Liu J, Li L*, 2022
  • Ash2l-1 is essential for mouse early hematopoietic development of yolk sac (in Chinese), Wang X, Lu X, Xiang Y, Li L*, 2021
  • Formative pluripotent stem cells show features of epiblast cells poised for gastrulation, Wang X, Xiang Y, Yu Y, Wang R, Zhang Y, Xu Q, Sun H, Zhao Z, Jiang X, Wang XQ, Lu X, Qin D, Zhang J, Quan Y, Shyh-Chang N, Wang H, Xie W*, Li L*, 2021
  • Stabilizing formative pluripotent states with germ cell competency, Shyn-Chang N* and Li L*, 2021
  • Retinoic acid promotes metabolic maturation of human embryonic stem cell-derived cardiomyocytes, Miao S, Zhao D, Wang X, Ni X, Fang X, Yu M, Ye L, Yang J, Wu H, Han X, Qu L, Li L, Lan F, Shen Z, Lei W, Zhao ZA, Hu S, 2020
  • Comments on 'In vitro culture of cynomolgus monkey embryos beyond early gastrulation', Ma H, Wang H*, Zheng P*, Li L*, 2020
  • Epigenomic analysis of gastrulation reveals a unique chromatin state for primed pluripotency, Xiang Y, Zhang Y, Xu Q, Zhou C, Liu B, Du Z, Zhang K, Zhang B, Wang X, Gayen S, Liu L, Wang Y, Li Y, Wang Q, Kalantry S, Li L, Xie W, 2020
  • In vitro culture of cynomolgus monkey embryos beyond early gastrulation, Ma H, Zhai J, Wan H, Jiang X, Wang X, Wang L, Xiang Y, He X, Zhao Z, Zhao B, Zheng P*, Li L*, Wang H*, 2019
  • The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution, Qin D, Gao Z, Xiao Y, Zhang X, Ma H, Yu X, Nie X, Fan N, Wang X, OuYang Y, Sun QY, Yi Z, Li L*, 2019
  • Compression generated by a 3D supracellular actomyosin cortex promotes embryonic stem cell colony growth and expression of Nanog and Oct4, Du J, Fan Y, Guo Z, Wang Y, Zheng X, Huang C, Liang B, Gao L, Cao Y, Chen Y, Zhang X, Li L, Xu L, Wu C, Weitz D, Feng X, 2019
  • Putting stem cells on a low-fat diet switches their pluripotent state, Jiang Z, Guang L, Li L, Shyh-Chang N, 2019
  • Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation, Meng T, Lu X, Guo L, Hou G, Ma X, Li Q, Huang L, Fan L, Zhao Z, Ou X, OuYang Y, Schatten H, Li L, Wang Z, Sun QY, 2019
  • An oocyte-embryo-specific subcortical maternal complex in mammals (in Chinese), Wang X, Qin D, Lu X, Li L*, 2018
  • Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs, Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q, 2018
  • Whole-transcriptome splicing profiling of E7.5 mouse primary germ layers reveals frequent usage of alternative promoter during early embryogenesis, Lu X, Zhao Z, Wang X, Zhang X, Zhai Y, Deng W, Yi Z*, Li L*, 2018
  • Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles, Gao Z, Zhang X, Yu X, Qin D, Yu Y, Liu W, Xiang Y, Xiao Y, Lu X, Yi Z, Li L*, 2018
  • ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast, Yu Y, Wang X, Zhang X, Zhai Y, Lu X, Ma H, Zhu K, Zhao T, Jiao J, Zhao Z*, Li L*, 2018
  • Dynamic epigenomic landscapes during early lineage specification, Zhang Y, Xiang Y, Yin Q, Du Z, Peng X, Wang Q, Fidalgo M, Xia W, Li Y, Zhao Z, Zhang W, Ma J, Xu F, Wang J, Li L, Xie W, 2018
  • A maternal functional module in the mammalian oocyte-to-embryo transition, Lu X, Gao Z, Qin D, Li L*, 2017
  • MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production, Zhang L, Zhang X, Zhang X, Lu Y, Li L, Cui S, 2017
  • First cell lineage specification in mammalian early development (in Chinese), Nie X, Lu X, Li L*, 2017
  • BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis, Liu W Wang F, Xu Q, Shi J, Zhang X, Lu X, Gao Z, Ma H, Zhao Z, Duan E, Gao F, Gao S*, Yi Z*, Li L*, 2017
  • Trp-Asp (WD) repeat domain 1 is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation, Xiao Y, Ma H, Wan P, Qin D, Zhang X, Xiang Y, Wang X, Liu W, Chen J*, Yi Z*, and Li L*, 2017
  • BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis, Liu Y, Lu X, Shi J, Yu X, Zhang X, Zhu K, Yi Z, Duan E, Li L*, 2016
  • MicroRNA-127 Promotes Mesendoderm Differentiation of Mouse Embryonic Stem Cells by Targeting Left-right Determination Factor 2, Ma H, Lin Y, Zhao Z, Lu X, Yu Y, Zhang X, Wang Q*, Li L*, 2016
  • Maternal BCAS2 protects genomic integrity in mouse early embryonic development, Xu Q, Wang F, Xiang Y, Zhang X, Zhao Z, Gao Z, Liu W, Lu X, Liu Y, Yu X, Wang H, Huang J, Yi Z, Gao S*, Li L*, 2015
  • The roles of ERAS during cell lineage specification of mouse early embryonic development, Zhao Z-A, Yu Y, Ma H-X, Wang X, Lu X, Zhai Y, Zhang X-X, Wang H, Li L*, 2015
  • Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability, Zhao B, Zhang W, Duan Y, Lu Y, Cun Y, Li C, Guo K, Nie W, Li L, Zhang R, Zheng P, 2015
  • Identification of a human subcortical maternal complex, Zhu K, Yan L, Zhang X, Lu X, Wang T, Yan J, Liu X, Qiao J*, Li L*, 2015
  • The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics, Yu X, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang Z, Zheng P, Zhu M, Wang H, Sun QY, Dean J*, Li L*, 2014
  • Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms, Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q, Duan E, Wang H, 2014
  • Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice, Fu Z, Wang B, Wang S, Wu W, Wang Q, Chen Y, Kong S, Lu J, Tang Z, Ran H, Tu Z, He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang YL, Li L, Wang F, Gao S, Wang H, 2014
  • The maternal to zygotic transition in mammals, Li L*, Lu X and Dean J*, 2013
  • WASH inhibits autophagy through suppression of Beclin 1 ubiquitination, Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B, Li C, Dai Z, Hou N, Cheng X, Sun Q, Li L, Yang X, Fan Z, 2013
  • The N-terminus of FILIA forms an atypical KH domain with a unique extension involved in interaction with RNA, Wang J, Xu M, Zhu K, Li L*, Liu X*, 2012
  • Regulation of asymmetrical cytokinesis by cAMP during meiosis I in mouse oocytes, Chen D, Zhang Y, Yi Q, Huang Y, Hou H, Zhang Y, Hao Q, Cooke HJ, Li L, Sun QY, Shi Q, 2012
  • Maternal Control of Early Mouse Development, Li L*, Zheng P and Dean J*, 2010
  • A Subcortical Maternal Complex Essential for Pre-implantation Mouse Embryogenesis, Li L*, Baibakov B and Dean J, 2008
  • Maternally Derived FILIA/MATER Complex Localizes Asymmetrically in Cleavage Stage Mouse Embryos, Ohsugi M, Zheng P, Baibakov B, Li L, and Dean J, 2008
  • Promotion of b-Cell Differentiation by Conophylline in Fetal and Neonatal Rat Pancreas, Ogata T, Li L, Yamada S, Yamamoto Y, Tanaka Y, Takei I, Umezawa K and Kojima I, 2004
  • Activin A and Betacellulin: Effect on Regeneration of Pancreatic b-Cells in Neonatal Streptozotocin-treated Rats, Li L, Yi Z, Seno M, and Kojima I, 2004
  • Betacellulin Improved Glucose Metabolism by Promoting Conversion of Intra-islet Precursor Cells to-cells in Streptozotocin-treated Diabetic Mice, Li L, Seno M, Yamada H, and Kojima I, 2003
  • Promotion of β-cell Regeneration by Betacellulin in 90% Pancreatectomized Rats, Li L, Seno M, Yamada H, and Kojima I, 2001
胚胎 发育 分子 机制 哺乳动物 母源 调控 基因 敲除 干细胞

联系我们

欢迎与我们交流!
* Required
* Required
* Required
* Invalid email address
提交此表单,即表示您同意 IoT ONE 可以与您联系并分享洞察和营销信息。
不,谢谢,我不想收到来自 IoT ONE 的任何营销电子邮件。
提交

感谢您的信息!
我们会很快与你取得联系。