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Wanzhu Jin
Zoology
Chinese Academy of Sciences
Beijing
Language: Chinese, English, Japanese
Brown Fat
Molecular Regulation
Differentiation
Activation
Transdifferentiation
Clinical Translation
Obesity
Energy Metabolism
Insulin Resistance
Stem Cells
Areas of Focus
- Molecular regulation mechanisms in brown fat differentiation
- Molecular regulation mechanisms in brown fat activation
- Transdifferentiation mechanisms and clinical translation of brown fat
Work Experience
- 2010/11 - Present: Researcher and Doctoral Supervisor at Institute of Zoology, Chinese Academy of Sciences
Academic Background & Achievements
- 2003 - PhD: Gifu University, Japan
- Postdoctoral research at RIKEN, Japan and Harvard Medical School, USA
- Established a lab focusing on brown fat regulation and its application in obesity-related diseases
Publications
- Reconstitution of UCP1 Using CRISPR/Cas9 in the White Adipose Tissue of Pigs Decreases Fat Deposition and Improves Thermogenic Capacity., Zheng Q, Lin J, Huang J, Zhang H, Zhang R, Zhang X, Cao C, Hambly C, Qin G, Yao J, Song R, Jia Q, Wang X, Li Y, Zhang N, Piao Z, Ye R, Speakman JR, Wang H, Zhou Q, Wang Y, Jin W, Zhao J., 2017
- Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice., Hu T, Yuan X, Wei G, Luo H, Lee HJ, Jin W., 2018
- Cyanidin-3-glucoside increases whole body energy metabolism by upregulating brown adipose tissue mitochondrial function., Yilin You, Xiaoxue Yuan, Xiaomeng Liu, Chen Liang, Minghui Meng, Yuanyuan Huang, Xue Han, Jielong Guo, Yu Guo, Chenglong Ren, Qianwen Zhang, Xiangyu Sun, Tingting Ma, Guojie Liu, Wanzhu Jin, Weidong Huang, Jicheng Zhan., 2017
- Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat., Hu T, Yuan X, Ye R, Zhou H, Jun Lin, Zhang C, Hanlin Zhang, Wei G, Meng Dong, Huang Y, Lim W, Liu Q, Lee H, Jin W., 2017
- DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue., Rong Wu, Xiao-meng Liu, Jian-guang Sun, Hong Chen, Jun Ma, Meng Dong, Shengyi Peng, Ji-qiu Wang, Jian-qing Ding, Dong-hao Li, John R Speakman, Guang Ning, Wanzhu Jin, Zengqiang Yuan., 2017
- Cold adaptation in pigs depends on UCP 3 in beige adipocytes., Lin J, Cao C, Tao C, Ye R, Dong M, Zheng Q, Wang C, Jiang X, Qin G, Yan C, Li K, Speakman J, Wang Y, Jin W, Zhao J., 2017
- Rutin ameliorates obesity through brown fat activation., Yuan X, Wei G, You Y, Huang Y, Lee H, Dong M, Lin J, Hu T, Zhang H, Zhang C, Zhou H, Ye R, Qi X, Zhai B, Huang W, Liu S, Xie W, Liu Q, Liu X, Cui C, Li D, Zhan J, Cheng J, Yuan Z, Jin W., 2017
- c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice., Wu R, Sun JG, Wang JQ, Li B, Liu Q, Ning G, Jin W, Yuan Z., 2017
- The Engrailed-1 Gene Stimulates Brown Adipogenesis., Zhang C, Weng Y, Shi F, Jin W., 2016
- Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice., Liu X, Wang S, You Y, Meng M, Zheng Z, Dong M, Lin J, Zhao Q, Zhang C, Yuan X, Hu T, Liu L, Huang Y, Zhang L, Wang D, Zhan J, Hyuek Jong Lee, Speakman J, Jin W., 2015
- Increased SRF transcriptional activity is a novel signature of insulin resistance in humans and mice., Jin W, Goldfine A, Boes T, Henry R, Ciaraldi T., 2011
- ATF2/ATFa regulate BMP induced adipogenesis., Maekawa T, Jin W, Ishii S., 2010
- Genetic determinants and molecular pathways in the pathogenesis of diabetes., Jin W, Patti ME., 2009
- Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins., Jin W, Takagi T, Kanesashi S, Kurahashi T, Nomura T., 2006
