Professor | Wanzhu Jin | Asia Growth Partners

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Name	Wanzhu Jin
Contact Information	jinw@ioz.ac.cn
Language ability	Chinese, English, Japanese
Province	Beijing

Upload Avatar (500 x 500)

Name

Wanzhu Jin

Contact Information

jinw@ioz.ac.cn

Language ability

Chinese, English, Japanese

Province

Beijing

University/Lab Affiliation and Title	Chinese Academy of Sciences
Faculty	Institute of Zoology
Academic Background & Achievements	2003 - PhD: Gifu University, Japan Postdoctoral research at RIKEN, Japan and Harvard Medical School, USA Established a lab focusing on brown fat regulation and its application in obesity-related diseases
Work Experience	2010/11 - Present: Researcher and Doctoral Supervisor at Institute of Zoology, Chinese Academy of Sciences

University/Lab Affiliation and Title

Chinese Academy of Sciences

Faculty

Institute of Zoology

Academic Background & Achievements

2003 - PhD: Gifu University, Japan
Postdoctoral research at RIKEN, Japan and Harvard Medical School, USA
Established a lab focusing on brown fat regulation and its application in obesity-related diseases

Work Experience

2010/11 - Present: Researcher and Doctoral Supervisor at Institute of Zoology, Chinese Academy of Sciences

Areas of Focus	Molecular regulation mechanisms in brown fat differentiation Molecular regulation mechanisms in brown fat activation Transdifferentiation mechanisms and clinical translation of brown fat
Publications	Reconstitution of UCP1 Using CRISPR/Cas9 in the White Adipose Tissue of Pigs Decreases Fat Deposition and Improves Thermogenic Capacity., Zheng Q, Lin J, Huang J, Zhang H, Zhang R, Zhang X, Cao C, Hambly C, Qin G, Yao J, Song R, Jia Q, Wang X, Li Y, Zhang N, Piao Z, Ye R, Speakman JR, Wang H, Zhou Q, Wang Y, Jin W, Zhao J., 2017 Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice., Hu T, Yuan X, Wei G, Luo H, Lee HJ, Jin W., 2018 Cyanidin-3-glucoside increases whole body energy metabolism by upregulating brown adipose tissue mitochondrial function., Yilin You, Xiaoxue Yuan, Xiaomeng Liu, Chen Liang, Minghui Meng, Yuanyuan Huang, Xue Han, Jielong Guo, Yu Guo, Chenglong Ren, Qianwen Zhang, Xiangyu Sun, Tingting Ma, Guojie Liu, Wanzhu Jin, Weidong Huang, Jicheng Zhan., 2017 Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat., Hu T, Yuan X, Ye R, Zhou H, Jun Lin, Zhang C, Hanlin Zhang, Wei G, Meng Dong, Huang Y, Lim W, Liu Q, Lee H, Jin W., 2017 DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue., Rong Wu, Xiao-meng Liu, Jian-guang Sun, Hong Chen, Jun Ma, Meng Dong, Shengyi Peng, Ji-qiu Wang, Jian-qing Ding, Dong-hao Li, John R Speakman, Guang Ning, Wanzhu Jin, Zengqiang Yuan., 2017 Cold adaptation in pigs depends on UCP 3 in beige adipocytes., Lin J, Cao C, Tao C, Ye R, Dong M, Zheng Q, Wang C, Jiang X, Qin G, Yan C, Li K, Speakman J, Wang Y, Jin W, Zhao J., 2017 Rutin ameliorates obesity through brown fat activation., Yuan X, Wei G, You Y, Huang Y, Lee H, Dong M, Lin J, Hu T, Zhang H, Zhang C, Zhou H, Ye R, Qi X, Zhai B, Huang W, Liu S, Xie W, Liu Q, Liu X, Cui C, Li D, Zhan J, Cheng J, Yuan Z, Jin W., 2017 c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice., Wu R, Sun JG, Wang JQ, Li B, Liu Q, Ning G, Jin W, Yuan Z., 2017 The Engrailed-1 Gene Stimulates Brown Adipogenesis., Zhang C, Weng Y, Shi F, Jin W., 2016 Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice., Liu X, Wang S, You Y, Meng M, Zheng Z, Dong M, Lin J, Zhao Q, Zhang C, Yuan X, Hu T, Liu L, Huang Y, Zhang L, Wang D, Zhan J, Hyuek Jong Lee, Speakman J, Jin W., 2015 Increased SRF transcriptional activity is a novel signature of insulin resistance in humans and mice., Jin W, Goldfine A, Boes T, Henry R, Ciaraldi T., 2011 ATF2/ATFa regulate BMP induced adipogenesis., Maekawa T, Jin W, Ishii S., 2010 Genetic determinants and molecular pathways in the pathogenesis of diabetes., Jin W, Patti ME., 2009 Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins., Jin W, Takagi T, Kanesashi S, Kurahashi T, Nomura T., 2006

Areas of Focus

Molecular regulation mechanisms in brown fat differentiation
Molecular regulation mechanisms in brown fat activation
Transdifferentiation mechanisms and clinical translation of brown fat

Publications

Reconstitution of UCP1 Using CRISPR/Cas9 in the White Adipose Tissue of Pigs Decreases Fat Deposition and Improves Thermogenic Capacity., Zheng Q, Lin J, Huang J, Zhang H, Zhang R, Zhang X, Cao C, Hambly C, Qin G, Yao J, Song R, Jia Q, Wang X, Li Y, Zhang N, Piao Z, Ye R, Speakman JR, Wang H, Zhou Q, Wang Y, Jin W, Zhao J., 2017
Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice., Hu T, Yuan X, Wei G, Luo H, Lee HJ, Jin W., 2018
Cyanidin-3-glucoside increases whole body energy metabolism by upregulating brown adipose tissue mitochondrial function., Yilin You, Xiaoxue Yuan, Xiaomeng Liu, Chen Liang, Minghui Meng, Yuanyuan Huang, Xue Han, Jielong Guo, Yu Guo, Chenglong Ren, Qianwen Zhang, Xiangyu Sun, Tingting Ma, Guojie Liu, Wanzhu Jin, Weidong Huang, Jicheng Zhan., 2017
Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat., Hu T, Yuan X, Ye R, Zhou H, Jun Lin, Zhang C, Hanlin Zhang, Wei G, Meng Dong, Huang Y, Lim W, Liu Q, Lee H, Jin W., 2017
DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue., Rong Wu, Xiao-meng Liu, Jian-guang Sun, Hong Chen, Jun Ma, Meng Dong, Shengyi Peng, Ji-qiu Wang, Jian-qing Ding, Dong-hao Li, John R Speakman, Guang Ning, Wanzhu Jin, Zengqiang Yuan., 2017
Cold adaptation in pigs depends on UCP 3 in beige adipocytes., Lin J, Cao C, Tao C, Ye R, Dong M, Zheng Q, Wang C, Jiang X, Qin G, Yan C, Li K, Speakman J, Wang Y, Jin W, Zhao J., 2017
Rutin ameliorates obesity through brown fat activation., Yuan X, Wei G, You Y, Huang Y, Lee H, Dong M, Lin J, Hu T, Zhang H, Zhang C, Zhou H, Ye R, Qi X, Zhai B, Huang W, Liu S, Xie W, Liu Q, Liu X, Cui C, Li D, Zhan J, Cheng J, Yuan Z, Jin W., 2017
c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice., Wu R, Sun JG, Wang JQ, Li B, Liu Q, Ning G, Jin W, Yuan Z., 2017
The Engrailed-1 Gene Stimulates Brown Adipogenesis., Zhang C, Weng Y, Shi F, Jin W., 2016
Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice., Liu X, Wang S, You Y, Meng M, Zheng Z, Dong M, Lin J, Zhao Q, Zhang C, Yuan X, Hu T, Liu L, Huang Y, Zhang L, Wang D, Zhan J, Hyuek Jong Lee, Speakman J, Jin W., 2015
Increased SRF transcriptional activity is a novel signature of insulin resistance in humans and mice., Jin W, Goldfine A, Boes T, Henry R, Ciaraldi T., 2011
ATF2/ATFa regulate BMP induced adipogenesis., Maekawa T, Jin W, Ishii S., 2010
Genetic determinants and molecular pathways in the pathogenesis of diabetes., Jin W, Patti ME., 2009
Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins., Jin W, Takagi T, Kanesashi S, Kurahashi T, Nomura T., 2006

Brown Fat Molecular Regulation Differentiation Activation Transdifferentiation Clinical Translation Obesity Energy Metabolism Insulin Resistance Stem Cells

Hongmei Wang - Chinese Academy of Sciences

Jinyong Wang - Chinese Academy of Sciences

Jingtao Guo - Chinese Academy of Sciences

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