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Jingtao Guo
Zoology
Chinese Academy of Sciences
Beijing
Language: English, Chinese
Spermatogenesis
Stem Cells
Molecular Biology
Cell Biology
High-Throughput Sequencing
Male Infertility
Testis Development
Germ Cells
Self-Renewal
Differentiation
Areas of Focus
- Molecular mechanisms of spermatogonial stem cell self-renewal and differentiation
- In vivo and in vitro models for human spermatogonial stem cells
- Molecular mechanisms of male infertility and new treatment methods
Work Experience
- 2020-07 - University of Utah School of Medicine - Tenure-track Assistant Professor
- 2021-12 - Chinese Academy of Sciences Institute of Zoology - Research Group Leader
Academic Background & Achievements
- 2013 - Bachelor of Science: Peking University
- 2018 - PhD in Cancer Science: University of Utah
- Postdoctoral Research: University of Utah School of Medicine
Publications
- Single-cell multi-omics analysis of human testicular germ cell tumor reveals its molecular features and microenvironment., Lu X, Luo Y, Nie X, Zhang B, Wang X, Li R, Liu G, Zhou Q, Liu Z, Fan L, Hotaling JM, Zhang Z, Bo H, Guo J., 2023
- Single-cell analysis of the developing human ovary defines distinct insights into ovarian somatic and germline progenitors., Wamaitha SE, Nie X, Pandolfi EC, Wang X, Yang Y, Stukenborg JB, Cairns BR, Guo J, Clark AT., 2023
- Single-cell analysis of human testis aging and correlation with elevated body mass index., Nie X, Munyoki SK, Sukhwani M, Schmid N, Missel A, Emery BR, DonorConnect, Stukenborg JB, Mayerhofer A, Orwig KE, Aston KI, Hotaling JM, Cairns BR, Guo J., 2022
- Comparative Single-Cell Analysis of Biopsies Clarifies Pathogenic Mechanisms in Klinefelter Syndrome., Mahyari E, Guo J, Lima AC, Vigh-Conrad KA, Nie X, Nagirnaja L, Rockweiler N, Carrell DT, Hotaling JM, Aston KI, Conrad DF., 2021
- Single-Cell Analysis of the Developing Human Testis Reveals Somatic Niche Cell Specification and Fetal Germline Stem Cell Establishment., Guo J, Sosa E, Chitiashvili T, Nie X, Rojas EJ, Oliver E, DonorConnect, Hotaling JM, Stukenborg J, Clark AT, Cairns BR., 2021
- NRF2 Loss Recapitulates Heritable Impacts of Paternal Cigarette Smoke Exposure., Murphy PJ, Guo J, Jenkins TG, James ER, Hoidal JR, Huecksteadt J, Hotaling JM, Carrell DT, Cairns BR, Aston KI., 2020
- No Evidence of SARS-CoV-2 in Semen of Males Recovering from COVID-19., Pan F, Xiao X, Guo J, Song Y, Li H, Patel DP, Spivak AM, Alukal JP, Zhang X, Xiong C, Li PS, Hotaling JM., 2020
- The Dynamic Transcriptional Cell Atlas of Testis Development During Human Puberty., Guo J, Nie X, Giebler M, Mlcochova H, Wang Y, Grow EJ, DonorConnect, Kim R, Tharmaligham M, Matilionyte G, Mitchell RT, Lindskog L, Carrell DT, Goriely A, Hotaling JM, Cairns BR., 2020
- The Adult Human Testis Transcriptional Cell Atlas., Guo J, Grow EJ, Mlcochova H, Maher GJ, Lindskog C, Nie X, Guo Y, Takei Y, Yun J, Cai L, Kim R, Carrell DT, Goriely A, Hotaling JM, Cairns BR., 2018
- Chromatin and Single-Cell RNA-seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development., Guo J, Grow EJ, Yi C, Mlcochova H, Maher GJ, Lindskog C, Murphy PJ, Wike CL, Carrell DT, Goriely A, Hotaling JM, Cairns BR., 2017
