1999 - PhD: Chinese Academy of Sciences, Institute of Botany
Achievement: Established the 'Immunity and Signal Transduction' research group
2000-2005 - University of Texas Southwestern Medical Center - Postdoctoral Researcher
2006-2007 - University of Texas Southwestern Medical Center - Researcher Instructor
2007-present - Chinese Academy of Sciences, Institute of Zoology - Research Group Leader
Research
Regulation mechanisms of innate immune responses Relationship between immune regulation, cancer therapy, and autoimmune diseases Molecular mechanisms of stem cell fate regulation
KIZ/GM114 balances the NF-κB signaling by antagonizing the association of TRAF2/6 with their upstream adaptors., Sun J, Yang Q, Liu E, Chen D*, Sun Q*., 2022
PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation., Gu H, Yang, Zhang J, Song Y, Zhang Y, Xu P, Zhu Y, Wang L, Zhang P, Li L, Chen D*, Sun Q*., 2022
Lipid mediated–phase separation of AGO proteins on ER controls nascent peptide ubiquitination., Gao Y, Zhu Y, Wang H, Cheng Y, Zhao D, Sun Q*, Chen D*., 2022
Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay., Zhang G, Xu Y, Wang X, Zhu Y, Wang L, Zhang W, Wang Y, Gao Y, Wu X, Cheng Y, Sun Q*, Chen D*., 2022
ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization., Liu E, Sun J, Yang J, Li L, Yang Q, Zeng J, Zhang J, Chen D, Sun Q*., 2021
USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I., Tao X, Chu B, Xin D, Li L, Sun Q*., 2020
6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda., He S, Zhang G, Wang J, Gao Y, Sun R, Cao Z, Chen Z, Zheng X, Yuan J, Luo Y, Wang X, Zhang W, Zhang P, Zhao Y, He C, Tao Y*, Sun Q*, Chen D*., 2019
LC* Domain-Mediated Coalescence Is Essential for Otu Enzymatic Activity to Extend Drosophila Lifespan., Ji S, Luo Y, Cai Q, Cao Z, Zhao Y, Mei J, Li C, Xia P, Xie Z, Xia Z, Zhang J, Sun Q*, Chen D., 2019
Parkin negatively regulates the antiviral signaling pathway by targeting TRAF3 for degradation., Xin D, Gu H, Liu E, Sun Q*., 2018
Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling., Li W, Li W, Zou L, Ji S, Li C, Liu K, Zhang G, Sun Q*, Xiao F*, Chen D*., 2017
Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A., Ji S, Li C, Hu L, Liu K, Mei J, Luo Y, Tao Y, Xia Z, Sun Q*, Chen D*., 2017
Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD., Lin W, Zhang J, Lin H, Li Z, Sun X, Xin D, Yang M, Sun L, Li L1, Wang H, Chen D, Sun Q*., 2016
MAVS maintains mitochondrial homeostasis via autophagy., Sun X, Sun L, Zhao Y, Li Y, Lin W, Chen D, Sun Q*., 2016
Critical POU domain residues confer Oct4 uniqueness in somatic cell reprogramming., Jin W, Wang L, Zhu F, Tan W, Lin W, Chen D, Sun Q*, Xia Z*., 2016
N6-methyladenine functions as a potential epigenetic mark in eukaryotes., Sun Q*, Huang S, Wang X, Zhu Y, Chen Z, Chen D*., 2015
PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation., Li Z, Liu G, Sun L, Teng Y, Guo X, Jia J, Sha J, Yang X, Chen D, Sun Q*., 2015
Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signaling by controlling MyD88 turnover in Drosophila., Ji S, Sun M, Zheng X, Li L, Sun L, Chen D* and Sun Q*., 2014
Coordination of engineered factors with TET 1/2 promotes the early stage epigenetic modification during somatic cell reprogramming., Zhu G, Li Y, Zhu F, Wang T, Jin W, Mu W, Lin W, Tan W, Sun Q*, Jin P* and Chen D*., 2014
Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover., Huang S, Zhang Z, Zhang C, Lv X, Zheng X, Chen Z, Sun L, Wang H, Zhu Y, Zhang J, Yang S, Lu Y, Sun Q, Tao Y, Liu F, Zhao Y, Chen D., 2013
Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease., Wang F, Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C, Han C, Tang TS., 2013
Dysregulation of mitochondrial calcium signaling and superoxide flashes cause mitochondrial genomic DNA damage in Huntington disease., Wang JQ, Chen Q, Wang X, Wang QC, Wang Y, Cheng HP, Guo C, Sun Q, Chen Q, Tang TS., 2013
COX5B Regulates MAVS-mediated Antiviral Signaling through Interaction with ATG5 and Repressing ROS Production., Zhao Y, Sun X, Nie X, Sun L, Tang TS, Chen D, Sun Q*., 2012
Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication., Dong X, Feng H, Sun Q, Li H, Wu TT, Sun R, Tibbetts SA, Chen ZJ, Feng P*., 2010
The Fused/Smurf complex controls the fate of Drosophila germline stem cells by generating a gradient BMP response., Xia L, Jia S, Huang S, Wang H, Zhu Y, Mu Y, Kan L, Zheng W, Wu D, Li X, Sun Q, Meng A, Chen D*., 2010
MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus., Bhoj VG, Sun Q, Bhoj EJ, Somers C, Chen X, Torres JP, Mejias A, Gomez AM, Jafri H, Ramilo O, Chen ZJ*., 2008
E1-L2 activates both ubiquitin and FAT10., Chiu YH, Sun Q, Chen ZJ*., 2007
Induction of IL-8 expression by human herpesvirus 8 encoded vFLIP K13 via NF-kappaB activation., Sun Q, Matta H, Lu G, Chaudhary PM., 2006
The specific and essential role of MAVS in antiviral innate immune responses., Sun Q, Sun L, Liu HH, Chen X, Seth RB, Forman J, Chen ZJ*., 2006
Kaposi's sarcoma associated herpes virus-encoded viral FLICE inhibitory protein activates transcription from HIV-1 Long Terminal Repeat via the classical NF-kappaB pathway and functionally cooperates with Tat., Sun Q, Matta H, Chaudhary PM*., 2005
The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-kappaB activation., Sun Q, Zachariah S, Chaudhary PM*., 2003
The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation., Sun Q, Matta H, Chaudhary PM*., 2003
