Professor | Gao Fei | Asia Growth Partners

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Name	Gao Fei
Contact Information	gaof@ioz.ac.cn
Language ability	Chinese, English
Province	Beijing

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Name

Gao Fei

Contact Information

gaof@ioz.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Chinese Academy of Sciences
Faculty	Institute of Zoology
Academic Background & Achievements	1991-1995 BS: Inner Mongolia University, Biochemistry 1995-1998 MS: Inner Mongolia University, Reproductive Biology 1998-2001 Ph.D.: Institute of Zoology, Chinese Academy of Sciences, Reproductive Biology 2015: Received National Science Fund for Distinguished Young Scholars
Work Experience	2001-2003 - Baylor College of Medicine, USA - Postdoctoral Research 2003-2008 - MD Anderson Cancer Center, University of Texas, USA - Postdoctoral Research
Awards	2015: National Science Fund for Distinguished Young Scholars

University/Lab Affiliation and Title

Chinese Academy of Sciences

Faculty

Institute of Zoology

Academic Background & Achievements

1991-1995 BS: Inner Mongolia University, Biochemistry
1995-1998 MS: Inner Mongolia University, Reproductive Biology
1998-2001 Ph.D.: Institute of Zoology, Chinese Academy of Sciences, Reproductive Biology
2015: Received National Science Fund for Distinguished Young Scholars

Work Experience

2001-2003 - Baylor College of Medicine, USA - Postdoctoral Research
2003-2008 - MD Anderson Cancer Center, University of Texas, USA - Postdoctoral Research

Awards

2015: National Science Fund for Distinguished Young Scholars

Areas of Focus	Regulation mechanisms of supporting and hormone-synthesizing somatic cell differentiation in gonads Regulation mechanisms of germ cell meiosis initiation Functional study of germ cell-specific gene expression
Publications	Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation, Zhang L, Chen M, Wen Q, Li Y, Wang Y, Wang Y, Qin Y, Cui X, Yang L, Huff V, Gao F, 2015 Prmt5 is required for germ cell survival during spermatogenesis in mice, Wang Y, Zhu T, Li Q, Liu C, Han F, Chen M, Zhang L, Cui X, Qin Y, Bao S, Gao F, 2015 Wt1 is involved in Leydig cell steroid hormone biosynthesis by regulating paracrine factors expression, Chen M, Wang XN, Wang YB, Zhang LJ, Xu BY, Lv LM, Cui XH, Li W, Gao F, 2014 Wt1 functions in ovarian follicle development by regulating granulosa cell differentiation, Gao F, Zhang J, Wang XN, Yang JL, Chen DH, Huff V, Liu YX, 2014 The Wilms Tumor Gene, Wt1, Is Critical for Mouse Spermatogenesis via Regulation of Sertoli Cell Polarity and Is Associated with Non-Obstructive Azoospermia in Humans, Wang XN, Li Z, Ren Y, Jiang T, Wang YQ, Chen M, Zhang J, Hao JX, Wang YB, Sha RN, Huang Y, Liu X, Hu JC, Sun GQ, Li HG, Xiong CL, Xie J, Jiang ZM, Cai ZM, Wang J, Wang J, Huff V, Gui YT, Gao F, 2013 Thewilms tumor gene, wt1, maintains testicular cord integrity by regulating the expression of col4a1 and col4a2, Chen SR, Chen M, Wang XN, Zhang J, Wen Q, Ji SY, Zheng QS, Gao F, Liu YX, 2013 Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration, Chen SR, Zheng QS, Zhang Y, Gao F, Liu YX, 2013 Expression of inhibin-alpha is regulated synergistically by wilms' tumor gene 1 (wt1) and steroidogenic factor-1 (sf1) in sertoli cells, Ji SY, Hao JX, Li L, Zhang J, Zheng QS, Li XX, Wang XN, Han CS, Gao F, Liu YX, 2013 Wt1 Ablation and Igf2-Up-regulation in Mice Result in Wilms Tumors with Activated pERK1/2, Hu QH, Gao F, Tian WH, Ruteshouser C, Wang YQ, Lazar A, Stewart J, Strong LC, Behringer RR, Huff V, 2011 Notch Signaling Is Involved in Ovarian Follicle Development by Regulating Granulosa Cell Proliferation, Zhang CP, Yang JL, Zhang J, Li L, Huang L, Ji SY, Hu ZY, Gao F, Liu YX, 2011 Testosterone Induces Redistribution of Forkhead Box-3a and Down-Regulation of Growth and Differentiation Factor 9 Messenger Ribonucleic Acid Expression at Early Stage of Mouse Folliculogenesis, Yang JL, Zhang CP, Li L, Huang L, Ji SY, Lu CL, Fan CH, Cai H, Ren Y, Hu ZY, Gao F, Liu YX, 2010 Wt1 negatively regulates (beta)-Catenin Signaling during testis development, Chang H, Gao F, Guillou F, Taketo MM, Huff V, Behringer RR, 2008 Wt1 is Required for Sox9 Expression and Normal Tubular Architecture in the Developing Testes, Gao F, Maiti S, Alam N, Zhang Z, Deng JM, Behringer RR, Lécureuil C, Guillou F, Huff V, 2006 Mouse WT1 missense mutation results in glomerulosclerosis characteristic of human Denys-Drash Syndrome, Gao F, Maiti S, Sun GZ, Huff V, 2004 Maspin plays an essential role in early embryonic development, Gao F, Shi HY, Daughty C, Cella N, Zhang M, 2004

Areas of Focus

Regulation mechanisms of supporting and hormone-synthesizing somatic cell differentiation in gonads
Regulation mechanisms of germ cell meiosis initiation
Functional study of germ cell-specific gene expression

Publications

Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation, Zhang L, Chen M, Wen Q, Li Y, Wang Y, Wang Y, Qin Y, Cui X, Yang L, Huff V, Gao F, 2015
Prmt5 is required for germ cell survival during spermatogenesis in mice, Wang Y, Zhu T, Li Q, Liu C, Han F, Chen M, Zhang L, Cui X, Qin Y, Bao S, Gao F, 2015
Wt1 is involved in Leydig cell steroid hormone biosynthesis by regulating paracrine factors expression, Chen M, Wang XN, Wang YB, Zhang LJ, Xu BY, Lv LM, Cui XH, Li W, Gao F, 2014
Wt1 functions in ovarian follicle development by regulating granulosa cell differentiation, Gao F, Zhang J, Wang XN, Yang JL, Chen DH, Huff V, Liu YX, 2014
The Wilms Tumor Gene, Wt1, Is Critical for Mouse Spermatogenesis via Regulation of Sertoli Cell Polarity and Is Associated with Non-Obstructive Azoospermia in Humans, Wang XN, Li Z, Ren Y, Jiang T, Wang YQ, Chen M, Zhang J, Hao JX, Wang YB, Sha RN, Huang Y, Liu X, Hu JC, Sun GQ, Li HG, Xiong CL, Xie J, Jiang ZM, Cai ZM, Wang J, Wang J, Huff V, Gui YT, Gao F, 2013
Thewilms tumor gene, wt1, maintains testicular cord integrity by regulating the expression of col4a1 and col4a2, Chen SR, Chen M, Wang XN, Zhang J, Wen Q, Ji SY, Zheng QS, Gao F, Liu YX, 2013
Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration, Chen SR, Zheng QS, Zhang Y, Gao F, Liu YX, 2013
Expression of inhibin-alpha is regulated synergistically by wilms' tumor gene 1 (wt1) and steroidogenic factor-1 (sf1) in sertoli cells, Ji SY, Hao JX, Li L, Zhang J, Zheng QS, Li XX, Wang XN, Han CS, Gao F, Liu YX, 2013
Wt1 Ablation and Igf2-Up-regulation in Mice Result in Wilms Tumors with Activated pERK1/2, Hu QH, Gao F, Tian WH, Ruteshouser C, Wang YQ, Lazar A, Stewart J, Strong LC, Behringer RR, Huff V, 2011
Notch Signaling Is Involved in Ovarian Follicle Development by Regulating Granulosa Cell Proliferation, Zhang CP, Yang JL, Zhang J, Li L, Huang L, Ji SY, Hu ZY, Gao F, Liu YX, 2011
Testosterone Induces Redistribution of Forkhead Box-3a and Down-Regulation of Growth and Differentiation Factor 9 Messenger Ribonucleic Acid Expression at Early Stage of Mouse Folliculogenesis, Yang JL, Zhang CP, Li L, Huang L, Ji SY, Lu CL, Fan CH, Cai H, Ren Y, Hu ZY, Gao F, Liu YX, 2010
Wt1 negatively regulates (beta)-Catenin Signaling during testis development, Chang H, Gao F, Guillou F, Taketo MM, Huff V, Behringer RR, 2008
Wt1 is Required for Sox9 Expression and Normal Tubular Architecture in the Developing Testes, Gao F, Maiti S, Alam N, Zhang Z, Deng JM, Behringer RR, Lécureuil C, Guillou F, Huff V, 2006
Mouse WT1 missense mutation results in glomerulosclerosis characteristic of human Denys-Drash Syndrome, Gao F, Maiti S, Sun GZ, Huff V, 2004
Maspin plays an essential role in early embryonic development, Gao F, Shi HY, Daughty C, Cella N, Zhang M, 2004

Gonads Somatic Cells Differentiation Hormone Synthesis Regulation Germ Cells Meiosis Gene Expression Cell Biology Mouse Models

Jingtao Guo - Chinese Academy of Sciences

Min Chen - Chinese Academy of Sciences

Yi Tao - Chinese Academy of Sciences

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