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Min Chen
Zoology
Chinese Academy of Sciences
Beijing
Language: Chinese, English
Gonadal
Somatic Cells
Germ Cells
Differentiation
Regulation
Sex Determination
Cell Biology
Reproductive Biology
Stem Cells
Developmental Biology
Areas of Focus
- Differentiation regulation of gonadal somatic and germ cells
Work Experience
- 2011-2014 - Postdoctoral Research: Institute of Zoology, Chinese Academy of Sciences
- 2014-Present - Member of the Sex Determination and Differentiation Research Group: Institute of Zoology, Chinese Academy of Sciences
- 2022-Present - Associate Researcher: Institute of Zoology, Chinese Academy of Sciences
Academic Background & Achievements
- 2007 - PhD in Science: Institute of Zoology, Chinese Academy of Sciences
Publications
- PRMT5 regulates ovarian follicle development by facilitating Wt1 translation., Chen M, Dong F, Chen M, Shen Z, Wu H, Cen C, Cui X, Bao S, Gao F., 2021
- Integration of single-cell transcriptome and chromatin accessibility of early gonads development among goats, pigs, macaques, and humans., Chen M, Long X, Chen M, Hao F, Kang J, Wang N, Wang Y, Wang M, Gao Y, Zhou M, et al., 2022
- PRMT5 Is Involved in Spermatogonial Stem Cells Maintenance by Regulating Plzf Expression via Modulation of Lysine Histone Modifications., Dong F, Chen M, Chen M, Jiang L, Shen Z, Ma L, Han C, Guo X, Gao F., 2021
- Abnormal Meiosis Initiation in Germ Cell Caused by Aberrant Differentiation of Gonad Somatic Cell., Chen M, Chen M, Chen S, Zhou J, Dong F, Shen Z, Wu H, Cui X, Gao F., 2019
- Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression., Chen M, Zhang L, Cui X, Lin X, Li Y, Wang Y, Wang Y, Qin Y, Chen D, Han C, Zhou B, Huff V, Gao F., 2017
- Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation., Zhang L, Chen M, Wen Q, Li Y, Wang Y, Wang Y, Qin Y, Cui X, Yang L, Huff V, Gao F., 2015
- Infection of SARS-CoV-2 causes severe pathological changes in mouse testis., Chen M, Li S, Liu S, Zhang Y, Cui X, Lv L, Liu B, Zheng A, Wang Q, Duo S, Gao F., 2023
- The functions of Wt1 in mouse gonad development and somatic cells differentiation., Chen M, Cen C, Wang N, Shen Z, Wang M, Liu B, Li J, Cui X, Wang Y, Gao F., 2022
- Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development., Cen C, Chen M, Zhou J, Zhang L, Duo S, Jiang L, Hou X, Gao F., 2020
- Wt1 is involved in leydig cell steroid hormone biosynthesis by regulating paracrine factor expression in mice., Chen M, Wang X, Wang Y, Zhang L, Xu B, Lv L, Cui X, Li W, Gao F., 2014
- Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells., Liu W, Chen M, Liu C, Wang L, Wei H, Zhang R, Ren Z, Chen Y, Luo M, Zhao J, Jiang H, Gao F, Li W., 2022
- The function of Foxo1 in spermatogonia development is independent of PI3K/PTEN signaling., Shen Z, Chen M, Gao Y, Dong F, Cen C, Wu H, Wang N, Cui X, Han C, Gao F., 2022
- The Wilms tumor gene, Wt1, maintains testicular cord integrity by regulating the expression of Col4a1 and Col4a2., Chen SR, Chen M, Wang XN, Zhang J, Wen Q, Ji SY, Zheng QS, Gao F, Liu YX., 2013
- Effect of heat stress on expression of junction-associated molecules and upstream factors androgen receptor and Wilms' tumor 1 in monkey sertoli cells., Chen M, Cai H, Yang JL, Lu CL, Liu T, Yang W, Guo J, Hu XQ, Fan CH, Hu ZY, Gao F, Liu YX., 2008
- Effect of 43 degrees treatment on expression of heat shock proteins 105, 70 and 60 in cultured monkey Sertoli cells., Chen M, Yuan JX, Shi YQ, Zhang XS, Hu ZY, Gao F, Liu YX., 2008
