Researcher at the State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Group Leader of Large Animal Genetic Modification Research Group
Professor at the University of Chinese Academy of Sciences
Adjunct Doctoral Supervisor at University of Science and Technology of China and Anhui University
Received National Outstanding Youth Science Fund in 2019
National Outstanding Youth Science Fund (2019)
Research
Functional gene analysis and mutant creation in pigs using forward and reverse genetics Genome editing for agricultural and biomedical applications Epigenetic regulation of early embryonic development and somatic cell nuclear transfer in pigs
A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment., Wang X, Cao C, Zhang Y, Jia Q, Zheng Q, Zhang H, Song R, Li Y, Luo A, Hong Q, Qin G, Yao J, Zhang N, Wang Y, Zhou Q, Zhao JG, 2019
Genome editing in large animals: Current status and future prospects., Zhao JG, Lai L, Ji W, Zhou Q, 2019
An exonic splicing enhancer mutation in DUOX2 causes aberrant alternative splicing and severe congenital hypothyroidism in Bama pigs., Cao C, Zhang Y, Jia Q, Wang X, Zheng Q, Zhang H, Song R, Li Y, Luo A, Hong Q, Qin G, Yao J, Zhang N, Wang Y, Wang H, Zhou Q, Zhao JG, 2019
A novel porcine model reproduces human oculocutaneous albinism type II., Zhang Y, Hong Q, Cao C, Yang L, Li Y, Hai T, Zhang H, Zhou Q, Sui R, Zhao J, 2019
Rescuing ocular development in an anophthalmic pig by blastocyst complementation., Zhang H, Huang J, Li Z, Qin G, Zhang N, Hai T, Hong Q, Zheng Q, Zhang Y, Song R, Yao J, Cao C, Zhao JG, Zhou Q, 2018
Gene engineering in swine for agriculture., Wang Y, Huang JJ, Zhao JG, 2017
Creation of miniature pig model of human Waardenburg syndrome type 2A by ENU mutagenesis., Hai T, Guo W, Yao J, Cao C, Luo A, Qi M, Wang X, Wang X, Huang J, Zhang Y, Wang D, Shang H, Hong Q, Zhang R, Jia Q, Zheng Q, Qin G, Li Y, Zhang T, Jin W, Chen ZY, Wang H, Zhou Q, Meng A, Wei H, Yang S, Zhao JG, 2017
Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decrease fat deposition and improve thermogenic capacity., Zheng Q, Lin J, Huang J, Zhang H, Zhang R, Zhang X, Cao C, Hambly C, Qin G, Yao J, Song R, Jia Q, Wang X, Li Y, Zhang N, Piao Z, Ye R, Speakman JR, Wang H, Zhou Q, Wang Y, Jin W, Zhao JG, 2017
Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis., Zhang Y, Xue Y, Cao C, Huang J, Hong Q, Hai T, Jia Q, Wang X, Qin G, Yao J, Wang X, Zheng Q, Zhang R, Li Y, Luo A, Zhang N, Shi G, Wang Y, Ying H, Liu Z, Wang H, Meng A, Zhou Q, Wei H, Liu F, Zhao JG, 2017
CRISPR editing in biological and biomedical investigation., Huang J, Wang Y, Zhao J, 2018
Pilot study of large-scale production of mutant pigs by ENU mutagenesis., Hai T, Cao C, Shang H, Guo W, Mu Y, Yang S, Zhang Y, Zheng Q, Zhang T, Wang X, Liu Y, Kong Q, Li K, Wang D, Qi M, Hong Q, Zhang R, Wang X, Jia Q, Wang X, Qin G, Li Y, Luo A, Jin W, Yao J, Huang J, Zhang H, Li M, Xie X, Zheng X, Guo K, Wang Q, Zhang S, Li L, Xie F, Zhang Y, Weng X, Yin Z, Hu K, Cong Y, Zheng P, Zou H, Xin L, Xia J, Ruan J, Li H, Zhao W, Yuan J, Liu Z, Gu W, Li M, Wang Y, Wang H, Yang S, Liu Z, Wei H, Zhao JG, Zhou Q, Meng A, 2017
Cold adaptation in pigs depends on UCP3 in beige adipocytes., Lin J, Cao C, Tao C, Ye R, Dong M, Zheng Q, Wang C, Jiang X, Qin G, Yan C, Li K, Speakman JR, Wang Y, Jin W, Zhao JG, 2017
A 2-bp insertion (c.67_68insCC) in MC1R causes recessive white coat color in Bama miniature pigs., Jia Q, Cao C, Tang H, Zhang Y, Zheng Q, Wang X, Zhang R, Wang X, Luo A, Wei H, Meng A, Zhou Q, Wang H, Zhao JG, 2017
Genome editing revolutionize the creation of genetically modified pigs for modeling human diseases., Yao J, Huang J, Zhao JG, 2016
One-step generation of triple gene targeted pigs using CRISPR/Cas9 system., Wang X, Cao C, Huang J, Yao J, Hai T, Zheng Q, Wang X, Zhang H, Qin G, Cheng J, Wang Y, Yuan Z, Zhou Q, Wang H, Zhao JG, 2016
BIX-01294 increases pig cloning efficiency by improving epigenetic reprogramming of somatic cell nuclei., Huang J, Zhang H, Yao J, Qin G, Wang F, Wang X, Luo A, Zheng Q, Cao C, Zhao JG, 2016
Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk., Zhao JG, Xu WJ, Ross JW, Walters EM, Butler SP, Whyte JJ, Kelso L, Fatemi M, Vanderslice NC, Giroux K, Spate LD, Samuel MS, Murphy CN, Wells KD, Masiello NC, Prather RS, Velander WH, 2015
Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs., Wang X, Zhou J, Cao C, Huang J, Hai T, Wang Y, Zheng Q, Zhang H, Qin G, Miao X, Wang H, Cao S, Zhou Q, Zhao JG, 2015
The dynamic distribution of porcine microbiota across different ages and gastrointestinal tract segments., Zhao W, Wang Y, Liu S, Huang J, Zhai Z, He C, Ding J, Wang J, Wang H, Fan W, Zhao JG, Meng H, 2015
Impairment of Preimplantation Porcine Embryo Development by Histone Demethylase KDM5B Knockdown Through Disturbance of Bivalent H3K4me3-H3K27me3 Modifications., Huang J, Zhang H, Wang X, Dobbs KB, Yao J, Qin G, Whitworth K, Walters EM, Prather RS, Zhao JG, 2015
Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs., Yao J, Huang JJ, HaiTang, Wang XL, Qin GS, Zhang HY, Wu R, Xi J, Yuan Z, Zhao JG, 2014
Knockdown of UCHL5IP causes abnormalities in γ-tubulin localisation, spindle organisation and chromosome alignment in mouse oocyte meiotic maturation., Wang YP, Qi ST, Wei Y, Ge ZJ, Chen L, Hou Y, Ouyang YC, Schatten H, Zhao JG, Sun QY, 2013
Gene Targeting with Zinc Finger Nucleases to Produce Cloned eGFP Knockout Pigs., Whyte JJ, Zhao JG, Samuel M, Laughlin HM, Prather RS, 2011
The effect of epigenetic regulation on somatic cell nuclear transfer., Zhao JG, Whyte JJ, Prather RS, 2010
Histone Deacetylase Inhibitors Improve In Vitro and In Vivo Developmental Competence of Somatic cell Nuclear Transfer Porcine Embryos., Zhao JG, Hao Y, Ross JW, Spate LD, Walters EM, Samuel MS, Rieke A, Murphy CN, Prather RS, 2010
Cloning and transgenics: progress and new approaches., Ross JW, Prather RS, Whyte JJ, Zhao JG, 2009
Significant Improvement in Cloning Efficiency of an Inbred Miniature Pig by Histone Deacetylase Inhibitor Treatment after Somatic Cell Nuclear Transfer., Zhao J, Ross JW, Hao Y, Spate LD, Walters EM, Samuel MS, Rieke A, Murphy CN, Prather RS, 2009
