1998 - PhD: Institute of Developmental Biology, Chinese Academy of Sciences
Discovered conserved ion channels and mechanisms maintaining cellular calcium homeostasis
Clarified molecular mechanisms of calcium signaling disorders in Huntington's disease and craniofacial dysmorphism dementia syndrome
Post-2000 - University of Texas Southwestern Medical Center, Department of Physiology - Postdoctoral Research and Lecturer
Current - Researcher at State Key Laboratory of Membrane Biology, Group Leader of Molecular Neurobiology Research Group
Research
Cellular and molecular mechanisms and treatment of neurodevelopmental and neurodegenerative diseases
Micropeptide PACMP Inhibition Elicits Synthetic-lethal Effects by Decreasing CtIP and Poly(ADP-ribosyl)ation., Zhang C, Zhou B, Gu F, Liu H, Wu H, Yao F, Zheng H, Fu H, Chong W, Cai S, Huang M, Ma X, Guo Z, Li T, Deng W, Zheng M, Ji Q, Zhao Y, Ma Y, Wang QE, Tang TS and Guo C, 2022
iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca2+ homeostasis and control tumor growth and drug resistance., Zheng S, Zhao D, Hou G, Zhao S, Zhang W, Wang X, Li L, Liang L, Tang TS, and Hu Y, 2022
Determining the Fate of Neurons in SCA3: ATX3, a Rising Decision Maker in Response to DNA Stresses and Beyond., Tu Y, Li X, Zhu X, Liu X, Guo C, Jia D, Tang TS, 2020
Miro2 supplies a platform for Parkin translocation to damaged mitochondria., Wang JQ, Zhu S, Wang Y, Wang F, An C, Jiang D, Gao L, Tu Y, Zhu X, Wang Y, Liu H, Gong J, Sun Z, Wang X, Liu L, Yang K, Guo C, Tang TS, 2019
RNA-splicing factor SART3 regulates translesion DNA synthesis., Huang M, Zhou B, Gong J, Xing L, Ma X, Wang F, Wu W, Shen H, Sun C, Zhu X, Yang Y, Sun Y, Liu Y, Tang TS, Guo C, 2018
TMCO1 is essential for ovarian follicle development by regulating ER Ca2+ store of granulosa cells., Sun Z, Zhang H, Wang X, Wang QC, Zhang C, Wang JQ, Wang YH, An CQ, Yang KY, Wang Y, Gao F, Guo C, Tang TS, 2018
Epigenetic profiles in polyglutamine disorders., Liu H, Tang TS, Guo C, 2018
Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis., Ma X, Liu H, Li J, Wang Y, Ding YH, Shen H, Yang Y, Sun C, Huang M, Tu Y, Liu Y, Zhao Y, Dong MQ, Xu P, Tang TS, Guo C, 2017
RBM45 competes with HDAC1 for binding to FUS in response to DNA damage., Gong J, Huang M, Wang F, Ma X, Liu H, Tu Y, Xing L, Zhu X, Zheng H, Fang J, Li X, Wang Q, Wang J, Sun Z, Wang X, Wang Y, Guo C, Tang TS, 2017
Ataxin-3 promotes genome integrity by stabilizing Chk1., Tu Y, Liu H, Zhu X, Shen H, Ma X, Wang F, Huang M, Gong J, Li X, Wang Y, Guo C, Tang TS, 2017
The Machado–Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53., Liu H, Li X, Ning G, Zhu S, Ma X, Liu X, Liu C, Huang M, Schmitt I, Wüllner U, Niu Y, Guo C, Wang Q, Tang TS, 2016
TMCO1 is an ER Ca2+ load-activated Ca2+ (CLAC) channel., Wang QC, Zheng Q, Tan H, Zhang B, Li X, Yang Y, Yu J, Liu Y, Chai H, Wang X, Sun Z, Wang JQ, Zhu S, Wang F, Yang M, Guo C, Wang H, Zheng Q, Li Y, Chen Q, Zhou A, Tang TS, 2016
FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress., Yang Y, Liu Z, Wang F, Temviriyanukul P, Ma X, Tu Y, Lv L, Lin YF, Huang M, Zhang T, Pei H, Chen BP, Jansen JG, de Wind N, Fischhaber PL, Friedberg EC, Tang TS, Guo C, 2015
Towards therapeutic targets for SCA3: insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance., Li X, Liu H, Fischhaber PL, Tang TS, 2015
CSB-PGBD3 Mutations Cause Premature Ovarian Failure., Qin Y, Guo T, Li G, Tang TS, Zhao S, Jiao X, Gong J, Gao F, Guo C, Simpson JL, Chen ZJ, 2015
Adult neural progenitor cells from Huntington’s disease mouse brain exhibit increased proliferation and migration due to enhanced Ca2+ ROS signals., Xie W, Wang JQ, Wang QC, Wang Y, Yao S, Tang TS, 2015
Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct., Liu Y, Yang Y, Tang TS, Zhang H, Wang Z, Friedberg E, Yang W, Guo C, 2014
Epigenetic modifications as novel therapeutic targets for Huntington's disease., Wang F, Fischhaber PL, Guo C, Tang TS, 2014
Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation., Lv L, Wang F, Ma X, Yang Y, Wang Z, Liu H, Li X, Liu Z, Zhang T, Huang M, Friedberg E, Tang TS, Guo C, 2013
Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease., Wang F, Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C, Han C, Tang TS, 2013
Mouse DNA Polymerase Kappa Has A Functional Role in the Repair of DNA Strand Breaks., Zhang X, Lv L, Chen Q, Yuan F, Zhang T, Yang Y, Zhang H, Wang Y, Qian L, Chen B, Zhang Y, Friedberg EC, Tang TS, Guo C, 2013
Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington’s Disease., Wang JQ, Chen Q, Wang X, Wang QC, Wang Y, Cheng HP, Guo C, Sun Q, Chen Q, Tang TS, 2013
The role of PARP1 in the DNA damage response and its application in tumor therapy., Wang Z, Wang F, Tang TS, Guo C, 2012
Tetrabenazine is neuroprotective in Huntington’s disease mice., Wang H, Chen X, Li Y, Tang TS and Bezprozvanny I, 2010
Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model., Tang TS, Guo C, Wang H, Chen X, Bezprozvanny I, 2009
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3., Chen X, Tang TS, Tu H, Nelson O, Pook M, Hammer R, Nukina N, Bezprozvanny I, 2008
Small molecule activation of neuronal cell fate., Schneider JW, Gao Z, Li S, Farooqi M, Tang TS, Bezprozvanny I, Frantz D, Hsieh J, 2008
Requirements for the interaction of mouse Polκ with ubiquitin, and its biological significance., Guo C, Tang TS, Bienko M, Dikic I and Friedberg EC, 2008
Dopaminergic signaling and apoptosis of medium spiny neurons in Huntington’s disease., Tang TS, Chen X, Liu J, Bezprozvanny I, 2007
REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo., Guo C, Sonoda E, Tang TS, Parker JL, Bielen AB, Takeda S, Ulrich HD, Friedberg EC, 2006
Ubiquitin-Binding Motifs in Rev1 Protein are Required for Its Role in the Tolerance of DNA Damage., Guo C, Tang TS, Bienko M, Sonoda E, Parker JL, Bielen AB, Takeda S, Ulrich HD, Dikic I, Friedberg EC, 2006
Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease., Tang TS, Slow E, Lupu V, Stavrovskaya IG, Sugimori M, Llinas R, Kristal BS, Hayden MR, Bezprozvanny I, 2005
Reelin modulates NMDA receptor activity in cortical neurons., Chen Y, Beffert U, Ertunc M, Tang TS, Kavalali ET, Bezprozvanny I, Herz J, 2005
Dopamine receptor-mediated Ca2+ signaling in striatal medium spiny neurons., Tang TS, Bezprozvanny I, 2004
Association of type 1 inositol 1,4,5-trisphosphate receptor with AKAP9 (Yotiao) and protein kinase A., Tu H, Tang TS, Wang Z, Bezprozvanny I, 2004
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) trisphosphate receptor type 1., Tang TS, Tu H, Chan EY, Maximov A, Wang Z, Wellington CL, Hayden MR, Bezprozvanny I, 2003
Modulation of the type 1 inositol (1,4,5)-trisphosphate receptor function by PKA and PP1-alpha., Tang TS, Tu H, Wang Z, and Bezprozvanny I, 2003
Ca2+ oscillations induced by a cytosolic sperm protein factor are mediated by a maternal machinery which functions only once in mammalian eggs., Tang TS, Dong JB, Huang XY and Sun FZ, 2000
