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唐铁山
tangtsh@ioz.ac.cn
中文, 英语
北京
中国科学院
Institute of Zoology
  • 1998 - 博士学位:中国科学院发育生物学研究所
  • 发现维持细胞钙稳态的保守离子通道和机制
  • 阐明钙信号紊乱参与亨廷顿氏舞蹈病和颅面畸形痴呆综合症病理发生的分子机制
  • 2000年后 - 美国德克萨斯大学西南医学研究中心生理系 - 博士后研究和讲师
  • 现任 - 膜生物学国家重点实验室研究员,分子神经生物学研究组组长
神经发育和神经退行性疾病的细胞分子机制与治疗
  • Micropeptide PACMP Inhibition Elicits Synthetic-lethal Effects by Decreasing CtIP and Poly(ADP-ribosyl)ation., Zhang C, Zhou B, Gu F, Liu H, Wu H, Yao F, Zheng H, Fu H, Chong W, Cai S, Huang M, Ma X, Guo Z, Li T, Deng W, Zheng M, Ji Q, Zhao Y, Ma Y, Wang QE, Tang TS and Guo C, 2022
  • iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca2+ homeostasis and control tumor growth and drug resistance., Zheng S, Zhao D, Hou G, Zhao S, Zhang W, Wang X, Li L, Liang L, Tang TS, and Hu Y, 2022
  • Determining the Fate of Neurons in SCA3: ATX3, a Rising Decision Maker in Response to DNA Stresses and Beyond., Tu Y, Li X, Zhu X, Liu X, Guo C, Jia D, Tang TS, 2020
  • Miro2 supplies a platform for Parkin translocation to damaged mitochondria., Wang JQ, Zhu S, Wang Y, Wang F, An C, Jiang D, Gao L, Tu Y, Zhu X, Wang Y, Liu H, Gong J, Sun Z, Wang X, Liu L, Yang K, Guo C, Tang TS, 2019
  • RNA-splicing factor SART3 regulates translesion DNA synthesis., Huang M, Zhou B, Gong J, Xing L, Ma X, Wang F, Wu W, Shen H, Sun C, Zhu X, Yang Y, Sun Y, Liu Y, Tang TS, Guo C, 2018
  • TMCO1 is essential for ovarian follicle development by regulating ER Ca2+ store of granulosa cells., Sun Z, Zhang H, Wang X, Wang QC, Zhang C, Wang JQ, Wang YH, An CQ, Yang KY, Wang Y, Gao F, Guo C, Tang TS, 2018
  • Epigenetic profiles in polyglutamine disorders., Liu H, Tang TS, Guo C, 2018
  • Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis., Ma X, Liu H, Li J, Wang Y, Ding YH, Shen H, Yang Y, Sun C, Huang M, Tu Y, Liu Y, Zhao Y, Dong MQ, Xu P, Tang TS, Guo C, 2017
  • RBM45 competes with HDAC1 for binding to FUS in response to DNA damage., Gong J, Huang M, Wang F, Ma X, Liu H, Tu Y, Xing L, Zhu X, Zheng H, Fang J, Li X, Wang Q, Wang J, Sun Z, Wang X, Wang Y, Guo C, Tang TS, 2017
  • Ataxin-3 promotes genome integrity by stabilizing Chk1., Tu Y, Liu H, Zhu X, Shen H, Ma X, Wang F, Huang M, Gong J, Li X, Wang Y, Guo C, Tang TS, 2017
  • The Machado–Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53., Liu H, Li X, Ning G, Zhu S, Ma X, Liu X, Liu C, Huang M, Schmitt I, Wüllner U, Niu Y, Guo C, Wang Q, Tang TS, 2016
  • TMCO1 is an ER Ca2+ load-activated Ca2+ (CLAC) channel., Wang QC, Zheng Q, Tan H, Zhang B, Li X, Yang Y, Yu J, Liu Y, Chai H, Wang X, Sun Z, Wang JQ, Zhu S, Wang F, Yang M, Guo C, Wang H, Zheng Q, Li Y, Chen Q, Zhou A, Tang TS, 2016
  • FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress., Yang Y, Liu Z, Wang F, Temviriyanukul P, Ma X, Tu Y, Lv L, Lin YF, Huang M, Zhang T, Pei H, Chen BP, Jansen JG, de Wind N, Fischhaber PL, Friedberg EC, Tang TS, Guo C, 2015
  • Towards therapeutic targets for SCA3: insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance., Li X, Liu H, Fischhaber PL, Tang TS, 2015
  • CSB-PGBD3 Mutations Cause Premature Ovarian Failure., Qin Y, Guo T, Li G, Tang TS, Zhao S, Jiao X, Gong J, Gao F, Guo C, Simpson JL, Chen ZJ, 2015
  • Adult neural progenitor cells from Huntington’s disease mouse brain exhibit increased proliferation and migration due to enhanced Ca2+ ROS signals., Xie W, Wang JQ, Wang QC, Wang Y, Yao S, Tang TS, 2015
  • Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct., Liu Y, Yang Y, Tang TS, Zhang H, Wang Z, Friedberg E, Yang W, Guo C, 2014
  • Epigenetic modifications as novel therapeutic targets for Huntington's disease., Wang F, Fischhaber PL, Guo C, Tang TS, 2014
  • Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation., Lv L, Wang F, Ma X, Yang Y, Wang Z, Liu H, Li X, Liu Z, Zhang T, Huang M, Friedberg E, Tang TS, Guo C, 2013
  • Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease., Wang F, Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C, Han C, Tang TS, 2013
  • Mouse DNA Polymerase Kappa Has A Functional Role in the Repair of DNA Strand Breaks., Zhang X, Lv L, Chen Q, Yuan F, Zhang T, Yang Y, Zhang H, Wang Y, Qian L, Chen B, Zhang Y, Friedberg EC, Tang TS, Guo C, 2013
  • Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington’s Disease., Wang JQ, Chen Q, Wang X, Wang QC, Wang Y, Cheng HP, Guo C, Sun Q, Chen Q, Tang TS, 2013
  • The role of PARP1 in the DNA damage response and its application in tumor therapy., Wang Z, Wang F, Tang TS, Guo C, 2012
  • SnapShot: Nucleotide Excision Repair., Guo C, Tang TS, Friedberg EC, 2010
  • Tetrabenazine is neuroprotective in Huntington’s disease mice., Wang H, Chen X, Li Y, Tang TS and Bezprozvanny I, 2010
  • Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model., Tang TS, Guo C, Wang H, Chen X, Bezprozvanny I, 2009
  • Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3., Chen X, Tang TS, Tu H, Nelson O, Pook M, Hammer R, Nukina N, Bezprozvanny I, 2008
  • Small molecule activation of neuronal cell fate., Schneider JW, Gao Z, Li S, Farooqi M, Tang TS, Bezprozvanny I, Frantz D, Hsieh J, 2008
  • Requirements for the interaction of mouse Polκ with ubiquitin, and its biological significance., Guo C, Tang TS, Bienko M, Dikic I and Friedberg EC, 2008
  • Dopaminergic signaling and apoptosis of medium spiny neurons in Huntington’s disease., Tang TS, Chen X, Liu J, Bezprozvanny I, 2007
  • REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo., Guo C, Sonoda E, Tang TS, Parker JL, Bielen AB, Takeda S, Ulrich HD, Friedberg EC, 2006
  • Ubiquitin-Binding Motifs in Rev1 Protein are Required for Its Role in the Tolerance of DNA Damage., Guo C, Tang TS, Bienko M, Sonoda E, Parker JL, Bielen AB, Takeda S, Ulrich HD, Dikic I, Friedberg EC, 2006
  • Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease., Tang TS, Slow E, Lupu V, Stavrovskaya IG, Sugimori M, Llinas R, Kristal BS, Hayden MR, Bezprozvanny I, 2005
  • Reelin modulates NMDA receptor activity in cortical neurons., Chen Y, Beffert U, Ertunc M, Tang TS, Kavalali ET, Bezprozvanny I, Herz J, 2005
  • Dopamine receptor-mediated Ca2+ signaling in striatal medium spiny neurons., Tang TS, Bezprozvanny I, 2004
  • Association of type 1 inositol 1,4,5-trisphosphate receptor with AKAP9 (Yotiao) and protein kinase A., Tu H, Tang TS, Wang Z, Bezprozvanny I, 2004
  • Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) trisphosphate receptor type 1., Tang TS, Tu H, Chan EY, Maximov A, Wang Z, Wellington CL, Hayden MR, Bezprozvanny I, 2003
  • Modulation of the type 1 inositol (1,4,5)-trisphosphate receptor function by PKA and PP1-alpha., Tang TS, Tu H, Wang Z, and Bezprozvanny I, 2003
  • Ca2+ oscillations induced by a cytosolic sperm protein factor are mediated by a maternal machinery which functions only once in mammalian eggs., Tang TS, Dong JB, Huang XY and Sun FZ, 2000
钙信号 线粒体 Dna修复 神经发育 神经退行性 亨廷顿氏病 渐冻症 脊髓小脑共济失调症 治疗策略 小鼠疾病模型

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