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Shunyi Zhu
Zoology
Chinese Academy of Sciences
Beijing
Language: English, Chinese
Peptides
Biology
Evolution
Research
Design
Molecules
Antimicrobial
Neurotoxins
Superfamilies
Innovation
Areas of Focus
- Peptide Biology and Evolution Research
- Evolution-guided Design of New Peptide Molecules
Work Experience
- 2001-2004 - Postdoctoral Research: University of Leuven, Belgium
- Current - Researcher, Group Leader: Institute of Zoology, Chinese Academy of Sciences
Academic Background & Achievements
- 2001 - PhD in Science: Wuhan University
- Achievement: Discovered new antimicrobial peptides and neurotoxins
- Achievement: Established evolutionary links between different functional classes of peptide superfamilies
Publications
- The evolutionary novelty of insect defensins: from bacterial killing to toxin neutralization, Gao B, Zhu S, 2024
- Single deletion unmasks hidden anti-Gram-negative bacterial activity of an insect defensin-derived peptide, Gao B, Li P, Zhu S, 2024
- Enhancement of SARS-CoV-2 receptor-binding domain activity by two microbial defensins, Gao B, Zhu S, 2023
- Mutation-driven parallel evolution in emergence of ACE2-utilizing sarbecoviruses, Gao B, Zhu S, 2023
- Mutation-driven evolution of antibacterial function in an ancestral antifungal scaffold: Significance for peptide engineering, Gu J, Isozumi N, Gao B, Ohki S, Zhu S, 2022
- A Fungal Defensin Inhibiting Bacterial Cell-Wall Biosynthesis with Non-Hemolysis and Serum Stability, Qi S, Gao B, Zhu S, 2022
- Adaptively evolved human oral actinomyces-sourced defensins show therapeutic potential, Zhu S, Gao B, Umetsu Y, Peigneur S, Li P, Ohki S, Tytgat J, 2022
- Evolution-based protein engineering for antifungal peptide improvement, Gu J, Isozumi N, Yuan S, Jin L, Gao B, Ohki S, Zhu S, 2021
- A fungal defensin targets the SARS-CoV-2 spike receptor-binding domain, Gao B, Zhu S, 2021
- Molecular diversity and evolution of antimicrobial peptides in Musca domestica, Qi S, Gao B, Zhu S, 2021
- Independent origins of scorpion toxins affecting potassium and sodium channels, Zhang S, Gao B, Zhu S, 2015
- Mesomartoxin, a new Kv1.2-selective scorpion toxin interacting with the channel selectivity filter, Wang X, Umetsu Y, Gao B, Ohki S, Zhu S, 2015
- Experimental conversion of a defensin into a neurotoxin: Implications for origin of toxic function, Zhu S, Peigneur S, Gao B, Umetsu Y, Ohki S, Jan Tytgat, 2014
- Nematode-derived drosomycin-type antifungal peptides provide evidence for plant-to-ecdysozoan horizontal transfer of a disease resistance gene, Zhu S, Gao B, 2014
- An insect defensin-derived β-hairpin peptide with enhanced antibacterial activity, Gao B, Zhu S, 2014
- Dermatophytic defensin with antiinfective potential, Zhu S, Gao B, Harvey P, Craik D, 2012
- Evolutionary diversification of Mesobuthus α-scorpion toxins affecting sodium channels, Zhu S, Peigneur S, Gao B, Lu X, Cao C, Tytgat J, 2012
- Convergent evolution-guided design of antimicrobial peptides derived from influenza A virus hemagglutinin, Zhu S, Aumelas A, Gao B, 2011
- Molecular diversity and functional evolution of scorpion potassium channel toxins, Zhu S, Peigneur S, Gao B, Luo L, Jin D, Zhao Y, Tytgat J, 2011
- Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides, Gao B, Sherman P, Luo L, Bowie J, Zhu S, 2009
- A fossil antibacterial peptide gives clues to structural diversity of cathelicidin-derived host defense peptides, Zhu S, Gao B, 2009
- Did cathelicidins, a family of multifunctional host-defense peptides, arise from a cysteine protease inhibitor?, Zhu S, 2008
- Evolutionary epitopes of Hsp90 and p23: implications for their interaction, Zhu S, Tytgat J, 2004
- Evolutionary origin of inhibitor cystine knot peptides, Zhu S, Darbon H, Dyason K, Verdonck F, Tytgat J, 2003
- Turret and pore block of K+ channels: what is the difference?, Xu C, Zhu S, Chi C, Tytgat J, 2003
Awards
- Hubei Province Natural Science First Prize
- State Council Government Special Allowance
