Professor | Shunyi Zhu | Asia Growth Partners

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Name	Shunyi Zhu
Contact Information	zhusy@ioz.ac.cn
Language ability	English, Chinese
Province	Beijing

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Name

Shunyi Zhu

Contact Information

zhusy@ioz.ac.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Chinese Academy of Sciences
Faculty	Institute of Zoology
Academic Background & Achievements	2001 - PhD in Science: Wuhan University Achievement: Discovered new antimicrobial peptides and neurotoxins Achievement: Established evolutionary links between different functional classes of peptide superfamilies
Work Experience	2001-2004 - Postdoctoral Research: University of Leuven, Belgium Current - Researcher, Group Leader: Institute of Zoology, Chinese Academy of Sciences
Awards	Hubei Province Natural Science First Prize State Council Government Special Allowance

University/Lab Affiliation and Title

Chinese Academy of Sciences

Faculty

Institute of Zoology

Academic Background & Achievements

2001 - PhD in Science: Wuhan University
Achievement: Discovered new antimicrobial peptides and neurotoxins
Achievement: Established evolutionary links between different functional classes of peptide superfamilies

Work Experience

2001-2004 - Postdoctoral Research: University of Leuven, Belgium
Current - Researcher, Group Leader: Institute of Zoology, Chinese Academy of Sciences

Awards

Hubei Province Natural Science First Prize
State Council Government Special Allowance

Areas of Focus	Peptide Biology and Evolution Research Evolution-guided Design of New Peptide Molecules
Publications	The evolutionary novelty of insect defensins: from bacterial killing to toxin neutralization, Gao B, Zhu S, 2024 Single deletion unmasks hidden anti-Gram-negative bacterial activity of an insect defensin-derived peptide, Gao B, Li P, Zhu S, 2024 Enhancement of SARS-CoV-2 receptor-binding domain activity by two microbial defensins, Gao B, Zhu S, 2023 Mutation-driven parallel evolution in emergence of ACE2-utilizing sarbecoviruses, Gao B, Zhu S, 2023 Mutation-driven evolution of antibacterial function in an ancestral antifungal scaffold: Significance for peptide engineering, Gu J, Isozumi N, Gao B, Ohki S, Zhu S, 2022 A Fungal Defensin Inhibiting Bacterial Cell-Wall Biosynthesis with Non-Hemolysis and Serum Stability, Qi S, Gao B, Zhu S, 2022 Adaptively evolved human oral actinomyces-sourced defensins show therapeutic potential, Zhu S, Gao B, Umetsu Y, Peigneur S, Li P, Ohki S, Tytgat J, 2022 Evolution-based protein engineering for antifungal peptide improvement, Gu J, Isozumi N, Yuan S, Jin L, Gao B, Ohki S, Zhu S, 2021 A fungal defensin targets the SARS-CoV-2 spike receptor-binding domain, Gao B, Zhu S, 2021 Molecular diversity and evolution of antimicrobial peptides in Musca domestica, Qi S, Gao B, Zhu S, 2021 Independent origins of scorpion toxins affecting potassium and sodium channels, Zhang S, Gao B, Zhu S, 2015 Mesomartoxin, a new Kv1.2-selective scorpion toxin interacting with the channel selectivity filter, Wang X, Umetsu Y, Gao B, Ohki S, Zhu S, 2015 Experimental conversion of a defensin into a neurotoxin: Implications for origin of toxic function, Zhu S, Peigneur S, Gao B, Umetsu Y, Ohki S, Jan Tytgat, 2014 Nematode-derived drosomycin-type antifungal peptides provide evidence for plant-to-ecdysozoan horizontal transfer of a disease resistance gene, Zhu S, Gao B, 2014 An insect defensin-derived β-hairpin peptide with enhanced antibacterial activity, Gao B, Zhu S, 2014 Dermatophytic defensin with antiinfective potential, Zhu S, Gao B, Harvey P, Craik D, 2012 Evolutionary diversification of Mesobuthus α-scorpion toxins affecting sodium channels, Zhu S, Peigneur S, Gao B, Lu X, Cao C, Tytgat J, 2012 Convergent evolution-guided design of antimicrobial peptides derived from influenza A virus hemagglutinin, Zhu S, Aumelas A, Gao B, 2011 Molecular diversity and functional evolution of scorpion potassium channel toxins, Zhu S, Peigneur S, Gao B, Luo L, Jin D, Zhao Y, Tytgat J, 2011 Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides, Gao B, Sherman P, Luo L, Bowie J, Zhu S, 2009 A fossil antibacterial peptide gives clues to structural diversity of cathelicidin-derived host defense peptides, Zhu S, Gao B, 2009 Did cathelicidins, a family of multifunctional host-defense peptides, arise from a cysteine protease inhibitor?, Zhu S, 2008 Evolutionary epitopes of Hsp90 and p23: implications for their interaction, Zhu S, Tytgat J, 2004 Evolutionary origin of inhibitor cystine knot peptides, Zhu S, Darbon H, Dyason K, Verdonck F, Tytgat J, 2003 Turret and pore block of K+ channels: what is the difference?, Xu C, Zhu S, Chi C, Tytgat J, 2003

Areas of Focus

Peptide Biology and Evolution Research
Evolution-guided Design of New Peptide Molecules

Publications

The evolutionary novelty of insect defensins: from bacterial killing to toxin neutralization, Gao B, Zhu S, 2024
Single deletion unmasks hidden anti-Gram-negative bacterial activity of an insect defensin-derived peptide, Gao B, Li P, Zhu S, 2024
Enhancement of SARS-CoV-2 receptor-binding domain activity by two microbial defensins, Gao B, Zhu S, 2023
Mutation-driven parallel evolution in emergence of ACE2-utilizing sarbecoviruses, Gao B, Zhu S, 2023
Mutation-driven evolution of antibacterial function in an ancestral antifungal scaffold: Significance for peptide engineering, Gu J, Isozumi N, Gao B, Ohki S, Zhu S, 2022
A Fungal Defensin Inhibiting Bacterial Cell-Wall Biosynthesis with Non-Hemolysis and Serum Stability, Qi S, Gao B, Zhu S, 2022
Adaptively evolved human oral actinomyces-sourced defensins show therapeutic potential, Zhu S, Gao B, Umetsu Y, Peigneur S, Li P, Ohki S, Tytgat J, 2022
Evolution-based protein engineering for antifungal peptide improvement, Gu J, Isozumi N, Yuan S, Jin L, Gao B, Ohki S, Zhu S, 2021
A fungal defensin targets the SARS-CoV-2 spike receptor-binding domain, Gao B, Zhu S, 2021
Molecular diversity and evolution of antimicrobial peptides in Musca domestica, Qi S, Gao B, Zhu S, 2021
Independent origins of scorpion toxins affecting potassium and sodium channels, Zhang S, Gao B, Zhu S, 2015
Mesomartoxin, a new Kv1.2-selective scorpion toxin interacting with the channel selectivity filter, Wang X, Umetsu Y, Gao B, Ohki S, Zhu S, 2015
Experimental conversion of a defensin into a neurotoxin: Implications for origin of toxic function, Zhu S, Peigneur S, Gao B, Umetsu Y, Ohki S, Jan Tytgat, 2014
Nematode-derived drosomycin-type antifungal peptides provide evidence for plant-to-ecdysozoan horizontal transfer of a disease resistance gene, Zhu S, Gao B, 2014
An insect defensin-derived β-hairpin peptide with enhanced antibacterial activity, Gao B, Zhu S, 2014
Dermatophytic defensin with antiinfective potential, Zhu S, Gao B, Harvey P, Craik D, 2012
Evolutionary diversification of Mesobuthus α-scorpion toxins affecting sodium channels, Zhu S, Peigneur S, Gao B, Lu X, Cao C, Tytgat J, 2012
Convergent evolution-guided design of antimicrobial peptides derived from influenza A virus hemagglutinin, Zhu S, Aumelas A, Gao B, 2011
Molecular diversity and functional evolution of scorpion potassium channel toxins, Zhu S, Peigneur S, Gao B, Luo L, Jin D, Zhao Y, Tytgat J, 2011
Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides, Gao B, Sherman P, Luo L, Bowie J, Zhu S, 2009
A fossil antibacterial peptide gives clues to structural diversity of cathelicidin-derived host defense peptides, Zhu S, Gao B, 2009
Did cathelicidins, a family of multifunctional host-defense peptides, arise from a cysteine protease inhibitor?, Zhu S, 2008
Evolutionary epitopes of Hsp90 and p23: implications for their interaction, Zhu S, Tytgat J, 2004
Evolutionary origin of inhibitor cystine knot peptides, Zhu S, Darbon H, Dyason K, Verdonck F, Tytgat J, 2003
Turret and pore block of K+ channels: what is the difference?, Xu C, Zhu S, Chi C, Tytgat J, 2003

Peptides Biology Evolution Research Design Molecules Antimicrobial Neurotoxins Superfamilies Innovation

Song Moshi - Chinese Academy of Sciences

Wei-Guo Du - Chinese Academy of Sciences

Fu-Wen Wei - Chinese Academy of Sciences

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