Upload Avatar (500 x 500)
Du Lei
Zoology
Chinese Academy of Sciences
Beijing
Language: Chinese, English
Cancer
Stem Cells
Tumorigenesis
Metastasis
Colorectal Cancer
Cd44
Prion Protein
Macrophages
Osteopontin
Wnt/Β-Catenin Signaling
Areas of Focus
- Tumor and Cancer Stem Cells
Work Experience
- 2014-present - Institute of Zoology, Chinese Academy of Sciences - Associate Researcher
- 2007-2014 - Institute of Zoology, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2014-present: Associate Researcher at Institute of Zoology, Chinese Academy of Sciences
- 2007-2014: Assistant Researcher at Institute of Zoology, Chinese Academy of Sciences
- 2002-2007: PhD at Institute of Zoology, Chinese Academy of Sciences
- 1998-2002: Bachelor's degree at Wuhan University, National Biology Talent Training Base
Publications
- CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer, Du L, Rao G, Wang H, Li B, Tian W, Cui JT, He L, Laffin B, Tian X, Hao C, Liu H, Sun X, Zhu Y, Tang DG, Mehrpour M, Lu Y*, Chen Q*, 2013
- Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs, Rao GH#, Liu HM#, Li BW, Hao JJ, Yang YL, Wang MR, Wang XH, Wang J, Jin HJ, Du L*, Chen Q*, 2013
- Reciprocal interactions between tumor-associated macrophages and CD44-Positive cancer cells via Osteopontin/CD44 promote tumorigenicity in colorectal cancer, Rao G, Wang H, Li B, Huang L, Xue D, Wang X, Jin H, Wang J, Zhu Y, Lu Y, Du L*, Chen Q*, 2013
- CD44 is of functional importance for colorectal cancer stem cell, Du L, Wang H, He L, Zhang J, Ni B, Wang X, Jin H, Cahuzac N, Mehrpour M, Lu Y*, Chen Q*, 2008
- Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signalling, Liu D, Du L, Chen D, Ye Z, Duan H, Tu T, Feng J, Yang Y, Chen Q, Yan X*, 2016
Awards
- 2016-2021: National Key R&D Program Subproject Leader
- 2014-2017: National Natural Science Foundation General Project Leader
- 2011-2013: National Natural Science Foundation Youth Science Fund Project Leader
