Upload Avatar (500 x 500)
Xianping Shi
Basic Medical Sciences
Guangzhou Medical University
Guangdong
Language: English, Chinese
Gene Expression
Molecular Therapy
Tumorigenesis
Super-Enhancer
Transcriptional Regulation
Drug Resistance
Ubiquitin
Proteasome
Tumor Development
Targeted Therapy
Areas of Focus
- Regulation of tumor-related gene expression and molecular targeted therapy
- Role of super-enhancer-driven core transcriptional regulation in tumorigenesis, recurrence, metastasis, and drug resistance
- Dysregulation of the ubiquitin-proteasome degradation system and tumor development
Academic Background & Achievements
- PhD in Biochemistry: Sun Yat-sen University
- Postdoctoral Research: Cedars Sinai Medical Center, University of California
- Guangdong Province 'Special Support Plan' Young Top Talent
- Guangzhou High-level Talent
- Guangzhou Medical University 'Nanshan Scholar'
Publications
- Inhibition of proteasomal deubiquitinases USP14 and UCHL5 overcomes tyrosine kinase inhibitor resistance in chronic myeloid leukemia., Jiang, Liling; He, Qingyan; Chen, Xin; Liu, Aochu; Ding, Wa; Zhang, Haichuan; Chen, Xinmei; Zhou, Huan; Meng, Yi; Liu, Bingyuan; Peng, Guanjie; Wang, Chunyan; Liu, Jinbao; Shi, Xianping., 2022
- Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells., Ding, Wa; Wang, Jinxiang; Wu, Junzheng; Liu, Aochu; Jiang, Liling; Zhang, Haichuan; Meng, Yi; Liu, Bingyuan; Peng, Guanjie; Lou, Enzhe; Mao, Qiong; Zhou, Huan; Tang, Daolin; Chen, Xin; Liu, Jinbao; Shi, Xianping., 2023
- Stabilization of MYC G-quadruplex DNA by ruthenium (II) complex overcomes imatinib resistance in chronic myeloid leukemia cells harboring T315I mutation., Sun, Yuening; Chen, Xin; Liao, Siyan; Liu, Aochu; Zhou, Huan; Jiang, Liling; Ding, Wa; Mei, Wenjie; Liu, Jinbao; Shi, Xianping., 2022
- EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma., Shi, Xianping; Zheng, Yueyuan; Jiang, Liling; Zhou, Bo; Yang, Wei; Li, Liyan; Ding, Lingwen; Huang, Moli; Gery, Sigal; Lin, De-Chen; Koeffler, H Phillip., 2020
- Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1., Lin, Lehang; Huang, Moli; Shi, Xianping; Mayakonda, Anand; Hu, Kaishun; Jiang, Yan Yi; Guo, Xiao; Chen, Li; Pang, Brendan; Doan, Ngan; Said, Jonathan W; Xie, Jianjun; Gery, Sigal; Cheng, Xu; Lin, Zhaoyu; Li, Jinsong; Berman, Benjamin P; Yin, Dong; Lin, De-Chen; Koeffler, H Phillip., 2019
- Proteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma., Jiang, Liling; Sun, Yuening; Wang, Jinxiang; He, Qingyan; Chen, Xinmei; Lan, Xiaoying; Chen, Jinghong; Dou, Q Ping; Shi, Xianping; Liu, Jinbao., 2019
- Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and -independent mechanisms., Lan, Xiaoying; Zhao, Chong; Chen, Xin; Zhang, Peiquan; Zang, Dan; Wu, Jinjie; Chen, Jinghong; Long, Huidan; Yang, Li; Huang, Hongbiao; Bing Z, Carter; Wang, Xuejun; Shi, Xianping; Liu, Jinbao., 2016
- Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation., Shi, Xianping; Chen, Xin; Li, Xiaofen; Lan, Xiaoying; Zhao, Chong; Liu, Shouting; Huang, Hongbiao; Liu, Ningning; Liao, Siyan; Song, Wenbin; Zhou, Ping; Wang, Shunqing; Xu, Li; Wang, Xuejun; Dou, Q. Ping; Liu, Jinbao., 2014
- Piperlongumine overcomes imatinib resistance by inducing proteasome inhibition in chronic myelogenous leukemia cells., Lan, Xiaoying; Hu, Min; Jiang, Liling; Wang, Jiamin; Meng, Yi; Chen, Xinmei; Liu, Aochu; Ding, Wa; Zhang, Haichuan; Zhou, Huan; Liu, Bingyuan; Peng, Guanjie; Liao, Siyan; Chen, Xin; Liu, Jinbao; Shi, Xianping., 2023
- TSCRE: a comprehensive database for tumor-specific cis-regulatory elements., Peng, Guanjie; Liu, Bingyuan; Zheng, Mohan; Zhang, Luowanyue; Li, Huiqin; Liu, Mengni; Liang, Yuan; Chen, Tianjian; Luo, Xiaotong; Shi, Xianping; Ren, Jian; Zheng, Yueyuan., 2024
Awards
- Second Prize of Higher Education Scientific Research Natural Science Award (2020): Ministry of Education
- Third Prize of Chinese Medical Science and Technology Award (2017)
- First Prize of Guangzhou Science and Technology Progress Award (2016)
