Professor | Zhentian Wang | Asia Growth Partners

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Name	Zhentian Wang
Contact Information	zhentian@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Zhentian Wang

Contact Information

zhentian@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2000.09—2004.06 Bachelor's Degree in Biological Sciences: Huazhong Agricultural University 2005.09—2012.01 Ph.D. in Biochemistry and Molecular Biology: Fudan University
Work Experience	2012.03—2014.03 Fudan University - Postdoctoral Researcher in Chemistry 2014.03—2019.03 Stanford University - Postdoctoral Researcher in Biology 2019.03—2021.01 Stanford University - Researcher in Basic Life Sciences
Awards	2021: Shanghai Leading Talent (Overseas) Project - 12th Batch

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2000.09—2004.06 Bachelor's Degree in Biological Sciences: Huazhong Agricultural University
2005.09—2012.01 Ph.D. in Biochemistry and Molecular Biology: Fudan University

Work Experience

2012.03—2014.03 Fudan University - Postdoctoral Researcher in Chemistry
2014.03—2019.03 Stanford University - Postdoctoral Researcher in Biology
2019.03—2021.01 Stanford University - Researcher in Basic Life Sciences

Awards

2021: Shanghai Leading Talent (Overseas) Project - 12th Batch

Areas of Focus	Epigenetic mechanisms in tumorigenesis, progression, metastasis, and drug resistance Regulation mechanisms of non-histone methylation disorders in malignant tumors and clinical drug targets
Publications	SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy, Wang Z#, Hausmann S#, Lyu R, Li TM, Lofgren SM, Flores NM, Fuentes ME, Caporicci M, Yang Z, Meiners MJ, Cheek MA, Howard SA, Zhang L, Elias JE, Kim MP, Maitra A, Wang H, Bassik MC, Keogh MC, Sage J, Gozani O, Mazur PK, 2020 SnapShot: Lysine Methylation beyond Histones, Biggar KK, Wang Z, Li SS, 2017 Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex, Shen H#, Xu W#, Guo R, Rong B, Gu L, Wang Z, He C, Zheng L, Hu X, Hu Z, Shao ZM, Yang P, Wu F, Shi YG, Shi Y, Lan F, 2016 Nono, a Bivalent Domain Factor, Regulates Erk Signaling and Mouse Embryonic Stem Cell Pluripotency, Ma C, Karwacki-Neisius V, Tang H, Li W, Shi Z, Hu H, Xu W, Wang Z, Kong L, Lv R, Fan Z, Zhou W, Yang P, Wu F, Diao J, Tan L, Shi YG, Lan F, Shi Y, 2016 BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing, Guo R#, Zheng L#, Park JW, Lv R, Chen H, Jiao F, Xu W, Mu S, Wen H, Qiu J, Wang Z, Yang P, Wu F, Hui J, Fu X, Shi X, Shi YG, Xing Y, Lan F, Shi Y, 2014 M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability, Ma H#, Chen H#, Guo X#, Wang Z, Sowa ME, Zheng L, Hu S, Zeng P, Guo R, Diao J, Lan F, Harper JW, Shi YG, Xu Y, Shi Y, 2012 PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression, Rajakumara E#, Wang Z#, Ma H, Hu L, Chen H, Lin Y, Guo R, Wu F, Li H, Lan F, Shi YG, Xu Y, Patel DJ, Shi Y, 2011 DNA repair gene XRCC3 polymorphisms and cancer risk: a meta-analysis of 48 case-control studies, Han S, Zhang HT, Wang Z, Xie Y, Tang R, Mao Y, Li Y, 2006 CTLA4 polymorphisms and ophthalmopathy in Graves' disease patients: association study and meta-analysis, Han S, Zhang S, Zhang W, Li R, Li Y, Wang Z, Xie Y, Mao Y, 2006 UHRF1 regulates alternative splicing by interacting with splicing factors and U snRNAs in a H3R2me involved manner, Peng Xu#, Lan Zhang#, Yao Xiao#, Wei Li#, Zhiqiang Hu#, Rukui Zhang, Jin Li, Feizhen Wu, Yanping Xi, Qingping Zou, Zhentian Wang, Rui Guo, Honghui Ma, Shihua Dong, Min Xiao, Zhicong Yang, Xiaoguang Ren, Chaochun Wei and Wenqiang Yu*, 2021

Areas of Focus

Epigenetic mechanisms in tumorigenesis, progression, metastasis, and drug resistance
Regulation mechanisms of non-histone methylation disorders in malignant tumors and clinical drug targets

Publications

SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy, Wang Z#, Hausmann S#, Lyu R, Li TM, Lofgren SM, Flores NM, Fuentes ME, Caporicci M, Yang Z, Meiners MJ, Cheek MA, Howard SA, Zhang L, Elias JE, Kim MP, Maitra A, Wang H, Bassik MC, Keogh MC, Sage J, Gozani O*, Mazur PK*, 2020
SnapShot: Lysine Methylation beyond Histones, Biggar KK, Wang Z, Li SS, 2017
Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex, Shen H#, Xu W#, Guo R, Rong B, Gu L, Wang Z, He C, Zheng L, Hu X, Hu Z, Shao ZM, Yang P, Wu F, Shi YG, Shi Y*, Lan F*, 2016
Nono, a Bivalent Domain Factor, Regulates Erk Signaling and Mouse Embryonic Stem Cell Pluripotency, Ma C, Karwacki-Neisius V, Tang H, Li W, Shi Z, Hu H, Xu W, Wang Z, Kong L, Lv R, Fan Z, Zhou W, Yang P, Wu F, Diao J, Tan L, Shi YG, Lan F*, Shi Y*, 2016
BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing, Guo R#, Zheng L#, Park JW, Lv R, Chen H, Jiao F, Xu W, Mu S, Wen H, Qiu J, Wang Z, Yang P, Wu F, Hui J, Fu X, Shi X, Shi YG, Xing Y*, Lan F*, Shi Y*, 2014
M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability, Ma H#, Chen H#, Guo X#, Wang Z, Sowa ME, Zheng L, Hu S, Zeng P, Guo R, Diao J, Lan F, Harper JW, Shi YG, Xu Y*, Shi Y*, 2012
PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression, Rajakumara E#, Wang Z#, Ma H, Hu L, Chen H, Lin Y, Guo R, Wu F, Li H, Lan F, Shi YG, Xu Y, Patel DJ*, Shi Y*, 2011
DNA repair gene XRCC3 polymorphisms and cancer risk: a meta-analysis of 48 case-control studies, Han S, Zhang HT, Wang Z, Xie Y, Tang R, Mao Y, Li Y, 2006
CTLA4 polymorphisms and ophthalmopathy in Graves' disease patients: association study and meta-analysis, Han S, Zhang S, Zhang W, Li R, Li Y, Wang Z, Xie Y, Mao Y, 2006
UHRF1 regulates alternative splicing by interacting with splicing factors and U snRNAs in a H3R2me involved manner, Peng Xu#, Lan Zhang#, Yao Xiao#, Wei Li#, Zhiqiang Hu#, Rukui Zhang, Jin Li, Feizhen Wu, Yanping Xi, Qingping Zou, Zhentian Wang, Rui Guo, Honghui Ma, Shihua Dong, Min Xiao, Zhicong Yang, Xiaoguang Ren, Chaochun Wei* and Wenqiang Yu*, 2021

Epigenetics Tumorigenesis Progression Metastasis Drug Resistance Non-Histone Methylation Malignant Tumors Clinical Drug Targets Crispr Screening Proteomics

Xiaojuan Du - Peking University

Hongquan Zhang - Peking University

Zhan Jun - Peking University

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