Professor | 汪振天 | 数字化转型顾问

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Name	汪振天
Contact Information	zhentian@fudan.edu.cn
Language ability	中文, 英语
Province	上海

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Name

汪振天

Contact Information

zhentian@fudan.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	复旦大学
Faculty	Basic Medical Sciences
Academic Background & Achievements	2000.09—2004.06 生物科学专业本科生: 华中农业大学 2005.09—2012.01 生物化学与分子生物学专业博士研究: 复旦大学
Work Experience	2012.03—2014.03 复旦大学 - 化学流动站博士后研究员 2014.03—2019.03 斯坦福大学 - 生物系博士后 2019.03—2021.01 斯坦福大学 - 基础生命科学研究员
Awards	2021: 上海市领军人才（海外）项目-第12批

University/Lab Affiliation and Title

复旦大学

Faculty

Basic Medical Sciences

Academic Background & Achievements

2000.09—2004.06 生物科学专业本科生: 华中农业大学
2005.09—2012.01 生物化学与分子生物学专业博士研究: 复旦大学

Work Experience

2012.03—2014.03 复旦大学 - 化学流动站博士后研究员
2014.03—2019.03 斯坦福大学 - 生物系博士后
2019.03—2021.01 斯坦福大学 - 基础生命科学研究员

Awards

2021: 上海市领军人才（海外）项目-第12批

Areas of Focus	肿瘤发生、发展、转移以及肿瘤耐药中的表观遗传机制非组蛋白甲基化紊乱的恶性肿瘤调控机理，及临床药物靶点
Publications	SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy, Wang Z#, Hausmann S#, Lyu R, Li TM, Lofgren SM, Flores NM, Fuentes ME, Caporicci M, Yang Z, Meiners MJ, Cheek MA, Howard SA, Zhang L, Elias JE, Kim MP, Maitra A, Wang H, Bassik MC, Keogh MC, Sage J, Gozani O, Mazur PK, 2020 SnapShot: Lysine Methylation beyond Histones, Biggar KK, Wang Z, Li SS, 2017 Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex, Shen H#, Xu W#, Guo R, Rong B, Gu L, Wang Z, He C, Zheng L, Hu X, Hu Z, Shao ZM, Yang P, Wu F, Shi YG, Shi Y, Lan F, 2016 Nono, a Bivalent Domain Factor, Regulates Erk Signaling and Mouse Embryonic Stem Cell Pluripotency, Ma C, Karwacki-Neisius V, Tang H, Li W, Shi Z, Hu H, Xu W, Wang Z, Kong L, Lv R, Fan Z, Zhou W, Yang P, Wu F, Diao J, Tan L, Shi YG, Lan F, Shi Y, 2016 BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing, Guo R#, Zheng L#, Park JW, Lv R, Chen H, Jiao F, Xu W, Mu S, Wen H, Qiu J, Wang Z, Yang P, Wu F, Hui J, Fu X, Shi X, Shi YG, Xing Y, Lan F, Shi Y, 2014 M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability, Ma H#, Chen H#, Guo X#, Wang Z, Sowa ME, Zheng L, Hu S, Zeng P, Guo R, Diao J, Lan F, Harper JW, Shi YG, Xu Y, Shi Y, 2012 PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression, Rajakumara E#, Wang Z#, Ma H, Hu L, Chen H, Lin Y, Guo R, Wu F, Li H, Lan F, Shi YG, Xu Y, Patel DJ, Shi Y, 2011 DNA repair gene XRCC3 polymorphisms and cancer risk: a meta-analysis of 48 case-control studies, Han S, Zhang HT, Wang Z, Xie Y, Tang R, Mao Y, Li Y, 2006 CTLA4 polymorphisms and ophthalmopathy in Graves' disease patients: association study and meta-analysis, Han S, Zhang S, Zhang W, Li R, Li Y, Wang Z, Xie Y, Mao Y, 2006 UHRF1 regulates alternative splicing by interacting with splicing factors and U snRNAs in a H3R2me involved manner, Peng Xu#, Lan Zhang#, Yao Xiao#, Wei Li#, Zhiqiang Hu#, Rukui Zhang, Jin Li, Feizhen Wu, Yanping Xi, Qingping Zou, Zhentian Wang, Rui Guo, Honghui Ma, Shihua Dong, Min Xiao, Zhicong Yang, Xiaoguang Ren, Chaochun Wei and Wenqiang Yu*, 2021

Areas of Focus

肿瘤发生、发展、转移以及肿瘤耐药中的表观遗传机制
非组蛋白甲基化紊乱的恶性肿瘤调控机理，及临床药物靶点

Publications

SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy, Wang Z#, Hausmann S#, Lyu R, Li TM, Lofgren SM, Flores NM, Fuentes ME, Caporicci M, Yang Z, Meiners MJ, Cheek MA, Howard SA, Zhang L, Elias JE, Kim MP, Maitra A, Wang H, Bassik MC, Keogh MC, Sage J, Gozani O*, Mazur PK*, 2020
SnapShot: Lysine Methylation beyond Histones, Biggar KK, Wang Z, Li SS, 2017
Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex, Shen H#, Xu W#, Guo R, Rong B, Gu L, Wang Z, He C, Zheng L, Hu X, Hu Z, Shao ZM, Yang P, Wu F, Shi YG, Shi Y*, Lan F*, 2016
Nono, a Bivalent Domain Factor, Regulates Erk Signaling and Mouse Embryonic Stem Cell Pluripotency, Ma C, Karwacki-Neisius V, Tang H, Li W, Shi Z, Hu H, Xu W, Wang Z, Kong L, Lv R, Fan Z, Zhou W, Yang P, Wu F, Diao J, Tan L, Shi YG, Lan F*, Shi Y*, 2016
BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing, Guo R#, Zheng L#, Park JW, Lv R, Chen H, Jiao F, Xu W, Mu S, Wen H, Qiu J, Wang Z, Yang P, Wu F, Hui J, Fu X, Shi X, Shi YG, Xing Y*, Lan F*, Shi Y*, 2014
M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability, Ma H#, Chen H#, Guo X#, Wang Z, Sowa ME, Zheng L, Hu S, Zeng P, Guo R, Diao J, Lan F, Harper JW, Shi YG, Xu Y*, Shi Y*, 2012
PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression, Rajakumara E#, Wang Z#, Ma H, Hu L, Chen H, Lin Y, Guo R, Wu F, Li H, Lan F, Shi YG, Xu Y, Patel DJ*, Shi Y*, 2011
DNA repair gene XRCC3 polymorphisms and cancer risk: a meta-analysis of 48 case-control studies, Han S, Zhang HT, Wang Z, Xie Y, Tang R, Mao Y, Li Y, 2006
CTLA4 polymorphisms and ophthalmopathy in Graves' disease patients: association study and meta-analysis, Han S, Zhang S, Zhang W, Li R, Li Y, Wang Z, Xie Y, Mao Y, 2006
UHRF1 regulates alternative splicing by interacting with splicing factors and U snRNAs in a H3R2me involved manner, Peng Xu#, Lan Zhang#, Yao Xiao#, Wei Li#, Zhiqiang Hu#, Rukui Zhang, Jin Li, Feizhen Wu, Yanping Xi, Qingping Zou, Zhentian Wang, Rui Guo, Honghui Ma, Shihua Dong, Min Xiao, Zhicong Yang, Xiaoguang Ren, Chaochun Wei* and Wenqiang Yu*, 2021

表观遗传学肿瘤发生进展转移耐药性非组蛋白甲基化恶性肿瘤临床药物靶点 Crispr筛选蛋白质组学

王青青 - 浙江大学

来利华 - 浙江大学

杜军 - 南京医科大学

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