Professor | Xu Wenwen | Asia Growth Partners

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Name	Xu Wenwen
Contact Information	xuwen6966@163.com
Language ability	Chinese, English
Province	Guangdong

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Name

Xu Wenwen

Contact Information

xuwen6966@163.com

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Guangzhou Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	Doctorate: Guangzhou Medical University PI at National Key Laboratory of Respiratory Diseases Distinguished Talent of Guangzhou Medical University 'Nanshan Scholar' Guangdong Outstanding Youth Hong Kong Young Scientist
Awards	2022: Guangdong Outstanding Youth 2021: Nanshan Scholar Leading Talent 2017: Guangdong 'Pearl River Scholar (Youth)' 2017: Hong Kong Young Scientist 2020: Wang Kuancheng Young Scholar

University/Lab Affiliation and Title

Guangzhou Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

Doctorate: Guangzhou Medical University
PI at National Key Laboratory of Respiratory Diseases
Distinguished Talent of Guangzhou Medical University 'Nanshan Scholar'
Guangdong Outstanding Youth
Hong Kong Young Scientist

Awards

2022: Guangdong Outstanding Youth
2021: Nanshan Scholar Leading Talent
2017: Guangdong 'Pearl River Scholar (Youth)'
2017: Hong Kong Young Scientist
2020: Wang Kuancheng Young Scholar

Areas of Focus	Functional screening and identification of tumor markers Tumor microenvironment and macro environment Screening and preclinical evaluation of targeted anticancer drugs
Publications	KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer., Zheng CC, et al, Xu WW., 2023 Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis., Xu WW#, Liao L#, Dai W, Zheng CC, Tan XP, He Y, Zhang QH, Huang ZH, Chen WY, Qin YR, Chen KS, He ML, Law S, Lung ML, He QY, Li B, 2023 Blockade of the nuclear β-catenin signaling via direct targeting of RanBP3 with NU2058 induces cell senescence to suppress colorectal tumorigenesis., Zheng CC#, Liao L#, Liu YP#, Yang YM, He Y, Zhang GG, Li S, Liu T, Xu WW, Li B, 2022 Molecular functions and therapeutic applications of exosomal noncoding RNAs in cancer., Liu QW, He Y, Xu WW., 2022 Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy., Zuo Q, Yao ZT, Liu YP, Wang DK, Liao L, Li SJ, Yin XF, He QY, Xu WW., 2021 Lomerizine 2HCl Inhibits Cell Proliferation and Induces Protective Autophagy in Colorectal Cancer via the PI3K/Akt/mTOR Signaling Pathway., Tan XP#, He Y#, Huang YN, Zheng CC, Li JQ, Liu QW, He ML, Li B, Xu WW., 2021 Maprotiline Suppresses Cholesterol Biosynthesis and Hepatocellular Carcinoma Progression Through Direct Targeting of CRABP1., Zheng CC#, Zhu YD#, Liu QW, Luo TT, Xu WW., 2021 Microbiota in cancer chemoradiotherapy resistance., He Y, Liu QW, Liao HX, Xu WW., 2021 Genome-wide identification of key regulatory lncRNAs in esophageal cancer metastasis., Xu WW#, Zheng CC#, Zuo Q#, Li JQ, Hong P, Qin YR, Guan XY, He QY, Liao HX, Li B., 2021 Direct Targeting of CREB1 with Imperatorin Inhibits TGFβ2-ERK Signaling to Suppress Esophageal Cancer Metastasis., Xu WW#, Huang ZH#, Liao L, Zhang QH, Li JQ, Zheng CC, He Y, Luo TT, Wang Y, Hu HF, Zuo Q, Chen WY, Yang QS, Zhao JF, Qin YR, Xu LY, Li EM, Liao HX, L Bi, He QY., 2020 Advances in targeted therapy for esophageal cancer., Yang YM#, Hong P#, Xu WW, He QY, Li B., 2020 Epigenetics in Esophageal Cancer: From Mechanisms to Therapeutics., Liao L, Yao ZT, Fang WK, He QY, Xu WW, Li B., 2020 Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis., Hong P#, Liu QW#, Xie Y, Zhang QH, Liao L, He QY, Li B, Xu WW., 2020 Identification of miR-29c and its target FBXO31 as key regulatory mechanism in esophageal cancer chemoresistance-functional validation and clinical significance., Li B, Hong P, Zheng CC, Dai W, Chen WY, Yang QS, Han L, Tsao SW, Chan KT, Lee NP, Simon Law, Xu LY, Li EM, Chan KW, Qin YR, Guan XY, Lung ML, He QY, Xu WW, Cheung AL., 2019 Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression., Xu WW#, Li B#, Guan XY, Chung SK, Wang Y, Yip YL, Law SY, Chan KT, Chan KT, Lee PY, Chan KW, Xu LY, Li EM, Tsao SW, He QY, Cheung AL*., 2017 MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF., Li B#, Xu WW#, Han L, Chan KT, Tsao SW, Lee NP, Law S, Xu LY, Li EM, Chan KW, Qin YR, Guan XY, He QY, Cheung AL., 2017

Areas of Focus

Functional screening and identification of tumor markers
Tumor microenvironment and macro environment
Screening and preclinical evaluation of targeted anticancer drugs

Publications

KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer., Zheng CC, et al, Xu WW., 2023
Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis., Xu WW#, Liao L#, Dai W, Zheng CC, Tan XP, He Y, Zhang QH, Huang ZH, Chen WY, Qin YR, Chen KS, He ML, Law S, Lung ML, He QY, Li B*, 2023
Blockade of the nuclear β-catenin signaling via direct targeting of RanBP3 with NU2058 induces cell senescence to suppress colorectal tumorigenesis., Zheng CC#, Liao L#, Liu YP#, Yang YM, He Y, Zhang GG, Li S, Liu T, Xu WW*, Li B*, 2022
Molecular functions and therapeutic applications of exosomal noncoding RNAs in cancer., Liu QW, He Y, Xu WW*., 2022
Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy., Zuo Q, Yao ZT, Liu YP, Wang DK, Liao L, Li SJ, Yin XF, He QY, Xu WW*., 2021
Lomerizine 2HCl Inhibits Cell Proliferation and Induces Protective Autophagy in Colorectal Cancer via the PI3K/Akt/mTOR Signaling Pathway., Tan XP#, He Y#, Huang YN, Zheng CC, Li JQ, Liu QW, He ML, Li B*, Xu WW*., 2021
Maprotiline Suppresses Cholesterol Biosynthesis and Hepatocellular Carcinoma Progression Through Direct Targeting of CRABP1., Zheng CC#, Zhu YD#, Liu QW, Luo TT, Xu WW*., 2021
Microbiota in cancer chemoradiotherapy resistance., He Y, Liu QW, Liao HX*, Xu WW*., 2021
Genome-wide identification of key regulatory lncRNAs in esophageal cancer metastasis., Xu WW#, Zheng CC#, Zuo Q#, Li JQ, Hong P, Qin YR, Guan XY, He QY, Liao HX*, Li B*., 2021
Direct Targeting of CREB1 with Imperatorin Inhibits TGFβ2-ERK Signaling to Suppress Esophageal Cancer Metastasis., Xu WW#*, Huang ZH#, Liao L, Zhang QH, Li JQ, Zheng CC, He Y, Luo TT, Wang Y, Hu HF, Zuo Q, Chen WY, Yang QS, Zhao JF, Qin YR, Xu LY, Li EM, Liao HX, L Bi*, He QY*., 2020
Advances in targeted therapy for esophageal cancer., Yang YM#, Hong P#, Xu WW*, He QY*, Li B*., 2020
Epigenetics in Esophageal Cancer: From Mechanisms to Therapeutics., Liao L, Yao ZT, Fang WK, He QY*, Xu WW*, Li B*., 2020
Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis., Hong P#, Liu QW#, Xie Y, Zhang QH, Liao L, He QY, Li B*, Xu WW*., 2020
Identification of miR-29c and its target FBXO31 as key regulatory mechanism in esophageal cancer chemoresistance-functional validation and clinical significance., Li B, Hong P, Zheng CC, Dai W, Chen WY, Yang QS, Han L, Tsao SW, Chan KT, Lee NP, Simon Law, Xu LY, Li EM, Chan KW, Qin YR, Guan XY, Lung ML, He QY, Xu WW*, Cheung AL*., 2019
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression., Xu WW#, Li B#, Guan XY, Chung SK, Wang Y, Yip YL, Law SY, Chan KT, Chan KT, Lee PY, Chan KW, Xu LY, Li EM, Tsao SW, He QY*, Cheung AL*., 2017
MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF., Li B#, Xu WW#, Han L, Chan KT, Tsao SW, Lee NP, Law S, Xu LY, Li EM, Chan KW, Qin YR, Guan XY, He QY, Cheung AL., 2017

Tumor Markers Screening Identification Tumor Microenvironment Macro Environment Targeted Drugs Anticancer Preclinical Evaluation Cancer Therapy

Jun Zhang - Peking University

Feng Li - Wuhan University

Yan Liu - Wuhan University

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