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Xu Wenwen
Basic Medical Sciences
Guangzhou Medical University
Guangdong
Language: Chinese, English
Tumor Markers
Screening
Identification
Tumor Microenvironment
Macro Environment
Targeted Drugs
Anticancer
Preclinical Evaluation
Cancer
Therapy
Areas of Focus
- Functional screening and identification of tumor markers
- Tumor microenvironment and macro environment
- Screening and preclinical evaluation of targeted anticancer drugs
Academic Background & Achievements
- Doctorate: Guangzhou Medical University
- PI at National Key Laboratory of Respiratory Diseases
- Distinguished Talent of Guangzhou Medical University 'Nanshan Scholar'
- Guangdong Outstanding Youth
- Hong Kong Young Scientist
Publications
- KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer., Zheng CC, et al, Xu WW., 2023
- Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis., Xu WW#, Liao L#, Dai W, Zheng CC, Tan XP, He Y, Zhang QH, Huang ZH, Chen WY, Qin YR, Chen KS, He ML, Law S, Lung ML, He QY, Li B*, 2023
- Blockade of the nuclear β-catenin signaling via direct targeting of RanBP3 with NU2058 induces cell senescence to suppress colorectal tumorigenesis., Zheng CC#, Liao L#, Liu YP#, Yang YM, He Y, Zhang GG, Li S, Liu T, Xu WW*, Li B*, 2022
- Molecular functions and therapeutic applications of exosomal noncoding RNAs in cancer., Liu QW, He Y, Xu WW*., 2022
- Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy., Zuo Q, Yao ZT, Liu YP, Wang DK, Liao L, Li SJ, Yin XF, He QY, Xu WW*., 2021
- Lomerizine 2HCl Inhibits Cell Proliferation and Induces Protective Autophagy in Colorectal Cancer via the PI3K/Akt/mTOR Signaling Pathway., Tan XP#, He Y#, Huang YN, Zheng CC, Li JQ, Liu QW, He ML, Li B*, Xu WW*., 2021
- Maprotiline Suppresses Cholesterol Biosynthesis and Hepatocellular Carcinoma Progression Through Direct Targeting of CRABP1., Zheng CC#, Zhu YD#, Liu QW, Luo TT, Xu WW*., 2021
- Microbiota in cancer chemoradiotherapy resistance., He Y, Liu QW, Liao HX*, Xu WW*., 2021
- Genome-wide identification of key regulatory lncRNAs in esophageal cancer metastasis., Xu WW#, Zheng CC#, Zuo Q#, Li JQ, Hong P, Qin YR, Guan XY, He QY, Liao HX*, Li B*., 2021
- Direct Targeting of CREB1 with Imperatorin Inhibits TGFβ2-ERK Signaling to Suppress Esophageal Cancer Metastasis., Xu WW#*, Huang ZH#, Liao L, Zhang QH, Li JQ, Zheng CC, He Y, Luo TT, Wang Y, Hu HF, Zuo Q, Chen WY, Yang QS, Zhao JF, Qin YR, Xu LY, Li EM, Liao HX, L Bi*, He QY*., 2020
- Advances in targeted therapy for esophageal cancer., Yang YM#, Hong P#, Xu WW*, He QY*, Li B*., 2020
- Epigenetics in Esophageal Cancer: From Mechanisms to Therapeutics., Liao L, Yao ZT, Fang WK, He QY*, Xu WW*, Li B*., 2020
- Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis., Hong P#, Liu QW#, Xie Y, Zhang QH, Liao L, He QY, Li B*, Xu WW*., 2020
- Identification of miR-29c and its target FBXO31 as key regulatory mechanism in esophageal cancer chemoresistance-functional validation and clinical significance., Li B, Hong P, Zheng CC, Dai W, Chen WY, Yang QS, Han L, Tsao SW, Chan KT, Lee NP, Simon Law, Xu LY, Li EM, Chan KW, Qin YR, Guan XY, Lung ML, He QY, Xu WW*, Cheung AL*., 2019
- Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression., Xu WW#, Li B#, Guan XY, Chung SK, Wang Y, Yip YL, Law SY, Chan KT, Chan KT, Lee PY, Chan KW, Xu LY, Li EM, Tsao SW, He QY*, Cheung AL*., 2017
- MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF., Li B#, Xu WW#, Han L, Chan KT, Tsao SW, Lee NP, Law S, Xu LY, Li EM, Chan KW, Qin YR, Guan XY, He QY, Cheung AL., 2017
Awards
- 2022: Guangdong Outstanding Youth
- 2021: Nanshan Scholar Leading Talent
- 2017: Guangdong 'Pearl River Scholar (Youth)'
- 2017: Hong Kong Young Scientist
- 2020: Wang Kuancheng Young Scholar
