Professor | Feng Li | Asia Growth Partners

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Name	Feng Li
Contact Information	fli222@whu.edu.cn
Language ability	Chinese, English
Province	Hubei

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Name

Feng Li

Contact Information

fli222@whu.edu.cn

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1998-2002: Bachelor's Degree from Huazhong Agricultural University 2002-2008: Joint PhD program at Huazhong Agricultural University & Institute of Biophysics, Chinese Academy of Sciences
Work Experience	2008-2013: Postdoctoral Researcher at University of Kentucky College of Medicine 2013-present: Professor and Doctoral Supervisor at Wuhan University, Department of Medical Genetics

University/Lab Affiliation and Title

Wuhan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1998-2002: Bachelor's Degree from Huazhong Agricultural University
2002-2008: Joint PhD program at Huazhong Agricultural University & Institute of Biophysics, Chinese Academy of Sciences

Work Experience

2008-2013: Postdoctoral Researcher at University of Kentucky College of Medicine
2013-present: Professor and Doctoral Supervisor at Wuhan University, Department of Medical Genetics

Areas of Focus	Targeted cancer therapy Epigenetic-based cancer therapy Tumor cell signaling pathways Subcellular structure mechanisms
Publications	Aggresome formation promotes ASK1/JNK signaling activation and stemness maintenance in ovarian cancer, Feng Li et al., 2024 KDM5C mediated recruitment of BRD4 to chromatin regulates enhancer activation and BET inhibitor sensitivity, Feng Li et al., 2024 A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis (NASH) in mice via binding and relocating acetyl-coA carboxylase, Feng Li et al., 2023 Oncogenic BRAF noncanonically promotes tumor metastasis by mediating VASP phosphorylation and filopodia formation, Feng Li et al., 2023 The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region, Feng Li et al., 2023 Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis, Feng Li et al., 2021 Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019, Feng Li et al., 2020 Histone demethylase KDM4B promotes DNA damage by activating long interspersed nuclear element-1, Feng Li et al., 2019 E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the EGFR and c-MET Oncogenes by Destabilizing the Histone Demethylase KDM5C, Feng Li et al., 2018 Regulation of Mismatch Repair by Histone Code and Posttranslational Modifications in Eukaryotic Cells, Feng Li et al., 2016 The histone mark H3K36me3 regulate human mismatch repair through its interaction with MutSalpha, Feng Li et al., 2013

Areas of Focus

Targeted cancer therapy
Epigenetic-based cancer therapy
Tumor cell signaling pathways
Subcellular structure mechanisms

Publications

Aggresome formation promotes ASK1/JNK signaling activation and stemness maintenance in ovarian cancer, Feng Li et al., 2024
KDM5C mediated recruitment of BRD4 to chromatin regulates enhancer activation and BET inhibitor sensitivity, Feng Li et al., 2024
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis (NASH) in mice via binding and relocating acetyl-coA carboxylase, Feng Li et al., 2023
Oncogenic BRAF noncanonically promotes tumor metastasis by mediating VASP phosphorylation and filopodia formation, Feng Li et al., 2023
The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region, Feng Li et al., 2023
Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis, Feng Li et al., 2021
Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019, Feng Li et al., 2020
Histone demethylase KDM4B promotes DNA damage by activating long interspersed nuclear element-1, Feng Li et al., 2019
E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the EGFR and c-MET Oncogenes by Destabilizing the Histone Demethylase KDM5C, Feng Li et al., 2018
Regulation of Mismatch Repair by Histone Code and Posttranslational Modifications in Eukaryotic Cells, Feng Li et al., 2016
The histone mark H3K36me3 regulate human mismatch repair through its interaction with MutSalpha, Feng Li et al., 2013

Cancer Therapy Targeted Epigenetics Signaling Protein Complexes Subcellular Mechanisms Pathophysiology Identification

Jing Liang - Peking University

Luyang Sun - Peking University

Zhang Yu - Peking University

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