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Zhang Yu
Basic Medical Sciences
Peking University
Beijing
Language: Chinese, English
Epigenetics
Gene Transcription
Cancer
Aging
Cellular Dysfunction
Dna Modifications
Histone Modifications
Transcription Factors
Chromatin Structure
3D Genome
Areas of Focus
- Epigenetic regulation of gene transcription and its dysregulation in cancer, aging, and other cellular dysfunctions
Academic Background & Achievements
- PhD: Peking University, Biochemistry and Molecular Biology
- Bachelor: Peking University, Clinical Medicine
Publications
- Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering, Zhang Yu et al., 2016
- UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1, Zhang Yu et al., 2021
- CRL4DCAF8 dependent opposing stability control over the chromatin remodeler LSH orchestrates epigenetic dynamics in ferroptosis, Zhang Yu et al., 2021
- FOXA1 mediates p16INK4a activation during cellular senescence, Zhang Yu et al., 2013
- TRPS1 drives heterochromatic origin refiring and cancer genome evolution, Zhang Yu et al., 2021
- EZH2 reduction is an essential mechanoresponse for the maintenance of super-enhancer polarization against compressive stress in human periodontal ligament stem cells, Zhang Yu et al., 2020
- TRAF-interacting protein with forkhead-associated domain (TIFA) transduces DNA damage–induced activation of NF-κB, Zhang Yu et al., 2018
Awards
- National Ten Thousand Talent Program 'Young Top-notch Talent' Award
