Professor | Zhengwei Xie | Asia Growth Partners

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Name	Zhengwei Xie
Contact Information	xiezhengwei@bjmu.edu.cn
Language ability	Chinese, English
Province	Beijing

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Name

Zhengwei Xie

Contact Information

xiezhengwei@bjmu.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Basic Medical Sciences
Academic Background & Achievements	PhD: Peking University Developed the first aging microfluidic chip and discovered aging marker protein HSP104 Discovered early senescence phenomena and its protective mechanisms during the initial period of telomerase inactivation Invented the Hyper-Cube Shrink Algorithm for calculating enzyme-flux relationships in metabolic networks Revealed the molecular mechanism by which berberine extends the lifespan of wild mice
Work Experience	Current - Peking University, Institute of Cancer Research and Basic Medical Sciences - Associate Researcher, Assistant Professor
Awards	2016: Top Ten Advances in Chinese Medical Science Research 2021: Top Ten Advances in Chinese Bioinformatics

University/Lab Affiliation and Title

Peking University

Faculty

Basic Medical Sciences

Academic Background & Achievements

PhD: Peking University
Developed the first aging microfluidic chip and discovered aging marker protein HSP104
Discovered early senescence phenomena and its protective mechanisms during the initial period of telomerase inactivation
Invented the Hyper-Cube Shrink Algorithm for calculating enzyme-flux relationships in metabolic networks
Revealed the molecular mechanism by which berberine extends the lifespan of wild mice

Work Experience

Current - Peking University, Institute of Cancer Research and Basic Medical Sciences - Associate Researcher, Assistant Professor

Awards

2016: Top Ten Advances in Chinese Medical Science Research
2021: Top Ten Advances in Chinese Bioinformatics

Areas of Focus	AI-based drug development systems Molecular mechanisms of aging and lifespan-extending drugs Drug development for diseases like cancer, obesity, non-alcoholic steatohepatitis, stem cells, gout, osteoporosis
Publications	Prediction of Drug Efficacy from Transcriptional Profiles with Deep Learning, Zhengwei Xie et al., 2021 Expression and Prognostic Characteristics of Ferroptosis-related Gene in Colon Cancer, Zhengwei Xie et al., 2021 Multiple-purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis, Zhengwei Xie et al., 2020 Prognostic model of patients with liver cancer based on tumor stem cell content and immune process, Zhengwei Xie et al., 2020 Prediction and Optimization of NaV1.7 Sodium Channel Inhibitors Based on Machine Learning and Simulated Annealing, Zhengwei Xie et al., 2020 Identification of Key Genes Related to Lung Squamous Cell Carcinoma Using Bioinformatics Analysis, Zhengwei Xie et al., 2020 Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression, Zhengwei Xie et al., 2020 Inhibition of Histone Acetyltransferase GCN5 Extends Lifespan in both Yeast and Human Cell Lines, Zhengwei Xie et al., 2020 Genome-scale fluxes were predicted under the guidance of enzyme abundance using a novel Hyper-Cube Shrink Algorithm, Zhengwei Xie et al., 2018 Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length, Zhengwei Xie et al., 2015 Molecular Phenotyping of Aging in Single Yeast Cells Using a Novel Microfluidic Device, Zhengwei Xie et al., 2012

Areas of Focus

AI-based drug development systems
Molecular mechanisms of aging and lifespan-extending drugs
Drug development for diseases like cancer, obesity, non-alcoholic steatohepatitis, stem cells, gout, osteoporosis

Publications

Prediction of Drug Efficacy from Transcriptional Profiles with Deep Learning, Zhengwei Xie et al., 2021
Expression and Prognostic Characteristics of Ferroptosis-related Gene in Colon Cancer, Zhengwei Xie et al., 2021
Multiple-purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis, Zhengwei Xie et al., 2020
Prognostic model of patients with liver cancer based on tumor stem cell content and immune process, Zhengwei Xie et al., 2020
Prediction and Optimization of NaV1.7 Sodium Channel Inhibitors Based on Machine Learning and Simulated Annealing, Zhengwei Xie et al., 2020
Identification of Key Genes Related to Lung Squamous Cell Carcinoma Using Bioinformatics Analysis, Zhengwei Xie et al., 2020
Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression, Zhengwei Xie et al., 2020
Inhibition of Histone Acetyltransferase GCN5 Extends Lifespan in both Yeast and Human Cell Lines, Zhengwei Xie et al., 2020
Genome-scale fluxes were predicted under the guidance of enzyme abundance using a novel Hyper-Cube Shrink Algorithm, Zhengwei Xie et al., 2018
Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length, Zhengwei Xie et al., 2015
Molecular Phenotyping of Aging in Single Yeast Cells Using a Novel Microfluidic Device, Zhengwei Xie et al., 2012

Artificial Intelligence Drug Development Aging Molecular Mechanisms Lifespan Extension Cancer Obesity Non-Alcoholic Steatohepatitis Stem Cells Osteoporosis

Zhang Yu - Peking University

Chengjun Hu - Wuhan University

Yueshan Lei - Wuhan University

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