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Zhengwei Xie
Basic Medical Sciences
Peking University
Beijing
Language: Chinese, English
Artificial Intelligence
Drug Development
Aging
Molecular Mechanisms
Lifespan Extension
Cancer
Obesity
Non-Alcoholic Steatohepatitis
Stem Cells
Osteoporosis
Areas of Focus
- AI-based drug development systems
- Molecular mechanisms of aging and lifespan-extending drugs
- Drug development for diseases like cancer, obesity, non-alcoholic steatohepatitis, stem cells, gout, osteoporosis
Work Experience
- Current - Peking University, Institute of Cancer Research and Basic Medical Sciences - Associate Researcher, Assistant Professor
Academic Background & Achievements
- PhD: Peking University
- Developed the first aging microfluidic chip and discovered aging marker protein HSP104
- Discovered early senescence phenomena and its protective mechanisms during the initial period of telomerase inactivation
- Invented the Hyper-Cube Shrink Algorithm for calculating enzyme-flux relationships in metabolic networks
- Revealed the molecular mechanism by which berberine extends the lifespan of wild mice
Publications
- Prediction of Drug Efficacy from Transcriptional Profiles with Deep Learning, Zhengwei Xie et al., 2021
- Expression and Prognostic Characteristics of Ferroptosis-related Gene in Colon Cancer, Zhengwei Xie et al., 2021
- Multiple-purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis, Zhengwei Xie et al., 2020
- Prognostic model of patients with liver cancer based on tumor stem cell content and immune process, Zhengwei Xie et al., 2020
- Prediction and Optimization of NaV1.7 Sodium Channel Inhibitors Based on Machine Learning and Simulated Annealing, Zhengwei Xie et al., 2020
- Identification of Key Genes Related to Lung Squamous Cell Carcinoma Using Bioinformatics Analysis, Zhengwei Xie et al., 2020
- Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression, Zhengwei Xie et al., 2020
- Inhibition of Histone Acetyltransferase GCN5 Extends Lifespan in both Yeast and Human Cell Lines, Zhengwei Xie et al., 2020
- Genome-scale fluxes were predicted under the guidance of enzyme abundance using a novel Hyper-Cube Shrink Algorithm, Zhengwei Xie et al., 2018
- Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length, Zhengwei Xie et al., 2015
- Molecular Phenotyping of Aging in Single Yeast Cells Using a Novel Microfluidic Device, Zhengwei Xie et al., 2012
Awards
- 2016: Top Ten Advances in Chinese Medical Science Research
- 2021: Top Ten Advances in Chinese Bioinformatics
