Professor | 李枫 | 数字化转型顾问

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Name	李枫
Contact Information	fli222@whu.edu.cn
Language ability	中文, 英语
Province	湖北省

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Name

李枫

Contact Information

fli222@whu.edu.cn

Language ability

中文, 英语

Province

湖北省

University/Lab Affiliation and Title	武汉大学
Faculty	Basic Medical Sciences
Academic Background & Achievements	1998-2002: 华中农业大学，攻读学士学位 2002-2008: 华中农业大学&中国科学院生物物理研究所联合培养，硕博连读
Work Experience	2008-2013: University of Kentucky College of Medicine, 博士后 2013-至今: 武汉大学医学遗传学系，教授、博导

University/Lab Affiliation and Title

武汉大学

Faculty

Basic Medical Sciences

Academic Background & Achievements

1998-2002: 华中农业大学，攻读学士学位
2002-2008: 华中农业大学&中国科学院生物物理研究所联合培养，硕博连读

Work Experience

2008-2013: University of Kentucky College of Medicine, 博士后
2013-至今: 武汉大学医学遗传学系，教授、博导

Areas of Focus	肿瘤靶向治疗基于肿瘤表观遗传的靶向治疗研究肿瘤细胞信号通路蛋白复合物的鉴定和功能研究新型亚细胞结构的发生机制与病理生理功能研究
Publications	Aggresome formation promotes ASK1/JNK signaling activation and stemness maintenance in ovarian cancer, 李枫等., 2024 KDM5C mediated recruitment of BRD4 to chromatin regulates enhancer activation and BET inhibitor sensitivity, 李枫等., 2024 A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis (NASH) in mice via binding and relocating acetyl-coA carboxylase, 李枫等., 2023 Oncogenic BRAF noncanonically promotes tumor metastasis by mediating VASP phosphorylation and filopodia formation, 李枫等., 2023 The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region, 李枫等., 2023 Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis, 李枫等., 2021 Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019, 李枫等., 2020 Histone demethylase KDM4B promotes DNA damage by activating long interspersed nuclear element-1, 李枫等., 2019 E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the EGFR and c-MET Oncogenes by Destabilizing the Histone Demethylase KDM5C, 李枫等., 2018 Regulation of Mismatch Repair by Histone Code and Posttranslational Modifications in Eukaryotic Cells, 李枫等., 2016 The histone mark H3K36me3 regulate human mismatch repair through its interaction with MutSalpha, 李枫等., 2013

Areas of Focus

肿瘤靶向治疗
基于肿瘤表观遗传的靶向治疗研究
肿瘤细胞信号通路蛋白复合物的鉴定和功能研究
新型亚细胞结构的发生机制与病理生理功能研究

Publications

Aggresome formation promotes ASK1/JNK signaling activation and stemness maintenance in ovarian cancer, 李枫等., 2024
KDM5C mediated recruitment of BRD4 to chromatin regulates enhancer activation and BET inhibitor sensitivity, 李枫等., 2024
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis (NASH) in mice via binding and relocating acetyl-coA carboxylase, 李枫等., 2023
Oncogenic BRAF noncanonically promotes tumor metastasis by mediating VASP phosphorylation and filopodia formation, 李枫等., 2023
The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region, 李枫等., 2023
Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis, 李枫等., 2021
Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019, 李枫等., 2020
Histone demethylase KDM4B promotes DNA damage by activating long interspersed nuclear element-1, 李枫等., 2019
E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the EGFR and c-MET Oncogenes by Destabilizing the Histone Demethylase KDM5C, 李枫等., 2018
Regulation of Mismatch Repair by Histone Code and Posttranslational Modifications in Eukaryotic Cells, 李枫等., 2016
The histone mark H3K36me3 regulate human mismatch repair through its interaction with MutSalpha, 李枫等., 2013

癌症治疗靶向表观遗传学信号蛋白复合体亚细胞机制病理生理鉴定

熊洁 - 武汉大学

Area of Focus
癌症 | 治疗 | 靶点 | 肿瘤 | 表观遗传学 | 信号 | 通路 | 鉴定 | 机制 | 蛋白

周艳宏 - 中南大学

Area of Focus
肿瘤 | 微环境 | 癌症 | 发展 | 细胞 | 信号 | 代谢 | 免疫 | 分子 | 病理 | 恶性 | 机制 | 遗传

唐修文 - 浙江大学

Area of Focus
Nrf2 | Are | 信号 | 通路 | 肿瘤 | 耐药 | 微环境 | 代谢 | 癌症 | 生物化学

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