Professor | Wang Jinheng | Asia Growth Partners

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Name	Wang Jinheng
Contact Information	wangjh89@gzhmu.edu.cn
Language ability	English, Chinese
Province	Guangdong

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Name

Wang Jinheng

Contact Information

wangjh89@gzhmu.edu.cn

Language ability

English, Chinese

Province

Guangdong

University/Lab Affiliation and Title	Guangzhou Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2016 - PhD: Vrije Universiteit Brussel Published over 20 SCI papers with more than 1300 citations Received 2 national invention patents
Awards	Guided students to win various academic awards

University/Lab Affiliation and Title

Guangzhou Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2016 - PhD: Vrije Universiteit Brussel
Published over 20 SCI papers with more than 1300 citations
Received 2 national invention patents

Awards

Guided students to win various academic awards

Areas of Focus	Regulation and modification of immune microenvironment by exosomes Role of exosomes in tumor development, drug resistance, and immunotherapy Exploration of new targets for tumor immunotherapy
Publications	Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells, Wang Jinheng, Hendrix An, Hernot Sophie, Lemaire Miguel, De Bruyne Elke, Van Valckenborgh Els, Lahoutte Tony, De Wever Olivier, Vanderkerken Karin, Menu Eline, 2014 Hypoxic bone marrow stromal cells secrete miR-140-5p and miR-28-3p that target SPRED1 to confer drug resistance in multiple myeloma, Zhang Hui, Du Zhimin, Tu Chenggong, Zhou Xinyan, Menu Eline, Wang Jinheng, 2024 Tumour-derived small extracellular vesicles contribute to the tumour progression through reshaping the systemic immune macroenvironment, Du Zhimin, Zhang Hui, Feng Yueyuan, Zhan Dewen, Li Shuya, Tu Chenggong, Liu Jinbao, Wang Jinheng, 2023 Loading of metal isotope-containing intercalators for mass cytometry-based high-throughput quantitation of exosome uptake at the single-cell level, Wang Jinheng, Tu Chenggong, Zhang Hui, Zhang Jian, Feng Yueyuan, Deng Yangyang, Huo Yongliang, Xie Maobin, Yang Bin, Zhou Miao, Liu Jinbao, 2020 Endocytic pathway inhibition attenuates extracellular vesicle-induced reduction of chemosensitivity to bortezomib in multiple myeloma cells, Tu Chenggong, Du Zhimin, Zhang Hui, Feng Yueyuan, Qi Yujun, Zheng Yongjiang, Liu Jinbao, Wang Jinheng, 2021 Melanoma-derived small extracellular vesicles remodel the systemic onco-immunity via disrupting hematopoietic stem cell proliferation and differentiation, Du Zhimin, Feng Yueyuan, Zhang Hui, Liu Jinbao, Wang Jinheng, 2022 Multiple myeloma exosomes establish a favourable bone marrow microenvironment with enhanced angiogenesis and immunosuppression, Wang Jinheng, De Veirman Kim, Faict Sylvia, Antonia Frassanito Maria, Ribatti Domenico, Vacca Angelo, Menu Eline, 2016 Induction of miR-146a by multiple myeloma cells in mesenchymal stromal cells stimulates their pro-tumoral activity, De Veirman Kim, Wang Jinheng, Xu Song, Leleu Xavier, Himpe Eddy, Maes Ken, De Bruyne Elke, Van Valckenborgh Els, Vanderkerken Karin, Menu Eline, Van Riet Ivan, 2016 Bilirubin ameliorates murine atherosclerosis through inhibiting cholesterol synthesis and reshaping the immune system, Wen Guanmei, Yao Leyi, Hao Yali, Wang Jinheng, Liu Jinbao, 2022 Induction of Heme Oxygenase-1 Modifies the Systemic Immunity and Reduces Atherosclerotic Lesion Development in ApoE Deficient Mice, Yao Leyi, Hao Yali, Wen Guanmei, Xiao Qingzhong, Wu Penglong, Wang Jinheng, Liu Jinbao, 2022 Single-cell analysis at the protein level delineates intracellular signaling dynamic during hematopoiesis, Wang Jinheng, Tu Chenggong, Zhang Hui, Huo Yongliang, Menu Eline, Liu Jinbao, 2021 Identification of the immune checkpoint signature of multiple myeloma using mass cytometry-based single-cell analysis, Wang Jinheng, Zheng Yongjiang, Tu Chenggong, Zhang Hui, Vanderkerken Karin, Menu Eline, Liu Jinbao, 2020 Inhibition of multiple myeloma-derived exosomes uptake suppresses the functional response in bone marrow stromal cell, Zheng Yongjiang, Tu Chenggong, Zhang Jingwen, Wang Jinheng, 2019 Exosome-Based Cancer Therapy: Implication for Targeting Cancer Stem Cells, Wang Jinheng, Zheng Yongjiang, Zhao Meng, 2017

Areas of Focus

Regulation and modification of immune microenvironment by exosomes
Role of exosomes in tumor development, drug resistance, and immunotherapy
Exploration of new targets for tumor immunotherapy

Publications

Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells, Wang Jinheng, Hendrix An, Hernot Sophie, Lemaire Miguel, De Bruyne Elke, Van Valckenborgh Els, Lahoutte Tony, De Wever Olivier, Vanderkerken Karin, Menu Eline, 2014
Hypoxic bone marrow stromal cells secrete miR-140-5p and miR-28-3p that target SPRED1 to confer drug resistance in multiple myeloma, Zhang Hui, Du Zhimin, Tu Chenggong, Zhou Xinyan, Menu Eline, Wang Jinheng, 2024
Tumour-derived small extracellular vesicles contribute to the tumour progression through reshaping the systemic immune macroenvironment, Du Zhimin, Zhang Hui, Feng Yueyuan, Zhan Dewen, Li Shuya, Tu Chenggong, Liu Jinbao, Wang Jinheng, 2023
Loading of metal isotope-containing intercalators for mass cytometry-based high-throughput quantitation of exosome uptake at the single-cell level, Wang Jinheng, Tu Chenggong, Zhang Hui, Zhang Jian, Feng Yueyuan, Deng Yangyang, Huo Yongliang, Xie Maobin, Yang Bin, Zhou Miao, Liu Jinbao, 2020
Endocytic pathway inhibition attenuates extracellular vesicle-induced reduction of chemosensitivity to bortezomib in multiple myeloma cells, Tu Chenggong, Du Zhimin, Zhang Hui, Feng Yueyuan, Qi Yujun, Zheng Yongjiang, Liu Jinbao, Wang Jinheng, 2021
Melanoma-derived small extracellular vesicles remodel the systemic onco-immunity via disrupting hematopoietic stem cell proliferation and differentiation, Du Zhimin, Feng Yueyuan, Zhang Hui, Liu Jinbao, Wang Jinheng, 2022
Multiple myeloma exosomes establish a favourable bone marrow microenvironment with enhanced angiogenesis and immunosuppression, Wang Jinheng, De Veirman Kim, Faict Sylvia, Antonia Frassanito Maria, Ribatti Domenico, Vacca Angelo, Menu Eline, 2016
Induction of miR-146a by multiple myeloma cells in mesenchymal stromal cells stimulates their pro-tumoral activity, De Veirman Kim, Wang Jinheng, Xu Song, Leleu Xavier, Himpe Eddy, Maes Ken, De Bruyne Elke, Van Valckenborgh Els, Vanderkerken Karin, Menu Eline, Van Riet Ivan, 2016
Bilirubin ameliorates murine atherosclerosis through inhibiting cholesterol synthesis and reshaping the immune system, Wen Guanmei, Yao Leyi, Hao Yali, Wang Jinheng, Liu Jinbao, 2022
Induction of Heme Oxygenase-1 Modifies the Systemic Immunity and Reduces Atherosclerotic Lesion Development in ApoE Deficient Mice, Yao Leyi, Hao Yali, Wen Guanmei, Xiao Qingzhong, Wu Penglong, Wang Jinheng, Liu Jinbao, 2022
Single-cell analysis at the protein level delineates intracellular signaling dynamic during hematopoiesis, Wang Jinheng, Tu Chenggong, Zhang Hui, Huo Yongliang, Menu Eline, Liu Jinbao, 2021
Identification of the immune checkpoint signature of multiple myeloma using mass cytometry-based single-cell analysis, Wang Jinheng, Zheng Yongjiang, Tu Chenggong, Zhang Hui, Vanderkerken Karin, Menu Eline, Liu Jinbao, 2020
Inhibition of multiple myeloma-derived exosomes uptake suppresses the functional response in bone marrow stromal cell, Zheng Yongjiang, Tu Chenggong, Zhang Jingwen, Wang Jinheng, 2019
Exosome-Based Cancer Therapy: Implication for Targeting Cancer Stem Cells, Wang Jinheng, Zheng Yongjiang, Zhao Meng, 2017

Exosomes Immune Microenvironment Tumor Development Drug Resistance Immunotherapy Tumor Targets Cancer Research Biomarkers Cell Communication Therapeutic Strategies

Genze Shao - Peking University

Yang Chen - Peking University

Qing Chang - Peking University

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