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Jinsai Shang
Basic Medical Sciences
Guangzhou Medical University
Guangdong
Language: English, Chinese
Antiviral
Antitumor
Small Molecules
Drug Development
Mechanism Of Action
Nuclear Receptors
Gpcrs
Structure
Function
High-Throughput Screening
Areas of Focus
- Development and mechanism of action of new small molecule drugs targeting antiviral and antitumor
- Structure and function of drug target nuclear receptors (NRs) and G protein-coupled receptors (GPCRs)
- Exploration of active compounds and high-throughput drug screening (HTS) based on antiviral and tumor drug targets
Work Experience
- 2015-2020 - Postdoctoral Research: The Scripps Research Institute
- Current - Researcher: Guangzhou Laboratory / Guangzhou Medical University
Academic Background & Achievements
- 2010 - Bachelor's Degree in Chemistry: Wuhan University
- 2015 - Ph.D. in Biochemistry: Southern Illinois University
- Chief Scientist of National Key R&D Program
- Published 22 SCI papers with a cumulative impact factor > 267
- Applied for 7 national patents
Publications
- PPARγ Modulators in Lung Cancer: Molecular Mechanisms, Clinical Prospects, and Challenges, Zhang J, Tang M*, Shang J*, 2024
- Structure-Activity Relationship and Biological Investigation of a REV-ERBα-Selective Agonist SR-29065 (34) for Autoimmune Disorders, He Y, Zhu D, Greenman K, Ruiz C, Shang J, Lu Q, Kojetin DJ, et al., Kamenecka TM, 2023
- Molecular basis of ligand-dependent Nurr1-RXRα activation, Yu X, Shang J, Kojetin DJ, 2023
- Structural Mechanism Underlying Ligand Binding and Activation of PPARγ, Shang J, Kojetin DJ, 2021
- CAR directs T cell adaptation to bile acids in the small intestine, Chen ML, Huang X, Wang H, Hegner C, Liu Y, Shang J, Eliason A, et al, Moore DD, Sundrud MS, 2021
- Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ, Mosure SA, Strutzenberg TS, Shang J, Munoz-Tello P, Solt LA, Griffin PR, Kojetin DJ, 2021
- A Molecular Switch Regulating Transcriptional Repression and Activation of PPARγ, Shang J, Mosure SA, Zheng J, Brust R, Bass J, Nichols A, Solt LA, Griffin PR and Kojetin DJ, 2020
- Quantitative Structural Assessment of Graded Receptor Agonism, Shang J, Brust R, Griffin PR, Kamenecka TM and Kojetin DJ, 2019
- Structural basis of altered potency and efficacy displayed by a major in vivo metabolite of the anti-diabetic PPARγ drug pioglitazone, Mosure S, Shang J, Eberhardt J, Brust R, Zheng J, Griffin PR, Forli S and Kojetin DJ, 2019
- Defining a canonical ligand-binding pocket in the orphan nuclear receptor Nurr1, de Vera IM, Munoz-Tello P, Zheng J, Dharmarajan V, Marciano DP, Matta-Camacho E, Giri PK, Shang J, et al., Kojetin DJ, 2019
- Cooperative Cobinding of Synthetic and Natural Ligands to the Nuclear Receptor PPARγ, Shang J, Brust R, Mosure SA, Bass J, Munoz-Tello P, Lin H, Hughes TS, Tang M, Ge Q, Kamenekca TM and Kojetin DJ, 2018
- A structural mechanism for directing corepressor-selective inverse agonism of PPARγ, Brust R, Shang J, Fuhrmann J, Mosure SA, Bass J, et al., Hughes TS and Kojetin DJ, 2018
- Defining a conformational ensemble that directs activation of PPARγ, Chrisman IM, Nemetchek MD#, De Vera IM#, Shang J#, Heidari Z, et al., Kojetin DJ and Hughes TS, 2018
- REV-ERBα Regulates TH17 Cell Development and Autoimmunity, Amir M, Chaudhari S, Wang R, Campbell S, Mosure SA, Chopp LB, Lu Q, Shang J, et al., Kojetin DJ, Kamenecka TM and Solt LA, 2018
- Chemical crosslinking mass spectrometry reveals the conformational landscape of the activation helix of PPARγ; a model for ligand-dependent antagonism, Zheng J, Corzo C, Chang MR, Shang J, Lam VQ, et al., Kojetin DJ and Griffin PR, 2018
- Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA, de Vera IMS, Zheng J, Novick S, Shang J, Hughes TS, et al., Griffin PR and Kojetin DJ, 2017
- Probing the complex binding modes of the PPARγ partial agonist (T2384) to orthosteric and allosteric sites with NMR spectroscopy, Hughes TS#, Shang J#, Brust R, de Vera IMS, Fuhrmann J, Ruiz C, Cameron MD, Kamenecka TM and Kojetin DJ, 2016
- Identification of a binding site for unsaturated fatty acids in the orphan nuclear receptor Nurr1, de Vera IM, Giri PK, Munoz-Tello P, Brust R, Fuhrmann J, Matta-Camacho E, Shang J, et al., Solt LA and Kojetin DJ, 2016
- The FP domains of PI31 and Fbxo7 have the same protein fold but very different modes of protein-protein interaction, Shang J, Huang X and Du Z, 2015
- Structure of the FP domain of Fbxo7 reveals a novel mode of protein–protein interaction, Shang J, Wang G, Yang Y, Huang X and Du Z, 2014
- Expression, purification and crystallization of the FP domain of the human F-box protein Fbxo7, Shang J, Wang G, Yang Y, Huang X and Du Z, 2013
- Fe-catalysed oxidative C–H functionalization /C–S bond formation, Wang H, Wang L, Shang J, Li X, Wang H, Gui J, Lei A, 2012
Awards
- 2023: Selected as Elite Talent (Innovation) in Guangzhou Huangpu District
- 2021: Selected for High-level Youth Talent Project
