Professor | 商锦赛 | 数字化转型顾问

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Name	商锦赛
Contact Information	shang_jinsai@gzlab.ac.cn
Language ability	英语, 中文
Province	广东

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Name

商锦赛

Contact Information

shang_jinsai@gzlab.ac.cn

Language ability

英语, 中文

Province

广东

University/Lab Affiliation and Title	广州医科大学
Faculty	Basic Medical Sciences
Academic Background & Achievements	2010 - 化学学士学位：武汉大学 2015 - 生物化学博士学位：美国南伊利诺伊大学国家重点研发计划首席科学家发表22篇SCI论文，累计影响因子>267 申请7项国家专利
Work Experience	2015-2020 - 博士后研究：美国斯克利普斯研究所现任 - 研究员：广州实验室 / 广州医科大学
Awards	2023年：入选广州市黄埔区广州开发区精英人才（创新） 2021年：入选高层次青年人才项目

University/Lab Affiliation and Title

广州医科大学

Faculty

Basic Medical Sciences

Academic Background & Achievements

2010 - 化学学士学位：武汉大学
2015 - 生物化学博士学位：美国南伊利诺伊大学
国家重点研发计划首席科学家
发表22篇SCI论文，累计影响因子>267
申请7项国家专利

Work Experience

2015-2020 - 博士后研究：美国斯克利普斯研究所
现任 - 研究员：广州实验室 / 广州医科大学

Awards

2023年：入选广州市黄埔区广州开发区精英人才（创新）
2021年：入选高层次青年人才项目

Areas of Focus	靶向抗病毒与抗肿瘤等新药小分子开发与作用机制药物靶标激素核受体(NRs)与G蛋白偶联受体(GPCRs)的结构与功能基于抗病毒与肿瘤药物靶点的活性化合物探究与高通量药物筛选（HTS）
Publications	PPARγ Modulators in Lung Cancer: Molecular Mechanisms, Clinical Prospects, and Challenges, Zhang J, Tang M, Shang J, 2024 Structure-Activity Relationship and Biological Investigation of a REV-ERBα-Selective Agonist SR-29065 (34) for Autoimmune Disorders, He Y, Zhu D, Greenman K, Ruiz C, Shang J, Lu Q, Kojetin DJ, et al., Kamenecka TM, 2023 Molecular basis of ligand-dependent Nurr1-RXRα activation, Yu X, Shang J, Kojetin DJ, 2023 Structural Mechanism Underlying Ligand Binding and Activation of PPARγ, Shang J, Kojetin DJ, 2021 CAR directs T cell adaptation to bile acids in the small intestine, Chen ML, Huang X, Wang H, Hegner C, Liu Y, Shang J, Eliason A, et al, Moore DD, Sundrud MS, 2021 Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ, Mosure SA, Strutzenberg TS, Shang J, Munoz-Tello P, Solt LA, Griffin PR, Kojetin DJ, 2021 A Molecular Switch Regulating Transcriptional Repression and Activation of PPARγ, Shang J, Mosure SA, Zheng J, Brust R, Bass J, Nichols A, Solt LA, Griffin PR and Kojetin DJ, 2020 Quantitative Structural Assessment of Graded Receptor Agonism, Shang J, Brust R, Griffin PR, Kamenecka TM and Kojetin DJ, 2019 Structural basis of altered potency and efficacy displayed by a major in vivo metabolite of the anti-diabetic PPARγ drug pioglitazone, Mosure S, Shang J, Eberhardt J, Brust R, Zheng J, Griffin PR, Forli S and Kojetin DJ, 2019 Defining a canonical ligand-binding pocket in the orphan nuclear receptor Nurr1, de Vera IM, Munoz-Tello P, Zheng J, Dharmarajan V, Marciano DP, Matta-Camacho E, Giri PK, Shang J, et al., Kojetin DJ, 2019 Cooperative Cobinding of Synthetic and Natural Ligands to the Nuclear Receptor PPARγ, Shang J, Brust R, Mosure SA, Bass J, Munoz-Tello P, Lin H, Hughes TS, Tang M, Ge Q, Kamenekca TM and Kojetin DJ, 2018 A structural mechanism for directing corepressor-selective inverse agonism of PPARγ, Brust R, Shang J, Fuhrmann J, Mosure SA, Bass J, et al., Hughes TS and Kojetin DJ, 2018 Defining a conformational ensemble that directs activation of PPARγ, Chrisman IM, Nemetchek MD#, De Vera IM#, Shang J#, Heidari Z, et al., Kojetin DJ and Hughes TS, 2018 REV-ERBα Regulates TH17 Cell Development and Autoimmunity, Amir M, Chaudhari S, Wang R, Campbell S, Mosure SA, Chopp LB, Lu Q, Shang J, et al., Kojetin DJ, Kamenecka TM and Solt LA, 2018 Chemical crosslinking mass spectrometry reveals the conformational landscape of the activation helix of PPARγ; a model for ligand-dependent antagonism, Zheng J, Corzo C, Chang MR, Shang J, Lam VQ, et al., Kojetin DJ and Griffin PR, 2018 Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA, de Vera IMS, Zheng J, Novick S, Shang J, Hughes TS, et al., Griffin PR and Kojetin DJ, 2017 Probing the complex binding modes of the PPARγ partial agonist (T2384) to orthosteric and allosteric sites with NMR spectroscopy, Hughes TS#, Shang J#, Brust R, de Vera IMS, Fuhrmann J, Ruiz C, Cameron MD, Kamenecka TM and Kojetin DJ, 2016 Identification of a binding site for unsaturated fatty acids in the orphan nuclear receptor Nurr1, de Vera IM, Giri PK, Munoz-Tello P, Brust R, Fuhrmann J, Matta-Camacho E, Shang J, et al., Solt LA and Kojetin DJ, 2016 The FP domains of PI31 and Fbxo7 have the same protein fold but very different modes of protein-protein interaction, Shang J, Huang X and Du Z, 2015 Structure of the FP domain of Fbxo7 reveals a novel mode of protein–protein interaction, Shang J, Wang G, Yang Y, Huang X and Du Z, 2014 Expression, purification and crystallization of the FP domain of the human F-box protein Fbxo7, Shang J, Wang G, Yang Y, Huang X and Du Z, 2013 Fe-catalysed oxidative C–H functionalization /C–S bond formation, Wang H, Wang L, Shang J, Li X, Wang H, Gui J, Lei A, 2012

Areas of Focus

靶向抗病毒与抗肿瘤等新药小分子开发与作用机制
药物靶标激素核受体(NRs)与G蛋白偶联受体(GPCRs)的结构与功能
基于抗病毒与肿瘤药物靶点的活性化合物探究与高通量药物筛选（HTS）

Publications

PPARγ Modulators in Lung Cancer: Molecular Mechanisms, Clinical Prospects, and Challenges, Zhang J, Tang M*, Shang J*, 2024
Structure-Activity Relationship and Biological Investigation of a REV-ERBα-Selective Agonist SR-29065 (34) for Autoimmune Disorders, He Y, Zhu D, Greenman K, Ruiz C, Shang J, Lu Q, Kojetin DJ, et al., Kamenecka TM, 2023
Molecular basis of ligand-dependent Nurr1-RXRα activation, Yu X, Shang J, Kojetin DJ, 2023
Structural Mechanism Underlying Ligand Binding and Activation of PPARγ, Shang J, Kojetin DJ, 2021
CAR directs T cell adaptation to bile acids in the small intestine, Chen ML, Huang X, Wang H, Hegner C, Liu Y, Shang J, Eliason A, et al, Moore DD, Sundrud MS, 2021
Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ, Mosure SA, Strutzenberg TS, Shang J, Munoz-Tello P, Solt LA, Griffin PR, Kojetin DJ, 2021
A Molecular Switch Regulating Transcriptional Repression and Activation of PPARγ, Shang J, Mosure SA, Zheng J, Brust R, Bass J, Nichols A, Solt LA, Griffin PR and Kojetin DJ, 2020
Quantitative Structural Assessment of Graded Receptor Agonism, Shang J, Brust R, Griffin PR, Kamenecka TM and Kojetin DJ, 2019
Structural basis of altered potency and efficacy displayed by a major in vivo metabolite of the anti-diabetic PPARγ drug pioglitazone, Mosure S, Shang J, Eberhardt J, Brust R, Zheng J, Griffin PR, Forli S and Kojetin DJ, 2019
Defining a canonical ligand-binding pocket in the orphan nuclear receptor Nurr1, de Vera IM, Munoz-Tello P, Zheng J, Dharmarajan V, Marciano DP, Matta-Camacho E, Giri PK, Shang J, et al., Kojetin DJ, 2019
Cooperative Cobinding of Synthetic and Natural Ligands to the Nuclear Receptor PPARγ, Shang J, Brust R, Mosure SA, Bass J, Munoz-Tello P, Lin H, Hughes TS, Tang M, Ge Q, Kamenekca TM and Kojetin DJ, 2018
A structural mechanism for directing corepressor-selective inverse agonism of PPARγ, Brust R, Shang J, Fuhrmann J, Mosure SA, Bass J, et al., Hughes TS and Kojetin DJ, 2018
Defining a conformational ensemble that directs activation of PPARγ, Chrisman IM, Nemetchek MD#, De Vera IM#, Shang J#, Heidari Z, et al., Kojetin DJ and Hughes TS, 2018
REV-ERBα Regulates TH17 Cell Development and Autoimmunity, Amir M, Chaudhari S, Wang R, Campbell S, Mosure SA, Chopp LB, Lu Q, Shang J, et al., Kojetin DJ, Kamenecka TM and Solt LA, 2018
Chemical crosslinking mass spectrometry reveals the conformational landscape of the activation helix of PPARγ; a model for ligand-dependent antagonism, Zheng J, Corzo C, Chang MR, Shang J, Lam VQ, et al., Kojetin DJ and Griffin PR, 2018
Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA, de Vera IMS, Zheng J, Novick S, Shang J, Hughes TS, et al., Griffin PR and Kojetin DJ, 2017
Probing the complex binding modes of the PPARγ partial agonist (T2384) to orthosteric and allosteric sites with NMR spectroscopy, Hughes TS#, Shang J#, Brust R, de Vera IMS, Fuhrmann J, Ruiz C, Cameron MD, Kamenecka TM and Kojetin DJ, 2016
Identification of a binding site for unsaturated fatty acids in the orphan nuclear receptor Nurr1, de Vera IM, Giri PK, Munoz-Tello P, Brust R, Fuhrmann J, Matta-Camacho E, Shang J, et al., Solt LA and Kojetin DJ, 2016
The FP domains of PI31 and Fbxo7 have the same protein fold but very different modes of protein-protein interaction, Shang J, Huang X and Du Z, 2015
Structure of the FP domain of Fbxo7 reveals a novel mode of protein–protein interaction, Shang J, Wang G, Yang Y, Huang X and Du Z, 2014
Expression, purification and crystallization of the FP domain of the human F-box protein Fbxo7, Shang J, Wang G, Yang Y, Huang X and Du Z, 2013
Fe-catalysed oxidative C–H functionalization /C–S bond formation, Wang H, Wang L, Shang J, Li X, Wang H, Gui J, Lei A, 2012

抗病毒抗肿瘤小分子药物开发作用机制核受体 Gpcrs 结构功能高通量筛选

商锦赛 - 广州医科大学

袁春华 - 南方医科大学

王应 - 北京大学

Area of Focus
趋化因子 | 人类基因组 | 基因表达 | 结构 | 功能 | 机制 | 药物开发 | 创新 | 疾病 | 生物医学研究

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