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Fengyan Han
Basic Medical Sciences
Guangzhou Medical University
Guangdong
Language: Chinese, English
Transcription
Tumor
Regulation
Gltscr1
Colorectal Cancer
Embryonic Development
Protein Transport
Nuclear Transport
Chromatin Remodeling
Mechanism
Areas of Focus
- Precise transcriptional regulation in tumor progression
- Biological function of GLTSCR1 in colorectal cancer and embryonic development
- Mechanism of protein nuclear transport and nuclear-cytoplasmic transport disorder in tumors
- Dynamic regulation of chromatin remodeling in tumor progression
Work Experience
- 2023.07 - Present Guangzhou Medical University, School of Basic Medical Sciences, Department of Pathology, Distinguished Professor
- 2020.01 - 2022.12 Zhejiang University School of Medicine, Postdoctoral Researcher in Clinical Medicine
Academic Background & Achievements
- 2014.09 - 2019.06 PhD in Pathology and Pathophysiology: Zhejiang University
- 2009.09 - 2014.06 Bachelor's in Basic Medicine: Southern Medical University
Publications
- GLTSCR1 Negatively Regulates BRD4-Dependent Transcription Elongation and Inhibits CRC Metastasis, Fengyan Han, Lei Zhang, Chaoyi Chen, Yan Wang, Yi Zhang, Lili Qian, Wenjie Sun, Dan Zhou, Beibei Yang, Honghe Zhang, Maode Lai, 2019
- Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription, Fengyan Han, Beibei Yang, Yan Chen, Lu Liu, Xiaoqing Cheng, Jiaqi Huang, Ke Zhou, Dandan Zhang, Enping Xu, Maode Lai, Bingjian Lv, Hongqiang Cheng, Honghe Zhang, 2023
- The interaction between S100A2 and KPNA2 mediates NFYA nuclear import and is a novel therapeutic target for colorectal cancer metastasis, Fengyan Han, Lei Zhang, Shaoxia Liao, Yanmin Zhang, Lili Qian, Feijun Hou, Jingwen Gong, Maode Lai, Honghe Zhang, 2022
- GLTSCR1 coordinates alternative splicing and transcription elongation of ZO1 to regulate colorectal cancer progression, Fengyan Han, Beibei Yang, Ming yue Zhou, Qiong Huang, Minglang Mai, Zhaohui Huang, Maode Lai, Enping Xu, Honghe Zhang, 2022
- Tumor-suppressive circRHOBTB3 is excreted out of cells via exosome to sustain colorectal cancer cell fitness, Chaoyi Chen, Hongfei Yu, Fengyan Han, Xuan Lai, Kehong Ye, Siqin Lei, Minglang Mai, Maode Lai, Honghe Zhang, 2022
- Long Noncoding RNA MIR4435-2HG Suppresses Colorectal Cancer Initiation and Progression By Reprogramming Neutrophils, Hongfei Yu, Chaoyi Chen, Fengyan Han, Jinlong Tang, Mengli Deng, Yumiao Niu, Maode Lai, Honghe Zhang, 2022
